젊은 남성에서 부하 적용이 어깨 벌림 동안 봉우리밑 공간 간격에 미치는 영향

박강희 ( Park Kanghui ),박한규 ( Park Hankyu ),박수경 ( Park Sookyoung ) 대한통합의학회 2020 대한통합의학회지 Vol.8 No.1

Purpose : This study was performed to comparison of distance change of subacromial space according to shoulder abduction angle in loaded and unloaded conditions. Methods : The subjects were 20 male college students, and the subacromial space was measured using an ultrasound diagnostic apparatus. The participants shoulder abduction was measured during each shoulder resting position and 45 ° abduction with loads of 1 ㎏, 2 ㎏, 3 ㎏. The collected data were analyzed by a paired t-test and repeated measure ANOVA with the SPSS (Ver. 22) program. Results : The subacromial space showed statistically significant decreased in 45 ° abduction than resting position (p<.001). All the subacromial space increased during the according to loads (1 ㎏, 2 ㎏, 3 ㎏) at the resting position but at 45 ° abduction showed statistically significant decreased as the load increases (p<.05). Also, subacromial space showed significant changes in the 2㎏, 3㎏ compared with the 0㎏ loads. Conclusion : These results identified that shoulder abduction angle and load were related to subacromial space. When resting position, subacromial space is larger at loads than unload. As the load and shoulder abduction angle increase, subacromial space is reduced compared to resting.

Effect of Kegel Exercise on Vital Capacity According to the Position: A Preliminary Study

( Kanghui Park ),( Hankyu Park ) 대한물리치료학회 2020 대한물리치료학회지 Vol.32 No.4

Purpose: This study examined the immediate effect of Kegel exercise on the vital capacity according to the position. Methods: Seventeen subjects participated in the study (male=7, female=10). The subjects performed Kegel exercise in two positions: sitting and hooklying. The order of exercise was conducted in a random order selected by the subjects to exclude the learning effect. The maximum voluntary ventilation (MVV) was measured using a spirometer. The vital capacity was measured according to the manual in the sitting position before the experiment. After each exercise, the vital capacity was also measured in the same way. One way repeated measures analysis of the variance (ANOVA) was used to compare the vital capacity according to the position, and a Bonferroni test was used for post hoc analysis. Results: Significant differences in vital capacity were observed after exercise than before exercise (p< 0.05). Post-hoc analysis, however, revealed no difference in vital capacity according to the position (p >0.05). Conclusion: This study was a preliminary study to determine the vital capacity according to the Kegel exercise and two positions. Nevertheless, further study with several revisions of the number of subjects, duration, and time for intervention will be needed.

Synergistic Effect of Melatonin on Exercise-Induced Neuronal Reconstruction and Their Functional Recovery in SCI Animal Model

Kanghui Park(박강휘),Youngjeon Lee,Seunghoon Lee,Sookyoung Park,Yonggeun Hong 한국실험동물학회 2009 한국실험동물학회 학술발표대회 논문집 Vol.2009 No.2

The effects of melatonin combined with exercise induces alteration in dendritic morphology and functional recovery after spinal cord contusion in rats

Kanghui Park,Youngjeon Lee,Yunkyung Hong,Seunghoon Lee,Yonggeun Hong 한국실험동물학회 2012 한국실험동물학회 학술발표대회 논문집 Vol.2012 No.8

Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model

Park, Kanghui,Lee, Youngjeon,Park, Sookyoung,Lee, Seunghoon,Hong, Yunkyung,kil Lee, Sang–,Hong, Yonggeun Blackwell Publishing Ltd 2010 Journal of pineal research Vol.48 No.3

<P>Abstract: </P><P>Nitric oxide (NO) may aggravate neuronal damage after spinal cord injury (SCI). We hypothesized that NO produced by inducible nitric oxide synthase (iNOS) accelerates secondary damage to spinal tissue, which may be reversed by the neuroprotectant, melatonin. This study investigated the effects of combination therapy with melatonin (10 mg/kg) and exercise (10 m/min) on recovery from SCI caused by contusion. We examined locomotor recovery, iNOS gene expression, autophagic and apoptotic signaling, including Beclin-1, LC3, p53 and IKK&agr; protein expression and histological alterations in the ventral horn of the spinal cord. Melatonin in combination with exercise resulted in significantly increased hindlimb movement (<I>P </I><<I> </I>0.05), a reduced level of iNOS mRNA (<I>P </I><<I> </I>0.05) and more motor neurons in the ventral horn, versus control SCI and SCI plus exercise alone, with no effect on the other signaling molecules examined. This study shows that combined therapy with melatonin and exercise reduces the degree of secondary damage associated with SCI in rats and supports the possible use of melatonin in combination with exercise to reduce the side effects related to exercise-induced fatigue and impairment.</P>

New Prophylactic and Therapeutic Strategies for Spinal Cord Injury

Park, Sookyoung,Park, Kanghui,Lee, Youngjeon,Chang, Kyu-Tae,Hong, Yonggeun Institute of Lifestyle Medicine, Yonsei University 2013 Journal of lifestyle medicine Vol.3 No.1

<P>Melatonin production by the pineal gland in the vertebrate brain has attracted much scientific attention. Pineal melatonin is regulated by photoperiodicity, whereas circadian secretion of melatonin produced in the gastrointestinal tract is regulated by food intake. Thus, the circadian rhythm of pineal melatonin depends upon whether a species is diurnal or nocturnal. Spinal cord injury (SCI) involves damage to the spinal cord caused by trauma or disease that results in compromise or loss of body function. Melatonin is the most efficient and commonly used pharmacological antioxidant treatment for SCI. Melatonin is an indolamine secreted by the pineal gland during the dark phase of the circadian cycle. Neurorehabilitation is a complex medical process that focuses on improving function and repairing damaged connections in the brain and nervous system following injury. Physical activity associated with an active lifestyle reduces the risk of obesity, cardiovascular disease, type 2 diabetes, osteoporosis, and depression and protects against neurological conditions, including Parkinson’s disease, Alzheimer’s disease, and ischemic stroke. Physical activity has been shown to increase the gene expression of several brain neurotrophins (brain-derived neurotrophic factor [BDNF], nerve growth factor, and galanin) and the production of mitochondrial uncoupling protein 2, which promotes neuronal survival, differentiation, and growth. In summary, melatonin is a neural protectant, and when combined with therapeutic exercise, the hormone prevents the progression of secondary neuronal degeneration in SCI. The present review briefly describes the pathophysiological mechanisms underlying SCI, focusing on therapeutic targets and combined melatonin and exercise therapy, which can attenuate secondary injury mechanisms with minimal side effects.</P>

Therapeutic physical exercise in neural injury: friend or foe?

Park, Kanghui,Lee, Seunghoon,Hong, Yunkyung,Park, Sookyoung,Choi, Jeonghyun,Chang, Kyu-Tae,Kim, Joo-Heon,Hong, Yonggeun The Society of Physical Therapy Science 2015 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.27 No.12

<P>[Purpose] The intensity of therapeutic physical exercise is complex and sometimes controversial in patients with neural injuries. This review assessed whether therapeutic physical exercise is beneficial according to the intensity of the physical exercise. [Methods] The authors identified clinically or scientifically relevant articles from PubMed that met the inclusion criteria. [Results] Exercise training can improve body strength and lead to the physiological adaptation of skeletal muscles and the nervous system after neural injuries. Furthermore, neurophysiological and neuropathological studies show differences in the beneficial effects of forced therapeutic exercise in patients with severe or mild neural injuries. Forced exercise alters the distribution of muscle fiber types in patients with neural injuries. Based on several animal studies, forced exercise may promote functional recovery following cerebral ischemia via signaling molecules in ischemic brain regions. [Conclusions] This review describes several types of therapeutic forced exercise and the controversy regarding the therapeutic effects in experimental animals versus humans with neural injuries. This review also provides a therapeutic strategy for physical therapists that grades the intensity of forced exercise according to the level of neural injury.</P>

플랭크 운동이 비대칭 골반 앞기울임을 가진 대상자의 복부근육 두께 변화에 미치는 영향

박강희 ( Park Kanghui ),김형수 ( Kim Hyoungsu ) 대한통합의학회 2018 대한통합의학회지 Vol.6 No.3

Purpose : This study investigated the effects of different types of plank exercise on abdominal muscle thickness in subjects with asymmetric pelvic anterior tilt. Methods : Participants with a diagnosis of pelvic anterior tilt were divided into an experimental group (n=12) and a control group (n=13). The thicknesses of the transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) muscles were measured using an ultrasound diagnostic apparatus. The data were analyzed using an SPSS (Ver. 21) program. Results : In the experimental group, there was a significant difference in the thicknesses of the left and right muscles in the standing and elbow plank exercises (p<.05). All the muscle thicknesses increased significantly during the plank exercises(elbow plank, right-side plank, and left-side plank) as compared with those in the standing position (p<.05). In addition, the side-plank exercise resulted in significantly higher muscle thickness of the supported side (p<.01, p<.001). Conclusion : These findings suggest that asymmetric exercise should be applied to the change of the left and right muscles of the abdominal when applying plank exercise according to pelvic anterior tilt.

인체대장암세포주 SW480에 대한 재배 와송의 항암효과 연구

박수경(Sookyoung Park),원진영(Jinyoung Won),박강희(Kanghui Park),홍용근(Yonggeun Hong) 한국생명과학회 2018 생명과학회지 Vol.28 No.7

와송(둥근바위솔, Orostachys japonicus, OJ)은 면역조절, 항노화, 항산화, 독성제거 등의 치료적 효과를 가진 약용식물로 알려져 있는데, 본 연구에서는 인체대장암세포에 대한 재배 와송의 항암효과를 규명하고자 하였다. 인체대장암세포주 SW480에 와송열수추출물을 72시간 동안 처리한 결과, 대장암세포의 생존율은 농도-의존적으로 유의하게 감소하였다. 또한, 와송은 SW480 세포의 증식과 이주를 억제하는 것으로 나타났는데, 대조군의 스크래치 gap은 24시간부터 유의하게 감소하는 반면, 와송열수추출물을 처리한 실험군 I과 II의 스크래치 gap은 48시간부터 감소하기 시작하였다. 특히 실험군 I의 스크래치 gap은 72시간까지 유의하게 유지되었다. 와송이 생체 내에서 종양의 형성에 어떠한 영향을 미치는지 알아보기 위하여 대장암세포 주사 전, 31일 동안 수컷 C57BL/6 마우스(4주령)에게 와송열수추출물을 경구로 자유 섭취하게 하였다. 이후 SW480 세포(1×107 cells/100 μl)를 피하로 주입한 후 7일, 14일 그리고 28일에서 종양의 형성을 관찰하였고, 각 실험동물을 희생하여 종양의 무게와 부피(㎣)를 측정하여 비교 분석하였다. 와송열수추출물을 섭취하는 동안 실험군 I, II의 체중은 대조군에 비해 지속적으로 유의하게 증가하였다. SW480 세포 주입 이후 모든 실험군의 체중은 감소하였으나, 세포 주입 후 14일부터 와송 섭취 실험군의 체중은 유의하게 증가하는 것으로 나타났다. 대장암세포 주입 후 7일과 14일에서 와송을 섭취한 실험군의 종양 무게와 부피는 대조군보다 높았으나, 28일에서는 대조군보다 낮게 나타났고, 특히 실험군 II에서 종양 무게와 부피는 유의하게 감소하는 것으로 확인되었다. 이상의 결과를 통해 와송이 인체 대장암세포의 성장, 증식 및 이주를 억제하며, 생체 내 종양형성(tumorigenesis)을 예방적으로 억제함을 알 수 있었다. 따라서, 재배와송은 천연 항암제 소재로서 활용될 가능성을 가지는 것으로 보이며, 이에 대한 심층적인 연구가 필요할 것으로 사료된다. Orostachys japonicus (OJ) is a medicinal herb with immunoregulatory, anti-aging, anti-oxidative, and many other therapeutic properties. The purpose of this study was to elucidate the anti-cancer property of cultivated OJ. SW480 cell viability was significantly reduced by cumulative exposure to OJ extract. We also observed inhibitory effects of OJ after 72 hr through the growth and migration of SW480 cells using scratch assay. SW480 cells in OJ-free medium began to move into the scratch site at 24 hr; however, cells in medium containing OJ did not migrate into the scratch site until 48 hr. Male C57BL/6 mice (4 weeks old) were orally administered OJ extract for 31 days before injection of SW480 cells. At 7, 14, and 28 days after subcutaneous injection of SW480 cells, tumor weight and volume were analyzed. The body weight of the OJ-treated group was continuously increased during administration of the OJ extract relative to the control group. Injection of SW480 cells caused a reduction in body weight in all groups; however, the OJ-treated group exhibited a significant increase in body weight after 14 days. Tumor weight and volume were lower in the OJ-treated group than in the control group after 28 days. Although these results suggest that OJ suppresses the proliferation and migration of human colon cancer cells, additional studies are required to provide preclinical evidence before launching clinical trials evaluating OJ as an anti-cancer biohealth product.

Beneficial effects of endogenous and exogenous melatonin in SCI animal model

Hyeongsun Seo,Inhee Park,Kanghui Park,Sookyoung Park,Yonggeun Hong 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.8