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The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients
( Mohamed S. Abdelhalim ),( Ahmed S. Kenawy ),( Heba H. El Demellawy ),( Amany A. Azouz ),( Sarah S. Alghanem ),( Torki Al-otaibi ),( Osama Gheith ),( Mohamed Abd Elmonem ),( Mohammed K. Afifi ),( Rag 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: The absorption rates of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (ECMPS) may be influenced by the concomitant use of omeprazole. Methods: One hundred kidney transplant patients were recruited during their outpatient visits, including 50 on MMF and 50 on EC-MPS. At the clinic, a predose mycophenolic acid (MPA) sample (C0) was collected; subsequently, the participants received the proton-pump inhibitor omeprazole along with either MMF or EC-MPS. Two more blood samples were collected at 1.5 and 3.5 hours and used to estimate an area under the curve (AUC) from zero to 12 hours [AUC (0-12)]. Results: The mean number of months after transplant was 92 months. The median AUC (0-12) and C0 results were 62.2 mg·h/L and 2.0 mg/L for the MMF group and 71.9 mg·h/L and 1.8 mg/L for the EC-MPS group (P = 0.160 and 0.225, respectively). Interestingly, 54% of the MMF group and 62% of the EC-MPS group showed AUCs above the target values. The correlation between MPA C0 and the predicted AUC was poor in both groups. Conclusion: Omeprazole can be safely co-administered with either MMF or EC-MPS, as it did not compromise the MPA exposure. Unexpectedly, however, a high percentage of patients presented MPA AUCs exceeding the target value, highlighting the importance of periodically assessing MPA level.
Fast and Compact ASIC Implementation of SFlash New Signature Scheme
Mohamed M.Abdelhalim,Raafat S.Elfouly 보안공학연구지원센터 2009 International Journal of Security and Its Applicat Vol.3 No.4
The idea of using multivariate polynomials as public keys has attracted several cryptographers, SFlash signature scheme is a variant of the Matsumoto and Imai multivariate public Key cryptosystem and selected by NESSIE Consortium. In this paper we describe a hardware implementation of SFlash based on bit-parallel architectures to achieve high speed circuits for operations on Finite Fields which can be efficiently used as an authentication unit in wireless devices, smart cards and RFID networks. We have proposed a new generalization to Karatsuba-Ofman multiplier as the core of the design. An ASIC chip can be realized with 78K gates counts and 2.8 mm2 die size with 0.35 mm CMOS technology, with a maximum clock frequency 140 MHZ, which takes about 21.5 ms to sign 259-Bits data.