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Kim, Heon Seok,Lee, Kyungjin,Bae, Sangsu,Park, Jeongbin,Lee, Chong-Kyo,Kim, Meehyein,Kim, Eunji,Kim, Minju,Kim, Seokjoong,Kim, Chonsaeng,Kim, Jin-Soo American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.25
<P>Several groups have used genome-wide libraries of lentiviruses encoding small guide RNAs (sgRNAs) for genetic screens. In most cases, sgRNA expression cassettes are integrated into cells by using lentiviruses, and target genes are statistically estimated by the readout of sgRNA sequences after targeted sequencing. We present a new virus-free method for human gene knockout screens using a genome-wide library of CRISPR/Cas9 sgRNAs based on plasmids and target gene identification via whole-genome sequencing (WGS) confirmation of authentic mutations rather than statistical estimation through targeted amplicon sequencing. We used 30,840 pairs of individually synthesized oligonucleotides to construct the genome-scale sgRNA library, collectively targeting 10,280 human genes (<I>i.e.</I> three sgRNAs per gene). These plasmid libraries were co-transfected with a Cas9-expression plasmid into human cells, which were then treated with cytotoxic drugs or viruses. Only cells lacking key factors essential for cytotoxic drug metabolism or viral infection were able to survive. Genomic DNA isolated from cells that survived these challenges was subjected to WGS to directly identify CRISPR/Cas9-mediated causal mutations essential for cell survival. With this approach, we were able to identify known and novel genes essential for viral infection in human cells. We propose that genome-wide sgRNA screens based on plasmids coupled with WGS are powerful tools for forward genetics studies and drug target discovery.</P>
Kim Jeong-Whun,Kim Hyo sang,Kim Minju,Kim Su Hwan,Cho Sung-Woo,김진엽 대한의학회 2021 Journal of Korean medical science Vol.36 No.6
Background: The patients with coronavirus disease 2019 (COVID-19), a worldwide pandemic infection, frequently complain of olfactory disorders. However, psychophysical olfactory tests performed by an examiner are very difficult in these highly infectious patients. This study aimed to develop and validate a questionnaire for olfactory function that can be readily used to evaluate olfactory loss. Methods: Fourteen smell-related questions were created based on smells familiar to Koreans. Among them, questions with a κ value of 0.6 or higher were finally selected through a test-retest reliability analysis. The correlations between the scores of the olfactory questionnaire and those of olfactory function tests (Butanol Threshold Test [BTT] and Cross Cultural Smell Identification Test [CCSIT]) were analyzed. To evaluate the predictive ability of the questionnaire and elicit cutoff values, receiver operating characteristic (ROC) curves were generated. Results: Out of the 14 questions in the questionnaire, 11 (κ > 0.6) were selected for the olfactory questionnaire. We analyzed 2,273 subjects, and there was a significant correlation between the total score of the olfactory questionnaire and the BTT (r = 0.643, P < 0.001) or CCSIT (r = 0.615, P < 0.001) scores. ROC curves for the olfactory questionnaire, BTT, and CCSIT all demonstrated high predictive power to discriminate anosmia and severe hyposmia from normosmia. Regarding mild to moderate hyposmia, however, ROC curve for the olfactory questionnaire alone showed high predictive power of discrimination from normosmia. Based on the results of ROC curves among the subclasses, we suggest the classification of the total score of the questionnaire as 0–4, 5–17, 18–27, 28–41, and 42–44, for anosmia, severe hyposmia, moderate hyposmia, mild hyposmia, and normosmia, respectively. Conclusion: The total scores of the questionnaires correlated with the BTT and CCSIT scores. The symptom questionnaire for olfactory dysfunction may be useful as an alternative tool for olfactory function testing, when unavailable.
A case of idiopathic hypertrophic pachymeningitis presented with seizures
Kim, Minju,Kim, Joong-Goo,Kang, Chul-Hoo,Kim, Hong Jun,Kang, Sa-Yoon,Oh, Jung-Hwan The Korean Society of Clinical Neurophysiology 2022 Annals of Clinical Neurophysiology Vol.24 No.2
Idiopathic hypertrophic pachymeningitis (IHP) is a rare disease involving localized inflammatory thickening of the intracranial or spinal dura mater without an identified cause. Seizure is a very unusual presentation of IHP. We present a 58-year-old-female patient with seizures caused by IHP. This case indicates that although IHP is rare, it has the potential to cause seizures.
Minju Kim,Beom-jun Jang,Jongwon Song,Dayeong Kim,Yijung Kim,Heejo Lee 한국응용곤충학회 2024 한국응용곤충학회 학술대회논문집 Vol.2024 No.04
2023년에 국내에서 보고된 적이 없던 외래흰개미 3종이 각각 인천, 서울, 창원에서 발견되었다. 종 동정 결과, 인천에서 출현한 종(Coptotermes gestroi)은 Subterranean termite로 밝혀졌으며, 서울과 창원에서 출현한 종 (Cryptotermes domesticus, Incisitermes minor)은 Drywood termite로 밝혀졌다. 본래 우리나라에는 Subterranean termite 흰개미가 2종이 분포하고 있다고 보고되어 있었으나, 새로운 과 또는 속의 외래흰개미가 발견되면서 국민 들의 우려가 커지고 있다. 국내에서는 일부 외래흰개미를 법적으로 지정(유입주의 생물 2종, 관리병해충 15종)하 여 관리하고 있는데, 해당 흰개미와 그 외의 신규 흰개미의 출현으로 인한 피해가 우려되는 상황이다. 본 연구에서 는 ‘23년 유입된 3종 및 기존 법정관리 외래흰개미, 그리고 국내 유입과 위해가 우려되는 외래흰개미 5과 (Archotermopsidae, Kalotermitidae, Rhinotermitidae, Termitidae, Termopsidae)를 조사하였으며, 이들의 생태적 특 징과 외국의 사례를 통해 외래흰개미 대비 방법에 대하여 고찰하였다.
김민주(Minju Kim),김소연(So Yeon Kim),장근정(Geun Jung Jang),이용호(Yong Ho Lee),홍선희(Sun Hee Hong),김성문(Songmun Kim) 한국잡초학회 2021 Weed & Turfgrass Science Vol.10 No.3
전 세계적으로 많은 사람들이 잡초의 꽃가루로 인해 알레르기 결막염, 비염, 천식, 아나필락시스 등 다양한 알레르기 관련 질환으로 고통받고 있으며, 한국 인구의 30% 이상이 꽃가루 알레르기를 앓고 있는 것으로 보고되고 있다. 공중 보건에 대한 악영향에도 불구하고 알레르기 잡초와 한국 내에서의 분포에 대해서는 알려진 바가 거의 없기에 저자들은 알레르기의 작용기전, 알레르기를 유발하는 국내 잡초와 국내에서의 분포, 그리고 알레르기 유발 잡초가 주는 시사점을 소개한다. 잡초에 의해 발생하는 알레르기성 질환은 일반적으로 꽃가루로 인해 발병하며, 현재 미세먼지와 꽃가루 수가 증가함에 따라 실제로 알레르기성 비염의 진단율은 가파르게 상승하고 있다. 알레르기 잡초가 국민건강에 미치는 경제·사회적인 영향은 매우 크기에, 본 리뷰에서는 이와 같은 알레르기 질환을 유발하는 환삼덩굴속(Humulus), 소리쟁이속(Rumex), 명아주속(Chenopodium), 댑싸리속(Kochia), 갯능쟁이속(Atriplex), 비름속(Amaranhus) 질경이속(Plantago), 돼지풀속(Ambrosia), 도꼬마리속(Xanthium), 미역취속(Solidago), 개망초속(Erigenom), 쑥갓속(Chrysanthemun)에 속하는 식물들에 대해 다루었으며, 이들과 같은 알레르기 잡초는 향후 한국 잡초학회 회원들의 주요 연구 주제가 될 것이라 기대된다. Many people in the world are suffering from various allergy-related diseases, such as allergic conjunctivitis, rhinitis, asthma, and anaphylaxis, caused by the pollen grains of weeds. More than thirty percent of the population in Korea is reported to have been suffering from pollen allergies. Despite their adverse effects on public health, little is known about allergic weeds and their distribution in Korea. The authors introduce the mechanism of action of allergies, the domestic weeds that cause allergies and their distribution in Korea, and the implications of the allergy-causing weeds. Most of allergies are caused by the pollen from the flower of weeds, e.g., Humulus, Rumex, Chenopodium, Kochia, Atriplex, Amaranthus, Plantago, Ambrosia, Xanthium, Solidago, Erigenom, and Chrysanthemun plants, which are discussed in this review. Recently the increasing of the concentration of fine dust and pollen became a great cause of an allergic disease, just like the diagnostic yield of allergic coryza. The effects of weeds on people"s health are expected to become an important research topic among members of the Korean society of weed science.