複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

The Industry Trends and Future Strategies of Korean MDF Business

Se-Hwi Park,Yong-Hwan Lim,Young-In Kim,Young-Do Woo,Jeong-Soo Kim 강원대학교 산림과학연구소 2022 강원대학교 산림과학연구소 학술대회 Vol.2022 No.10

Dry-process MDF is the material that overcomes heterogeneous characteristics of woody resources, and it has been used steadily in many industrial and life fields. In terms of MDF business, raw materials should be considered preferentially because they are responsible for the largest aspect of manufacturing costs. MDF process, which has the process of disassembly into fibers and reassembly into panel, received influence of wood properties such as fiber length, extractives content, and maturity. Looking at the usage of species by region, softwood species are used in Europe and North America, hardwood species are in Asia, respectively. In the case of South Korea, red pine and radiate pine have been mainly used due to optimized manufacture condition and excellent board quality result from long fiber length characteristics. However, the governmental price support for bio-energy industry and the reduction of logging by environmental issues continue to reduce the supply of raw materials for board business. There are two strategies to solve resources shortage problem. Firstly, as a method of moving production bases to overseas regions rich in raw materials, such as Vietnam and Malaysia, it is mainly used by this company (Korea). Once the production is optimized for the new species in the area, it can be successfully profitable. Before, it should be necessary to overcome the problem that it is not easy to build deforestation infrastructure in develop forest area. Secondly, recycled materials is researched and applied by several companies. Outstanding technique and effort are required in order to solve some problem such as difficulty in perfect refining, low fiber quality, and impurities addition. On the other hand, the fact that can contribute to carbon neutrality is fascinating. Korean companies are taking a multi-pronged approach to securing MDF resources. Our company is currently undergoing a new development in northern Vietnam, but is struggling with a number of issues, including the absence of professional logging companies and the establishment of rival company around our site. Expansion to new regions that have not yet entered the market is also being planned, with Cambodia, Laos, and Indonesia being cited as the next destinations.

[< 전시-P-20 >] Physicochemical Properties of Carbonized Bamboo using Indonesian Bamboo Species

( Se-hwi Park ),( Jae-hyuk Jang ),( Min Lee ),( Won-jae Youe ),( Nam-hun Kim ),( Nyoman Wistara ),( Fauzi Febrianto ) 한국목재공학회 2017 한국목재공학회 학술발표논문집 Vol.2017 No.2

The Effects of the Position of Ipsilateral Neck Rotation on the Inhibition of the Upper Trapezius Muscle During Lower Trapezius Exercises

Se-in Park,Ji-yeong Chae,Hyeong-hwi Kim,Yu-geoung Cho,Kyue-nam Park 한국전문물리치료학회 2016 한국전문물리치료학회지 Vol.23 No.1

Background: The unilateral prone arm lift (UPAL) is commonly used to exercise the lower trapezius muscle. However, overactivation of the upper trapezius can induce pain during UPAL exercises in subjects with upper trapezius tenderness. Objects: The purpose of this study was to investigate the effects of position of ipsilateral neck rotation (INR) on the inhibition of upper trapezius muscle activity and the facilitation of the lower trapezius muscle when performing UPAL exercises. Methods: In total, 19 subjects with upper trapezius tenderness were recruited for the study. Electromyographic (EMG) activity was measured in the upper, middle, and lower trapezius muscles during UPAL with and without INR position. Wilcoxon signed-rank test was used to compare EMG activity in the trapezius muscles and the muscle ratios. Results: EMG activity in the upper trapezius muscles was decreased significantly in the INR condition compared to without the position with INR during UPAL exercises (p<.05). EMG activity in the middle and lower trapezius was not significantly different between the with and without INR conditions (p>.05). However, the ratio of lower to upper trapezius activation showed a significant increase in the INR condition compared to the without INR condition (p<.05), indicating greater lower trapezius activation relative to the upper trapezius in the INR position than in the without INR position. Conclusions: The EMG results obtained in this study suggest that the position with INR reduced overactivation in the upper trapezius and improved muscle imbalance during lower trapezius exercises in individuals with upper trapezius tenderness.

Anatomical and Physical Properties of Indonesian Bamboos Carbonized at Different Temperatures

( Se-hwi Park ),( Jae-hyuk Jang ),( Nyoman J Wistara ),( Wahyu Hidayat ),( Min Lee ),( Fauzi Febrianto ) 한국목재공학회 2018 목재공학 Vol.46 No.6

Tropical bamboo species, which have a very rapid growth rate, are considered as a promising non-timber forest product capable of exhibiting new functionality by carbonization technology. This study was conducted to compare the characteristics of carbonized bamboos from Andong (G. pseuudoarundinacea (Steudel) Widjaja), Hitam (G. atrovialacea), Tali (G. apus), Kuning (B. vulgaris Var. striata (Lodd. Ex Lindl)), and Ampel (B. vulgaris Scharad. ex Wendland), and Betung (D. asper). Each bamboo was carbonized at 200, 400, 600, 800, and 1,000 ℃, respectively, and their physical and anatomical characteristics were investigated. The result showed that the volume and weight of carbonized bamboo decreased with increasing carbonization temperature and showed the substantial changes of volume and weight between 200 and 400 ℃. The highest and the lowest density of carbonized samples were found in Ampel bamboo and Betung bamboo, respectively. The density of all carbonized bamboos tended to decrease after carbonization at 200 and 400 ℃ and relatively become constant afterwards. The carbonized bamboo prepared at 800 and 1,000 ℃ showed better refining degree. The results of the anatomical observation showed that the vascular diameter of carbonized bamboo decreased with increasing carbonization temperature, and the shrinkage in radial and tangential direction showed similar tendency. Statistical analysis showed that there was significant correlation between physical contraction and anatomical contraction. Based on the results of this study, comprehensive data about Indonesian bamboo charcoals could be obtained and it will be useful for future application studies.

고열처리 맹종죽의 육안적 및 물리적 특성

박세휘 ( Se-hwi Park ),강은창 ( Eun-chang Kang ),이민 ( Min Lee ),김영진 ( Young-jin Kim ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.1

방치되어 가는 국산 대나무의 고부가·신산업화 방안을 모색하기 위해 고열처리 방법이 적용되었다. 기존의 연구에서는 플레이크 형태로 잘게 나누어진 재료가 주를 이루었으나, 본 실험에서는 대나무를 작게 가공하지 않은 원재료 그대로가 사용되었다. 대나무 원통을 대형챔버형 과열증기 목재고열처리기에 서 승온-유지-냉각 스케줄에 따라 건조시켰다. 건조시 유지온도 조건을 130, 140 및 150 ℃ 3가지로 적용하였으며, 각각의 시편에 대한 육안적 및 물리적 평가를 수행하였다. 건조에 따른 재색변화를 정확하기 분석하기 위해 색차계 측정을 실시하였다. 육안적 관찰 결과, 건조온도 140 ℃ 이하에서는 할렬이 거의 발생하지 않았다. 하지만, 150 ℃부터는 마디 주위가 수축되었으며, 일부 할렬이 관찰되었다. 150℃ 처리시편에서는 그을음 또는 초산 냄새가 감지되었다. 온도가 증가함에 따라 대나무 시편의 명도 L*은 59.24∼23.54까지 감소하였다. 채도 a*(적색-녹색)는 130 ℃까지 상승폭을 나타냈으며, 140℃부터 감소하였다. 채도 b*(황색-청색)는 17.09∼1.33으로 꾸준하게 감소하였다. 물리적 특성평가는 대나무의 상부 중부 및 하부로 구별하여 수행하였다. 함수율은 처리온도가 높고 상부에서 채취된 시편일수록 수치가 낮아졌다. 기건밀도와 기건비중 차이는 생재시편이 가장 높았으며, 150 ℃ 시편의 차이가 가장 작았다. 무처리 및 온도별 시편의 기건밀도는 각각 0.96, 0.88, 0.83 및 0.99 g/㎤로 나타났으며, 150 ℃ 시편의 밀도 증가는 대나무 표면 왁스층의 융해 및 경화에 의한 것으로 분석된다. 종합적으로 140 ℃ 처리재의 낮은 함수율, 적은 할렬 발생 빈도, 무향 등의 장점에 따라 내부 인테리어나 울타리와 같은 건축 소재로의 활용이 가능할 것으로 기대된다.

파티클 원료 및 구성에 따른 구조용 파티클보드의 제조특성

박세휘 ( Se-hwi Park ),강은창 ( Eun-chang Kang ),이민 ( Min Lee ),이상민 ( Sang-min Lee ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.1

국내 경골목구조 시공에서 구조용 판상재는 주로 수입산 OSB가 쓰이고 있으며, 이를 대체하기 위한 구조용 파티클보드(Structural particleboard, 이하 S-PB)를 제조하였다. S-PB 제조조건 확립을 위해 파티클 원료와 구성에 따른 성능을 평가하였다. 파티클은 국내 섬유판 제조사에서 시제품 생산에 사용하고 있는 파티클(조건1)과 본원 장비에서 직접 제조한 파티클(조건2)을 구분하여 사용하였다. 각각의 파티클의 mesh별 길이와 분포를 조사하였다. 해외 S-PB용 기준에 명시되어 있는 습윤 조건을 충족시키기 위해 멜라민-요소-폼알데하이드 수지 접착제(F/MU=1.00, 멜라민함량 27%, 고형분 62%)를 합성하여 20% 염화암모늄 수용액 (접착제 고형분 대비 3%, 중층에만 적용)과 왁스에멀젼(고형분 39.1%, 전건파티클 중량 대비 1%)을 함께 혼합하였다. 이때 파티클 구성에 따른 S-PB의 강도 차이를 분석하기 위해 표층과 중층 비율을 각각 50:50(조건A), 40:60(조건B) 및 30:70(조건C)으로 구분하였다. 함지율은 전건파티클 중량 대비 표층 15% 및 중층 12%였으며, 도포 후 매트함수율은 각각 9.68% 및 9.45%로 나타났다. 열압조건은 온도(180 ℃), 목표밀도(720 ㎏/㎥) 및 시간(15 s/㎜)으로 설정하였으며, 압력은 3단계(40 ㎏f/㎠-32 ㎏f/㎠-20 ㎏f/㎠)로 나누어 가압하였다. 제조된 보드는 ISO 16893에 따라 물성을 평가하였다. 파티클 길이 및 분포 조사에서 조건2 파티클 크기가 전반적으로 컸으며, 이는 성능평가에서 조건1보다 높은 수치를 나타냈다. 중층 파티클 비율이 높아질수록 MOR, MOE 및 박리강도와 같은 강도적 성질은 향상되었으나, 흡수두께팽창률은 수치가 증가하여 기준 12%를 상회하였다. 최종적으로 표층 중층 비율 40:60이 적절한 제조조건으로 판단되었으며, 입자 크기가 큰 파티클 재료를 사용하는 것이 보드의 성능을 개선시킬 것으로 판단된다.

자외선 조사에 의한 인도네시아 주요 조림수종 목재의 재색변화

박세휘 ( Se Hwi Park ),장재혁 ( Jae Hyuk Jang ),( Yue Qi ),( Wahyu Hidayat ),황원중 ( Won Joong Hwang ),( Fauzi Febrianto ),김남훈 ( Nam Hun Kim ) 한국목재공학회 2016 목재공학 Vol.44 No.1

This study was performed to understand wood durability to climate deterioration of planted Indonesian wood specie such as Albizia, Gmelina, Mangium and Mindi. Wood samples were exposed to indoor and outdoor condition. L*a*b* and Color changes (ΔE*ab) were determined by a spectrophotometer. As a result, color of all samples was changed more markedly by ultraviolet radiation. In indoor test with UV, brightness of wood specimens from four species was not changed and all samples were changed into more reddish and yellowish. In accelerated weathering test, all samples were bleached and changed into more greenish and blueish. In outdoor test, brightness of wood specimens decreased in Albizia and Gmelina and increased in Mangium and Mindi. All wood specimens in outdoor test were changed into more greenish and blueish. Albizia and Gmleina woods showed greater color change than those of Mangium and Mindi. Especially, color change of wood samples might be influenced greatly by moisture. In conclusion, wood color changed into more clearly by UV radiation. Therefore, exposing woods to UV radiation could be one of reasonable methods to improve wood quality on visual characteristic.

인도네시아 주요 조림수종의 연소특성

박세휘 ( Se Hwi Park ),장재혁 ( Jae Hyuk Jang ),( Wahyu Hidayat ),( Yue Qi ),( Fauzi Febrianto ),김남훈 ( Nam Hun Kim ) 한국목재공학회 2015 목재공학 Vol.43 No.6

This study was performed to understand combustion properties four major Indonesian wood species such as Albizia, Gmelina, Mangium and Mindi were investigated by cone-calorimeter for better utilization of theses wood species. Heat release rate (HRR), total heat release (TSR), specific mass loss rate (SMLR), effective heat of combustion (EHC), time to ignition (TTI), flame time (FT), specific extinction area (SEA), smoke production rate (SPR) and CO compound production rate were measured. HRR, THR and FT were proportional to the density of woods. Albizia showed the highest HRR, while Mindi had the lowest HRR. For SPR, Albizia showed the highest value due to its higher SEA. On the other hand, Mindi had the lowest SPR due to a lower SEA value. The highest smoke emission was for Albizia at the beginning of combustion. After 300 seconds, smoke emission of Gmleina and Mangium was increased greatly. Mangium and Mindi showed the highest total carbon dioxide emission. Expecially, Gmelina released the highest carbon monoxide during the combustion period and presented three times higher CO/CO2 ratio than those of other species due to incomplete combustion.

Porous Ceramics의 연삭특성에 관한 연구

박휘근(Hwi-Keun Park),박세진(Se-Jin Park),최윤서(Yun-Seo Choi),황인환(In-Hwan Hwang),이종찬(Jong-Chan Lee) 한국기계가공학회 2012 한국기계가공학회지 Vol.11 No.2

The resin bonded diamond wheel is used to grind the difficult-to-cut materials. Traditionally, the resin bonded diamond wheel is manufactured without any pores due to the characteristics of resin bond. In this study, two porous resin bonded diamond wheel were made and the grinding characteristics were compared with traditional nonporous ones. The experimental results indicate that the porous resin bond diamond wheel require less grinding forces and powers.