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The In Vitro Antioxidant Properties of Chinese Highland Lichens
( Heng Luo ),( Yoshikazu Yamamoto ),( Yan Peng Liu ),( Jae Sung Jung ),( Hyung Yeel Kahng ),( Young Jin Koh ),( Jae Seoun Hur ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.11
The antioxidant properties of 46 lichen species, collected from the highly UV-exposed alpine areas of southwestern China, were evaluated for their potential therapeutic utilization. The anti-linoleic acid peroxidation activity, 1,1- diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity, reducing power, and total phenolic contents were all assessed in vitro in the methanol extract of the lichens. A potent reducing power was detected in a number of the lichen extracts, when compared with butylated hydroxyanisole (BHA). In general, it was found that many of the lichens, with antioxidant properties, contained large quantities of phenolic content. Extracts of Peltigera praetextata and Sticta nylanderiana were found to exhibit the most potent activity in all of the antioxidant tests. In particular, extracts of S. nylanderiana displayed a 1.37 times greater anti-linoleic acid peroxidation activity, when compared with the ascorbic acid used as the positive control. S. nylanderiana also possessed the strongest free radical scavenging activity amongst all the tested species, with an inhibition rate of 90.4% at concentration of 330 ?g/ml. Activity-guided bioautographic TLC and HPLC analyses were used to establish which compounds were responsible for the potent antioxidant activities of the S. nylanderiana extract. These analyses revealed lecanoric acid to be primarily responsible for the effective antioxidant properties of S. nylanderiana. Overall, these results have indicated that several highland lichens have the potential of being utilized as novel bioresources for naturally occurring antioxidant therapies.
Heng Jin,Wei Wei,Yibo Zhao,Ai Ma,Keke Sun,Xiaoxi Lin,Qihui Liu,Songtao Shou,Yan Zhang 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.6
Background: The aim of this study was to evaluate the roles of interleukin (IL)-17A in risk stratification and prognosis of patients with sepsis-associated acute kidney injury (SAKI). Methods: We enrolled 146 sepsis patients (84 non-SAKI and 62 SAKI patients) admitted to the emergency department from November 2020 to November 2021. Patients with SAKI were differentiated based on the severity of acute kidney injury. All clinical parameters were evaluated upon admission before administering antibiotic treatment. Inflammatory cytokines were assessed using flow cytometry and the Pylon 3D automated immunoassay system (ET Healthcare). In addition, a receiver operating characteristic (ROC) curve was utilized to determine the prognostic values of IL-17A in SAKI. Results: The levels of creatinine, IL-2, IL-4, IL-6, IL-17A, tumor necrosis factor alpha, C-reactive protein, and procalcitonin (PCT) were significantly higher in the SAKI group than in the non-SAKI group (p < 0.05). The level of IL-17A revealed significant differences among stages 1, 2, and 3 in SAKI patients (p < 0.05). The mean levels of PCT, IL-4, and IL-17A were significantly higher in the non-survival group than in the survival group in SAKI patients (p < 0.05). In addition, the area under the ROC curve of IL-17A was 0.811. Moreover, the IL-17A cutoff for differentiating survivors from non-survivors was 4.7 pg/mL, of which the sensitivity and specificity were 77.4% and 71.0%, respectively. Conclusion: Elevated levels of IL-17A could predict that SAKI patients are significantly prone to worsening kidney injury with higher mortality. The usefulness of IL-17A in treating SAKI requires further research.
An Effective FastSLAM Algorithm Based on CUDA
Heng Zhang,Yanli Liu,Mengyu Zhu,Naixue Xiong,Tai-hoon Kim 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.12
Compute Unified Device Architecture (CUDA) is a mature parallel computing architecture, which can significantly accelerate performance of the computation intensive algorithm. In this paper, FastSLAM algorithm based on the probability model is further studied and the resampling algorithm for the path estimation is improved. In the resampling phase, resampling rules are redesigned and the previous data limitations are broken for the purpose of parallelization. We propose the FastSLAM algorithm based on CUDA, which accelerates robot localization and mapping. The experiment results show that FastSLAM_CUDA can achieve a significant speedup over the FastSLAM with many particles.
( Heng Liu ),( Yan Wang ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.11
Wireless Sensor Network (WSN) is made up of a number of sensor nodes and base stations. Traffic flow in WSN appears self-similar due to its data delivery process, and this impacts queue length greatly and makes queuing delay worse. Active queue management can be designed to improve QoS performance for WSN. In this paper, we propose self-similar traffic rate estimating algorithm named Power-Law Moving Averaging (PLMA) to regulate packet marking probability. This algorithm improves the availability of the rate estimation algorithm under the self-similar traffic condition. Then, we propose an adaptive Proportional Integral algorithm (SSPI) based on the estimation of the Self-Similar traffic rate by PLMA. Simulation results show that SSPI can achieve lower queue length jitter and smaller setting time than PI.
Heng Luo,Yoshikazu Yamamoto,Hae-Sook Jeon,Yan Peng Liu,Jae Sung Jung,Young Jin Koh,허재선 한국미생물학회 2011 The journal of microbiology Vol.49 No.1
The present study was conducted to evaluate the antibacterial activity of lichen-forming fungi (LFF) against Helicobacter pylori, and to optimize the culture conditions of LFF for maximum production of natural antibiotics against H. pylori. To accomplish this, a screening assay was first conducted among 19 species of LFF. The extract of Nephromopsis pallescens (KOLRI-040516) exhibited the strongest anti-H. pylori activity. Bioautograghic TLC and HPLC analysis identified usnic acid as the main antibacterial substance produced by N. pallescens. The growth of N. pallescens and production of antibacterial substances produced by the fungus were then investigated under several culture conditions including the culture media, initial medium pHs, incubation temperatures, and the degree of aeration. The results indicated that culture in MY medium with an initial pH of 6.0, a temperature of 15°C and a low degree of aeration supported the largest usnic acid production of the fungus (16.4 μg usnic acid/g dry biomass). Especially, aeration was found to be an important factor that affect both growth and usnic acid production of N. pallescens.
Guojun Liu,Xiao-Heng Chang,Yong-Yan Cao 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5
This paper concerns with the problem of designing fault detection (FD) observer for Takagi-Sugeno (TS)fuzzy systems subject to local nonlinear models. Different from the quadratic Lyapunov function approaches,fuzzy Lyapunov function approach is applied to design the fault detection observer, and corresponding sufficientconditions are given in terms of linear matrix inequalities. In addition, combined with nonlinear local modelsscheme and slack variable technique, the T-S fuzzy systems have fewer fuzzy rules to reduce the computationalburden. Compared with the existing results, less conservative results on existence of fuzzy fault detection observersare derived. Moreover, the designed fuzzy fault detection observer not only guarantees the residual system stabilitybut also improves the H_ index estimation. It is noted that the H_ index is employed to measure the worst-cast faultsensitivity performance. Finally, a numerical simulation is given to illustrate the effectiveness of the designed faultdetection observer.
Chien-Heng Lin,Huang-Li Lin,Chih-Lin Chiang,Yi-Wen Chen,Yan-Fang Liu,Yen Kuang Yang,Chao-Hsiun Tang 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.3
Objective: Limited evidence exists regarding real-world 3-monthly paliperidone palmitate (PP3M) treatment retention and associated factors. Methods: We conducted a retrospective, nationwide cohort study using the Taiwan National Health Insurance Research Database between October 2017 and December 2019. Adult patients with schizophrenia initiated on PP3M were enrolled. The primary outcomes were time to PP3M discontinuation, time to psychiatric hospitalization, and the proportions of patients receiving the next PP3M dose within 120 days among first-, second-, and third-dose completers. Key covariates included prior PP1M duration and adequate PP3M initiation. Results: The PP3M treatment retention rates were 79.7%, 66.3%, and 52.5% after 6, 12, and 24 months, respectively, with 86.4%, 90.6%, and 90.0% of respective first-, second-, and third-dose completers receiving the next PP3M dose. Adequate PP3M initiation and prior PP1M treatment duration > 180 days were associated with favorable PP3M treatment retention. In multivariate analyses, PP1M durations of 180−360 days (adjusted relative risk [aRR], 1.76) or < 180 days (aRR, 2.79) were associated with PP3M discontinuation at the second dose. Inadequate PP3M initiation was associated with discontinuation at the third dose (aRR, 2.18). Patients fully adherent to PP3M treatment in the first year had a higher probability of being free from psychiatric hospitalization (86.7% at 2 years), compared with those partially adherent or non-adherent to PP3M in the first year. Conclusion: Prior PP1M duration and adequate PP3M initiation are major factors affecting PP3M treatment retention. Higher PP3M treatment retention is associated with a lower risk of psychiatric hospitalization.
( Luo Heng ),( Chang Tian Li ),( Jin Cheol Kim ),( Yan Peng Liu ),( Jae Sung Jung ),( Young Jin Koh ),( Jae Seoun Hur ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.2
At present, acetylcholinesterase (AChE) inhibitors are the first group of drugs to treat mild to moderate Alzheimer`s disease (AD). Although beneficial in improving cognitive and behavioral symptoms, the effectiveness of AChE inhibitors has been questioned since they do not delay or prevent neurodegeneration in AD patients. Therefore, in the present study, in order to develop new and effective anti-AD agents from lichen products, both the AChE inhibitory and the neuroprotective effects were evaluated. The AChE inhibitory assay was performed based on Ellman`s reaction, and the neuroprotective effect was evaluated by using the MTT method on injured PC12 cells. One AChE inhibitor (IC50 = 27.1 μg/ml) was isolated by means of bioactivity-guided isolation from the extract of lichen-forming fungus Cladonia macilenta, which showed the most potent AChE inhibitory activity in previous screening experiment. It was then identified as biruloquinone by MS, and 1H- and 13C-NMR analyses. The inhibitory kinetic assay suggested that biruloquinone is a mixed-II inhibitor on AChE. Meanwhile, biruloquinone improved the viability of the H2O2- and β-amyloid-injured PC12 cells at 1 to 25 μg/ml. The protective effects are proposed to be related to the potent antioxidant activities of biruloquinone. These results imply that biruloquinone has the potential to be developed as a multifunctional anti- AD agent.
Xu, Heng,Tian, Yan-Na,Dun, Bo-Ying,Liu, Hai-Tao,Dong, Guang-Kuo,Wang, Jin-Hua,Lu, Shang-Su,Chen, Bo,She, Jin-Xiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.