Outcome of Surgical Resection of Symptomatic Cerebral Lesions in Non-Small Cell Lung Cancer Patients with Multiple Brain Metastases

Noah Hong,유헌,Ho Shin Gwak,Sang Hoon Shin,Seung Hoon Lee 대한뇌종양학회 2013 Brain Tumor Research and Treatment Vol.1 No.2

Objective Patients with symptomatic brain metastases secondary to mass effect are often candidates for surgery. However, many of these surgical candidates are also found to have multiple asymptomatic tumors. This study aimed to determine the outcome of surgical resection of symptomatic brain metastases followed by chemotherapy or radiotherapy (RT) for the remnant asymptomatic lesions in non-small cell lung cancer (NSCLC) patients with multiple brain metastases. Methods We conducted a retrospective review of the medical records of 51 NSCLC patients with symptomatic multiple brain metastases who underwent surgical resection, of whom 38 had one or more unresected asymptomatic lesions subsequently treated with chemotherapy and/or RT. Thirteen patients underwent resection of all metastatic lesions. Results Median survival for overall patient population after surgical resection was 10.8 months. Median survival for patients with surgical resection of all brain metastases was not significantly different with patients who underwent surgical resection of only symptomatic lesions (6.5 months vs. 10.8 months; p=0.97). There was no statistically significant difference in survival according to the number of tumors (p=0.86, 0.16), or post-surgical treatment modalities (p=0.69). Conclusion The survival time of NSCLC patients with multiple brain metastases after surgery for only symptomatic brain metastases is similar to that of patients who underwent surgery for all brain metastases. The remaining asymptomatic lesions may be treated with chemotherapy or radiotherapy. The optimal treatment modality, however, needs to be defined in prospective trials with larger patient cohort.

The Efficacy of Postoperative Chemotherapy for Patients with Metastatic Brain Tumors from Non-Small Cell Lung Cancer

( Noah Hong ),( Jung Nam Joo ),( Sang Hoon Shin ),( Ho Shin Gwak ),( Seung Hoon Lee ),( Heon Yoo ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2015 Brain Tumor Research and Treatment Vol.3 No.2

Background The purpose of this study is to evaluate the effect of postoperative chemotherapy on recurrence and survival in patients after resection of metastatic brain tumors from non-small cell lung cancers. Methods Patients who went through resection of a single metastatic brain tumor from non-small cell lung cancer from July 2001 to December 2012 were reviewed. Those selected were 77 patients who survived more than 3 months after surgery were selected. Among them, 44 patients received various postoperative systemic chemotherapies, 33 patients received postoperative adjuvant whole brain radiotherapy (WBRT). Local/distant recurrence rate, local/distant recurrence free survival, disease free survival (DFS), and overall survival were compared between the two groups. Results Among the 77 patients, there were 19 (24.7%) local recurrences. Local recurrence occurred in 7 (21.2%) of 33 patients in the adjuvant radiotherapy (RT) group and in 12 (27.3%) of the 44 patients in the chemotherapy group (p=0.542). Among the 77 patients, there were 34 (44.1%) distant recurrences. Distant recurrence occurred in 7 (21.2%) of the 33 patients in the adjuvant RT group and in 27 (61.4%) of the 44 patients in the chemotherapy group (p<0.0005). Patients’ survival in terms of local recurrence free survival, distant recurrence free survival, DFS, and overall survival was not shown to be statistically different between the two groups before and after adjusting for covariates. Conclusion There was no significant difference observed between postoperative adjuvant chemotherapy and adjuvant WBRT in terms of patients’ survival. Postoperative chemotherapy is more feasible and may be an appropriate option for simultaneous control of both primary and metastatic lesions.

CASE REPORT : A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma

( Noah Hong ),( Heon Yoo ),( Sang Hoon Shin ),( Ho Shin Gwak ),( Seung Hoon Lee ) 대한뇌종양학회·대한신경종양학회 2015 Brain Tumor Research and Treatment Vol.3 No.2

Radiation therapy has an important role in postoperative treatment of neoplasms originated from central nervous system, but may induce secondary malignancies like as sarcomas, gliomas, and meningiomas. The prognosis of radiation-induced osteosarcomas is known as poor, because they has aggressive nature invasive locally and intractable to multiple treatment strategies like as surgical resection, chemotherapy, and so on. We report a case of radiation-induced osteosarcoma developed from skull after 7 years of craniospinal radiotherapy for pineoblastoma.

Outcome of Surgical Resection of Symptomatic Cerebral Lesions in Non-Small Cell Lung Cancer Patients with Multiple Brain Metastases

( Noah Hong ),( Heon Yoo ),( Ho Shin Gwak ),( Sang Hoon Shin ),( Seung Hoon Lee ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2013 Brain Tumor Research and Treatment Vol.1 No.2

Objective: Patients with symptomatic brain metastases secondary to mass effect are often candidates for surgery. However, many of these surgical candidates are also found to have multiple asymptomatic tumors. This study aimed to determine the outcome of surgical resection of symptomatic brain metastases followed by chemotherapy or radiotherapy (RT) for the remnant asymptomatic lesions in non-small cell lung cancer (NSCLC) patients with multiple brain metastases. Methods: We conducted a retrospective review of the medical records of 51 NSCLC patients with symptomatic multiple brain metastases who underwent surgical resection, of whom 38 had one or more unresected asymptomatic lesions subsequently treated with chemotherapy and/or RT. Thirteen patients underwent resection of all metastatic lesions. Results: Median survival for overall patient population after surgical resection was 10.8 months. Median survival for patients with surgical resection of all brain metastases was not significantly different with patients who underwent surgical resection of only symptomatic lesions (6.5 months vs. 10.8 months; p=0.97). There was no statistically significant difference in survival according to the number of tumors (p=0.86, 0.16), or post-surgical treatment modalities (p=0.69). Conclusion: The survival time of NSCLC patients with multiple brain metastases after surgery for only symptomatic brain metastases is similar to that of patients who underwent surgery for all brain metastases. The remaining asymptomatic lesions may be treated with chemotherapy or radiotherapy. The optimal treatment modality, however, needs to be defined in prospective trials with larger patient cohort.

“Textured” Network Devices: Overcoming Fundamental Limitations of Nanotube/Nanowire Network-Based Devices

Lee, Minbaek,Noah, Meg,Park, June,Seong, Maeng-Je,Kwon, Young-Kyun,Hong, Seunghun WILEY-VCH Verlag 2009 Small Vol.5 No.14

<B>Graphic Abstract</B> <P>Textured network devices are proposed as a solution to the fundamental problems of nanotube/nanowire network-based devices (see image). Significantly, both experiment and simulation show that “textured” network channels have enhanced mobility and conductivity with reduced channel width, which makes this strategy ideal for nanoscale device applications. <img src='wiley_img/16136810-2009-5-14-SMLL200801500-content.gif' alt='wiley_img/16136810-2009-5-14-SMLL200801500-content'> </P>

Surgical strategy for patients with supratentorial spontaneous intracerebral hemorrhage: minimally invasive surgery and conventional surgery

Je Hun Jang,Won-Sang Cho,Noah Hong,Chang Hwan Pang,Sung Ho Lee,Hyun-Seung Kang,Jeong Eun Kim 대한뇌혈관외과학회 2020 Journal of Cerebrovascular and Endovascular Neuros Vol.22 No.3

Objective: The role of surgery in spontaneous intracerebral hemorrhage (sICH) is still controversial. We aimed to investigate the effectiveness of minimally invasive surgery (MIS) compared to conventional surgery (CS) for supratentorial sICH. Methods: The medical data of 70 patients with surgically treated supratentorial sICH were retrospectively reviewed. MIS was performed in 35 patients, and CS was performed in 35 patients. The surgical technique was selected based on the neurological status and radiological findings, such as hematoma volume, neurological status and spot signs on computed tomographic angiography. Treatment outcomes, prognostic factors and the usefulness of the spot sign were analyzed. Results: Clinical states in both groups were statistically similar, preoperatively, and in 1 and 3 months after surgery. Both groups showed significant progressive improvement till 3 months after surgery. Better preoperative neurological status, more hematoma removal and intensive care unit (ICU) stay ≤7 days were the significant prognostic factors for favorable 3-month clinical outcomes (odds ratio [OR] 0.31, 95% confidence interval [CI] 0.10-0.96, p=0.04; OR 1.04, 95% CI 1.01-1.08, p=0.02; OR 26.31, 95% CI 2.46-280.95, p=0.01, respectively). Initial hematoma volume and MIS were significant prognostic factors for a short ICU stay (≤7 days; OR 0.95; 95% CI 0.91-0.99; p=0.01; OR 3.91, 95% CI 1.03-14.82, p=0.045, respectively). No patients in the MIS group experienced hematoma expansion before surgery or postoperative rebleeding. Conclusions: MIS was not inferior to CS in terms of clinical outcomes. The spot sign seems to be an effective radiological marker for predicting hematoma expansion and determining the surgical technique.

Physical properties of Maria asteroid family

Myung-Jin Kim,Young-Jun Choi,Hong-Kyu Moon,Noah Brosch,Yong-Ik Byun 한국천문학회 2012 天文學會報 Vol.37 No.1

Rotational Properties of the Maria Asteroid Family

Myung-Jin Kim,Young-Jun Choi,Hong-Kyu Moon,Yong-Ik Byun,Noah Brosch,Murat Kaplan,Suleyman Kaynar,Omer Uysal,Eda Guzel,Raoul Behrend,Joh-Na Yoon,Stefano Mottola,Stephan Hellmich,Tobias C. Hinse,Zeki Ek 한국천문학회 2014 天文學會報 Vol.39 No.1

Nanowire and nanotube transistors for lab-on-a-chip applications

Lee, Minbaek,Baik, Ku Youn,Noah, Meg,Kwon, Young-Kyun,Lee, Jeong-O,Hong, Seunghun Royal Society of Chemistry 2009 Lab on a chip Vol.9 No.16

<P>Implementation of one-dimensional nanostructure-based devices in the lab-on-a-chip framework can allow us to impart various functionalities such as highly-sensitive sensors to a single chip. However, it is still extremely difficult to position nanowires or nanotubes on a defined area of solid substrates to build integrated functional devices. Herein, we review promising strategies for the massive integration of nanowires/nanotubes on lab-on-a-chip and their practical applications to sensors. The theoretical understanding and sensor characteristics of nanowire/nanotube-based devices are also discussed.</P> <P>Graphic Abstract</P><P>Nanowire/nanotube-based transistors can be a new versatile component for Lab-on-a-Chip applications because they can add various new capabilities such as ultra-sensitive and miniaturized sensors. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b905185f'> </P>

The relationship between non-aneurysmal spontaneous subarachnoid hemorrhage and basilar tip anatomy

Park Hangeul,Son Young-Je,Hong Noah,Kim Seung Bin 대한뇌혈관외과학회 2022 Journal of Cerebrovascular and Endovascular Neuros Vol.24 No.3

Objective: Non-aneurysmal spontaneous subarachnoid hemorrhage (NASAH) has a good prognosis, but its cause has not been clearly identified. In this study, we assessed the clinical and radiological features of NASAH and suggested an anatomical relationship between the basilar tip anatomy and NASAH. Methods: From August 2013 to May 2020, 21 patients were diagnosed with NASAH at our institution. We evaluated the clinical features of NASAH. NASAH was classified into a perimesencephalic pattern and aneurysmal pattern according to the distribution of hemorrhage based on initial brain computed tomography. Digital subtraction angiography was used to classify the basilar tip anatomy into symmetric cranial fusion, symmetric caudal fusion, or asymmetric fusion types. Results: Of the 21 patients, twenty patients had a good clinical outcome (modified Rankin Scale (mRS) 1–2; Glasgow Outcome Scale (GOS) 4–5). These patients showed improvement in mRS and Glasgow Coma Scale (GCS) at the last follow-up (P=.003 and P=.016, respectively). Eighteen patients with NASAH (85.7%) had the caudal fusion type, and only three patients with NASAH (14.3%) had the cranial fusion type. Seven patients with the perimesencephalic pattern (77.8%) had the caudal fusion type, and eleven patients with the aneurysmal pattern (91.7%) had the caudal fusion type. Conclusions: In NASAH patients, the caudal fusion tends to occur frequently among patients with basilar tip anatomy. In the case of the caudal fusion, the perforators around the basilar tip would be more susceptible to hemodynamic stress, which could contribute to the occurrence of NASAH.