http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yewon Kang,Ji-Eun Park,Heeji Shin,So-Young Kang,Nam Soo Han,Tae-Jip Kim 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
Arabinans can be synergistically degraded into L-arabinose and arabinooligosaccharides (AOS) by the actions of exo-arabinofuranosidase (AF) and endo-arabinanase (ABN). Bifidobacterium spp., the well-known probiotic bacteria, were reported to utilize linear AOS as the prebiotic carbohydrates. Two different endo-arabinanase genes were previously found and cloned from the genome of Bifidobacterium longum subsp. suis DSM 20211. In this study, the modes of action for both endo-arabinanases, BflsABN-B1 and B2, were comparatively characterized, and their gene cluster was analyzed in detail. The gene cluster analysis revealed that the corresponding contig 11 of Bf. longum subsp. suis includes several putative exo-acting AF genes, the ABC transporter-related genes, ATP-binding protein genes, as well as both ABNs-B. According to the gene cluster analysis, the extracellular BflsABN-B1 hydrolyzes arabinan polymers to the short chain AOS, which are imported into the cell membrane through the ABC transporters. Within a cell, AOS can be hydrolyzed into L-arabinose by an intracellular BflsABN-B2 and various exo-AFs. These results proposed the hypothetical enzymatic system for the arabinan utilization in Bf. longum subsp. suis.
Utilization of Preventive Therapy in Korean Migraine Patients
Yewon Kim,Susin Park,Eonjeong Kim,Nam Kyung Je 한국임상약학회 2021 한국임상약학회지 Vol.31 No.1
Background: Migraine is a common neurological disorder that affects the quality of life and causes several health problems. Preventive migraine treatment can reduce migraine frequency, headache severity, and health care costs. This study aimed to estimate the utilization of migraine preventive therapy and associated factors in eligible patients. Methods: We studied 534 patients with migraine who were eligible for migraine preventive therapy using 2017 National Patient Sample (NPS) data from the Health Insurance Review and Assessment Service (HIRA). We estimated the migraine days by calculating the monthly average number of defined daily dose (DDD) of migraine-specific acute drug. Patients with a monthly average number of DDD of 4 or more were considered as subjects for preventive treatment. Chi-square test and multiple logistic regression analysis were used to determine the association between the preventive therapy and the influencing variables. Results: Less than half of the eligible patients for prophylaxis (n=234, 43.8%) were prescribed preventive therapy. Multiple logistic regression results show that migraine preventive therapy was influenced by age, the type of migraine, and some comorbidities. Patients over the age of 50 tend to receive less prophylactic treatment than under the age of 40. On the other hand, migraine patients with epilepsy or depression were more likely to receive preventive therapy. Sumatriptan was the most preferred medication for acute treatment, and propranolol was the most commonly prescribed drug for prevention. Conclusions: More than half of the patients who were candidates for migraine prophylaxis were not receiving suitable preventive treatment. Positive factors affecting the use of migraine prevention were the presence of comorbidities such as epilepsy and depression.
Yewon Park,WonTae Jung,양은솔,Kyu-Yeol Nam,Woo-Ri Bong,Jaehee Kim,Kyu Yeon Kim,SeungHwan Lee,Joo-Youn Cho,Jang-Hee Hong,JaeWoo Kim 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.1
UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract and Coptis extract. The bioactive compounds of Pelargonium sidoides and Coptisextracts were identified as epicatechin and berberine, respectively. This study evaluated the effect of food on the pharmacokinetics (PKs) and safety of UI026. A randomized, openlabel, single-dose, 2-treatment, parallel study in 12 healthy male subjects was performed. Subjects received a single oral dose of UI026 (27 mL of syrup) under a fed or fasted condition according to their randomly assigned treatment. Blood samples for the PK analysis were obtained up to 24 hours post-dose for berberine and 12 hours post-dose for epicatechin. The PK parameters were calculated by non-compartmental analysis. In the fed condition, the mean maximum plasma concentration (C max ) and mean area under the plasma concentrationtime curve from time zero to the last observed time point (AUC last ) for berberine were approximately 33% and 67% lower, respectively, compared with the fasted condition, both showing statistically significant difference. For epicatechin, the mean C max and mean AUC lastwere about 29% and 45% lower, respectively, compared to the fasting condition, neither of which showed a statistically significant difference. There were no drug-related adverse events. This finding suggests that food affects the systemic exposure and bioavailability of berberine and epicatechin.
Choi, Yewon,Lee, Sang Won,Kim, Anhye,Jang, Kyungho,Nam, Heesook,Cho, Young Lag,Yu, Kyung-Sang,Jang, In-Jin,Chung, Jae-Yong Oxford University Press 2018 The Journal of antimicrobial chemotherapy Vol.73 No.1
<P>Conclusions: LCB01-0371 is well tolerated in healthy male subjects with comparable haematology profiles to placebo, after multiple doses of up to 1200 mg twice daily for 21 days.</P>
Ji-Eun Park,Yewon Kang,Chang-Yun Choi,Sung Hwan Jeon,Nam Soo Han,Tae-Jip Kim 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
endo-(1,5)-α-L-Arabinanase (ABN, EC 3.2.1.99) is an endo-acting arabinosyl hydrolase that can cleave α-(1,5)-L-arabinofuranosidic linkages in arabinan and arabinooligosaccharides(AOS). In the present study, a putative gene encoding ABN (LbshABN-B) has been found from the genome of Lactobacillus shenzhenensis LY-73 which is isolated from a dairy beverage in China's Shenzhen market. The open reading frame of LbshABN-B consists of total 1,242 bp nucleotides encoding 414 amino acids with a predicted signal peptide of 24 amino acids. The molecular mass of LbshABN-B without signal peptide is 46.2 kDa. It shares approximately 50% of amino acid sequence identities with the other known ABNs type-B, whereas it showed less than 29% of sequence identities with ABNs type-A. The LbshABN-B gene being fused with six-histidines at its C-terminus was constitutively expressed and purified from Escherichia coli. Although the debranched (linear) arabinan is the most preferred substrate, LbshABN-B showed the significant activity towards sugar beet (branched) arabinan as well. This enzyme showed the highest activity on debranched arabinan at 45oC and pH 6.0 in 50 mM sodium acetate buffer, respectively. LbshABN-B can be applicable to the production of various branched AOS from sugar beet arabinan.
( Gyo Won Oh ),( Yewon Kang ),( Chang-yun Choi ),( So-yeong Kang ),( Jung-hyun Kang ),( Min-jae Lee ),( Nam Soo Han ),( Tae-jip Kim ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.1
The gene encoding an α-L-arabinofuranosidase (BvAF) GH51 from Bacillus velezensis FZB42 was cloned and expressed in Escherichia coli. The corresponding open reading frame consists of 1,491 nucleotides which encode 496 amino acids with the molecular mass of 56.9 kDa. BvAF showed the highest activity against sugar beet (branched) arabinan in 50 mM sodium acetate buffer (pH 6.0) at 45℃. However, it could hardly hydrolyze debranched arabinan and arabinoxylans. The time-course hydrolyses of branched arabinan and arabinooligosaccharides (AOS) revealed that BvAF is a unique exo-hydrolase producing exclusively L-arabinose. BvAF could cleave α-(1,2)- and/or α-(1,3)-L-arabinofuranosidic linkages of the branched substrates to produce the debranched forms of arabinan and AOS. Although the excessive amount of BvAF could liberate L-arabinose from linear AOS, it was extremely lower than that on branched AOS. In conclusion, BvAF is the arabinan-specific exo-acting α-L-arabinofuranosidase possessing high debranching activity towards α-(1,2)- and/or α-(1,3)-linked branches of arabinan, which can facilitate the successive degradation of arabinan by endo-α-(1,5)-Larabinanase.