http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients
( Mohamed S. Abdelhalim ),( Ahmed S. Kenawy ),( Heba H. El Demellawy ),( Amany A. Azouz ),( Sarah S. Alghanem ),( Torki Al-otaibi ),( Osama Gheith ),( Mohamed Abd Elmonem ),( Mohammed K. Afifi ),( Rag 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: The absorption rates of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (ECMPS) may be influenced by the concomitant use of omeprazole. Methods: One hundred kidney transplant patients were recruited during their outpatient visits, including 50 on MMF and 50 on EC-MPS. At the clinic, a predose mycophenolic acid (MPA) sample (C0) was collected; subsequently, the participants received the proton-pump inhibitor omeprazole along with either MMF or EC-MPS. Two more blood samples were collected at 1.5 and 3.5 hours and used to estimate an area under the curve (AUC) from zero to 12 hours [AUC (0-12)]. Results: The mean number of months after transplant was 92 months. The median AUC (0-12) and C0 results were 62.2 mg·h/L and 2.0 mg/L for the MMF group and 71.9 mg·h/L and 1.8 mg/L for the EC-MPS group (P = 0.160 and 0.225, respectively). Interestingly, 54% of the MMF group and 62% of the EC-MPS group showed AUCs above the target values. The correlation between MPA C0 and the predicted AUC was poor in both groups. Conclusion: Omeprazole can be safely co-administered with either MMF or EC-MPS, as it did not compromise the MPA exposure. Unexpectedly, however, a high percentage of patients presented MPA AUCs exceeding the target value, highlighting the importance of periodically assessing MPA level.
Fuzhang Wang,Tanveer Sajid,Nek Muhammad Katbar,Wasim Jamshed,Usman,Mohamed R Eid,Assmaa Abd-Elmonem,Siti Suzilliana Putri Mohamed Isa,Sayed M El Din 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.4
The goal of this research is to provide a novel conceptual base for ternary hybridity nanofluids that will improve heat transmission. This model illustrates how to produce heat conduction that is superior to the hybridity nanofluid. The ternary hybridity nanofluid is made by suspending three distinct kinds of nanostructures (TiO2, Al2O3, and SiO2) in ethylene glycol with varying physical and chemical linkages. The combination of these nanoparticles aids in the decomposition of hazardous compounds, environment cleansing, and the cooling of other equipment. This article describes the ternary hybrid nanofluids such as the conductivity of thermal and electrical, specific heat capacitance, viscosity, and density. The ordinary differential equations for the liquid and temperature are solved utilizing the Keller box method (KBM). The main finding discovered that the tri-hybrid nanofluid transferred more heat compared to the hybrid nanofluid. The velocity and temperature field diminishes for these ranges of parameters: 0≤γ≤2 (velocity slipγ ) and 0≤γ1≤2 (temperature slip γ1). The Darcy–Forchheimer Fr ranges between 0.5≤Fr≤1.4 diminishes the fluid velocity. The fluid moving subjected to a rotating cone has various applications in engineering like cone clutch, steam generators, loudspeaker cooling, lubricating grease for seals, hydrology, geosciences, etc.