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Hwang, Dae Y,Cho, Jung S,Kim, Chuel K,Shim, Sun B,Jee, Seung W,Lee, Su H,Seo, Su J,Choi, Soo Y,Kim, Yong K Springer Science + Business Media 2006 NEUROMOLECULAR MEDICINE Vol. No.
<P>Nonregulatable promoters have been mainly used to produce transgenic mice that express the human genes for Alzheimer's disease (AD). The aim of this study was to produce doubly transgenic mice expressing the regulatable tet promoter-controlled transactivator (tTA) and human mutant presenilin 2 (N141I, hPS2m) genes in order to examine the AD-related phenotypes at the basal and inducible levels. To achieve this, the first lineage of the transgenic line, expressing Tet/tTA and the second lineage of transgenic mice, expressing Tet/hPS2m, were created, and the doubly transgenic mice were produced by crossing the Tet/tTA-transgenic mice with the Tet/hPS2m-transgenic mice. The doubly transgenic mice and nontransgenic littermates were then treated with or without doxycycline. The results showed that removing doxycycline from the transgenic mice resulted in the induction of the transgene, a Wnt signaling defect, behavioral impairment, elevated amyloid-beta-42 and gamma-secretase activity compared with in the group given doxycyline. Moreover, the expression levels of the hPS2m transgene decreased gradually in the transgenic males, with clear changes becoming apparent between 2 and 4 wk of age. Castrating these males resulted in an increased expression level of the hPS2m gene. This was restored to the normal levels by treatment with testosterone. Therefore, tetregulated transgenic mice can be used to examine the effect of the basal or inducible expression levels of hPS2m on the pathology of AD at the 'on/off' states at any stage of development.</P>
Stability of graphene band structures against an external periodic perturbation: Na on graphene
Hwang, C. G.,Shin, S. Y.,Choi, Seon-Myeong,Kim, N. D.,Uhm, S. H.,Kim, H. S.,Hwang, C. C.,Noh, D. Y.,Jhi, Seung-Hoon,Chung, J. W. American Physical Society 2009 Physical review. B, Condensed matter and materials Vol.79 No.11
Hwang, Sohyun,Rhee, Seung Y,Marcotte, Edward M,Lee, Insuk Nature Publishing Group, a division of Macmillan P 2011 NATURE PROTOCOLS -ELECTRONIC EDITION- Vol.6 No.9
AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.
Prognostic Impact of β-Blocker Dose After Acute Myocardial Infarction
Hwang, Doyeon,Lee, Joo Myung,Kim, Hyun Kuk,Choi, Ki Hong,Rhee, Tae-Min,Park, Jonghanne,Park, Taek Kyu,Yang, Jeong Hoon,Song, Young Bin,Choi, Jin-Ho,Hahn, Joo-Yong,Choi, Seung-Hyuk,Koo, Bon-Kwon,Kim, Y UNKNOWN 2019 CIRCULATION JOURNAL Vol.83 No.2