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Kim, Youn Jung,Cha, Sung Ho,Lee, Ho Yun,Lee, Sun Kyu,Chung, Hee Yong,Yeo, Joon Hyung,Kim, Young Il,Yeo, Seung Geun Korean Society of Otorhinolaryngology-Head and Nec 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.1
<P><B>Objectives</B></P><P>To assess innate and humoral immune responses in middle ear effusion of obese pediatric patients with otitis media with effusion (OME).</P><P><B>Methods</B></P><P>We evaluated 219 children with OME, of whom 21 were obese and 198 were non-obese. We compared the expression in middle ear effusion of mRNAs encoding toll-like receptors (TLR) 2, 4, 5, and 9; nucleotide-binding oligomerization domains (NOD) 1 and 2; retinoic acid-inducible gene (RIG)-I; interleukins (IL)-6, -10, and -12; interferon (IFN)-γ; and tumor necrosis factor (TNF)-α mRNAs. We also compared the expression of immunoglobulins IgG, IgA, and IgM and the bacterial detection rate in the two groups.</P><P><B>Results</B></P><P>TLR2-mediated expression of IL-6 mRNA, TLR4-mediated expression of IL-6 and IL-10 mRNA, TLR5-mediated expression of IL-6, IL-10, and TNF-α mRNA, TLR9-mediated expression of IL-6 mRNA, and NOD2-mediated expression of IL-6, IL-12, and TNF-α mRNA were significantly lower in obese than in non-obese children (<I>P</I><0.05). However, concentrations of IgG, IgA, and IgM in middle ear effusion were lower in obese than in non-obese children, but none of these differences was significant (<I>P</I>>0.05).</P><P><B>Conclusion</B></P><P>Mean body mass index was higher and pattern-recognition receptor-mediated cytokine mRNA expression was lower in obese than in non-obese children with OME.</P>
Yeo, Seung Geun,Park, Dong Choon,Eun, Young Gyu,Cha, Chang Il WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Purpose: The pathogenesis of otitis media with effusion(OME) is considered multifactorial, with viral upper respiratory tract infection and eustachian tube dysfunction. Allergy may be related to the pathogenesis of OME or to another etiological factor. We investigated the role of allergic rhinitis(AR) in children with OME and evaluated eustachian tube function in patients with AR. Materials and methods: We prospectively analyzed the prevalence of AR. serum eosinophil count and serum total IgE concentrations in 123 children with OME and in 141 controls. IgE concentration in middle ear effusion was compared in children with OME with and without AR, and eustachian tube function after a nasal provocation test was compared between patients with AR and controls. Results: The prevalence of AR in children with OME (28.4%) and control subjects (24.1 %) did not differ significantly. These 2 groups also showed no differences in total eosinophil count and serum and middle car effusion IgE concentration. Abnormalities in eustachian tube function were the same in patients with AR and controls. Conclusions: Allergic rhinitis may not be related to the development of OME in children.
The Effect of Process Parameters on 4H-SiC Single Crystal Grown by a PVT Method
Yeo, Im Gyu,Lee, Tae Woo,Park, Jong Hwi,Yang, Woo Sung,Ryu, Heui Bum,Park, Mi Seon,Kim, Il Soo,Shin, Byoung Chul,Lee, Won Jae,Eun, Tai Hee,Lee, Seung Seok,Chun, Myong Chuel Trans Tech Publications, Ltd. 2011 Materials science forum Vol.679 No.-
<P>Extensive study of various process parameters to influence on the growth of 4H-SiC crystal has been carried out using the transformation of the 6H-SiC seed by a PVT method. The axial temperature gradients were increased throughout increasing the crucible length along growth direction in order to enhance the growth rate and transformed crystal yield. The N2/Ar gas ratio used during the crystal growth related with carrier concentration/mobility of grown crystal. In the initial stage of growth, foreign polytypes such as 6H/15R were observed on 6H-SiC seed crystal but 4H crystals were entirely grown after the process optimization. While the typical absorption spectrum of SiC seed crystal indicated that the SiC polytype was the 6H-SiC with fundamental absorption energy of about 3.02eV, absorption spectrum of grown SiC crystal exhibited 4H-SiC with fundamental absorption energy of about 3.26eV. The entirely transformed SiC region exhibited lower micropipe density than 6H/4H transition region.</P>
Phellinone, a New Furanone Derivative from the Phellinus linteus KT&G PL-2
Yeo, Woon-Hyung,Hwang, Eui-Il,So, Seung-Ho,Lee, Sang-Myung 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
Phellinone, a new furanone derivative, has been isolated from the stem-cooked rice culture broth of Phellinus linteus KT&GPL-2. Phellinone was purified by consecutive solvet partition, silica gel, preparative TLC and preparative HPLC. The structure of phellinone was assigned as a furanone derivative on the basis of various spectroscopic analyses, including Mass and NMR spectroscopies. Its molecular weight and formula were found to be 248 and $C_{15}H_{20}O_{3}$, respectively, and showed antimicrobial activity against Bacillus subtilis IAM 1090.
Bacteriology of chronic suppurative otitis media : a multicenter study
YEO, SEUNG GEUN,PARK, DONG CHOON,HONG, SEOK MIN,CHA, CHANG IL,KIM, MYUNG GU WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Conclusions. Bacterial predominance and antibiotic sensitivity have changed over time, making continuous and periodic surveillance necessary in guiding appropriate antibacterial therapy. Objectives. With the development and widespread use of antibiotics, the types of pathogenic microorganisms and their resistance to antibiotics have changed. Knowledge of the species and resistance rates of current pathogens is important for determining the appropriate antibiotics for patients with chronic suppurative otitis media. We investigated the current bacteriology of chronic suppurative otitis media. Subjects and methods. This was a retrospective study of 1102 patients with chronic suppurative otitis media seen at six hospitals in Korea from January 2001 to December 2005. Results. The most commonly identified pathogenic bacterial species was Pseudomonas, with the next most prevalent being methicillin-resistant Staphylococcus aureus (MRSA).
Seung-Il Cho,Sung-Dae Yeo,Seong-Kweon Kim,Michio Yokoyama 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.9
The environment development for deep sleep has been studied using analysis results of the big data about vital signs and parameters in the bedroom. The organic light emitting diode (OLED) illuminations of the bedroom are dimming using analysis results of the big data. Therefore, a low-power and compact design of dimming part is required for OLED illumination system. In this paper, the optimized control block of the clock cut-off circuit was designed using De Morgan’s laws with adiabatic dynamic CMOS logic (ADCL) digital 3-bit pulse width modulation (PWM). The designed clock cut-off circuit pauses the D-flipflops (D-ffs) after cutting off the clock at both 0 % and 100 % pulse width of PWM output for dimming. As a result, 10 transistors of the miniaturized control block were reduced and layout area of the optimized control block is 2,198.0μm2 using Rohm 0.18μm standard CMOS model .The operation of control block of clock cut-off circuit with ADCL 3-bit digital PWM is confirmed by post-simulation of hspice.
Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Yeo, Seung-Geun,Cha, Chang-Il,Park, Dong-Choon The Korean Association of Immunobiologists 2006 Immune Network Vol.6 No.1
Background: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small pro portion of splenic B cells and they are larger and less dense than B-2 cells in morphology. This study was designed to compare the differences in their proliferation and differentiation between B-1 and B-2 cell. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. Secreted IgM was measured by enzyme-linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Cell cycle analysis by propidium iodide was performed. p21 expression was assessed by real time PCR. Results: Cell proliferation and cell cycle progression in B-1 and B-2 cells, which did not occur in the absence of LPS, required LPS stimulation. After LPS stimulation, B-1 and B-2 cells were shifted to Sand G2/M phases. p21 expression by resting B-1 cells was higher than that of resting B-2 cells. Conclusion: B-1 cells differ from conventional B-2 cells in proliferation, differentiation and cell cycle.