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Ambrin Fatima,Muhammad Farooq,Uzma Abdullah,Muhammad Tariq,Tanveer Mustafa,Muhammad Iqbal,Niels Tommerup,Shahid Mahmood Baig 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.5
Objective: Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. Recently, MIR137, CACNA1C, CSMD1, DRD2, and GRM3 have been reported as the most robustly emerging candidates involved in the etiology of schizophrenia. In this case control study, we performed an association analysis of rs1625579 (MIR137), rs1006737, rs4765905 (CACNA1C), rs10503253 (CSMD1), rs1076560 (DRD2), rs12704290, rs6465084, and rs148754219 (GRM3) in Pakistani population. Methods: Schizophrenia was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV). Detailed clinical information, family history of all patients and healthy controls were collected. RFLP based case control association study was performed in a Pakistani cohort of 508 schizophrenia patients and 300 healthy control subjects. Alleles and genotype frequencies were calculated using SPSS. Results: A significant difference in the genotype and allele frequencies for rs4765905, rs1076560 and rs6465084 were found between the patients and controls (p=0.000). Conclusion: This study provides substantial evidence supporting the role of CACNA1C, GRM3 and DRD2 as schizophrenia susceptibility genes in Pakistani population.
CONFORMAL HEMI-SLANT SUBMERSION FROM KENMOTSU MANIFOLD
( Mohammad Shuaib ),( Tanveer Fatima ) 호남수학회 2023 호남수학학술지 Vol.45 No.2
As a generalization of conformal semi-invariant submersion, conformal slant submersion and conformal semi-slant submersion, in this paper we study conformal hemi-slant submersion from Kenmotsu manifold onto a Riemannian manifold. The necessary and sufficient conditions for the integrability and totally geodesicness of distributions are discussed. Moreover, we have obtained sufficient condition for a conformal hemi-slant submersion to be a homothetic map. The condition for a total manifold of the submersion to be twisted product is studied, followed by other decomposition theorems.
New antimicrobial flavonoids and chalcone from Colutea armata
Farah Inamullah,Itrat Fatima,Sadia Khan,Mehdi Hassan Kazmi,Abdul Malik,Rasool Bakhsh Tareen,Tanveer Abbas 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.8
Colucins A (1) and B (2), new flavonoids andcolucone (3), the new chalcone derivative, have been isolatedfrom the CHCl3-soluble fraction of the whole plant ofColutea armata along with luteolin (4), luteolin 7-O-b-Dglucoside(5), isoliquiritigenin (6), trans-caffeic acid (7)and stigmasterol (8) reported for the first time from thisspecies. Their structures were elucidated by spectroscopictechniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobialactivity against two Gram positive and three Gram negativebacterial strains while 3 was moderately active.