Effect of Electromagnetic Navigated Ventriculoperitoneal Shunt Placement on Failure Rates

Jung, Nayoung,Kim, Dongwon The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.53 No.3

Objective : To evaluate the effect of electromagnetic (EM) navigation system on ventriculoperitoneal (VP) shunt failure rate through comparing the result of standard shunt placement. Methods : All patients undergoing VP shunt from October 2007 to September 2010 were included in this retrospective study. The first group received shunt surgery using EM navigation. The second group had catheters inserted using manual method with anatomical landmark. The relationship between proximal catheter position and shunt revision rate was evaluated using postoperative computed tomography by a 3-point scale. 1) Grade I; optimal position free-floating in cerebrospinal fluid, 2) Grade II; touching choroid or ventricular wall, 3) Grade III; tip within parenchyma. Results : A total of 72 patients were participated, 27 with EM navigated shunts and 45 with standard shunts. Grade I was found in 25 patients from group 1 and 32 patients from group 2. Only 2 patients without use of navigation belonged to grade III. Proximal obstruction took place 7% in grade I, 15% in grade II and 100% in grade III. Shunt revision occurred in 11% of group 1 and 31% of group 2. Compared in terms of proximal catheter position, there was growing trend of revision rate according to increase of grade on each group. Although infection rate was similar between both groups, the result had no statistical meaning (p=0.905, chi-square test). Conclusion : The use of EM navigation in routine shunt surgery can eliminate poor shunt placement resulting in a dramatic reduction in failure rates.

THE EFFECT OF CONSUMER INTEREST IN GLOBAL COUNTRIES ON DIGITAL SHOPPING

Nayoung Jung,Sue Ryung Chang 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07

Since consumers have expanded their interest in global countries with the ease of access to global content through online platforms such as YouTube, marketing practitioners endeavor to uncover an underlying mechanism on how consumers’ interest in global countries would prompt their digital shopping behavior. However, prior literature has not concentrated on the influence of watching videos about global countries on consumers’ digital shopping intentions. By scrutinizing a proprietary dataset regarding consumers’ YouTube watching history and shopping website/app usage behavior, we find that watching global content could increase consumers’ digital shopping duration. In addition, we also find that consumers watching more global content have variety-seeking tendencies when they use shopping websites and apps. Furthermore, we investigate the moderating factors such as social media search and consumers’ sentiment toward different countries on digital shopping. Our findings contribute to the international marketing literature and provide managerial implications to digital media platforms and global companies that utilize target recommendations strategy for marketing communication.

Mutations of <i>Helicobacter pylori</i> Associated with Fluoroquinolone Resistance in Korea

Lee, Jung W.,Kim, Nayoung,Nam, Ryoung H.,Park, Ji H.,Kim, Jung M.,Jung, Hyun C.,Song, In S. Blackwell Publishing Ltd 2011 Helicobacter Vol.16 No.4

<P><B>Abstract</B></P><P><B>Background and Aim: </B> Fluoroquinolone resistance of <I>Helicobacter pylori</I> is known to be dependent on mutations in the QRDR of <I>gyrA</I>. This study was performed to investigate the distribution of <I>gyrA</I> point mutations and to evaluate the impact of the mutations on second‐line <I>H.?pylori</I> eradication therapy.</P><P><B>Methods: </B> After <I>H.?pylori</I> isolation from gastric mucosal specimens, fluoroquinolone resistance was examined using the agar dilution method. DNA sequencing of the QRDR of <I>gyrA</I> was performed in 89 fluoroquinolone‐resistant and 27 fluoroquinolone‐susceptible isolates. Transformation experiments were performed to confirm mutations in the resistant strains. The eradication rates of moxifloxacin‐containing triple therapy were evaluated depending on the resistance of fluoroquinolone.</P><P><B>Results: </B> The <I>gyrA</I> mutations were detected in 75.3% (55 of 73 strains) of the primary resistant strains and 100% (16 strains) of the secondary resistant strains. The most common mutations were Asp‐91 (36.0%) and Asn‐87 (33.7%). The MIC values in the transformed strains differed depending on the <I>gyrA</I> mutations, N87, and D91. Six patients with fluoroquinolone‐resistant strains received moxifloxacin‐containing triple therapy as the second‐line therapy, and two of three patients with Asn‐87 mutations (66.7%) failed in the eradication. By contrast, three patients with Asp‐91 mutations had successful eradication treatment.</P><P><B>Conclusions: </B> Fluoroquinolone resistance of <I>H.?pylori</I> was caused by <I>gyrA</I> Asn‐87 and Asp‐91 point mutations. The Asn‐87 mutation seems to be an important determinant of failure of fluoroquinolone‐containing triple eradication therapy based on eradication results.</P>

트립토렐린 아세테이트 1차 투여에 과민반응을 보인 8세 여아

정나영 ( Nayoung Jung ),이지은 ( Ji Eun Lee ),임대현 ( Dae Hyun Lim ),김정희 ( Jeong Hee Kim ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4

Triptorelin is a synthetic gonadotropin-releasing hormone agonist for the treatment of precocious puberty in children. Among the triptorelin side effects, drug hypersensitivity reactions, including anaphylaxis, can rarely occur, mostly after repeated exposure to the drug. We present a first case of an 8-year-old girl with central precocious puberty who developed anaphylaxis to the first injection of decapeptyl depot, which contains triptorelin acetate (D,L lactide coglycolide), dextran 70, and polysorbate 80. She showed 2 posi-tive reactions in an intradermal test to decapeptyl depot, suggesting that it is an IgE-mediated reaction to one of its components. Considering this was the first exposure to tryptorelin, it might be a reaction to polysorbate. As there are many therapeutic products containing polysorbate which can cross-react with polyethylene glycols, physicians should pay attention to immediate reactions to drugs containing polysorbate. (Allergy Asthma Respir Dis 2021;9:255-258)

Differential MicroRNA Expression Between Gastric Cancer Tissue and Non-cancerous Gastric Mucosa According to <i>Helicobacter pylori</i> Status

Lee, Jung Won,Kim, Nayoung,Park, Ji Hyun,Kim, Hee Jin,Chang, Hyun,Kim, Jung Min,Kim, Jin-Wook,Lee, Dong Ho Korean Society of Cancer Prevention 2017 Journal of cancer prevention Vol.12 No.2

<P><B>Background</B></P><P>MicroRNAs (miRNAs) are key post-translational mechanisms which can regulate gene expression in gastric carcinogenesis. To identify miRNAs responsible for gastric carcinogenesis, we compared expression levels of miRNAs between gastric cancer tissue and non-cancerous gastric mucosa according to <I>Helicobacter pylori</I> status.</P><P><B>Methods</B></P><P>Total RNA was extracted from the cancerous regions of formalin-fixed, paraffin-embedded tissues of <I>H. pylori</I>-positive (n = 8) or <I>H. pylori</I>-negative (n = 8) patients with an intestinal type of gastric cancer. RNA expression was analyzed using a 3,523 miRNA profiling microarray based on the Sanger miRBase. Validation analysis was performed using TaqMan miRNA assays for biopsy samples from 107 patients consisted of control and gastric cancer with or without <I>H. pylori</I>. And then, expression levels of miRNAs were compared according to subgroups.</P><P><B>Results</B></P><P>A total of 156 miRNAs in the aberrant miRNA profiles across the miRNA microarray showed differential expression (at least a 2-fold change, <I>P</I> < 0.05) in cancer tissue, compared to noncancerous mucosa in both of <I>H. pylori</I>-negative and -positive samples. After 10 promising miRNAs were selected, validations by TaqMan miRNA assays confirmed that two miRNAs (hsa-miR-135b-5p and hsa-miR-196a-5p) were significantly increased and one miRNA (hsa-miR-145-5p) decreased in cancer tissue compared to non-cancerous gastric mucosa at <I>H. pylori</I>-negative group. For <I>H. pylori</I>-positive group, three miRNAs (hsa-miR-18a-5p, hsa-miR-135b-5p, and hsa-miR-196a-5p) were increased in cancer tissue. hsa-miR-135b-5p and hsa-miR-196a-5p were increased in gastric cancer in both of <I>H. pylori</I>-negative and -positive.</P><P><B>Conclusions</B></P><P>miRNA expression of the gastric cancer implies that different but partially common gastric cancer carcinogenic mechanisms might exist according to <I>H. pylori</I> status.</P>

The guggulsterone derivative GG-52 inhibits NF-κB signaling in gastric epithelial cells and ameliorates ethanol-induced gastric mucosal lesions in mice.

Kim, Jung Mogg,Kim, Su Hyun,Ko, Su Hyuk,Jung, Jireh,Chun, Jaeyoung,Kim, Nayoung,Jung, Hyun Chae,Kim, Joo Sung American Physiological Society 2013 American journal of physiology, Gastrointestinal a Vol.304 No.2

<P>Gastric mucosal inflammation can develop after challenge with noxious stimuli such as alcohol. Specially, alcohol stimulates the release of inflammatory cytokines but does not increase gastric acid secretion, leading to gastric mucosal damage. The plant sterol guggulsterone and its novel derivative GG-52 have been reported to inhibit nuclear factor-κB (NF-κB) signaling in intestinal epithelial cells and experimental colitis. In the present study, we investigated the anti-inflammatory effects of GG-52 on gastric epithelial cells and on ethanol-induced gastric mucosal inflammation in mice. GG-52 inhibited the expression of interleukin-8 (IL-8) in gastric epithelial AGS and MKN-45 cell lines stimulated with tumor necrosis factor (TNF)-α in a dose-dependent manner. Pretreatment with GG-52 suppressed TNF-α-induced activation of IκB kinase (IKK) and NF-κB signaling in MKN-45 cells. In contrast, the inactive analog GG-46 did not produce significant changes in IL-8 expression or NF-κB activation. In a model of ethanol-induced murine gastritis, administration of GG-52 significantly reduced the severity of gastritis, as assessed by macroscopic and histological evaluation of gastric mucosal damage. In addition, the ethanol-induced upregulation of chemokine KC, a mouse homolog of IL-8, and phosphorylated p65 NF-κB signals were significantly inhibited in murine gastric mucosa pretreated with GG-52. These results indicate that GG-52 suppresses NF-κB activation in gastric epithelial cells and ameliorates ethanol-induced gastric mucosal lesions in mice, suggesting that GG-52 may be a potential gastroprotective agent.</P>

CDX1 and CDX2 Expression in Intestinal Metaplasia, Dysplasia and Gastric Cancer

Kang, Jung Mook,Lee, Byoung Hwan,Kim, Nayoung,Lee, Hye Seung,Lee, Hee Eun,Park, Ji Hyun,Kim, Joo Sung,Jung, Hyun Chae,Song, In Sung The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.5

<P>Intestinal metaplasia (IM) has been regarded as a premalignant condition. However, the pathogenesis of IM is not fully understood. The aim of this study was to evaluate the role of CDX1 and CDX2 in the formation of IM and the progression to dysplasia and gastric cancer (GC). A total of 270 subjects included 90 with GC, dysplasia and age- and sex-matched controls. Real-time PCR (RT-PCR) was performed with body specimens for CDX1 and CDX2. The expression of CDX2 was significantly higher in <I>H. pylori</I> positive group than <I>H. pylori</I> negative group (<I>P</I> = 0.045). CDX1 and CDX2 expression increased proportional to the IM grade of the body (<I>P</I> < 0.001). CDX2 expression was significantly higher in incomplete type of IM than in complete type (<I>P</I> = 0.045). The expression of CDX1 in dysplasia group was significantly higher than in the control group (<I>P</I> = 0.001); in addition, CDX1 and CDX2 in cancer group was significantly higher than control group (<I>P</I> < 0.001, and <I>P</I> < 0.001, respectively). Aberrant expression of CDX1 and CDX2 correlated with <I>H. pylori</I> infection and grade of IM in the body. Furthermore, the results suggest that CDX1 and CDX2 play a role in the progression to GC and dysplasia.</P>

Distribution of fluoroquinolone MICs in <i>Helicobacter pylori</i> strains from Korean patients

Kim, Jung Mogg,Kim, Joo Sung,Kim, Nayoung,Jung, Hyun Chae,Song, In Sung Oxford University Press 2005 The Journal of antimicrobial chemotherapy Vol.56 No.5

<P><I>Objectives</I>: The aim of this study was to assess the prevalence rate of primary fluoroquinolone resistance in <I>Helicobacter pylori</I> isolates from Korean patients over the past 16 years.</P><P><I>Methods</I>: One hundred and thirty-five strains of <I>H. pylori</I> (34 strains in 1987, 36 in 1994 and 65 in 2003) were isolated from antral gastric mucosal biopsy specimens. The determination of MICs for the <I>H. pylori</I> isolates of ciprofloxacin, levofloxacin and moxifloxacin was examined by using the serial 2-fold agar dilution method. DNA sequences of the <I>gyrA</I> gene in fluoroquinolone-resistant strains were determined.</P><P><I>Results</I>: The distribution of fluoroquinolone MICs (ciprofloxacin, levofloxacin and moxifloxacin) shifted to higher concentrations during 1987–2003. All of the levofloxacin- or moxifloxacin-resistant strains were resistant to ciprofloxacin. Sequence analysis in fluoroquinolone-resistant strains showed point mutation of the <I>gyrA</I> gene at A272G and G271A, indicating mutations of the codon Asp-91 in the fluoroquinolone-resistance-determining region of the DNA gyrase.</P><P><I>Conclusions</I>: These results suggest that resistance to fluoroquinolones has been increasing in the Korean population and the resistance is most likely mediated through point mutation in <I>gyrA</I>.</P>

The Role of Serum Pepsinogen and Gastrin Test for the Detection of Gastric Cancer in Korea

Kang, Jung Mook,Kim, Nayoung,Yoo, Ji Youn,Park, Young Soo,Lee, Dong Ho,Kim, Hyun Young,Lee, Hye Seung,Choe, Gheeyoung,Kim, Joo Sung,Jung, Hyun Chae,Song, In Sung Blackwell Publishing Ltd 2008 HELICOBACTER -CAMBRIDGE USA- Vol.13 No.2

<P>Abstract</P><P>Background and Aim: </P><P>This study was performed to determine whether serum pepsinogen (PG) and gastrin testing can be used to detect gastric cancer in Korea.</P><P>Methods: </P><P>Serum levels of PG I (sPGI) and sPGII, PG I/II ratios, and gastrin levels were measured in 1006 patients with gastroduodenal diseases including cancer. Follow-up tests were performed 1 year after <I>Helicobacter pylori</I> eradication.</P><P>Results: </P><P>sPGI and sPGII levels increased and PG I/II ratios decreased in line with the severity of activity, chronic inflammation, and the presence of <I>H. pylori</I> (<I>p</I> < .01). In contrast, sPGI levels and PG I/II ratios decreased in proportion with the severity of atrophic gastritis (AG)/intestinal metaplasia (<I>p</I> < .01). Gastrin levels were found to be correlated with chronic inflammation negatively in the antrum but positively in the corpus. <I>H. pylori</I> eradication reduced sPGI, sPGII, and gastrin levels, and increased PG I/II ratios to the levels of <I>H. pylori</I>-negative patients, and was found to be correlated with reductions in activity and chronic inflammation of gastritis. The sensitivity and specificity of a PG I/II ratio of ≤ 3.0 for the detection of dysplasia or cancer were 55.8–62.3% and 61%, respectively. In addition, sPGI and sPGII levels of intestinal-type cancer were significantly lower than those of the diffuse type, respectively (<I>p</I> = .008 and <I>p</I> = .05, respectively). Gastric cancer risk was highest in the <I>H. pylori</I>-positive, low PGI/II ratio (≤ 3.0) group with an odds ratio of 5.52 (confidence interval: 2.83–10.77).</P><P>Conclusion: </P><P>PG I/II ratio (≤ 3.0) was found to be a reliable marker for the detection of dysplasia or gastric cancer, especially of the intestinal type. This detection power of PG I/II ratio (≤ 3.0) significantly increased in the presence of <I>H. pylori</I>, and thus, provides a means of selecting those at high risk of developing gastric cancer in Korea.</P>

Long-term Follow up of<i>Helicobacter pylori</i>IgG Serology After Eradication and Reinfection Rate of<i>H. pylori</i>in South Korea

Lee, Jung Hoon,Kim, Nayoung,Chung, Jae Il,Kang, Kyung Phil,Lee, Sang Hyup,Park, Young Soo,Hwang, Jin-Hyeok,Kim, Jin-Wook,Jeong, Sook-Hyang,Lee, Dong Ho,Jung, Hyun Chae,Song, In Sung Wiley (Blackwell Publishing) 2008 HELICOBACTER -CAMBRIDGE USA- Vol.13 No.4

<P>BACKGROUND: Serology is widely used for epidemiologic research of Helicobacter pylori. However, there is limited information on the long-term follow up of H. pylori titers after eradication. In addition, it is presumed that the reinfection rate decreases as the H. pylori infection rate decreases. The aim of this study was to investigate the long-term follow up of H. pylori IgG, and to evaluate the reinfection rate of H. pylori in Korea. METHODS: Among 247 patients, who were enrolled during 2003-07, 185 patients with invasive H. pylori test positive received proton pump inhibitor-based triple therapy, and follow-up H. pylori testing, including histology, CLOtest, culture, and serology, were evaluated 2, 10, and 18 months after H. pylori eradication. RESULTS: The initial H. pylori IgG optical density (OD(450 nm)), 2.06, gradually decreased to 0.63 (67% reduction) at 18 months after H. pylori eradication. The seroreversion rate was 5, 10, and 45% at 2, 10, and 18 months after H. pylori eradication, respectively. The recrudescence of H. pylori was 3.49%, and the annual reinfection rate was 2.94% per year. H. pylori IgG titers abruptly increased in cases with recrudescence and reinfection, and correlated with the results of the invasive H. pylori tests. CONCLUSION: The results of this study showed that H. pylori IgG serology could be used for the determination of reinfection of H. pylori, but not for the diagnosis of H. pylori eradication. The reinfection rate of H. pylori, in Korea, was found to be very low, 2.94% per year.</P>