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Blocking Fas Ligand on Leukocytes Attenuates Kidney Ischemia-Reperfusion Injury
Ko, Gang Jee,Jang, Hye Ryoun,Huang, Yanfei,Womer, Karl L.,Liu, Manchang,Higbee, Elizabeth,Xiao, Zuoxiang,Yagita, Hideo,Racusen, Lorraine,Hamad, Abdel Rahim A.,Rabb, Hamid American Society of Nephrology 2011 Journal of the American Society of Nephrology Vol.22 No.4
( Gang-jee Ko ),( Kamyar Kalantar-zadeh ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.4
High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0.8 g/kg/day) is recommended for the management of CKD. There are evidences that dietary protein restriction mitigate progression of CKD and retard the initiation of dialysis or facilitate incremental dialysis. LPD is also helpful to control metabolic derangements in CKD such as metabolic acidosis and hyperphosphatemia. Recently, a growing body of evidence has emerged on the benefits of plant-dominant low-protein diet (PLADO), which composed of > 50% plant-based sources. PLADO is considered to be helpful for relieving uremic burden and metabolic complications in CKD compared to animal protein dominant consumption. It may also lead to favorable alterations in the gut microbiome, which can modulate uremic toxin generation along with reducing cardiovascular risk. Alleviation of constipation in PLADO may minimize the risk of hyperkalemia. A balanced and individualized dietary approach for good adherence to LPD utilizing various plant-based sources as patients’ preference should be elaborated for the optimal care in CKD. Periodic nutritional assessment under supervision of trained dietitians should be warranted to avoid protein-energy wasting.
고강지 ( Gang Jee Ko ) 대한내과학회 2015 대한내과학회지 Vol.88 No.4
Radiocontrast-induced nephropathy (CIN) is the third most common cause of acute renal failure among inpatients. The number of patients undergoing examinations using radiocontrast is increasing, and the population at risk for CIN is growing; this population includes older individuals and those with underlying diabetes mellitus, chronic kidney disease, hypertensive nephropathy, and concomitant use of nephrotoxic drugs. However, little progress in CIN treatment has been made. CIN remains a substantial medical problem because of its association with prolonged hospitalization, the potential need for renal replacement therapy, and increased mortality. The exact pathogenesis of CIN has not been fully elucidated―and multiple factors including tubular renal vasoconstriction, direct renal tubular toxicity, increased oxidative stress, and cellular apoptosis―may contribute to the proximal tubular damage that occurs in patients with CIN. Despite the exploration of numerous prophylactic regimens and treatments, definite therapeutic and preventive strategies for CIN have not been established. This article reviews recent studies involving the risk factors for CIN as well as its pathophysiology and prevention.
급성 신부전으로 발현되어 다발성 장기부전을 동반한 λ형 경쇄침착질환
고강지 ( Gang Jee Ko ),김정엽 ( Jeong Yup Kim ),김명규 ( Myung Kyu Kim ),최혜민 ( Hye Min Choi ),현영율 ( Young Youl Hyun ),부창수 ( Chang Su Boo ),성수아 ( Su Ah Sung ),원남희 ( Nam Hui Won ),조상경 ( Sang Kyung Jo ),조원용 ( Won 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.6
당뇨병성 신증 : 아포지단백 E 제거 백서에서 장기적인 Deoxycorticosterone acetate 투여가 미치는 영향에 관한 연구
고강지 ( Gang Jee Ko ),강영선 ( Young Sun Kang ),송혜경 ( Hye Kyoung Song ),이미화 ( Mi Hwa Lee ),권오성 ( Oh Sung Kwon ),한금현 ( Kum Hyun Han ),한상엽 ( Sang Youb Han ),한지영 ( Jee Young Han ),김형규 ( Hyoung Kyu Kim ),차대룡 ( 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1
혈액투석을 시행하는 만성 신부전 환자에서 IL-10 유전자형 및 혈중농도와 심혈관계 합병증과의 관계에 대한 고찰
고강지 ( Gang Jee Ko ),김정엽 ( Jeong Yup Kim ),김명규 ( Myung Kyu Kim ),서순용 ( Soon Yong Suh ),최혜민 ( Hye Min Choi ),현영율 ( Young Youl Hyun ),부창수 ( Chang Su Boo ),이지은 ( Jee Eun Lee ),성수아 ( Su Ah Sung ),조상경 ( San 대한내과학회 2005 대한내과학회지 Vol.68 No.5
목적 : 혈액투석을 시행하는 만성 신부전 환자에서 만성 염증상태가 지속되는 것이 영양 결핍과 심혈관계 합병증 증가와 관련되어 있다는 연구가 이루어지고 있다. IL-10은 항염증 사이토카인 중 중추적 역할을 담당하는 것으로 유전자형에 따라 혈중 농도의 변화가 보고된 바 있다. 이에 본 연구에서는 만성 신부전 환자에서의 IL-10 혈중농도를 정상군과 비교하고 유전자형에 따른 농도변화와 심혈관계 질환 위험인자와의 상관성을 분석하였다. 방법 : 정상군 98명, Background : Chronic systemic inflammation in ESRD patients due to uremia and hemodialysis procedure itself comes into notice as a main factor for premature mortality secondary to rapid progressing atherosclerosis. Various pro-inflammatory cytokine, known
KIM, HYE WON,KO, GANG JEE,KANG, YOUNG SUN,LEE, MI HWA,SONG, HYE KYOUNG,KIM, HYOUNG KYU,CHA, DAE RYONG Blackwell Publishing Asia 2009 Nephrology Vol.14 No.7
<P>SUMMARY:</P><P>Aim: </P><P>Vascular endothelial growth factor (VEGF) is important in the pathogenesis of diabetic microvascular complications and the genetic polymorphism of this gene may contribute to the development and progression of diabetic microvascular complications. In this study, we investigated whether a genetic polymorphism of <I>VEGF</I> is associated with diabetic complications.</P><P>Methods: </P><P>A total of 398 type 2 diabetic patients and 526 healthy controls were enrolled. The study subjects were divided based on the state of nephropathy, retinopathy and neuropathy. The <I>VEGF</I> 936 C/T polymorphism was evaluated using standard PCR techniques, and plasma and urinary levels of VEGF were determined by enzyme-linked immunosorbent assay.</P><P>Results: </P><P>There was no difference in <I>VEGF</I> genotype distribution between the control and diabetic patients based on the state of diabetic nephropathy and neuropathy. However, a higher frequency of the TT genotype was observed in patients with proliferative diabetic retinopathy. Additionally, plasma levels of VEGF were significantly higher in the TT genotype. However, urinary levels of VEGF did not show a significant relationship with the <I>VEGF</I> genotype. Urinary VEGF levels showed a significant relationship with urinary albumin excretion, proteinuria, serum creatinine level and creatinine clearance, as well as fasting blood glucose levels, postprandial 2 h glucose levels and C-reactive protein.</P><P>Conclusion: </P><P>Our study suggests that the 936 C/T polymorphism of the <I>VEGF</I> gene may be an important factor determining plasma VEGF levels and that its polymorphism is related with diabetic retinopathy. Urinary levels of VEGF are not associated with plasma VEGF levels and associated with the stage of diabetic nephropathy.</P>