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      • KCI등재

        韩国汉语学习者的礼貌用语教学研究

        张蕊 ( Zhang¸ Rui ) 중국어문학회 2021 中國語文學誌 Vol.- No.74

        Chinese and Korean have differences in traditional culture, way of thinking, psychological quality and customs due to their different nationalities. These differences are also reflected in the polite expressions that reflect social etiquette norms. This paper first combed the definition of Chinese politeness and politeness principles, and analyzed the differences and similarities between Chinese and Korean in politeness terms through specific examples. Secondly, a questionnaire survey is conducted among Korean undergraduates who have different degrees of Chinese learning experience. It analyzed the misuse and characteristics of Korean students’ Polite expressions, and understands the interference factors in the acquisition of polite expressions “Depreciate yourself and respect others” is one of the five principles of polite language in Chinese, and it is also the center of the five principles, and is an important connotation of Chinese culture. Chinese polite language requires high vocabulary changes. Different pragmatic phenomena will produce different polite effects. In the choice of wording, full consideration should be given to the identity, age, and occasion of both parties in the conversation. On the one hand, Korean uses a respectful vocabulary system to highlight the speaker’s respect for the other party. On the other hand, Korean has a very strict honorific style, which expresses respect through a grammatical system. At the end of the thesis, three suggestions for polite language teaching were put forward, and the teaching plan was designed. First, understand the obstacles to students’ acquisition and increase the importance of polite language teaching. Second, pay attention to the understanding and application of pragmatic functions, and emphasize cultural cognition in combination with specific scenarios. Third, make up for the lack of teaching and teaching materials, and conduct polite language teaching in stages.

      • KCI등재

        Study and Design of High Strength and Low Heat Generation Polymer Composites by Molecular Dynamics Simulation

        Rui-Rui Zhang,Bin Wu,Peng Chen,Jia-Sheng Qian 한국고분자학회 2020 폴리머 Vol.44 No.6

        The molecular dynamics simulation was used to study and design a polymer composites system with excellent mechanical strength and less heat generation in a dynamic process. A series of system factors such as filler loading, surface modification onto filler, and network of cross-linking filler particles on mechanical and heat generation of polymer composites are systematically considered. It is found that the surface grafting onto fillers can restrain the heat generation of polymer composite in the dynamic process, while it shows less effect on the mechanical property. A network of cross-linking filler particles can be fabricated by a combination of grafting chains onto fillers. By filling such a network into the polymer, the mechanical and heat generation properties of polymer composites are significantly improved. Simulation results can help experimental fabrication of polymer composites with excellent mechanical and heat generation properties.

      • Historical Long-term Exposure to Pentachlorophenol Causing Risk of Cancer - A Community Study

        Zheng, Rui-Zhi,Zhang, Qing-He,He, Yi-Xin,Zhang, Qian,Yang, Lin-Shen,Zhang, Zhi-Hua,Zhang, Xiu-Jun,Hu, Jing-Ting,Huang, Fen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

        Background: Pervious studies suggested occupational workers exposure to pentachlorophenol (PCP) might contribute to increased risk of cancer. However, few studies have focused on associations between PCP and cancer risk at the community level. Objective: The present study was to explore the cancer risk for the community population living long-term in a PCP contaminated area. Methods: All the cancer cases diagnosed in 2009-2011 in Tongling City were collected. The cancer patients' residencies were geo-referenced in each district. The historical PCP usage for each district of Tongling was calculated as the PCP pollution index, which was further used to divide into PCP exposure categories. Standardized rate ratios (SRRs) of cancer incidence were applied to detect the cancer risk as exposure grade elevated. Correlation analysis was performed to analyze the relationship between PCP pollution and cancer incidence. Results: A total of 5,288 cancer cases (3,451 male and 1,837 female) were identified. PCP usage was correlated with the incidence of leukemia (r=0.88, P=0.002) for males, and with cancer of the esophagus for males (r=0.83, P=0.008) and females (r=0.71, P=0.020). Compared with the low exposure category, significant SRRs for total cancer sites was obtained for high PCP exposure category (SRR=1.61, 95%CI=1.59-1.62). Most SRR values of the cancer sites were significantly increased as exposure grade elevated and exposure time extended. Conclusion: The present study found that community residents living in the PCP contaminated area had increased risk of cancers. Leukemias, lymphomas and nasopharyngeal and esophageal cancers are most possibly associated with PCP exposure.

      • KCI등재

        A magnetostrictive self-powered biosensor based on Au-BaTiO3-FeGa & PDMS

        Qiang Zhang,Meng Xu,Yan Liu,Chunyan Zhang,Rui Zhang,Zhiyuan Fu,Jianlong Ji,Riguang Zhang,Shengbo Sang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-

        Piezoelectric flexible sensors have been used to detect biomolecules such as sweat and glucose because oftheir passive, simple structure and high sensitivity. This paper proposes a novel flexible piezoelectric Au-BaTiO3-FeGa & PDMS biosensor in which magnetostrictive deformation amplifies the surface stress generatedby biomolecules combining on the thin film. The modification process of bovine serum albumin(BSA) binding with the sensor was initially determined by the first principles approach. Then, the sensingmechanism was verified by finite-element simulation. Based on the simulation results, flexible Au-BaTiO3-FeGa & PDMS biosensors were prepared, modified, and measured. The structure, modification,and detection of the sensors were analyzed by digital microscopy, Fourier transform infrared spectrometry(FTIR), atomic force microscopy (AFM), and scanning electron microscopy (SEM). The responses ofthe biosensors detecting different BSA solution concentrations under magnetic fields were then investigated. Experimental results indicate that the biosensor has the highest sensitivity under a magnetic fieldof 30 mT.

      • SCISCIESCOPUS

        Epigenetic alterations are involved in the overexpression of glutathione S-transferase π-1 in human colorectal cancers.

        Zhang, Rui,Kang, Kyoung Ah,Piao, Mei Jing,Kim, Ki Cheon,Zheng, Jian,Yao, Cheng Wen,Cha, Ji Won,Maeng, Young Hee,Chang, Weon Young,Moon, Pyong-Gon,Baek, Moon-Chang,Hyun, Jin Won Lychnia 2014 International journal of oncology Vol.45 No.3

        <P>Glutathione S-transferase pi-1 (GSTP-1) is a member of the glutathione S-transferase enzyme superfamily, which catalyzes the conjugation of electrophiles to glutathione during the process of detoxification. In this study, the epigenetic alterations of GSTP-1 expression in human colorectal cancers and the underlying mechanisms were investigated. In 10 colon cancer patients, proteomic analysis revealed that expression of GSTP-1 protein was higher in tumor tissues than in paired adjacent normal tissues. Likewise, in 7 of 10 colon cancer patients, GSTP-1 protein expression was more than 1.5-fold higher in tumor tissues than in adjacent normal tissues, as determined by western blotting. Immunohistochemical data confirmed that GSTP-1 protein was expressed at higher levels in colon cancer tissues compared to normal mucosa. GSTP-1 enzyme activity was closely correlated with GSTP-1 protein expression in colon cancer patients. Consistent with this, GSTP-1 mRNA, protein and activity levels were higher in the colorectal cancer cell lines Caco-2, HCT-116, HT-29, SNU-407 and SNU-1033 compared to the normal colon cell line FHC. Methylation-specific PCR results indicated that the high levels of GSTP-1 in human colorectal cancer cell lines were likely due to the lower degree of promoter methylation in colon cancer cell lines compared to the normal colon cell line, consistent with findings in colon cancer patients. Moreover, the levels of specific activator-protein complexes and histone marks were higher in human colorectal cancer cells compared to the normal human colon cell line, whereas the repressor protein complexes exhibited the opposite pattern. Furthermore, chromatin immunoprecipitation assays demonstrated that expression levels of the transcription factors AP-1 and SP-1 were correlated with the upregulation of GSTP-1 expression in colorectal cancer cells. Finally, knockdown of GSTP-1 promoted the sensitivity of SNU-407 cells to the anticancer agent 5-fluorouracil. These data indicate that GSTP-1 may serve as a clinically useful biomarker of colon cancer and a target for anti-colon cancer drugs.</P>

      • KCI등재

        Tri-stimuli responsive carbon nanotubes covered by mesoporous silica graft copolymer multifunctional materials for intracellular drug delivery

        Rui-Qian Zhang,Zhan-Qing Liu,Yan-Ling Luo,Feng Xu,Ya-Shao Chen 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-

        To overcome premature drug leakage and instability in drug delivery systems, we designed tri-stimuliresponsive multiwalled carbon nanotubes covered by mesoporous silica graft poly(N-isopropylacryla-mide-block-poly(2-(4-formylbenzoyloxy) ethyl methacrylate) multifunctional materials via disulfidelinkages (MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA). The multifunctional materials could covalentlybind and physically load anticancer drug doxorubicin (DOX), and exhibited pH-, temperature- andreductant-induced multi-stimuli responsiveness, significantly enhancing drug loading capacity andimproving the release dynamics of drug. The DOX-loaded multifunctional materials exhibited theoptimal release behavior in cancer environments compared with in normal cells upon simultaneouslytriggered by these stimuli. It meant that the MWCNTs@MSN-s-s-g-PNIPAM-b-PFBEMA could serve asefficient gatekeepers to control the mesopore on–off and thus to modulate drug release. Themultifunctional materials were proved to be low toxic, whereas the DOX-loaded counterparts had almostthe same toxicity as free DOX to cancer cells. Therefore, the developed multifunctional materials can beused as promising drug controlled delivery platforms for cancer therapy.

      • Focus Improvement of High-Squint SAR Based on Azimuth Dependence of Quadratic Range Cell Migration Correction

        Zhang, Shuang-Xi,Xing, Meng-Dao,Xia, Xiang-Gen,Zhang, Lei,Guo, Rui,Bao, Zheng IEEE 2013 IEEE geoscience and remote sensing letters Vol.10 No.1

        <P>In this letter, we discuss the problem that linear range cell walk correction in the azimuth time domain may cause space variation along the azimuth not only to the quadratic phase but also to the quadratic range cell migration (QRCM) under the conditions of high resolution and large scene along the azimuth. Moreover, an algorithm is proposed to deal with this problem. The proposed algorithm adopts the azimuth space variation filtering in the range frequency domain. In addition, the range-dependence component of QRCM is corrected by linear chirp scaling, and the unified QRCM can be corrected in the 2-D frequency domain. The proposed algorithm, without interpolation, can be easily implemented by integrating with motion compensation for image processing. Simulation and airborne strip-map real data show the accuracy and efficiency of the proposed algorithm.</P>

      • Bayesian empirical likelihood inference for the generalized binomial AR(1) model

        Zhang Rui,Wang Dehui 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.4

        In this paper, the Bayesian empirical likelihood (BEL) inference is considered for the generalized binomial AR(1) model. We establish a nonparametric likelihood using the empirical likelihood (EL) approach and consider a specific prior based on copulas. An efficient Markov chain Monte Carlo (MCMC) procedure is described for the required computation of the posterior distribution. In the simulation study, we analyze the accuracy and sensitivity of the MCMC algorithm. We also study the robustness of the new method. The results imply that our algorithm converges quickly and not strongly influenced by the model assumptions. Furthermore, the BEL method is robust. Finally, a real data example is analyzed to illustrate of our method.

      • KCI등재

        Low-noise reconstruction method for coded-aperture gamma camera based on multi-layer perceptron

        Rui Zhang,Xiaobin Tang,Pin Gong,Peng Wang,Cheng zhou,Xiaoxiang Zhu,Dajian Liang,Zeyu Wang 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.10

        Accurate localization of radioactive materials is crucial in homeland security and radiological emergencies. Coded-aperture gamma camera is an interesting solution for such applications and can be developed into portable real-time imaging devices. However, traditional reconstruction methods cannot effectively deal with signal-independent noise, thereby hindering low-noise real-time imaging. In this study, a novel reconstruction method with excellent noise-suppression capability based on a multi-layer perceptron (MLP) is proposed. A coded-aperture gamma camera based on pixel detector and coded-aperture mask was constructed, and the process of radioactive source imaging was simulated. Results showed that the MLP method performs better in noise suppression than the traditional correlation analysis method. When the Co-57 source with an activity of 1 MBq was at 289 different positions within the field of view which correspond to 289 different pixels in the reconstructed image, the average contrast-to-noise ratio (CNR) obtained by the MLP method was 21.82, whereas that obtained by the correlation analysis method was 5.85. The variance in CNR of the MLP method is larger than that of correlation analysis, which means the MLP method has some instability in certain conditions.

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