Signal processing method based on energy ratio for detecting leakage of SG using EVFM

Xu Wei,Xu Ke-Jun,Yan Xiao-Xue,Yu Xin-Long,Wu Jian-Ping,Xiong Wei 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8

In the sodium-cooled fast reactor, the steam generator is a heat exchange device between sodium and water, which may cause leakage, resulting in a sodium-water reaction accident, which in turn affects the safe operation of the entire nuclear reactor. To this end, the electromagnetic vortex flowmeter is used to detect leakage of the steam generator and its signal processing method is studied in this paper. The hydraulic experiment was carried out by using water instead of liquid sodium, and the sensor output signal of the electromagnetic vortex flowmeter under different gas injection volumes was collected. The bubble noise signal is reflected by the base line of the sensor output signal. According to the relationship between the proportion of the bubble noise signal in the sensor output signal and the gas injection volume, a signal processing method based on the energy ratio calculation is proposed to detect whether the water contains bubbles. The gas injection experiment of liquid sodium was conducted to verify the effectiveness of the signal processing method in the detection of bubbles in sodium, and the minimum detectable leak rate of water in the steam generator was detected to be 0.2 g/s.

Stretchable Wire-Shaped Asymmetric Supercapacitors Based on Pristine and MnO₂ Coated Carbon Nanotube Fibers

Xu, Ping,Wei, Bingqing,Cao, Zeyuan,Zheng, Jie,Gong, Ke,Li, Faxue,Yu, Jianyong,Li, Qingwen,Lu, Weibang,Byun, Joon-Hyung,Kim, Byung-Sun,Yan, Yushan,Chou, Tsu-Wei American Chemical Society 2015 ACS NANO Vol.9 No.6

<P>While the emerging wire-shaped supercapacitors (WSS) have been demonstrated as promising energy storage devices to be implemented in smart textiles, challenges in achieving the combination of both high mechanical stretchability and excellent electrochemical performance still exist. Here, an asymmetric configuration is applied to the WSS, extending the potential window from 0.8 to 1.5 V, achieving tripled energy density and doubled power density compared to its asymmetric counterpart while accomplishing stretchability of up to 100% through the prestrainning-then-buckling approach. The stretchable asymmetric WSS constituted of MnO<SUB>2</SUB>/CNT hybrid fiber positive electrode, aerogel CNT fiber negative electrode and KOH-PVA electrolyte possesses a high specific capacitance of around 157.53 μF cm<SUP>–1</SUP> at 50 mV s<SUP>–1</SUP> and a high energy density varying from 17.26 to 46.59 nWh cm<SUP>–1</SUP> with the corresponding power density changing from 7.63 to 61.55 μW cm<SUP>–1</SUP>. Remarkably, a cyclic tensile strain of up to 100% exerts negligible effects on the electrochemical performance of the stretchable asymmetric WSS. Moreover, after 10 000 galvanostatic charge–discharge cycles, the specific capacitance retains over 99%, demonstrating a long cyclic stability.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-6/acsnano.5b01244/production/images/medium/nn-2015-012442_0007.gif'></P>

Neoadjuvant Chemotherapy for Resectable Esophageal Carcinoma: A Meta-analysis of Randomized Clinical Trials

Xu, Xiao-Hua,Peng, Xue-Hong,Yu, Ping,Xu, Xiao-Yuan,Cai, Er-Hui,Guo, Pi,Li, Ke Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Neoadjuvant chemotherapy for resectable esophageal carcinoma has been a focus of study, but no agreement has been reached on clinical randomized controlled trials and relevant systematic evaluation. The purpose of this study was to perform a meta-analysis on published randomized controlled trials (RCTs) that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Medline and manual searches was conducted in PubMed, ASCO (American Society of Clinical Oncology) meeting summary, Embase, the Cochrane Library (up to October 2010), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database. The selection contents were to identify all published and unpublished RCTs that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Sixteen RCTs which included 2,594 patients were selected. The risk ratio (RR) (95% confidence interval [CI]; P value), expressed as neoadjuvant chemotherapy and surgery versus surgery alone (treatment versus control), was 1.02 (0.95, 1.10; P=0.54) for 1-year survival, 1.29 (1.13, 1.47; P=0.0001) for 3-year survival, 1.31 (1.13, 1.51; P=0.0003) for 5-year survival, 1.00 (0.95, 1.04; P= 0.85) for rate of resection and 0.89 (0.64, 1.23; P=0.48) for operative mortality. The results showed that neoadjuvant chemotherapy for resectable esophageal carcinoma can raise the overall survival rate of patients with esophageal carcinoma, but it does not affect treatment-related mortality.

Expression and Significance of Microsomal Prostaglandin Synthase-1 (mPGES-1) and Beclin-1 in the Development of Prostate Cancer

Xu, Lu-Wei,Qian, Ming,Jia, Rui-Peng,Xu, Zheng,Wu, Jian-Ping,Li, Wen-Cheng,Huang, Wen-Bin,Chen, Xing-Guo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

The aim of this study was to investigate the expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer (PCa). Immunohistochemistry was performed on paraffin-embedded sections with rabbit polyclonal against mPGES-1 and Beclin-1 in 40 PCa, 40 benign prostatic hyperplasia (BPH) and 10 normal prostate specimens for this purpose. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied for mRNA expression of mPGES-1 and Beclin-1, while MTT assays were used to ascertain the best working concentration of the mPGES-1 inhibitor (CAY10526). The effect of CAY10526 treatment on expression of Beclin-1 in DU-145 cells was studied using Western blot analysis. Localization of Beclin-1 and mPGES-1 was in endochylema. Significant differences in expression was noted among PCa, BPH and normal issues (P<0.05). Beclin-1 expression inversely correlated with mPGES-1 expression in PCa tissue (P<0.05). CAY10526 could significantly block mPGES-1 expression and the proliferation of DU-145 cells (P<0.05), while increasing Beclin-1 levels (P<0.05). Overexpression of mPGES-1 could decrease the autophagic PCa cell death. Inhibiting the expression of mPGES-1 may lead to DU-145 cell death and up-regulation of Beclin-1. The results suggest that inhibition of mPGES-1 may have therapeutic potential for PCa in the future.

The Experimental Study of CSJN Anti-Vacular Dementia and Its Mechanisms

Xu, Qui Ping,Zhao, Ling 경희대학교 2001 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.2001 No.1

Vascular Deventia (VD) is one of common disease with high incidence, disability and mortality. Cong Sheng Jiao Nang(CSJN) is Chinese Medicine ancient prescription, It has been proved clinically effection on VD disease. This paper, we researched pharmacological actions of CSJN anti-VD and mechanism, the main results showed such as: 1. CSJN could improve pathological changes of brain tissue and memory disfunction of mouse brain ischemia induced by repeated ischemia reperfusion with bleeding. 2. To cultured neurocytes of newborn rat brain cotex, serum of containing CSJN could reduce neurocytes damage (it was reflected by decrease of LDH release from cell into medium) and neurocytes apoptosis (estimated by flow cytometry) induced by hypoxia or hypoglycemia 3h and reoxygeneration 18h in vitro. 3. CSJN could increrase the cerebral blood flow at different time after rat BCAL (bilateral carotid artery ligation). 4. CSJN could decrease NO level, and NOS activity, decrease the intrasynaptesomal calcium concertration, increase expression of HSP 70 mRNA, decrease expression of c-fos gene of brain tissue of aged mice induced by repeated ischemia reperfusion. 5. We also measured free calcium concentration in neurocytes. Results showed containing CSJN serum could inhibit the [Ca2+]i increase caused by hypoxia/hypoglycemia 1h and 200㎛ol/L glutamate, partially inhibit the [Ca2+]i increase coused by 2㎛ol/ L A23187 and 2nmol/L thapsigargin, and CSJN has no effect on the increase of the [Ca2+]I caused by high K+. Sum up above, CSJN is considered to be a promising brain protective agent with many beneficial actions on VD disease, the results of the study provided all experimental basis of using CSJN treating VD disease.

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

Xu, Ping,Zhang, Wen-Bo,Cai, Xin-Hua,Lu, Dan-Dan,He, Xiao-Yang,Qiu, Pei-Yong,Wu, Jiao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of $30{\mu}g/mL$. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Ping Xu,Jie Chen,Cheng Tan,Ren-Sheng Lai,Zhong-Sheng Min 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3

Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, 102 nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, 102 and 103 nM significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to 102 nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at 102 nM. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.

Retraction notice to: Myosin VI contributes to malignant proliferation of human glioma cells

Xu, Rong,Fang, Xu-hao,Zhong, Ping The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.5

Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Xu, Ping,Chen, Jie,Tan, Cheng,Lai, Ren-Sheng,Min, Zhong-Sheng The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3

Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, $10^2$nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, $10^2$ and $10^3nM$ significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to $10^2$nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at $10^2nM$. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.

Active mass driver control system for suppressing wind-induced vibration of the Canton Tower

Xu, Huai-Bing,Zhang, Chun-Wei,Li, Hui,Tan, Ping,Ou, Jin-Ping,Zhou, Fu-Lin Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.2

In order to suppress the wind-induced vibrations of the Canton Tower, a pair of active mass driver (AMD) systems has been installed on the top of the main structure. The structural principal directions in which the bending modes of the structure are uncoupled are proposed and verified based on the orthogonal projection approach. For the vibration control design in the principal X direction, the simplified model of the structure is developed based on the finite element model and modified according to the field measurements under wind excitations. The AMD system driven by permanent magnet synchronous linear motors are adopted. The dynamical models of the AMD subsystems are determined according to the open-loop test results by using nonlinear least square fitting method. The continuous variable gain feedback (VGF) control strategy is adopted to make the AMD system adaptive to the variation in the intensity of wind excitations. Finally, the field tests of free vibration control are carried out. The field test results of AMD control show that the damping ratio of the first vibration mode increases up to 11 times of the original value without control.