GRAPHENE AS TUNABLE STATIONARY PHASE ADDITIVE FOR ENANTIOSEPARATION

FEI-YUE TU,LIN-YAN YU,JIN-GANG YU,XIAOQING CHEN,QIANG FU,FEI-PENG JIAO,ZHI-GUANG PENG,TING ZHANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.6

Graphene-based biosensor and chiral sensor have made significant progress in recent years. Because of the similarity of the optical enantiomers, enantioseparation is perhaps the most subtle to achieve. Developing more effectively chiral separation techniques based on graphene is highly desirable. Herein, pristine graphene was prepared and then applicated to assist resolution of two racemic drugs of propranolol and ofloxacin using thin-layer chromatography (TLC). In comparison with TLC chiral separation by only using pure D-(-)-tartaric acid as a selector with relatively low degree of separation, a mixture of graphene and D-(-)-tartaric acid is more attractive, efficient and ready available. The high specific resolution ability for racemic compounds aided by graphene might allow its potential application in future chiral separation technologies.

The Development of Clinical Document Standards for Semantic Interoperability in China

Peng Yang,Feng Pan,Danhong Liu,Yongyong Xu,Yi Wan,Haibo Tu,Xuejun Tang,Jianping Hu 대한의료정보학회 2011 Healthcare Informatics Research Vol.17 No.4

Objectives: This study is aimed at developing a set of data groups (DGs) to be employed as reusable building blocks for the construction of the eight most common clinical documents used in China’s general hospitals in order to achieve their structural and semantic standardization. Methods: The Diagnostics knowledge framework, the related approaches taken from the Health Level Seven (HL7), the Integrating the Healthcare Enterprise (IHE), and the Healthcare Information Technology Standards Panel (HITSP) and 1,487 original clinical records were considered together to form the DG architecture and data sets. The internal structure, content, and semantics of each DG were then defined by mapping each DG data set to a corresponding Clinical Document Architecture data element and matching each DG data set to the metadata in the Chinese National Health Data Dictionary. By using the DGs as reusable building blocks, standardized structures and semantics regarding the clinical documents for semantic interoperability were able to be constructed. Results: Altogether, 5 header DGs, 48 section DGs, and 17 entry DGs were developed. Several issues regarding the DGs, including their internal structure, identifiers,data set names, definitions, length and format, data types, and value sets, were further defined. Standardized structures and semantics regarding the eight clinical documents were structured by the DGs. Conclusions: This approach of constructing clinical document standards using DGs is a feasible standard-driven solution useful in preparing documents possessing semantic interoperability among the disparate information systems in China. These standards need to be validated and refined through further study.

Timing-reliable Design of High-speed TigerSHARC 201 Link Transceiver

Peng Wang,Ke Gong,You-chao Tu,Xiao-li Zhang,Xin-wu Chen 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.8

TigerSHARC 201 link interface is a very efficient double data rate protocol. However, its inconsecutive characteristic of clock adds great difficulty for FPGA implementation when transmission rate is too high. In this paper, with specially-designed clock tree, ingenious rate decreasing strategy, plus proper control on FPGA place & routing processing, 8 group link transceivers with data rate over 500MB/s per lane were designed successfully on Xilinx Virtex6 XC6VLX130. Besides, no sophistic IOSERDES component was utilized. Whole design was completed via Verilog RTL code and Xilinx user constrained file. Presented design also has experienced harsh environment test, proved its efficiency and reliability.

Targeting of COX-2 Expression by Recombinant Adenovirus shRNA Attenuates the Malignant Biological Behavior of Breast Cancer Cells

Tu, Bo,Ma, Ting-Ting,Peng, Xiao-Qiong,Wang, Qin,Yang, Hong,Huang, Xiao-Ling Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Background: Cyclooxygenase-2 (COX-2), considered to have tumor-promoting potential, is highly expressed in a variety of tumors, including breast cancer. Since the functions and action mechanisms of COX-2 in breast cancer have not been fully elucidated, in the present study, the effects of target inhibiting COX-2 with recombinant adenovirus Ad-COX-2-shRNA on malignant biological behavior were investigated in representative cell lines. Materials and Methods: Breast cancer MDA-MB-231 and MCF-7 cells were transfected with Ad-COX-2-shRNA and COX-2 expression was tested by RT-PCR and Western blotting. Changes in proliferation, apoptosis and invasion of breast cancer cells were detected with various assays including MTT, colony forming, flowcytometry and Transwell invasion tests. The expression of related proteins involved in the cell cycle, apoptosis, invasion and signaling pathways was assessed by Western blotting. Results: COX-2 expression was significantly reduced in both breast cancer cell lines infected with Ad-COX-2-shRNA, with obvious inhibition of proliferation, colony forming rate, G2/M phase passage and invasion, as well as induction of apoptosis, in MDA-MB-231 and MCF-7 cells, respectively. At the same time, proteins related to the cell cycle, anti-apoptosis and invasion were significantly downregulated. In addition, c-myc expression and phosphorylation activation of Wnt/${\beta}$-catenin and p38MAPK pathways were reduced by the Ad-COX-2-shRNA. Conclusions: COX-2 expression is associated with proliferation, apoptosis and invasion of breast cancer cells, and its mechanisms of action involve regulating expression of c-myc through the p38MAPK and Wnt/${\beta}$-catenin pathways.

— Invited Review — Reproductive technologies needed for the generation of precise gene-edited pigs in the pathways from laboratory to farm

Tu Ching-Fu,Peng Shu-Hui,Chuang Chin-kai,Wong Chi-Hong,Yang Tien-Shuh 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.2

Gene editing (GE) offers a new breeding technique (NBT) of sustainable value to animal agriculture. There are 3 GE working sites covering 5 feasible pathways to generate GE pigs along with the crucial intervals of GE/genotyping, microinjection/electroporation, induced pluripotent stem cells, somatic cell nuclear transfer, cryopreservation, and nonsurgical embryo transfer. The extension of NBT in the new era of pig breeding depends on the synergistic effect of GE and reproductive biotechnologies; the outcome relies not only on scientific due diligence and operational excellence but also on the feasibility of application on farms to improve sustainability.

Modulation of the Self-Assembly of Collagen by Phytic Acid: An In Vitro Study

Xiao Tu,Xincheng Chen,Ying Peng,Jie Nan,Benmei Wei,Lang He,Chengzhi Xu,Yuling Xu,Dong Xie,Juntao Zhang,Haibo Wang 한국고분자학회 2018 Macromolecular Research Vol.26 No.13

Phytic acid, containing a myoinositol ring coupled with six phosphate groups, can react with the amino groups of collagen to regulate their self-assembly behavior. The aim of this research is to evaluate the effects of phytic acid on the selfassembly behavior of collagen, the structures and properties of the resulting fibrils and hydrogels. Turbidity and chloramine T assay suggested that phytic acid could improve the self-assembly kinetics and degree of collagen, and the optimal ratio of phytic acid/collagen was 1/1 (w/w). Scanning electron microscopy (SEM) analysis indicated that co-fibrils of collagen with phytic acid are more slender than that of pure collagen, and transmission electron microscopy (TEM) reveals that the characteristic D-periodicity of collagen fibrils is not affected by phytic acid. Besides, differential scanning calorimetry (DSC) and rheology revealed that the thermal stability of collagen fibrils and the viscoelasticity of collagen hydrogels could be improved by phytic acid and the optimal ratio of phytic acid/collagen is 1/1 (w/w).

The Dependency Theory : Influx on China

Huazhong Tu,Zhaoxia Peng 한국정치사회연구소 2020 한국과 국제사회 Vol.4 No.4

의존성 이론은 불평등한 국제시스템에서 개발도상국의 지속적인 빈곤과 후진의 근본 원인을 설명한다. 이 이론은 국제규칙을 수립하는 과정에서 개발도상국이 선진국의 패권에 맞서 싸울 수 있도록 하는 필수적인 이론적 무기가 되었다. 의존성이론에서 파생된 중국의 의존성 이론은 최근 몇 년간 일부 서양 학자에 의해 공식화되었으나, 이는 중국과 다른 개발도상국 간의 상호의존관계가 중국의 일방적인 의존성에 의한 것이라고 말하고 있다. 서양학자들은 본 이론을 통해 중국이 다른 개발도상국의 원자재를 착취하고 열등한 산업제품을 덤핑한다고 지적하고 있다. 또한 중국이 개발도상국에서 신 식민주의를 행하고 있다고 비난한다. 중국 의존성이론은 많은 개발도상국에 알려져 있으며, 이는 중국의 ‘일대일로’ 구상에 불안정한 변수 중 하나이며 다른 개발도상국과의 관계를 손상시키고 있다. 본 논문은 이러한 배경 하에, 중국 의존성이론을 형성하는 원인과 성장과정 및 영향을 변증적으로 분석하여, 중국 의존성이론을 지지하는 개발도상국의 일부 학자들의 관점을 논리적으로 비판한 후에, 마지막으로 중국 의존성이론에 대한 중국 측의 관점을 도출한다. Dependency Theory explains the underlying causes of persistent poverty and backwardness of developing countries in the unequal international system. This theory has become an essential theoretical weapon to guide developing countries to fight against the hegemony of western developed countries in the process of making international rules. China Dependency Theory, derived from the Dependency Theory, is formulated by some western scholars in recent years, which misconstrues the mutually dependent relationship between China and other developing countries into a unidirectional dependency on China. The China Dependency Theory prevails in many developing countries, which is not only one of the unstable variables to the construction of the Road and Belt Initiative but also undermines China s relations with other developing countries. Forty years after the implementation of reform and opening-up policy, China has made remarkable economic achievements. In terms of the development path and achievements, China is a successful paragon of breaking the dependent relationship on the West, which set a good example for other developing countries for reference. This paper differentiates and analyzes the cause, process and, influence of Chinese Dependency Theory, and discusses with some scholars from developing countries who give support to it. Finally, it puts forward China’s perspective on this theory.

Predictive Current Control for Multilevel Cascaded H-Bridge Inverters Based on a Deadbeat Solution

Qi, Chen,Tu, Pengfei,Wang, Peng,Zagrodnik, Michael The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.1

Finite-set predictive current control (FS-PCC) is advantageous for power converters due to its high dynamic performance and has received increasing interest in multilevel inverters. Among multilevel inverter topologies, the cascaded H-bridge (CHB) inverter is popular and mature in the industry. However, a main drawback of FS-PCC is its large computational burden, especially for the application of CHB inverters. In this paper, an FS-PCC method based on a deadbeat solution for three-phase zero-common-mode-voltage CHB inverters is proposed. In the proposed method, an inverse model of the load is utilized to calculate the reference voltage based on the reference current. In addition, a cost function is directly expressed in the terms of the voltage errors. An optimal control actuation is selected by minimizing the cost function. In the proposed method, only three instead of all of the control actuations are used for the calculations in one sampling period. This leads to a significant reduction in computations. The proposed method is tested on a three-phase 5-level CHB inverter. Simulation and experimental results show a very similar and comparable control performance from the proposed method compared with the traditional FS-PCC method which evaluates the cost function for all of the control actuations.

PROMISE: A QR Code PROjection Matrix Based Framework for Information Hiding Using Image SEgmentation

Yixiang Fang,Kai Tu,Kai Wu,Yi Peng,Yun-Qing Shi 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.2

As data sharing increases explosively, such information encoded in QR code is completely public as private messages are not securely protected. This paper proposes a new 'PROMISE' framework for hiding information based on the QR code projection matrix by using image segmentation without modifying the essential QR code characteristics. Projection matrix mapping, matrix scrambling, fusion image segmentation and steganography with SEL(secret embedding logic) are part of the PROMISE framework. The QR code could be mapped to determine the segmentation site of the fusion image as a binary information matrix. To further protect the site information, matrix scrambling could be adopted after the mapping phase. Image segmentation is then performed on the fusion image and the SEL module is applied to embed the secret message into the fusion image. Matrix transformation and SEL parameters should be uploaded to the server as the secret key for authorized users to decode the private message. And it was possible to further obtain the private message hidden by the framework we proposed. Experimental findings show that when compared to some traditional information hiding methods, better anti-detection performance, greater secret key space and lower complexity could be obtained in our work.

Predictive Current Control for Multilevel Cascaded H-Bridge Inverters Based on a Deadbeat Solution

Chen Qi,Pengfei Tu,Peng Wang,Michael Zagrodnik 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.1

Finite-set predictive current control (FS-PCC) is advantageous for power converters due to its high dynamic performance and has received increasing interest in multilevel inverters. Among multilevel inverter topologies, the cascaded H-bridge (CHB) inverter is popular and mature in the industry. However, a main drawback of FS-PCC is its large computational burden, especially for the application of CHB inverters. In this paper, an FS-PCC method based on a deadbeat solution for three-phase zero-common-mode-voltage CHB inverters is proposed. In the proposed method, an inverse model of the load is utilized to calculate the reference voltage based on the reference current. In addition, a cost function is directly expressed in the terms of the voltage errors. An optimal control actuation is selected by minimizing the cost function. In the proposed method, only three instead of all of the control actuations are used for the calculations in one sampling period. This leads to a significant reduction in computations. The proposed method is tested on a three-phase 5-level CHB inverter. Simulation and experimental results show a very similar and comparable control performance from the proposed method compared with the traditional FS-PCC method which evaluates the cost function for all of the control actuations.