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Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
Park Junsoo,Park Rackhyun,Jang Minsu,Park Yea-In,Park Yeonjeong 한국미생물학회 2022 The journal of microbiology Vol.60 No.3
Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNAdependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds.
Park, Junsoo,Jeong, In Gab,Bang, Jeong Kyoon,Cho, Young Mee,Ro, Jae Y.,Hong, Jun Hyuk,Ahn, Hanjong,Kim, Choung-Soo The Korean Urological Association 2010 Korean Journal of Urology Vol.51 No.6
<P><B>Purpose</B></P><P>To analyze the preoperative clinical and pathological characteristics of patients with pT0 prostate cancer.</P><P><B>Materials and Methods</B></P><P>We retrospectively reviewed the records of 702 patients who underwent radical prostatectomy (RP) at our institution between January 2004 and July 2008 for clinically localized prostate cancer. If there was no evidence of residual tumor in the pathological specimen of the prostate, a patient was staged as pT0. Patients with pT0 disease were compared with a control group of patients who were operated on during the same period.</P><P><B>Results</B></P><P>Overall, 9 (1.3%) patients were staged as pT0 on the pathologic examination. Significant differences were observed between the pT0 group and the control patients in the biopsy Gleason score (p=0.004), the number of positive cores on biopsy (p=0.018), the tumor length of positive cores (p<0.001), and prostate volume (p=0.015). Cutoff values predictive of pT0 tumor status were defined as a biopsy Gleason score sum ≤6, 2 or fewer positive biopsy cores, tumor length on biopsy ≤2 mm, and prostate volume >30 cm<SUP>3</SUP>. Whereas 8 of the 9 (88.9%) pT0 patients showed all of these characteristics, only 55 of the 693 (7.9%) control patients fulfilled the criteria. The combination suggested above afforded a sensitivity of 88.8% and a specificity of 92.1% for the prediction of pT0 status.</P><P><B>Conclusions</B></P><P>The frequency of pT0 prostate cancer seen on RP was 1.3%. A combination of clinicopathological features, incorporating a biopsy Gleason score, the number of positive biopsy cores, tumor length on biopsy, and prostate volume, was useful to predict pT0 stage on RP.</P>
Park, Junsoo,Seo, Taegun,Kim, Hakzoo,Choe, Joonho American Society for Microbiology 2005 Molecular and cellular biology Vol.25 No.18
<B>ABSTRACT</B><P>Replication protein A (RPA) is a single-stranded-DNA-binding protein composed of three subunits with molecular masses of 70, 32, and 14 kDa. The protein is involved in multiple processes of eukaryotic DNA metabolism, including DNA replication, repair, and recombination. In <I>Xenopus</I>, <I>Xenopus</I> RPA-interacting protein α has been identified as a carrier molecule of RPA into the nucleus. In this study, human RPA-interacting protein α (hRIPα) and five novel splice isoforms (named hRIPα, hRIPβ, hRIPγ, hRIPδ1, hRIPδ2, and hRIPδ3 according to the lengths of their encoding peptides) were cloned. Among hRIP isoforms, hRIPα and hRIPβ were found to be the major splice isoforms and to show different subcellular localizations. While hRIPα localized to the cytoplasm, hRIPβ was found in the PML nuclear body. Modification of hRIPβ by sumoylation was found to be required for localization to the PML nuclear body. The results of the present work demonstrate that hRIPβ transports RPA into the PML nuclear body and releases RPA upon UV irradiation. hRIPβ thus plays an important role in RPA deposition in PML nuclear bodies and thereby supplements RPA for DNA metabolism.</P>
Park, Junsoo,Lee, Myung-Shin,Yoo, Seung-Min,Jeong, Kwi Wan,Lee, Daeyoup,Choe, Joonho,Seo, Taegun American Society for Microbiology 2007 Journal of virology Vol.81 No.22
<B>ABSTRACT</B><P>Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal transduction. The amino-terminal region of vIRF1 displays significant homology to the DNA-binding domain of cellular interferon regulatory factors, supporting the theory that the protein interacts with specific DNA sequences. Here, we identify the consensus sequence of vIRF1-binding sites from a pool of random oligonucleotides. Moreover, our data show that vIRF1 interacts with the K3:viral dihydrofolate reductase:viral interleukin 6 promoter region in the KSHV genome.</P>
Park, Junsoo,Lee, Jae-Won The Korean Powder Metallurgy Institute 2015 한국분말재료학회지 (KPMI) Vol.22 No.1
The composite of porous silicon (Si) and amorphous carbon (C) is prepared by pyrolysis of a nano-porous Si + pitch mixture. The nano-porous Si is prepared by mechanical milling of magnesium powder with silicon monoxide (SiO) followed by removal of MgO with hydrochloric acid (etching process). The Brunauer-Emmett-Teller (BET) surface area of porous Si ($64.52m^2g^{-1}$) is much higher than that before etching Si/MgO ($4.28m^2g^{-1}$) which indicates pores are formed in Si after the etching process. Cycling stability is examined for the nano-porous Si + C composite and the result is compared with the composite of nonporous Si + C. The capacity retention of the former composite is 59.6% after 50 charge/discharge cycles while the latter shows only 28.0%. The pores of Si formed after the etching process is believed to accommodate large volumetric change of Si during charging and discharging process.
박준수(Junsoo Park) 현대미술사학회 2013 현대미술사연구 Vol.0 No.34
This paper analyzes Barnett Newman’s works of art with horizontal zips, <Untitled 2, 1949> <Dionysius> <Argos> <Horizon Light> which have deviated from dominant discourse on his artworks, and intends to deploy them in the center of his oeuvre. Newman’s primary artistic purpose was to make “creative painting”. This conceptually synthesizes his artistic practice and subject-matter. In the next year after finishing <Onement 1> in 1948, an inaugural work of his mature style, Newman was possessed of a derivative condition, “verticality”. With regard to maintain his artistic creativity, the subject-matter of “Creation” of God played an important role. Newman applied geometrical elements, which had been denounced through his whole artistic life due to the relation to Mondrian, in his artwork with the experiment of horizontal zip paintings. Specifically Newman’s use of “dynamic symmetry” on void canvas parallels the given order in the beginning of the world by God. Furthermore, his use of horizontal works against the fossilized label of “verticalline-painter” demonstrates how he located himself on the state of artist as a creator. In addition, despite the laudatory criticism from 1940s on Newman, their modernist explanation referring to his pictorial space was merely another condition to be got over. It led him to pursue a “sensation of time” extended from “temporality” firstly implied in his horizontal works . Newman’s four horizontal artworks were a necessary stage in pursuit of being an artist as a creator in 1949. They granted Newman a significant possibility to secure creativity on his later artistic life.
당송산문선집(唐宋散文選集)의 체계(體系)와 내용(內容) 연구(硏究) ― ≪고문관건(古文關鍵)≫ 선문(選文)과 평점(評點)을 중심으로
박준수 ( Park Junsoo ) 중국어문연구회 2017 中國語文論叢 Vol.0 No.81
The Prose Selections of Tang-Song is a specific and precise expression of Tang-Song concepts of writing styles and literature. In terms of rules of compilation, The Prose Selections of Tang-Song were generally compiled in order of writing styles, writers, types, and skills. Lu, Zuqian`s commented and appreciated `the Prose of Eight Masters in Tang-Song Dynasty`. Especially Guwenguanjian focusing on the structure and the style of Classical prose. This book established the literary school through the criticism of comments about selection and appreciating the prose of Tang and Song, which could help efficiently the a candidate for an examination to learn and follow it, and moreover to success the civil service examination. The critical reception through the criticism of commentaries by Lu Zuqian could be explained in three introductions. First, it focused on the one of the Song Period, `Wen-yi-zai-dao`. Second, it expressed the model and the structure of Classical prose and constructed the literary theory which established the consciousness of criticism and appreciation by comments. Third, it also emphasized the feeling of the prose and the private distinction of the author, which included contents of the Classical prose.
박준수(Junsoo Park),박성준(Sungjoon Park),임영재(Youngjae Lim),정의승(Eui S. Jung) 대한인간공학회 2010 大韓人間工學會誌 Vol.29 No.6
This study aims to systematically develop a usability evaluation model using the Structural Equation Model (SEM) from experiment of usability on using vehicle. Vehicle developers have been adding many functions for enhance the user satisfaction. But it will be made the trade-off problem of usability and design elements of vehicle interior from attempt to make best usability satisfaction in a restricted space. To solve the trade-off problem, we set a new solution criterion from usability evaluation model. The usability experiment is based on major activity pool from derived user's acts pattern in vehicle for make more accurate usability evaluation model. And this model was built with twenty-nine measurement variables for the evaluation of usability of vehicle user. As a result, the proposed SEM model showed statistical significance as well as a high level of R Square (0.7144). This model shows the relationships of detailed usability and design elements. According to the result, this study introduces the criterion to secure the best satisfaction of usability and design elements.