Representation of bounded Linear Operators on Reproducing Kernel Hilbert Space

변두원,이성희,박달원,노영순,김승동 공주대학교 과학교육연구소 2001 과학교육연구 Vol.32 No.1

재생핵 힐버트공간에서 유계인 작용소는 어떤 적분변환의 형태로 표시된다. 또한 재생핵을 이용하여 어떤 적분변환의 형태가 유계인 작용소이기 위한 필요충분조건을 구한다. The bounded linear operators on a reproducing kernel Hilbert space can be represented in the form of generalized integral transform. Also, they are completely characterized by integral kernels.

교정환자에서 MRI를 이용한 측두하악관절 장애의 연구

김태우,변은선,백승학,장영일,남동석,양원식 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.2

측두하악관절의 자기공명영상(MRI)은 하악과두와 관절원판(disc)의 관계를 잘 보여주기 때문에 관절내장증(internal derangement)의 진단을 위해 매우 유용하다. 이번 연구의 목적은 서울대학교 치과병원 교정과에 내원한 측두하악관절 장애가 의심되는 환자들의 MRI자료를 평가하여 관절 내장증의 유무, 발생빈도 및 심도를 파악하는 것이다. MRI를 촬영한 표본은 남자 10명, 여자 40명으로 총 50명이었고 평균 나이는 22.9세였다. 전체 50명 중에 43명에서 positive finding이 관찰되었다. Positive finding을 나타낸 환자 중에서 전방관절원판변위 (anterior disc displacement : ADD)는 비정복성이 56%로 가장 많았으며, 양쪽 관절에서 동시에 일어난 경우가 65%로 가장 많았다. Positive finding을 나타낸 환자를 Angle 분류 시, Ⅱ급 1류 부정교합 환자가 39.6%, Ⅱ급 2류 부정교합 환자가 2.3%로 Ⅱ급 부정교합이 41.9%로 가장 많았고, 1급 부정교합 환자는 37.2%, Ⅲ급 부정결합 환자가 18.6%, 확인 안된 경우가 2.3%였다. Positive finding을 나타낸 환자 중에서 안면 비대칭 환자는 8.6%, 개교 환자는 55.8%였다. 결론적으로 측두하악관절의 관절 내장증을 가진 환자에서는 Ⅱ급 부정교합이 차지하는 비율이 매우 크다고 할 수 있다. 개교나 안면 비대칭은 측두하악관절 장애로 인한 보상적 또는 비보상적인 변형에 의해 나타날 수 있으며 퇴행성 관절 질환으로 진행되는 과정 중 안면 골격 개조의 결과로 보인다. 그러므로 개교 및 안면 비대칭이 있는 환자는 교정 치료 시작 전에 측두하악관절의 이상 유무를 MRI로 확인(screening)할 것이 권장된다. 측두하악관절 장애가 있는 경우 교정 치료 후에도 재발의 경향이 크고 측두하악관절에 대한 계속적인 관찰이 필요하므로 감별진단이 필수적이다. Magnetic resonance imaging(MRI) of the temporomandibular joint(TMJ) is very useful method to diagnose internal derangement of the TMJ because of its high specificity for identification of condyle-disc relationships. The purpose of this study was to evaluate the existence, incidence and severity of internal derangement of the TMJ by the MRI of patients who are suspected to leave TMJ disorder. MRI sample was composed of 50 subjects(10 males, 40 females) and the mean age was 22.9 years. 43 subjects of the sample were found to have positive findings. 56% of the subjects with positive findings had ADD(anterior disc displacement) without reduction, and 65% had internal derangement of bilateral joints. Distributions in the types of malocclusion in patients with positive findings, the Angle's classification had shown : the largest 41.9% for Cl II(39.6% for Cl II div 1 and 2.3% for Cl II div 2), 37.2% for Cl I, 18.6% for Cl III, and 2.3% for the unidentified. 8.6% of the subjects with positive findings had facial asymmetry and 55.8% had openbite. We can conclude that the percentage of Cl II is the highest in patients with internal derangement of the TMJ. Openbite or facial asymmetry is considered to be uncompensated or compensated deformity which results from facial skeleton remodeling in the process of degenerative joint disease(DJD) due to TMJ degeneration. Therefore it is recommended to screen the patients with facial asymmetry or openbite by MRI before the beginning of orthodontic treatment. Differential diagnosis is essential because the tendency of relapse is high after the orthodontic treatment and continuous observation of TMJ is needed in patients with TMJ disorder.

Numerical expression of hydration status by multifrequency bioelectrical impedance analysis: pilot study (초)

( Seung Woon Byun ),( Ji Young Lee ),( Jai Won Chang ),( Won Seok Yang ),( Soon Bae Kim ),( Su Kil Park ),( Jung Sik Park ) 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-

GO-21 : Efficacy of preemptive port site local analgesia for wound pain after gynecologic laparoendoscopic single-site surgery

( Byun Seung Won ),( Kim Jin Hwi ),( Park Tae Chul ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: We aimed to evaluate the efficacy of preoperative port site infiltration of bupivacaine solution for the relief of pain after gynecologic laparoendoscopic single-site surgery. 방법: Twenty six women aged 22 to 79 years who underwent gynecologic laparoendoscopic single-site surgery from March 2014 to April 2014, Uijeong-bu St. Mary`s hospital were enrolled. The patients were divided by two groups. Group A (n =13) and Group B (n=13) underwent preoperative port site 20ml infiltration of 0.5% bupivacaine and normal saline, each other. Abdominal wall pain was recorded on a visual analog scale(VAS) and at 15 minutes ,1, and 24 hours postoperatively. Patient Control Analgesia(PCA) consumption was calculated by the difference of Patient Control Analgesia(PCA) device weight(mg) between start and post-operative 24 hours 결과: Mean visual analog scale(VAS) in group A was less than group B at 1(3.8 vs 4.7) and 24 hours(2.5 vs 3.4) postoperatively. And mean consumption of Patient Control Analgesia(PCA) in group A(40mg) also was less than group B(47.7mg), postoperatively. Mean VAS differences between group A and B were 0.9 at 1(p=.20), 24(p=.18) hours, postoperatively. Mean consumption difference of Patient Control Analgesia(PCA) was 7.7mg(p=.43) postoperatively. But, the differences were not statistically significant. 결론: Preoperative port site bupivacaine administration before placement of trocars might be effective and safe in reducing the intensity of postoperative 1, 24 hours abdominal wall pain after gynecologic laparoendoscopic single site surgery even if these results did not show statistically significant differences in this pilot study. Further large-scaled prospective study will be needed to confirm the efficacy of preoperative port site infiltration of bupivacaine solution in gynecologic laparoendoscopic single site surgery.

ADCYAP1, PAX1, CADM1 and MAL Gene Promotor Methylation Level Is Not Different Between Human Papillomavirus Persistent Infection Group and Clearance Group In Korean HPV Cohort Study

( Seung Won Byun ),( Eun Young Ki ),( Jong Sup Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

It has been well known that cervical intraepithelial neoplasia is preceded by persistent infections with human papillomavirus (HPV) types that carry a high oncogenic risk. About 80% of young women who become infected with HPV have transient infections that clear within 12-18 months. Only a small fraction of women with HPV infection will eventually develop persistent infections. There are no definite molecular evidence that is associated with persistent infection. In this study, we aim to determine the difference of promotor methylation level in cervical cell gene(ADCYAP1, PAX1, CAMD1 and MAL) between persistence and clearance with HPV infection. Exfoliated cervical scraps from HPV persistent group (n=25) and HPV clearance group (n=25) in Korean HPV Cohort Study were used to interrogate the methylation patterns of four host nuclear genes(ADCYAP1, PAX1, CAMD1 and MAL) each group at 6, 12 month follow-up DNA isolated from exfoliated cervical scraps was treated with bisulfite, specific regions of host genome were PCR amplified and CpG mehtylation was quantified using pyrosequencing HPV persistent infection group is not significantly different from HPV clearance group in global methylation level over time. In analysis with high risk HPV infection subgroup, MAL (-190bp) CpG site methylation level of high risk HPV infection persistent infection group(n=16) at 6 months follow-up was significantly lower than the one of high risk HPV infection clearance group (n=11) at that time. But the methylation levels of both group were below 5 %, not biologically significant because the lower detection level of pyrosequencing is 5 %. To validate this finding, we need more sensitive tool to detect methylation level. ADCYAP1,PAX1, CADM1 AND MAL Gene promotor methylation level is not different between human papillomavirus persistent infection group and clearance group in Korean HPV Cohort Study

Numerical expression of hydration status by multifrequency bioelectrical impedance analysis: Pilot study (초)

( Seung Woon Byun ),( Ji Young Lee ),( Jai Won Chang ),( Won Seok Yang ),( Soon Bae Kim ),( Su Kil Park ),( Jung Sik Park ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1S

The feasibility of Laparoscopic sacrocolpexy with prolene suture following totallaparoscopic hysterectomy in uterine prolapse patients

( Seung Won Byun ),( Jin Wie Kim ),( Tae Chul Park ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

Effects of Repeated Steroid Injection at Subacromial Bursa With Different Interval

Seung Deuk Byun,Yong Ho Hong,Sung Kyung Hong,Jin Won Song,Seung Beom Woo,Jae Hyun Noh,Jong Min Kim,Zee Ihn Lee 대한재활의학회 2014 Annals of Rehabilitation Medicine Vol.38 No.6

Objective To evaluate the effects of repeated steroid injection at subacromial bursa with different interval for patient with periarticular shoulder disorder.Methods Group A (n=10) received subacromial bursa injection only on their first visit, group C (n=10) received the injection on their first visit and one week later, and group B (n=10) received the injection on their first visit and two weeks later. All injections were done with a combination of 40 mg (1.0 mL) of triamcinolone and 5.0 mL 0.5% lidocaine (6 mL total). We examined the active range of motion (AROM) of the shoulder joint, visual analogue scale (VAS), and shoulder disability questionnaire (SDQ) at baseline at 1, 2, and 4 weeks after the initial injection.Results In VAS, comparing the changes in VAS between groups, group B showed significant improvements compared with group A or C at 4 weeks after the initial injection (p<0.05). In SDQ, comparing the changes in SDQ between the groups, group B and C showed more improvement than group A at 4 weeks after the initial injection, but these results were not statistically significant (p>0.05). In AROM, comparing the changes in AROM of external rotation between groups, group B and C showed significant improvement compared with group A at 4 weeks after the initial injection (p<0.05). Conclusion It may be more effective in pain relief for patients with periarticular disorder to receive subacromial bursa injections twice with 2-week interval, as opposed to once.

GO-33 : Comparative study of currently FDA-approved HPV tests

( Seung Won Byun ),( Song Sup Park ),( Soo Young Hur ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Human papillomavirus (HPV), the known cause of cervical cancer, is found in essentially all cervical cancer specimens. Infection with high-risk HPV genotypes carries the greatest risk of viral persistence and the potential to develop precancerous lesions or cervical cancer. Thus, the detection of high-risk HPV infection is essential to manage precancerous lesion of cervix. But the main concern has been its lower specificity, due to the fact that it cannot separate transient from persistent infections, and only the latter are associated with an increased risk of high-grade CIN and cancer, compared to Pap smear cytology. Recently new HPV tests having more clinical specificity and reproducibility has been developed from different company. APTIMA HPV test, Hybrid Capture 2 test , Cervista HR HPV test and Cobas4800 test of them was approved by U.S. Food and Drug Administration up to date. In current study, we aimed to overview the HPV high risk type detection power ,clinical implication and limitation of four FDA-approved HPV tests. Using MEDLINE, we reviewed the literlature from 2001 through to 2008 to compare between FDA-approved HPV tests in a same cohort. There were six studies which compare these HPV tests with the Hybrid Capture 2 test. But there was one study which compare between other HPV tests except the Hybrid Capture 2 test. Two prospective cohort studies demonstrated the performance of Hybdrid capture 2 test by itself. Up to date, according to comparison studies of FDA-approved HPV tests, Cervista HR, Aptima HPV, Cobas 4800 tests demonstrated comparable clinical performance to detect CIN≥2 with HC2. But there are not enough evidences which one has the best clinical performance to detect CIN≥2. In one study, Aptima have higher specificity to detect CIN≥2 in all ages. In an analytical performance, all HPV tests had fulfilled all the criteria issued by the US FDA. But HC2 test had cross reactivity with some low risk HPV type. Only Cobas 4800 test had no cross reactivity with low or undetermined risk HPV type. Each HPV test has pros and cons. So this study can be used to guide the clinicians to choose the HPV test in clinical practice.

Intracardiac metastasis from known cervical cancer

( Seung Won Byun ),( Sung Taek Park ),( Eun Young Ki ),( Hyun Song ),( Suk Hee Hong ),( Jong Sup Park ) 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-