Polymorphisms of Inflammatory Cytokine Genes and Risk for Intracranial Aneurysm: A Systematic Review and Meta-Analysis

Liming Hu,Bingyang Li,Xin Liao,Junxia Yan 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.5

Purpose: Inflammatory cytokines are thought to be involved in the pathogenesis of intracranial aneurysm (IA), although results among studies in the literature are inconsistent. This article sought to review studies on the associations among polymorphisms in inflammatory cytokine genes and IA risk and to provide recommendations for future research. Materials and Methods: A systematic search of PubMed, Embase, and Web of Science was conducted up to August 4, 2019. The associations between polymorphisms of inflammatory cytokine genes and IA risk were estimated by pooled odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses were performed according to race. Qualitative systematic review was conducted for variants that were studied in only one study. All analyses were performed using STATA 12.0. Results: 13 studies investigating the associations between polymorphisms in five inflammatory cytokine genes (TNF-α, IL-1α, IL-1β, IL6, and IL-12B) and IA were reviewed. Combined results showed that the A allele of TNF-α rs1800629 polymorphism has a protective effect against IA (dominant model: OR=0.65, 95% CI=0.47–0.89, p=0.007). No associations were identified between polymorphisms in IL-1α rs1800587, IL-1β rs16944, IL6 rs1800795 and rs1800796, or IL-12B rs3212227 and IA risk. Conclusion: This review demonstrated an association between TNF-α rs1800629 polymorphism and IA in Caucasians, illustrating the potentially important role of genes involved in inflammation in IA.

Yeast Surface Display of Capsid Protein VP7 of Grass Carp Reovirus: Fundamental Investigation for the Development of Vaccine Against Hemorrhagic Disease

( Shaoxiang Luo ),( Liming Yan ),( Xiaohua Zhang ),( Li Yuan ),( Qin Fang ),( Yong An Zhang ),( Heping Dai ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.12

VP7, an outer capsid protein of grass carp reovirus (GCRV), was expressed and displayed on the surface of Saccharomyces cerevisiae for developing an efficient vaccine against hemorrhagic disease of grass carp. The result of flow cytometry analysis indicated that protein VP7 could be displayed on the surface of yeast cells after inducing with galactose. The expression of VP7 was confirmed by western blot analysis and further visualized with confocal microscopy. The specific antibodies against VP7 generated from mice were detectable from all immune groups except the control group, which was immunized with untransformed yeast cells. The displaying VP7 on glycosylation-deficient strain EBYΔMnn9 was detected to induce a relatively low level of specific antibody amongst the three strains. However, the antiserum of EBYΔM9-VP7 showed relative high capacity to neutralize GCRV. Further neutralization testing assays indicated that the neutralizing ability of antiserum of the EBYΔM9-VP7 group appeared concentration dependent, and could be up to 66.7% when the antiserum was diluted to 1:50. This result indicates that appropriate gene modification of glycosylation in a yeast strain has essential effect on the immunogenicity of a yeast-based vaccine.

Solution-processed WOx hole injection layer for efficient fluorescent blue organic light-emitting diode

Wanshu Li,Yan Zhang,Qinghong Zheng,Kai Xu,Xiuyun Zhang,Liming Liu,Bin Wei,Lihui Wang,Jiwen Xu,Xiaowen Zhang 한국물리학회 2018 Current Applied Physics Vol.18 No.5

Solution-processed tungsten oxide (s-WOx) interfacial layer for efficient hole injection in fluorescent blue organic light-emitting diode (OLED) is demonstrated. The OLED using 2-methyl-9,10-bis(naphthalen-2- yl)anthracene (MADN) as emitter shows luminous efficiency of 3.3 cd/A, power efficiency of 2.5 lm/W and external quantum efficiency of 4.6% with Commission Internationale d'Eclairage (CIE) color coordinates of (0.154, 0.102). Using MADN doped 1-4-di-[4-(N,N-diphenyl)amino]styryl-benzene as emitter, luminous efficiency of 10.8 cd/A, power efficiency of 6.4 lm/W and external quantum efficiency of 7.2% with CIE color coordinates of (0.167, 0.283) are achieved. Atomic force microscopy and X-ray photoelectron spectroscopy show that s-WOx features superior film morphology and non-stoichiometry with slight oxygen deficiency. Current-voltage characteristics and impedance spectroscopy analysis indicate that s-WOx behaves slightly enhanced hole injection and accordingly contributes to improved device performance in comparison with conventional vacuum thermal evaporation WOx. Our results pave an alternative way for broadeningWOx application with solution process and advancing fluorescent blue OLEDs.

A Recommendation Method basing on Synthetic Strategy for Agricultural Science and Technology Information

Song Jinling,Huang Liming,Gao Yan,Liu Aiyong,Liu Haibin 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.5

To ameliorate the limitations of traditional collaborative filtering technologies and enhance the recommendation quality of agricultural science and technology information, a collaborative filtering recommendation method based on synthetic strategy is proposed. Firstly, filter the user set and user-item rating matrix according to the location of target user, which can solve the regional problem. Then, predict ratings of items according to the similarity of users or item content, which can relax the impact of the sparse rating. In addition, add the rating time to the user-item rating matrix to distinguish the timeliness of the user preference, and add user preference shifting in the similarity formula as a factor which can express the similarity of users or item content better. Our method can not only guarantee the recommended information is local and suit to current season of agricultural production, but also ensure the recommending precision under sparse rating data.

Soluble P3HT-Grafted Graphene for Efficient Bilayer−Heterojunction Photovoltaic Devices

Yu, Dingshan,Yang, Yan,Durstock, Michael,Baek, Jong-Beom,Dai, Liming American Chemical Society 2010 ACS NANO Vol.4 No.10

<P>CH<SUB>2</SUB>OH-terminated regioregular poly(3-hexylthiophene) (P3HT) was chemically grafted onto carboxylic groups of graphene oxide (GO) <I>via</I> esterification reaction. The resultant P3HT-grafted GO sheets (G-P3HT) are soluble in common organic solvents, facilitating the structure/property characterization and the device fabrication by solution processing. The covalent linkage and the strong electronic interaction between the P3HT and graphene moieties in G-P3HT were confirmed by spectroscopic analyses and electrochemical measurements. A bilayer photovoltaic device based on the solution-cast G-P3HT/C<SUB>60</SUB> heterostructures showed a 200% increase of the power conversion efficiency (η = 0.61%) with respect to the P3HT/C<SUB>60</SUB> counterpart under AM 1.5 illumination (100 mW/cm<SUP>2</SUP>).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2010/ancac3.2010.4.issue-10/nn101671t/production/images/medium/nn-2010-01671t_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn101671t'>ACS Electronic Supporting Info</A></P>

Hydrothermal Synthesis of Hierarchical Hollow Li(Ni0.8Co0.15Al0.05)O2 Microspheres for Lithium Ion Batteries

Liu Wenlong,Jiang Weiwei,Yan Chenran,Feng Wei,Wang Dongxia,Zhao Liming,Feng Tingting,Gong Feng 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.11

Li(Ni0.8Co0.15Al0.05)O2 (NCA) cathode material for lithium ion batteries is synthesized by calcining Ni–Co–Al hydroxide or carbonate hydroxide hydrate precursor, which is obtained by hydrothermal method, and the NCA cathode material is hierarchical hollow microspheres with the diameter in the range of 3–5 µm and composed of nanoflakes and/or nanowires. The effect of hydrothermal reaction time on the morphologies and the crystalline quality of the NCA cathode material is investigated on the basis of scanning electron microscopy, X-ray diffraction, and tunneling electron microscopy. The NCA cathode material shows smooth and monotonous charge/discharge characteristics, delivers a reversible capacity as 144.4 mAh/g and retains 90.4% after 50 cycles at a current density of 0.1 C between 2.5 and 4.3 V.

Molecular Epidemiology and Prevalence of Echovirus 30 in Zhejiang Province, China, from 2002 to 2015

( Yin Chen ),( Yi Sun ),( Juying Yan ),( Ziping Miao ),( Changping Xu ),( Yanjun Zhang ),( Haiyan Mao ),( Liming Gong ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.12

Echovirus serotype 30 (ECHO30) has been responsible for several recent worldwide outbreaks of viral meningitis. In Zhejiang Province, China, ECHO30 has been one of the main causes of viral meningitis for years. This study, using phylogenetic analysis of the VP1 gene, was performed to investigate the general molecular epidemiology and genetic patterns of ECHO30 circulating in Zhejiang Province between the years 2002 and 2015. The nucleotide sequences of ECHO30 VP1 showed that they were 64.8% identical with the prototype strain, Bastianni, while the amino acids were 84.9% identical. Phylogenetic analyses showed that ECHO30 in the Zhejiang area has diverged into two genotypes. Genotype I consists of strains isolated since 2002, whereas genotype II includes strains that were mainly isolated during the 2002 to 2004 outbreak. ECHO30 has been endemically circulating in both humans and the environment for a long period of time. Additionally, we evaluated the significance of recombination presented during the years 2005 to 2007 to demonstrate that recombination plays an important role in the prevalence of ECHO30 in the Zhejiang area.