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Medicinal Chemistry : ELSEVIER ; Enantioselective syntheses of (+) and (-) - brazilin
( Umair Javed ),( Moinul Karim ),( Katherine C. Jahng ),( Jae Gyu Park ),( Yurng Dong Jahng ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Two enantiomers of brazilin were prepared in 9 steps from 7-hydroxychroman-4-one using the AD-mix-α and AD-mix-β-directed enantioselective dihydroxylation of 3-(4-hydroxy-3-methoxy-phenyl)-2H-chromen-7-ol as a key step. ⓒ 2014 Elsevier Ltd. All rights reserved.
Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase
Liang, Jing Lu,Javed, Umair,Lee, Seung Ho,Park, Jae Gyu,Jahng, Yurngdong 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at $IC_{50}=18.3{\mu}M$.
RESEARCH ARTICLE : Synthesis of 6-dexymollugins and their inhibitory activities on tyrosinase
( Jing Lu Liang ),( Umair Javed ),( Seung Ho Lee ),( Jae Gyu Park ),( Yurngdong Jahng ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at IC50 = 18.3 μM.
Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase
Jing Lu Liang,Umair Javed,이승호,박재규,장영동 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Aseries of 6-deoxymollugins were prepared fivesteps from benzaldehyde and its derivatives via phenylboronicacid-catalyzed chromenylation as a key step. Theirinhibitory activities against tyrosinase from mushroom wereevaluated to show that the parent, methyl 2,2-dimethyl-2Hbenzo[h]chromene-5-carboxylate (9a) showed best andpromising inhibitory activity at IC50 = 18.3 lM.
Component Alignment in Simultaneous Bilateral versus Unilateral Total Knee Arthroplasty
Irfan Qadir,Bahar Shah,Muhammad Waqas,Umair Ahmad,Shahzad Javed,Amer Aziz 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.1
Purpose: The purpose of this study was to investigate differences in component alignment between first and second knees in simultaneous bilateral total knee arthroplasty (SBTKA) and unilateral TKA (UTKA).Materials and Methods: 274 SBTKAs and 198 UTKAs were included in study. Patients were divided into three groups as SBTKA on the right knee (group A), SBTKA on the left knee (group B) and UTKA (group C). Femoral and tibial component alignment was checked in both coronal plane (alpha [α] and beta [β] angles) and sagittal plane (gamma [γ] and delta [δ] angles) radiographs.Results: There were no statistically significant differences among groups in the preoperative anatomical varus angle and Kellgren–Lawrence gonarthrosis classification grade (p=0.139 and p=0.329, respectively). In the coronal plane, the alignment of femoral component (α angle) and tibial component (β angle) was similar in all three groups (α angle, 95.01 vs. 95.14 vs. 94.9, p=0.945; β angle, 90.03 vs. 89.67 vs. 89.98, p=0.483). The sagittal plane alignment of femoral component (γ angle) and tibial component (δ angle) did not show significant differences (γ angle, 7.04 vs. 6.98 vs. 7.00, p=0.132; δ angle, 86.56 vs. 87.41 vs. 86.73, p=0.610).Conclusions: The angular alignment of components was similar between SBTKA and UTKA.
Mubashir Ali Siddiqui,Hassan Ahmed,Muhammad Bilal Javed,Umair Shahid 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1
This study aims to present a parametric analysis of combined use of two surge protection devices in a relatively very long up-pumping water supply pipeline. Transient conditions are induced by sudden pump tripping. The effects of four parameters of hydropneumatic tank, i.e., polytropic exponent, initial air volume, orifice diameter and wave celerity and two parameters of surge tank, i.e., tank volume and tank orifice diameter are investigated on pressure surges. The parameters are optimized to achieve reduced pressure fluctuations throughout the pipe length. A numerical model is developed to perform hydraulic transient analysis in the pipeline system. Governing partial differential equations for unsteady flows are solved by the method of characteristics (MOC) and are subsequently converted into algebraic form using finite difference method. To establish the authenticity of the model, it is experimentally validated by comparing the model results with the experimental results. The validated model is then employed to analyze the effects of various parameters of the two surge protection devices on pressure fluctuations along the pipe length. The results obtained from the study are optimized for safe operation and economic use of the system.
Muhammad Altaf Nazir,Tayyaba Najam,Muhammad Sohail Bashir,Muhammad Sufyan Javed,Muhammad Aswad Bashir,Muhammad Imran,Umair Azhar,Syed Shoaib Ahmad Shah,Aziz ur Rehman 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.1
The use of highly efficient, environment-friendly and economically inexpensive materials for the adsorption removal of contaminants from water has always been considered as emerging task. In this study, we synthesized hybrid tri-metallic nickel cobalt layered double hydroxide (NiCoAl-LDH) porous material for the adsorption removal of Eosin yellow (EY) and Malachite green (MG) from water. The characterization results disclosed that tri-metallic LDH has been synthesized with extraordinary purity, identical morphology and high surface area (134.21 m2·g−1). The NiCoAl-LDH performs the best for adsorption of EY (qe=37.30mg·g−1 at pH=2) and MG (qe=39.61 mg·g−1 at pH=10). The Langmuir and Freundlich isotherm models were applied to explain the adsorption process of dyes on the surface of LDH. The Langmuir model (R2=0.991 and 0.999 for Eosin Y and Malachite G, respectively) was very appropriate to explain the process of adsorption on NiCoAl-LDH as homogeneous (monolayer). The maximum adsorption capacity of EY and MG calculated with Langmuir model was 78.74 and 110.13 mg·g−1 at 30 °C, respectively. Also with 240 minutes contact time 94.8% EY and 89.9% MG was adsorbed by as synthesized NiCoAl-LDH nanosheets. The NiCoAl-LDH nanosheets showed excellent performance of reusability of up to five regeneration cycles. The results showed that the adsorption capacity of NiCoAl-LDH nanosheets after five regeneration cycles, to adsorb EY, decreased only from 40.80 to 36.93 mg·g−1 and that of MG from 79.21 to 75.42 mg·g−1, which is acceptable. The overall results Suggest that the fabricated NiCoAl-LDH is favorable for the purification of dye contaminated water.