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- 저자 : ( Mingyo Seo ) (검색결과 3 건)
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( Mingyo Seo ),( Jae Ha Lee ),( Hang Jea Jang ),( Jin Han Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Backgrounds: Acute exacerbation of interstitial lung disease (AE-ILD) was defined as an acute, clinically significant deterioration with high mortality. There are no currently proven effective management strategies. Recently some studies proposed the effectiveness of PMX-DHP in patients with AE-ILD as potential therapy. Methods: Clinical data were retrospectively analyzed in 12 patients with AE-ILD (13 episodes of AE), who were treated by PMX-DHP, enrolled from January 2018 to June 2019 at Haeundae-Paik hospital, Busan, Korea. We compared laboratory results, the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PF ratio), C-reactive protein (CRP), Interleukin-6 (IL-6) before and after PMX-DHP. Results: Twelve patients with idiopathic pulmonary fibrosis (IPF) and one patient with fibrotic nonspecific interstitial pneumonia (fNSIP) were included. Most patients (92.3%) were treated with high dose steroid and five patients (38.5%) with immunosuppressant. Mean number of PMX-DHP cycle was 2.4 times and mean duration of each cycle was 6.8 hours. After PMX-DHP, PF ratio was significantly improved at the end of PMX-DHP (109.3 ± 66.2 vs. 182.7 ± 96.2, p = 0.041) and after 72 hours (109.3 ± 66.2 vs. 173.7 ± 81.9, p = 0.044) compare to before. IL-6 was also significantly decreased at the end of PMX-DHP (330.6±600.5 vs. 18.3±15.5, p=0.0049) and after 72 hours (330.6±600.5 vs. 17.9±15, p=0.0078). There was no difference in CRP. 28-days mortality was 76.9% and there was no adverse event of PMX-DHP. Conclusions: Considering PF ratio improvement and removal of cytokine (IL-6), PMX-DHP would be helpful in patients with AE-ILD. But the improvement of oxygenation and cytokine removal always might not lead improvement of survival rate in our study. A larger prospective well controlled trial is needed to determine usefulness of PMX-DHP in patient with AE-ILD.
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Mingyo Seo(서민교),Woosub Lee(이우섭) Korean Society for Precision Engineering 2019 한국정밀공학회지 Vol.36 No.4
This paper reviews design elements and presents a mobile platform that has full access of wheel actuation for explicit steering with a minimized number of actuators. For the purpose of exploring lunar surfaces, there are two main design perspectives to be considered. First, the mobile system should guarantee traversability on rough terrain in microgravity condition. Secondly, the system should be sustainable in the extreme environment of the lunar surface including cosmic rays and excessive temperature changes. One of the potential solutions to improve the reliability of the rover system is to reduce the chance of failure by minimizing the number of electronic components including actuators and their following components and installing them in the rover’s warm-box. We approached the design of the mobile system in the aspect of its kinematics with assumptions of pure-rolling and non-lateral slip. We found a relation that a pair of front and rear wheels on the same side is coupled so that their alignment and rotational speed can be coupled by a mechanism. This allows advantages of explicit steering, minimizing redundancy of actuators and isolating all the electronic components from the effects of external environments. To demonstrate the feasibility of the system, we developed a rover testbed and presented its mobility of explicit steering by experiments of open-loop trajectory traveling.
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Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury
Park, Inwon,Kim, Mingyo,Choe, Kibaek,Song, Eunjoo,Seo, Howon,Hwang, Yoonha,Ahn, Jinhyo,Lee, Seung-Hyo,Lee, Jae Hyuk,Jo, You Hwan,Kim, Kyuseok,Koh, Gou Young,Kim, Pilhan European Respiratory Society 2019 The European respiratory journal Vol.53 No.3
<▼1><P>The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by disturbances in the pulmonary microcirculation is poorly understood. This study aimed to investigate how the pulmonary microcirculation is distorted in sepsis-induced acute lung injury (ALI) and reveal the underlying cellular pathophysiologic mechanism.</P><P>Using a custom-made intravital lung microscopic imaging system in a murine model of sepsis-induced ALI, we achieved direct real-time visualisation of the pulmonary microcirculation and circulating cells <I>in vivo</I>. We derived the functional capillary ratio (FCR) as a quantitative parameter for assessing the fraction of functional microvasculature in the pulmonary microcirculation and dead space.</P><P>We identified that the FCR rapidly decreases in the early stage of sepsis-induced ALI. The intravital imaging revealed that this decrease resulted from the generation of dead space, which was induced by prolonged neutrophil entrapment within the capillaries. We further showed that the neutrophils had an extended sequestration time and an arrest-like dynamic behaviour, both of which triggered neutrophil aggregates inside the capillaries and arterioles. Finally, we found that Mac-1 (CD11b/CD18) was upregulated in the sequestered neutrophils and that a Mac-1 inhibitor restored the FCR and improved hypoxaemia.</P><P>Using the intravital lung imaging system, we observed that Mac-1-upregulated neutrophil aggregates led to the generation of dead space in the pulmonary microcirculation that was recovered by a Mac-1 inhibitor in sepsis-induced ALI.</P></▼1><▼2><P><B>Neutrophils induce dead space in the pulmonary microcirculation in sepsis-induced ALI, recovered by a Mac-1 inhibitor</B>http://ow.ly/vUzO30nbUyU</P></▼2>
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