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      • Study on Effect of Massage Technique based on Chaos Theory

        Ping Feng,Xiao-li Wang,Chao Zhang,Wei Sun,Dai-min Chen 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.12

        According to the mechanism of EMG signal, we know that the sacrificial electrical signal is with weak signal, low frequency, alternating, nonlinear and non-stationary characteristics. Nonlinear analysis includes higher order spectral analysis and fractal and chaos analysis.Chaos theory is one of the main parts of nonlinear science, and the electrical signal of the surface has a strong randomness, so we could consider the nonlinear analysis of EMG signals from the perspective of chaos. We mainly studied on the nonlinear analysis algorithm of EMG signal detailedly in this paper. Experiments show that,according to the quantitative analysis of several important parameters of rolling massage with chaos theory, we can measure objectively the action situation of related muscle groups in the operation course, then guide the professional massage students to understand the norms of operation in training of operation and help to lead their manipulation to the best power structure.

      • Regulatory Mechanisms of Annexin-Induced Chemotherapy Resistance in Cisplatin Resistant Lung Adenocarcinoma

        Wang, Chao,Xiao, Qian,Li, Yu-Wen,Zhao, Chao,Jia, Na,Li, Rui-Li,Cao, Shan-Shan,Cui, Jia,Wang, Lu,Wu, Yin,Wen, Ai-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

        Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.

      • KCI등재

        Discussion on the Religiousness of Confucianism in the Past Century

        ( Wang Xiao-chao ) 성균관대학교 유교문화연구소 2017 儒敎文化硏究(中文版) Vol.0 No.27

        百年來對於儒家宗敎性問題的討論, 呈現出多種思想匯流交錯的格局。胡適、馮友蘭一直到陳來所代表的理性人文主義, 在相當長的時間內都占據主流。在這個大的背景下, 很多哲學以及宗敎社會學學者, 將宗敎性視爲儒家思想的殘餘。牟宗三、唐君毅等以“內在超越”來解釋儒家“天人合一”的宗敎性, 其主張影響深遠。任繼愈、李申出於批判傳統社會現實的需要, 認爲儒家就是宗敎;而蔣慶、陳明等重提康有爲孔敎論, 意圖將儒家重建爲國敎或公民宗敎。然而, 大多數學者幷不接受“儒家是敎”, 而僅肯定儒家有終極關懷。著眼於社會實踐, 安樂哲認爲儒家是“以禮爲中心”的角色倫理, 在社群對個體的塑造過程中體現出相當的宗敎性;而著眼於個人的修身實踐, 張學智等也論述了傳統士大夫實現終極關懷的功夫論進路。最終, 與“內在超越”一脈相承, 杜維明提出精神性人文主義, 堅決區別於缺乏宗敎關懷的凡俗人文主義。同時, 他也指出, “內在超越”的儒家傳統可以與“外在超越”的西方宗敎傳統幷行不悖, 互相對話。 There have been wide-ranging discussions on the religiousness of Confucianism in the past century. The rational humanism occupied the mainstream for quite long time. In the context of rational humanism, many philosophers and sociologists regard the religiousness of Confucianism as remains. Mou Zongsan proposes the theory of “immanent transcendence” to explain the “unity of heaven and man.” For negative or positive purposes, some scholars consider Confucianism as a religion. Meanwhile, many others offer different interpretations: Confucianism only has ultimate concern in either social or personal practice. Tu Weiming proposes “spiritual humanism” to draw a clear distinction from “secular humanism.” He also points out that “immanent transcendence” and “external transcendence” can develop independently and should engage in meaningful cultural dialogue. [Article in Chinese]

      • KCI등재

        Elongation Prediction of Steel-Strips in Annealing Furnace with Deep Learning via Improved Incremental Extreme Learning Machine

        Chao Wang,Jian-Hui Wang,Shu-Sheng Gu,Xiao Wang,Yu-Xian Zhang 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.3

        The elongation of steel-strips in annealing furnace is an important factor that affects the position ofwelding line and safety of air-knife since there is no extra space to install welding line detector in field conditions. Therefore, predicting the elongation of steel-strips in the annealing process is important to fulfill the requirementsof eliminating security risks and improving economic performance. In this paper, we propose a deep architecturescalled I-ELM/MLCSA autoencoders with the concept of stacked generalization philosophy to solve large and complexdata mining problems. The comparison results of the case studies indicate that D-ELMs-AE/MLCSA is apromising prediction algorithm and can be employed for steel-strips elongation predictions with excellent performance.

      • Taxol Produced from Endophytic Fungi Induces Apoptosis in Human Breast, Cervical and Ovarian Cancer Cells

        Wang, Xin,Wang, Chao,Sun, Yu-Ting,Sun, Chuan-Zhen,Zhang, Yue,Wang, Xiao-Hua,Zhao, Kai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

        Currently, taxol is mainly extracted from the bark of yews; however, this method can not meet its increasing demand on the market because yews grow very slowly and are a rare and endangered species belonging to first-level conservation plants. Recently, increasing efforts have been made to develop alternative means of taxol production; microbe fermentation would be a very promising method to increase the production scale of taxol. To determine the activities of the taxol extracted from endophytic fungus N. sylviforme HDFS4-26 in inhibiting the growth and causing the apoptosis of cancer cells, on comparison with the taxol extracted from the bark of yew, we used cellular morphology, cell counting kit (CCK-8) assay, staining (HO33258/PI and Giemsa), DNA agarose gel electrophoresis and flow cytometry (FCM) analyses to determine the apoptosis status of breast cancer MCF-7 cells, cervical cancer HeLa cells and ovarian cancer HO8910 cells. Our results showed that the fungal taxol inhibited the growth of MCF-7, HeLa and HO8910 cells in a dose-and time-dependent manner. IC50 values of fungal taxol for HeLa, MCF-7 and HO8910 cells were $0.1-1.0{\mu}g/ml$, $0.001-0.01{\mu}g/ml$ and $0.01-0.1{\mu}g/ml$, respectively. The fungal taxol induced these tumor cells to undergo apoptosis with typical apoptotic characteristics, including morphological changes for chromatin condensation, chromatin crescent formation, nucleus fragmentation, apoptotic body formation and G2/M cell cycle arrest. The fungal taxol at the $0.01-1.0{\mu}g/ml$ had significant effects of inducing apoptosis between 24-48 h, which was the same as that of taxol extracted from yews. This study offers important information and a new resource for the production of an important anticancer drug by endofungus fermentation.

      • SCIESCOPUSKCI등재
      • KCI등재

        Beneficial effects of natural Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats

        Yan-chao Wang,Jin-miao Lu,Hui-zi Jin,Ai-niu Ma,Jin-yang Zhang,Nian Gong,Qi Xiao,Bin Zhu,Ying-fang Lv,Na Yu,Wei-dong Zhang,Yong-xiang Wang 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2

        BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (SamdasooTM), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.

      • KCI등재

        Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle

        Xiao Gang Weng,Quan Jiang Song,Qiong Wu,Ming Chao Liu,Meng Ling Wang,Jiu Feng Wang 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.4

        To acquire epidemiological data on the bovine viral diarrhea virus (BVDV) and identify cattle persistently infected (PI) with this virus, 4,327 samples from Holstein dairy cows were screened over a four-year period in Beijing, China. Eighteen BVD viruses were isolated, 12 from PI cattle. Based on genetic analysis of their 5’-untranslated region (5’-UTR), the 18 isolates were assigned to subgenotype BVDV-1m, 1a, 1d, 1q, and 1b. To investigate the innate immune responses in the peripheral-blood mononuclear cells of PI cattle, the expression of Toll-like receptors (TLRs), RIG-I-like receptors, interferon-a (IFN-a), IFN-b, myxovirus (influenza virus) resistance 1 (MX1), and interferon stimulatory gene 15 (ISG15) was assessed by qPCR. When compared with healthy cattle, the expression of TLR-7, IFN-a, and IFN-b mRNA was downregulated, but the expression of MX1 and ISG-15 mRNA was upregulated in PI cattle. Immunoblotting analysis revealed that the expression of interferon regulatory factor 3 (IRF-3) and IRF-7 was lower in PI cattle than in healthy cattle. Thus, BVDV-1m and 1a are the predominant subgenotypes in the Beijing region, and the strains are highly divergent. Our findings also suggest that the TLR-7/IRF-7 signaling pathway plays a role in evasion of host restriction by BVDV.

      • Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

        Wang, Xue-Jun,Zeng, Xian-Tao,Duan, Xiao-Li,Zeng, Huan-Chao,Shen, Rui,Zhou, Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

        Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor. Methods: PubMed was searched up to May $10^{th}$, 2012 for relevant studies, and references of included studies were manually searched. Finally 13 eligible studies, involving 12,636 cases and 38,419 controls were identified. After data extraction, a meta-analysis was performed using CMA v2 software. Results: The results indicated there may be a weak but not statistically significant reduced risk of colorectal cancer with high dose of green tea intake (OR=0.95, 95% CI:0.81-1.11, p=0.490.69-0.98). This protective effect was also found in all subgroups, except in American and European populations. Sensitivity analysis indicated the result to be robust. Publication bias was not detected by either funnel plot or Egger tests. Conclusion: The results of this meta-analysis indicate a weak lower tendency for colorectal cancer development with green tea consumption, but available epidemiologic data are insufficient to conclude that green tea may protect against colorectal cancer in humans.

      • KCI등재

        A Fault Diagnostic Method for Position Sensor of Switched Reluctance Wind Generator

        Chao Wang,Xiao Liu,Hui Liu,Zhe Chen 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

        Fast and accurate fault diagnosis of the position sensor is of great significance to ensure the reliability as well as sensor fault tolerant operation of the Switched Reluctance Wind Generator (SRWG). This paper presents a fault diagnostic scheme for a SRWG based on the residual between the estimated rotor position and the actual output of the position sensor. Extreme Learning Machine (ELM), which could build a nonlinear mapping among flux linkage, current and rotor position, is utilized to design an assembled estimator for the rotor position detection. The data for building the ELM based assembled position estimator is derived from the magnetization curves which are obtained from Finite Element Analysis (FEA) of an SRWG with the structure of 8 stator poles and 6 rotor poles. The effectiveness and accuracy of the proposed fault diagnosis method are verified by simulation at various operating conditions. The results provide a feasible theoretical and technical basis for the effective condition monitoring and predictive maintenance of SRWG.

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