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Recombinant Human Erythropoietin 및 N-acetylcysteine의 방사선 조영제에 의한 신독성 예방효과
정사라 ( Sa Rah Chung ),김의식 ( Eui Sik Kim ),정지윤 ( Ji Yoon Jung ),김난희 ( Nan Hee Kim ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),신영태 ( Young Tai Shin ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.6
Purpose : We investigated the effects of recombinant human erythropoietin (EPO) and N-acetylcysteine (NAC) in the prevention of radiocontrast-induced nephrotoxicity in patients with underlying renal ysfunction, who are regarded as a high risk group. Methods : This study included 77 individuals with renal insufficiency, defined by a serum creatinine concentration above 1.2 mg/dL or creatinine clearance of more than 15 mL/min/1.73m2 and less than 60 mL/min/1.73m2. These patients who needed radiologic interventions including the use of radiocontrast materials from August 2006 to May 2007 were randomly assigned to one of four groups, which were treated with EPO only, NAC only, EPO plus NAC and placebo respectively. The serum creatinine and cystatin-C were measured before, 24 hours and 48 hours after the intervention. The creatinine clearance was obtained using the Cockcroft-Gault equation. Results : The serum level of creatinine in EPO plus NAC group was not significantly elevated 24 and 48 hours after radiocontrast exposure compared to control group (p=0.012). Also, the creatinine clearance of EPO plus NAC group was not significantly decreased after radiocontrast exposure compared to control group (p=0.046). The serum level of creatinine in EPO and NAC group increased less than control group, but there were no significant differences between the groups. Also, the creatinine clearance in EPO and NAC group decreased less than control group, but there were no significant differences between the groups. Conclusion : EPO plus NAC showed a renoprotective effect on radiocontrast study in patients with underlying renal dysfunction.
타목시펜과 프레드니솔론으로 호전된 경화성 피막성 복막염 (sclerosing encapsulating peritonitis)
정지윤 ( Ji Yoon Jung ),장원익 ( Won Ik Jang ),윤지현 ( Ji Hyun Yoon ),김의식 ( Eui Sik Kim ),정사라 ( Sa Rah Chung ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),강대영 ( Dae Young Kang ),신영태 ( Young 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Sclerosing encapsulating peritonitis (SEP) is an uncommon but serious complication of long-term peritoneal dialysis (PD). Entrapment of the intestine in fibrous tissue, causing complete intestinal obstruction, is referred to as SEP. The usual clinical presentation is with partial or complete small bowel obstruction, ascites, abdominal mass, or impaired peritoneal ultrafiltration. Conservative treatment carries a poor outcome and surgery has offered variable results. Even though there is no established medical treatment, immunosuppressive drugs, steroid and tamoxifen are often used. Tamoxifen is a nonsteroidal anti-estrogenic drug commonly used in the management of breast cancer. To our knowledge, this is the first case of sclerosing encapsulating peritonitis successfully treated with tamoxifen and prednisolone in Korea. Recently, we have treated three SEP patients with tamoxifen and prednisolone. All three patients showed clinical improvement within a few months.
Lee, Sang-Yoon,Kim, Bo-Kyung,Yoon, Sa-Rah,Kim, Yeon-Joo,Liu, Tian,Woo, Joo-Hong,Chwae, Yong-Joon,Joe, Eun-Hye,Jou, Il-O Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.9
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase ${\alpha}$ ($PIP5K{\alpha}$) that is responsible for production of phosphatidylinositol 4,5-bisphosphate ($PI[4,5]P_2$) regulates many important cell functions at the cell surface. Here, we have examined whether $PIP5K{\alpha}$ is associated with astrocyte inflammatory responses. Gangliosides are releasable from damaged cell membranes of neurons and capable of inducing inflammatory responses. We found that treatment of primary cultured astrocytes with gangliosides significantly enhanced $PIP5K{\alpha}$ mRNA and protein expression levels. $PI(4,5)P_2$ imaging using a fluorescent tubby (R332H) expression as a $PI(4,5)P_2$-specific probe showed that ganglioside treatment increased $PI(4,5)P_2$ level. Interestingly, microRNA-based $PIP5K{\alpha}$ knockdown strongly reduced ganglioside-induced transcription of proinflammatory cytokines IL-$1{\beta}$ and $TNF{\alpha}$. $PIP5K{\alpha}$ knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-${\kappa}B$ and the degradation of $l{\kappa}B-{\alpha}$, indicating that $PIP5K{\alpha}$ knockdown interfered with the ganglioside-activated NF-${\kappa}B$ signaling. Together, these results suggest that $PIP5K{\alpha}$ is a novel inflammatory mediator that undergoes upregulation and contributes to immune responses by facilitating NF-${\kappa}B$ activation in ganglioside-stimulated astrocytes.