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Im, Chong Kun,Rha, Sun Young,Jeung, Hei-Cheul,Ahn, Joong Bae,Shin, Sang Joon,Noh, Sung Hoon,Roh, Jae Kyung,Chung, Hyun Cheol Lippincott Williams Wilkins, Inc. 2010 American journal of clinical oncology: cancer clin Vol.33 No.1
BACKGROUND:: There is no universally confirmed standard chemotherapeutic regimen for advanced gastric cancer (AGC). The aim of this study was to investigate the efficacy and safety of combined biweekly irinotecan and monthly cisplatin treatments of patients with AGC. The primary end point was progression-free survival. MATERIAL AND METHODS:: AGC patients with or without measurable lesions received 70 mg/m irinotecan on days 1 and 15, and 80 mg/m cisplatin on day 1 every 4 weeks. RESULTS:: Of 40 enrolled patients, 21 patients had measurable disease. With a median follow-up duration of 35 weeks, the median progression-free survival and overall survival were 2.2 months and 8.0 months, respectively. The progression-free survival rate at 6 months was 30.0%. The most common adverse event of grade 3 to 4 was neutropenia (32.5%). Grade 3 diarrhea was observed in 2 patients (5.0%). There was no treatment-related death. CONCLUSION:: Current combined biweekly irinotecan and monthly cisplatin treatment did not show activity comparable with other active regimens in AGC.
ARM TrustZone 을 이용한 결제 단말기 민감한 정보 보호에 관한 연구
임원배(Won Bae Lim),노동건(Dong Kun Noh) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2
해킹 기술이 발전함에 따라 신용카드 결제 단말기에서의 보안 위협도 지속적으로 시도되고 있다. 따라서 이를 방어하기 위한 결제 단말기의 하드웨어 또는 소프트웨어 적인 보안 기술 강화가 요구되고 있는데, 이는 결과적으로 보안 단말기의 비용 상승을 유발한다. 단말기 비용상승을 억제함과 동시에 보안 수준 강화를 유도하기 위해, 본 연구에서는 결제 어플리케이션 및 민감 정보 처리를 ARM TrustZone 영역에서 실행하여 모든 결제 관련 보안 처리를 Secure World 에서 수행함으로써 결제에 필요한 민감한 정보를 보호할 수 있는 결제 단말기 구성을 제시한다.
( Chul Min Choi ),( Dae Hoon Hong ),( Young Oh ),( Kun Bae Noh ),( Jin Yeol Kim ),( Leon Chen ),( Sy Hwang Liou ),( Sung Ho Jin ) 대한금속재료학회 ( 구 대한금속학회 ) 2010 ELECTRONIC MATERIALS LETTERS Vol.6 No.3
The structure and properties of nanoscale magnetic island arrays for bit patterned media (BPM) have been studied. A periodic Si nano-island array was fabricated by nano-imprint-lithography (NIL), with the trench-filling and flattening achieved by resist spin coating followed by reactive ion back-etching. A Co/Pd multilayer magnetic media with a perpendicular anisotropy was then sputtered and lifted-off so that the processed nanostructure array now has the magnetic material only on the top of the pillars. This process significantly improved the magnetic characteristics of BPM. A planarization by hydrogen silsesquioxane filling reduced the tribological interference of the protruding nanoisland heights in BPM.
Jeung, Hei‐,Cheul,Rha, Sun Young,Im, Chong Kun,Shin, Sang Joon,Ahn, Joong Bae,Yang, Woo Ick,Roh, Jae Kyung,Noh, Sung Hoon,Chung, Hyun Cheol Wiley Subscription Services, Inc., A Wiley Company 2011 Cancer Vol.117 No.10
<P><B>Abstract</B></P><P><B>BACKGROUND:</B></P><P>The purpose of this study was to compare 2 weekly docetaxel‐based regimens as first‐line treatments for advanced gastric cancer and to investigate the expression of secreted protein acidic and rich in cysteine (SPARC) and its abilities to predict treatment‐related clinical outcomes.</P><P><B>METHODS:</B></P><P>Patients were randomly selected to receive 3 weekly cycles of docetaxel (35 mg/m<SUP>2</SUP> on days 1 and 8) plus S‐1 (35 mg/m<SUP>2</SUP> each twice daily on days 1‐14) (DS), or docetaxel plus cisplatin (35 mg/m<SUP>2</SUP> each on days 1 and 8) (DC). Endpoints included overall response rate (primary), survival, toxicity, and quality of life (secondary). SPARC expression in prechemotherapy specimens of primary gastric tumors was evaluated via immunohistochemical analysis.</P><P><B>RESULTS:</B></P><P>Eighty patients were enrolled in the study. Confirmed overall response rates were 46% (95% confidence interval, 30%‐62%) for DS and 24% (95% confidence interval, 11%‐38%) for DC via intent‐to‐treat analysis. Median progression‐free survival was 7.3 and 4.9 months and overall survival was 16.0 and 8.3 months for DS and DC, respectively. The most common grade ≥3 toxicity was neutropenia. Grade ≥3 mucositis (18%) and hand‐foot syndrome (8%) were the toxicities most associated with DS, whereas anorexia (20%) and lethargy (20%) were more common with DC. High SPARC expression was related to early progression (hazard ratio, 3.67; <I>P</I> = .042) and poor overall survival (hazard ratio, 2.01; <I>P</I> = .010) in docetaxel chemotherapy on multivariate analysis.</P><P><B>CONCLUSIONS:</B></P><P>The outcomes in this study favored DS over DC for further phase 3 study. The findings suggest that split‐dose weekly docetaxel alleviates hematological toxicity without compromising efficacy, and that SPARC expression may help individualize therapy in advanced gastric cancer. Cancer 2011. © 2010 American Cancer Society.</P>