급성 연쇄상구균 감염후 사구체 신염에 동반된 고혈압 뇌증 1례

하태선,차상훈,이경은,엄정민 충북대학교 의과대학 충북대학교 의학연구소 1999 忠北醫大學術誌 Vol.9 No.2

고혈압성 뇌병증은 고혈압 환자에서 고혈압과 관련된 두통, 경련, 시각장애 및 다른 신경학적 장애를 동반하는 증후군이다. 증례는 13세 여자환아로 급성 연쇄상구균 감염후 사구체 신염에 동반된 고혈압성 뇌병증 환자였다. 내원시 혈압은 150/110 mmHg 였고 내원당시 검사소견상 단백뇨, 혈뇨, C3의 감소 소견을 보였다. 내원 2일째 자기공명영상을 시행하였고 스핀에코 T2 강조영상에서 양 후두엽과 후 측두엽에 고신호의 이상 부위들이 발견되었다. 치료후 실시한 자기공명영상은 정상 소견을 보였다. 본 저자들은 급성 사구체 신염 환자에서 자기공명영상으로 고혈압성 뇌병증을 진단하고 치료한 1례를 문헌고찰과 함께 보고하는 바이다. Hypertensive encephalopathy is a syndrome consisting of headache, seizures, visual changes, and other neurologic disturbances in patients with elevated systemic blood pressure. We experienced a 13-year-old girl who presented with the manifestations of hypertensive encephalopathy in acute post-streptococcal glomerulonephritis. She visited our hospital because of generalized tonic-clonic seizure after severe headache. On admission her blood pressure was 150/110 mmHg and initial laboratory findings revealed proteinuria, hematuria and decreased C3 level and, T2-weighted MR image showed increased T2 signal in both occipital lobes, suggesting cerebral edema. On follow-up MRI, pathologic lesions were improved. We described a case of hypertensive encephalopathy in acute post-streptococcal glomerulonephritis diagnosed by MRI with a brief review of some related literatures.

Articulation error of children with adenoid hypertrophy

Eom, Tae-Hoon,Jang, Eun-Sil,Kim, Young-Hoon,Chung, Seung-Yun,Lee, In-Goo The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.7

Purpose: Adenoid hypertrophy is a physical alteration that may affect speech, and a speech disorder can have other negative effects on a child's life. Airway obstruction leads to constricted oral breathing and causes postural alterations of several oro-facial structures, including the mouth, tongue, and hyoid bone. The postural modifications may affect several aspects of speech production. Methods: In this study, we compared articulation errors in 19 children with adenoid hypertrophy (subject group) to those of 33 children with functional articulation disorders independent of anatomical problems (control group). Results: The mean age of the subject group was significantly higher (P=0.016). Substitution was more frequent in the subject group (P=0.003; odds ratio [OR], 1.80; 95% confidence interval [CI], 1.23- 2.62), while omission was less frequent (P<0.001; OR, 0.43; 95% CI, 0.27-0.67). Articulation errors were significantly less frequent in the palatal affricative in the subject group (P=0.047; OR, 0.25; 95% CI, 0.07-0.92). The number of articulation errors in other consonants was not different between the two groups. Nasalization and aspiration were significantly more frequent in the subject group (P=0.007 and 0.014; OR, 14.77 and 0.014; 95% CI, [1.62-135.04] and NA, respectively). Otherwise, there were no differences between the two groups. Conclusion: We identified the characteristics of articulation errors in children with adenoid hypertrophy, but our data did not show the relationship between adenoid hypertrophy and oral motor function that has been observed in previous studies. The association between adenoid hypertrophy and oral motor function remains doubtful.

Electrical structure, magnetic polaron and lithium ion dynamics in four mixed-metal oxide multiple-phase electrode cathode material for Li ion batteries from density functional theory study

Eom, Tae Hoon,Xiao, Yi,Han, Jeong In,Zhang, Fu Chun Elsevier 2017 Computational Materials Science Vol. No.

<P><B>Abstract</B></P> <P>This study present results derived from first-principles calculations, at density functional level, and molecular dynamics simulations. Calculations of perfect LiMO<SUB>2</SUB> (M=Mn, Co and Ni) and their mixed-metal oxide (LiMn<SUB>1/3</SUB>Co<SUB>1/3</SUB>Ni<SUB>1/3</SUB>O<SUB>2</SUB>) were performed by PBE with the GGA method in the VASP Package. Atomistic simulation calculation was used for searching the electrical structure, magnetic polaron and lithium ion dynamics properties. The results were suitable for the measured valence-band structure, also with the magnetic and electrical properties of the Li-transition metal oxide. The band gap is determined by the charge-transfer and the main contributions from the magnetic polaron produced spin electron−hole pairs that were smaller than that of the states of the M3d and O2p orbitals. When anisotropic O2p-M3d orbital hybridization occurs, a highly-delocalized characteristic was shown in the M3d hole state owing to the states mixing. The extended M4p orbital improved the exchange interaction between Mn3d and Op which led to an asymmetric charge distribution in the MO bonds. The delocalized characteristic of Mn3d holes is a vital part of the mechanism of spin-dependent ligand (O<SUP>2−</SUP>) hybridization. Due to the decrease in inter-molecular attractive forces, a decrease in the order parameter of crystalline was derived from the increase of temperature. Moreover, the transition metal-oxygen and lithium-oxygen radial distribution functions (RDF) at temperatures of 300 and 900K were compared to each other. The results indicate that the height of the peaks decrease and the system becomes more stable due to increasing temperature. Overall, because of the increase of thermal motion with increasing temperature, lithium ions showed a gradual evolution of mobility.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Electrical structure, magnetic polaron and lithium ion dynamic properties by atomistic simulation. </LI> <LI> Electron spin polarization has localized states at the bottom of the conduction band. </LI> <LI> Local electron density was derived from partially occupied and unoccupied band. </LI> <LI> Magnetic polarization results in partial charge transfer from O2p to M3d to occur. </LI> <LI> Due to thermal motion with increased temperature, mobility of Li ions is improved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Electroencephalography source localization

Eom Tae-Hoon 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.5

Electroencephalography (EEG) has been and is still widely used in brain function research. EEG has advantages over other neuroimaging modalities. First, it not only directly images the electrical activity of neurons; it has a higher temporal resolution. Furthermore, current advanced technologies enable accurate mathematical calculations and sophisticated localization from EEG data. Several important factors should be considered for EEG analysis using these advanced technologies. First, raw EEG data contain physiological or nonphysiological artifacts. Therefore, preprocessing methods and algorithms to detect and remove these artifacts have been proposed and developed. In the analysis of preprocessed EEG, forward and inverse problems require solving and several proposed models have been applied. To solve the forward problem, the source information and matrix parameters from which the EEG originates are essential. Therefore, an accurate head model is required. In contrast, the possible combinations of the current sources computed inversely from EEG measured at a limited number of electrodes are infinite, referring to the inverse problem. The inverse problem can be solved by setting limits based on assumptions made of the anatomy and physiology on the generation and propagation of the current sources. Thus, methods such as dipole source models and distributed source models have been proposed. Source localization requires the consideration of many factors such as the preprocessing of raw EEG data, artifact removal, accurate head models and forward problems, and inverse computation problems. This review summarizes the methods and considerations applied to the above EEG source localization process. It also introduces the applications of EEG source localization for epilepsy and other diseases as well as brain function studies and discusses future directions.

Single fiber UV detector based on hydrothermally synthesized ZnO nanorods for wearable computing devices

Eom, Tae Hoon,Han, Jeong In Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.428 No.-

<P><B>Abstract</B></P> <P>There has been increasing interest in zinc oxide (ZnO) based ultraviolet (UV) sensing devices over the last several decades owing to their diverse range of applications. ZnO has extraordinary properties, such as a wide band gap and high exciton binding energy, which make it a beneficial material for UV sensing device. Herein, we show a ZnO UV sensing device fabricated on a cylindrical Polyethylene terephthalate (PET) monofilament. The ZnO active layer was synthesized by hydrothermal synthesis and the Cu electrodes were deposited by radio frequency (RF) magnetron sputtering. Cu thin film was deposited uniformly on a single PET fiber by rotating it inside the sputtering chamber. Various characteristics were investigated by changing the concentration of the seed solution and the growth solution. The growth of ZnO nanorods was confirmed by Field Emission Scanning Electron Microscopy (FESEM) to see the surface state and structure, followed by X–ray Diffraction (XRD) and X–ray photoelectron spectroscopy (XPS) analysis. Also, current–voltage (I–V) curves were obtained to measure photocurrent and conductance. Furthermore, falling response time, rising response time, and responsivity were calculated by analyzing current-time (I–t) curves.</P> <P><B>Highlights</B></P> <P> <UL> <LI> UV sensing device was fabricated on a cylindrical PET monofilament for wearable computing devices. </LI> <LI> ZnO nanorod was coated by two-step hydrothermal synthesis by varying the concentration of seed solution and growth solution. </LI> <LI> The Cu thin film was deposited uniformly by RF magnetron sputtering for electrodes. </LI> <LI> Electrical properties were investigated by measuring I-V curves and I-t curves when UV light was illuminated. </LI> <LI> XRD, XPS and FESEM was used for characterization of surface morphology, surface state and crystallinity of synthesized ZnO nanorod. </LI> </UL> </P>

Clinical practice guidelines for attention-deficit/hyperactivity disorder: recent updates

Tae Hoon Eom,Young-Hoon Kim 대한소아청소년과학회 2024 Clinical and Experimental Pediatrics (CEP) Vol.67 No.1

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders found in children and adolescents. The American Academy of Pediatrics (AAP) first published a clinical practice guideline on ADHD in 2000, which was revised in 2011 and republished together with an accompanying process-of-care algorithm. More recently, the 2019 clinical practice guideline revision was published. Since the 2011 guideline,the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM5), was released. In addition, the Society of Developmental and BehavioralPediatrics (SDBP) recently releasedanother clinical practice guideline for complex ADHD. Although there are nonessential changes reflected in these updates, a number of changes have still been made; for example, the DSM-5 criteria lowered the diagnostic threshold for ADHD in older teens and adults. Additionally, the criteria were revised to facilitate application to older teens and adults,and a comorbid diagnosis with autism spectrum disorder is now allowed. Meanwhile, the 2019 AAP guideline added the recommendation related to comorbid conditions with ADHD. Lastly, SDBP developed a complex ADHDguideline, covering areas such as comorbid conditions, moderate-to-severe impairment, treatment failure, anddiagnostic uncertainty. In addition, other national ADHD guidelines have been published, as have European guidelines for managing ADHD during the coronavirus disease 2019 pandemic. To facilitate ADHD management in a primary care, it is important to provide and review clinical guidelines and recent updates. In this article, we willreview and summarize the recent clinical guidelines and their updates

ESS용 모듈형 AC/DC 컨버터의 다병렬 운전 기법

엄태호(Tae-Ho Eom),김준모(Jun-Mo Kim),이정(Jeong Lee),김성훈(Sung-Hoon Kim),배기훈(Ki-Hoon Bae),원충연(Chung-Yuen Won) 한국조명·전기설비학회 2018 한국조명·전기설비학회 학술대회논문집 Vol.2018 No.5

자동차 실내 공기질 가스 센서 소재 기술 연구 동향

엄태훈(Tae Hoon Eom),장호원(Ho Won Jang) 한국고분자학회 2018 고분자 과학과 기술 Vol.29 No.6

서울 경기 일부지역 고등학생의 목통증호소와 관련요인에 관한 연구

정영훈 ( Young Hoon Chung ),엄태웅 ( Tae Woong Eom ),문태웅 ( Tae Woong Moon ),조태영 ( Tae Young Cho ),이시하 ( Ki Ha Lee ),고영타 ( Young Tak Ko ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.4

Objectives :The purpose of this study is to evaluate the status of neck pain and related factors among high school students, and to establish neck pain prevention program based on conclusion made from this study. Methods : The study population consisted of high school students in the vicinity of Seoul and Kyung Ki province. Total number of self-reporting questionnaire provided was 500 but only 493 questionnaires submitted for evaluation. Among those submitted there were 2 questionnaires which were incompleted and not counted in for evaluation. The above data have been collected from June 2007 through August 2007. Total 491 subjects were consisted of male and female students from 4 different high schools. A participant was classified into the pain group or into the no pain group according to the frequency of neck pain. The data were analyzed in frequency, percentile scores, X2-test in SPSS 10.0 for windows. Results : Among 491 subjects, the prevalence rate of the neck pain have showed 61.1%. In relation to general characteristic, sex was insignificant. In relation to school activity and habit, the level of sitting time in a day(p<0.05), PC time in a day(p<0.001) were significant. In relation to health habit, sleep time in a day(p<0.001) was significant. In relation to disturbance of daily life, reading disturbance(p<0.001), leisure activity disturbance(p<0.001) were significant. Conclusions : Based on the above evaluation, it shows that high school students have a relatively high prevalence of neck pain. Therefore, proper neck pain prevention program and early management of the neck pain are well indicated since neck pain could influence student`s school life

Enhancement of the Efficiency of Secretion of Heterologous Lipase in Escherichia coli by Directed Evolution of the ABC Transporter System

Eom, Gyeong Tae,Song, Jae Kwang,Ahn, Jung Hoon,Seo, Yeon Soo,Rhee, Joon Shick American Society for Microbiology 2005 Applied and environmental microbiology Vol.71 No.7

<B>ABSTRACT</B><P>The ABC transporter (TliDEF) from <I>Pseudomonas fluorescens</I> SIK W1, which mediated the secretion of a thermostable lipase (TliA) into the extracellular space in <I>Escherichia coli</I>, was engineered using directed evolution (error-prone PCR) to improve its secretion efficiency. TliD mutants with increased secretion efficiency were identified by coexpressing the mutated <I>tliD</I> library with the wild-type <I>tliA</I> lipase in <I>E. coli</I> and by screening the library with a tributyrin-emulsified indicator plate assay and a microtiter plate-based assay. Four selected mutants from one round of error-prone PCR mutagenesis, T6, T8, T24, and T35, showed 3.2-, 2.6-, 2.9-, and 3.0-fold increases in the level of secretion of TliA lipase, respectively, but had almost the same level of expression of TliD in the membrane as the strain with the wild-type TliDEF transporter. These results indicated that the improved secretion of TliA lipase was mediated by the transporter mutations. Each mutant had a single amino acid change in the predicted cytoplasmic regions in the membrane domain of TliD, implying that the corresponding region of TliD was important for the improved and successful secretion of the target protein. We therefore concluded that the efficiency of secretion of a heterologous protein in <I>E. coli</I> can be enhanced by in vitro engineering of the ABC transporter.</P>