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Tatsuya Sato,Taro Bannai,Toru Miyake,Keita Murakami,Risa Maekawa,Yasushi Shiio 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.1
Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory process characterized by hyperostosis at tendon insertions and around joint capsules and ossification of the anterior longitudinal ligament of the spine. The flexibility of the spinal column is reduced in DISH and affects the movement of the thorax, leading to restrictive ventilatory function. In this report, we describe the first two cases of severe type 2 (hypercapnic) respiratory failure associated with DISH. Two older men presented with histories of shortness of breath. Radiography of the spine revealed DISH with coexisting ankylosis of the costovertebral joints. The patients’ thoracic motion was severely restricted, reducing the mechanism of lung expansion to diaphragm contraction only. Both patients required non-invasive positive-pressure ventilation therapy to cope with their conditions. Our report sheds light on the risk of potentially life-threatening respiratory manifestations of DISH among older adults.
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Two-Phase Interleaved Bidirectional Converter Input-Parallel Output-Series Connection
Yuji Yamamoto,Taro Takiguchi,Takaharu Sato,Hirotaka Koizumi 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
The interleaved bidirectional converter (IBC) has lower input current ripple and higher power conversion efficiency than the bidirectional chopper because of the current sharing operation. However, the step up/down ratio of the IBC is the same as that of the bidirectional chopper. As a converter with high step up ratio, the two-phase interleaved DC-DC converter with parallel-input seriesoutput connection (ICPS) is proposed. The ICPS realizes twice the step up ratio of the interleaved boost converter. Also, the ICPS has lower input ripple than the interleaved boost converter at the same step up ratio. This paper proposes bidirectional operation of the ICPS, which realizes the high step up/down ratio and the reduction of current ripple on the low voltage side. The proposed bidirectional operational principles and the steady-state analysis have been verified by simulation and circuit experiment.
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Evaluation of the drug-induced lymphocyte stimulation test for diagnosing mesalazine allergy
( Daisuke Saito ),( Mari Hayashida ),( Taro Sato ),( Shintaro Minowa ),( Osamu Ikezaki ),( Tatsuya Mitsui ),( Miki Miura ),( Akihito Sakuraba ),( Tadakazu Hisamatsu ) 대한장연구학회 2018 Intestinal Research Vol.16 No.2
Background/Aims: Mesalazine is an effective drug for treating ulcerative colitis (UC), but causes allergic symptoms in a few cases. Therefore, the objective of this study was to evaluate the usefulness of the drug-induced lymphocyte stimulation test (DLST) for the diagnosis of mesalazine allergy. Methods: Patients with UC treated with mesalazine with or without a history of associated adverse events (AEs) were enrolled at Kyorin University Hospital from July 2016 to April 2017. Results: The DLST was performed in 104 patients with UC, of which 24 had a history of AEs due to mesalazine treatment. The control value of DLST was 337.4±296.3 counts per minute (cpm) in the AE<sup>+</sup> group and 408.0±371.9 cpm in the AE<sup>-</sup> group. The measured value of DLST was 578.8±424.7 cpm in the AE<sup>+</sup> group and 476.5±471.8 cpm in the AE<sup>-</sup> group. The stimulation index (SI) was 243.9%±291.1% in the AE<sup>+</sup> group and 119.8%±53.0% in the AE<sup>-</sup> group. The SI value and DLST positivity were significantly higher in the AE<sup>+</sup> group than in the AE<sup>-</sup> group (P=0.030 and P=0.029, respectively). The test sensitivity and specificity were 0.240 and 0.805, respectively, and the false-positive and false-negative rate was 0.195 and 0.760, respectively. Conclusions: The DLST for mesalazine showed low sensitivity and high specificity, suggesting that it may be useful for the definitive diagnosis of allergy to mesalazine. (Intest Res 2018;16:273-281)
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Mei Uemura,Yutaka Yano,Toshinari Suzuki,Taro Yasuma,Toshiyuki Sato,Aya Morimoto,Samiko Hosoya,Chihiro Suminaka,Hiromu Nakajima,Esteban C. Gabazza,Yoshiyuki Takei 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.4
patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting hyperglycemia using CGM data as a reference. Methods: Thirty-eight inpatients with diabetes undergoing CGM were enrolled. MIET comprised a pretreatment step using a plastic microneedle array and glucose accumulation step with a hydrogel patch, which was placed on two sites from 9:00 AM to 5:00 PM or from 10:00 PM to 6:00 AM. IG AUC was calculated by accumulated glucose extracted by hydrogel patches using sodium ion as standard. Results: A significant correlation was observed between the predicted AUC by MIET and CGM in daytime (r=0.76) and nighttime (r=0.82). The optimal cutoff for the IG AUC value of MIET to predict hyperglycemia over 200 mg/dL measured by CGM for 8 hours was 1,067.3 mg·hr/dL with 88.2% sensitivity and 81.5% specificity. Conclusion: We showed that 8-hour IG AUC levels using MIET were valuable in estimating the blood glucose AUC without blood sampling. The results also supported the concept of using this technique for evaluating glucose excursion and for screening hyperglycemia during 8 hours in patients with diabetes at any time of day.
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Cho, Su-Hee,Kim, Seung-Young,Tomita, Takeo,Shiraishi, Taro,Park, Jin-Soo,Sato, Shusuke,Kudo, Fumitaka,Eguchi, Tadashi,Funa, Nobutaka,Nishiyama, Makoto,Kuzuyama, Tomohisa AMERICAN CHEMICAL SOCIETY 2017 ACS CHEMICAL BIOLOGY Vol.12 No.8
<P>Fosfomycin is a wide-spectrum phosphonate antibiotic that is used clinically to treat cystitis, tympanitis, <I>etc</I>. Its biosynthesis starts with the formation of a carbon–phosphorus bond catalyzed by the phosphoenolpyruvate phosphomutase Fom1. We identified an additional cytidylyltransferase (CyTase) domain at the Fom1 <I>N</I>-terminus in addition to the phosphoenolpyruvate phosphomutase domain at the Fom1 <I>C</I>-terminus. Here, we demonstrate that Fom1 is bifunctional and that the Fom1 CyTase domain catalyzes the cytidylylation of the 2-hydroxyethylphosphonate (HEP) intermediate to produce cytidylyl-HEP. On the basis of this new function of Fom1, we propose a revised fosfomycin biosynthetic pathway that involves the transient CMP-conjugated intermediate. The identification of a biosynthetic mechanism <I>via</I> such transient cytidylylation of a biosynthetic intermediate fundamentally advances the understanding of phosphonate biosynthesis in nature. The crystal structure of the cytidylyl-HEP-bound CyTase domain provides a basis for the substrate specificity and reveals unique catalytic elements not found in other members of the CyTase family.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2017/acbcct.2017.12.issue-8/acschembio.7b00419/production/images/medium/cb-2017-004199_0006.eps'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb7b00419'>ACS Electronic Supporting Info</A></P>
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