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Surface Modification with Heparin and Copper Nanoparticles to Enhance In situ Re-endothelialization
( Tran Dieu Linh ),박기동 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Delayed re-endothelialization and impaired endothelial function are link to the thrombosis and restenosis of cardiovascular implant. Therefore, the rapid re-endothelialization is the main focus in the increasing strategies for cardiovascular applications. Herein, polyvinyl chloride (PVC) substrate was immobilized with heparin and copper nanoparticles (CuNPs), a NO-catalytic agent, to enhance the attachment and functionalization of endothelial cells. Heparin-tyramine (HT) and CuNPs were immobilized onto PVC substrate via tyrosinasemediated reaction. The amount of immobilized heparin and released NO were controllable by varying the feeding concentration of HT and CuNPs. In vitro studies revealed that the HT/Cu coatings sustainedly released NO (0.2-18 μM for 14 days) resulting in the decrease of platelets and smooth muscle cells adhesion, and the increase of endothelialization. In conclusion, HT/Cu coating is expected to be useful in supporting the treatment of cardiovascular diseases.
( Tran Dieu Linh ),( Thai Thanh Hoang Thi ),( Phuong Le Thi ),류승배,박기동 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Nowadays, to overcome the implant-related infection issue, many researches have been done to develop the antimicrobial surfaces, including the immobilization of antibacterial agents. Herein, graphene oxide (GO), a popular antibacterial agent with long-term and excellent activity, was immobilized on titanium dioxide (TiO<sub>2</sub>) substrates via tyrosinase-catalyzed reaction. GO was oxidized from graphene, following by the conjugation of the phenol groups using EDC/NHS chemistry, making GO capable to be oxidized by tyrosinase. These phenol moieties were oxidized into o-quinones by tyrosinase, can easily attach to TiO<sub>2</sub>. The GO immobilized surface show the antibacterial effect against both E.coli and S.aureus. Besides, they also show the biocompatibility with human dermal fibroblasts (hDFBs). This study presents a facile and rapid approach for enhancing antibacterial activity of TiO<sub>2</sub>.
Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007
Dieu Linh Tran,Kangmo Kim,Jae Yoo Choi,백현동,Si-Woo Choi,마진열,Sung-Soon Kim,Sung Joon Ahn,김영봉 한국미생물학회 2011 The journal of microbiology Vol.49 No.2
Highly pathogenic H5N1 avian influenza A virus (AIV) crossed the species barrier and caused a number of deaths in humans in Vietnam and 14 other countries. Since the last report of human H5N1 infection in November 2005, the first documented H5N1 human infection was reported in June 2007 in Vietnam and was followed by 7 more cases, including 5 fatalities. In this study, we isolated and analyzed the full length of the H5N1 genome from a sample from the first patient in 2007. Phylogenetic analysis of eight genomic segments of the H5N1 virus strain (A/Vietnam/HN/2007, VNH07) revealed that this strain appears to be of genotype V and contains the HA gene, which is classified into clade 2.3.4. The deduced amino acid sequence of the HA protein has a typical affinity sequence for α2,3 linkage (SAα2,3-Gal) receptors and typical multibasic cleavage sequences. Compared with other H5N1 isolates, VNH07 showed that the possible reassortments for the NA and NP segments occurred between A/goose/Guangxi/3017/2005-like isolates (2.3.2) and A/human/Zhejiang/16/2006-like isolates (2.3.4).
Dieu Linh Tran,Soi Kim,Thi Phuong Le,박기동 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
The chronic wound due to the extended inflammatory phase and the reduced vascularization has caused serious problems to human health. Currently, nitric oxide (NO) is an endogenous gas molecule that involves in many physiological processes. However, the clinical application of NO is limited due to their burst and short half-life release from the biomaterials. In this study, copper nanoparticles (a NO-generating catalyst) were incorporated in the gelatin-based hydrogel (GH) for in situ generation of NO in the presence of endogenous S-nitrosothiol. The fabricated hydrogel presented the sustained release of NO for over 3 weeks within the physiological level, which stimulated the in vitro anti-inflammatory and angiogenic properties. Besides, the chorioallantoic membrane and in vivo animal study also confirm the angiogenic activity of GH/Cu hydrogel. Overall, GH/Cu hydrogel presented as a promising material for wound healing treatment.
Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007
Tran, Dieu Linh,Kim, Kang-Mo,Choi, Jae-Yoo,Paik, Hyun-Dong,Choi, Si-Woo,Ma, Jin-Yeul,Kim, Sung-Soon,Ahn, Sung-Joon,Kim, Young-Bong 한국미생물학회 2011 The journal of microbiology Vol.49 No.2
Highly pathogenic H5N1 avian influenza A virus (AIV) crossed the species barrier and caused a number of deaths in humans in Vietnam and 14 other countries. Since the last report of human H5N1 infection in November 2005, the first documented H5N1 human infection was reported in June 2007 in Vietnam and was followed by 7 more cases, including 5 fatalities. In this study, we isolated and analyzed the full length of the H5N1 genome from a sample from the first patient in 2007. Phylogenetic analysis of eight genomic segments of the H5N1 virus strain (A/Vietnam/HN/2007, VNH07) revealed that this strain appears to be of genotype V and contains the HA gene, which is classified into clade 2.3.4. The deduced amino acid sequence of the HA protein has a typical affinity sequence for ${\alpha}2,3$ linkage ($SA{\alpha}2,3$-Gal) receptors and typical multibasic cleavage sequences. Compared with other H5N1 isolates, VNH07 showed that the possible reassortments for the NA and NP segments occurred between A/goose/Guangxi/3017/2005-like isolates (2.3.2) and A/human/Zhejiang/16/2006-like isolates (2.3.4).
Novel antibiotic delivery using graphene oxide immobilized surfaces
( Tran Dieu Linh ),( Thai Thanh Hoang Thi ),( Phuong Le Thi ),박기동 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Implant-related infection is a noteworthy issue because of their negative effect to the success of implantation, and the cost of treatment. To solve this problem, the development of antimicrobial surface has been considered as an urgent mission. Herein, we demonstrated that graphene oxide (GO)-immobilized TiO<sub>2</sub> surface is an efficient carrier for the local delivery of antibiotic. The phenol-functionalized GO deriva-tive was synthesized and immobilized on TiO<sub>2</sub> under the catalysis of tyrosinase, following by the loading of doxycycline hyclate (Dox). The modified surface was able to carry 36 μg of Dox and ensured the release for a month. These surfaces also showed good antibacterial activity against both E. coli and S. aureus, without the cytotoxic effect on hDFBs. It is expected that the release of Dox from GO-immobilized surfaces can solve the pressing need for enhanced infection control
Dieu Linh Tran,Anh Phuong Nguyen Hong,Ngoc Hoi Nguyen,Ngoc Trinh Huynh,Bao Ha Le Tran,Cam Tu Tran,Minh Dung Truong,Quan Dang Nguyen,박기동,Dai Hai Nguyen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
α-calcium sulfate hemihydrate (α-HH) was synthesized by salt solution methods to prepare a promising biomaterial for bone tissue repair and regeneration. The successful synthesis of α-HH was evaluated by field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) scanning. The sterility of α-HH before and after irradiation with gamma ray was firstly confirmed by Colonies Forming Units (CFU) counting assay, to target the surgical grade application. In vitro tetrazolium bromide (MTT) assay, crystal violet (CV) and acridine orange (AO) staining was performed to assess the initial cytotoxicity and cell attachment ability of α-HH. Further in vivo implantation into rabbit distal femoral condyles defect exhibited the ability of salt solution-synthesized α-HH to promote the localization of osteocytes and osteoblasts, which improve the bone tissue repair and regeneration. The findings suggested that α-calcium sulfate hemihydrate synthesized by salt solution method is a potential material that can be used as bone substitutes.