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RISS 인기검색어
- 검색키워드
- 저자 : ( Nader Tanideh ) (검색결과 6 건)
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Sasan Amanat,Fatemeh Ashkar,Mohammad Hassan Eftekhari,Nader Tanideh,Saeid Doaei,Maryam Gholamalizadeh,Farhad Koohpeyma,Maral Mokhtari 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.3
Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, irregular menstruation, ovulatory dysfunction, and insulin resistance. Recent studies have reported the possible role of phytoestrogens in PCOS. This animal study aimed to evaluate the effects of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices on PCOS. Methods: PCOS was induced by 1 mg/kg of letrozole in adult Sprague-Dawley rats. The rats then received normal saline (PCOS group), 150 mg/kg of metformin, or 20 mg/kg of genistein dissolved in 1% methylcellulose solution for 42 days. Body weight, the glycemic and lipid profile, and inflammatory, antioxidative, and histopathological parameters were assessed at the end of the intervention. Results: Treatment with genistein significantly alleviated the increased level of fasting blood insulin (p=0.16) and the homeostatic model assessment of insulin resistance (p=0.012). In addition, the genistein group had significantly lower levels of serum malondialdehyde (p=0.039) and tumor necrosis factor-alpha (p=0.003), and higher superoxide dismutase enzyme activity (p<0.001). Furthermore, the histopathological analysis indicated that genistein administration led to an increase in luteinization and the development of fewer cysts (p<0.05). Conclusion: Biochemical and histopathological analyses indicated that genistein administration to rats with PCOS induced significant remission in oxidative, inflammatory, and glycemic and histopathologic parameters (all p<0.05).
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( Syed Vahid Hosseini ),( Seyed Mahmoud Adjjadi ),( Davood Mehrabani ),( Kurosh Ghanbarzaden ),( Zahra Barzin ),( Nader Tanideh ),( Masoud Amini ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: The treatment of choice for Hydatidosis is surgery, but before evacuation of a cyst, protoscolicidal agents are needed to be injected to prevent a secondary cyst formation and the spreading of the disease. This study was performed to determine the protoseolicidal effect of various concentrations of hypertonic glucose in an animal model infected to hydatid cyst. Methods: Sheep liver hydatid cyst surface were sterilized by heat and the cyst contents were evacuated completely and transferred into falcon tubes, where protoscolices were precipitated and separated. The viability of protoseolices was determined by using eosin stain method. A total of 1500 protoscolices were exposed to 0.5% cetrimide, 0.5% silver nitrate, 0.9% and 20% sodium chloride and 10%, 15%, 25%, and 50% concentrations of glucose with exposure times of one, 2 and 5 minutes and were injected into the peritoneal cavity of 5 BALB/c mice for each agent. The animals were kept for 9 months and then were autopsied. Blood sample for countercurrent immunoelectrophoresis (CCIEP) was provided and the animals were examined for presence of any cyst in peritoneal cavity and recorded. Results: A total of 40 BALB/C mice were used in all exposure times while 24, 21 and 32 mice survived when exposed to different protoscilicidal agents after 1, 2 and 5 minutes respectively. None of the mice were infected to cysts after exposure to 50% hypertonic glucose solution. Identical to 50% glucose solution no infection was noticed for 0.5% cetrimide and 20% sodium chloride solutions too. The CCIEP results of animals indicating to cyst formation confirmed the presence of antibody in the circulation. Conclusions: Similarity of 50% glucose solution and cetrimide and 20% sodium chloride in complete killing of protoscolices present it as potent protoscolicidal agent and the side effects of cetrinide and hypertonic sodium chloride indicate to further studies on probable side effects.
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Mehdi Shirazi,Mohammad-Reza Soltani,Zahra Jahanabadi,Mohammad Amin Abdollahifar,Nader Tanideh,Ali Noorafshan 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.11
Purpose: Limited studies have shown antifibrotic effects of pentoxifylline, captopril,simvastatin, and tamoxifen. No comparisons are available of the effects of these drugson prevention of renal and bladder changes in partial urethral obstruction (PUO). Materials and Methods: The rats were divided into six groups (n=7). The sham-operatedrats (group I) only underwent laparotomy and did not receive any treatments. The PUOgroups (group II–VI) received normal saline (PUO+NS), pentoxifylline (100 mg/kg/d;PUO+PEN), captopril (35 mg/kg/d; PUO+CAP), simvastatin (15 mg/kg/d; PUO+SIM),or tamoxifen (10 mg/kg/d; PUO+TAM) by gavage for 28 days. Then, the volume and/orlength of the kidney components (tubules, vessels, and fibrous tissue) and the bladdercomponents (epithelial and muscular layers, fibrous tissue, fibroblast and fibrocytenumber) were quantitatively evaluated on the microscopic sections by use of stereologicaltechniques. Results: The volume of renal and bladder fibrosis was significantly ameliorated in thePUO+PEN group, followed by the PUO+CAP, PUO+SIM, and PUO+TAM groups. Also,the volume and length of the renal tubules and vessels and bladder layers were moresignificantly protected in the PUO+PEN group, followed by the PUO+CAP, PUO+SIM,and PUO+TAM groups. Conclusions: Treatment of PUO with PEN was more effective in the prevention of renaland bladder fibrosis and in the preservation of renal and bladder structures.
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Application of bioactive glasses in various dental fields
Nazanin Jafari,Mina Seyed Habashi,Alireza Hashemi,Reza Shirazi,Nader Tanideh,Amin Tamadon 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3
Bioactive glasses are a group of bioceramic materials that have extensive clinical applications. Their properties such as high biocompatibility, antimicrobial features, and bioactivity in the internal environment of the body have made them useful biomaterials in various fields of medicine and dentistry. There is a great variation in the main composition of these glasses and some of them whose medical usage has been approved by the US Food and Drug Administration (FDA) are called Bioglass. Bioactive glasses have appropriate biocompatibility with the body and they are similar to bone hydroxyapatite in terms of calcium and phosphate contents. Bioactive glasses are applied in different branches of dentistry like periodontics, orthodontics, endodontics, oral and maxillofacial surgery, esthetic and restorative dentistry. Also, some dental and oral care products have bioactive glasses in their compositions. Bioactive glasses have been used as dental implants in the human body in order to repair and replace damaged bones. Other applications of bioactive glasses in dentistry include their usage in periodontal disease, root canal treatments, maxillofacial surgeries, dental restorations, air abrasions, dental adhesives, enamel remineralization, and dentin hypersensitivity. Since the use of bioactive glasses in dentistry is widespread, there is a need to find methods and extensive resources to supply the required bioactive glasses. Various techniques have been identified for the production of bioactive glasses, and marine sponges have recently been considered as a rich source of it. Marine sponges are widely available and many species have been identified around the world, including the Persian Gulf. Marine sponges, as the simplest group of animals, produce different bioactive compounds that are used in a wide range of medical sciences. Numerous studies have shown the anti-tumor, anti-viral, anti-inflammatory, and antibiotic effects of these compounds. Furthermore, some species of marine sponges due to the mineral contents of their structural skeletons, which are made of biosilica, have been used for extracting bioactive glasses.
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Disorders of Liver : The Role Of Germinative Layer In Inducing Hydatid Cyst
( Seyed Vahid Hosseini ),( Soheal Mansoorian ),( Seyed Mahmood Sadjjadi ),( Davood Mehrabani ),( Zahra Barzin ),( Nader Tanideh ),( Afshin Amini ),( All Rafati ),( Masoud Amini ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: In spite of use of protoseololeidal agents during surgery, a notable rate of recurrence of disease in post-operation patients is still observed. The question exists is that alive scolices would cause any recurrence or is due to the presence of the germinative layer. The aim of this study was to evaluate the effect of scolicidal agents on this layer as well as its ability of the layer to produce any hydatid disease in an in vivo condition. Methods: Germinative layer of hydatid cyst was separated under sterile condition, was divided into 0.5 cm parts, exposed to various protoseolicidal agents for 2 minutes, and implanted in peritoneal cavity of 62 BALB-C mice. After 9 months, the peritoneum was evaluated macroscopically and microscopically for the presence of any hydatid disease. Results: After 9 months, no hydatid disease was visible in the peritoneum of all the sixty two mice. Conclusions: In this study, the germinative layer could not cause any hydatid disease but positive results of Tarakanovet al. with cultures of protoseolices and the germinative layer cells in the peritoneal cavity mice indicate to a need of another study of implantation of culture cells of the germinated layer lacking protoscolices in a larger animal study to clarify the differences.
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