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Anti-proliferative Activity of 3,5-Diaminoindazole Analogues
Jongwon Park,Jinho Lee 계명대학교 자연과학연구소 2019 Quantitative Bio-Science Vol.38 No.1
Cancer is the second leading cause of death worldwide. Small-molecule anticancer agents with tolerable safety profiles have been developed to improve survival rates. Indazole analogues have received considerable attention due to their anticancer properties. A series of N3-acyl-N5-pyrimidinyl-3,5-diaminoindazoles were synthesized and their antiproliferative activities were evaluated in Caki, A549, HepG2, AMC-HN4, and SNU484 human cancer cell lines. Cellular selectivity of 3,5-diaminoindazole with a modified structure of the N5-pyrimidinyl substituent was studied. While both compounds 9a and 9b showed a high selectivity for the HepG2 cell line, compound 9b had a higher selectivity than 9a, with an IC50«0.1 μM.
Glomerular crescents are associated with worse graft outcome in allograft IgA nephropathy
Park, Sehoon,Baek, Chung Hee,Cho, Hyunjeong,Yu, Mi‐,yeon,Kim, Yong Chul,Go, Heounjeong,Kim, Young Hoon,Lee, Jung Pyo,Min, Sang Il,Ha, Jongwon,Moon, Kyung Chul,Kim, Yon Su,Ahn, Curie,Park, Su Wiley (Blackwell Publishing) 2019 American journal of transplantation Vol.19 No.1
Jongwon Choi,Byung-Jae Yoon,Keun Huh,Kun-Young Park,Kyung-Tae Lee,Hee-Juhn Park 한국식품영양과학회 2002 Preventive Nutrition and Food Science Vol.7 No.4
The present study was undertaken to evaluate the anti-rheumatoidal arthritis effect of the R. verniciflua heartwood extract, its EtOAc fraction, and its primary flavonoids, sulfuretin and fustin. All test samples showed variably significant inhibitory effects on hind paw edema and trypsin inhibitor activity induced by Freund's complete adjuvant reagent (FCA reagent), and on vascular permeability caused by acetic acid. Treatment with 10 mg/kg (i.p.) sulfuretin for seven days inhibited edema formation by 54.2±3.0%. Test samples, especially sulfuretin, shifted the values of biochemical parameters such as serum-cholesterol, serumtriglyceride and serum-total protein toward the normal and restored the numbers of leucocytes and platelets. These results suggest that the heartwood of R. verniciflua reduces immunological injuries caused by FCA reagent provides evidence that suluretin is an active anti-rheumatoid arthritis agent.
Jongwon Park(박종원) 한국자동차공학회 2023 한국자동차공학회 부문종합 학술대회 Vol.2023 No.5
To cope with increasing demand of higher fuel economy and stringent emission regulations in the global market, Geely powertrain research institute (GPRI) has been developing the new Dedicated Hybrid Engine (GHE) series, aiming for lower fuel consumption, lower emission, higher performance and NVH enhancement. GHE family contains two series variants: one is 1.5L TGDI with two derivatives of 3 cylinders, the other is 2.0 TGDI derivatives with diverse fuel economy and high power. GHE family is state of the art engine, being the first ICE conceived to fulfill the stretched targets of the next generation of hybrid vehicles for Geely Holding Group. Also GHE is modular manufacturing concept to produce the engine family in the existing engine plants, which are currently producing GEP3, 1.5TD. In developing higher fuel economy variants, deep investigations of the required ICE working conditions led to the correct targets setting for whole BSFC map, BTE (42+ %), vehicle WLTC fuel economy but mainly at real-world customer driving condition. Then, GHE is being developed to serve high performance output combined with lambda =1 full map and also being compliant with future emission regulations and RDE. The concept and development of GHE set in a high efficiency Miller-cycle and transversal combustion system with higher tumble and turbulent kinematic energy (TKE), lowest friction, improved mixture formation including new fuel injection system (FIS) with 350bar, higher 13:1 compression ratio, optimized turbocharging combined with high cooled EGR rates and water-CAC. Besides, utilizing frontier technology on cooling system and lubrication system, such as electric water pump, split cooling, CTAM and E-PCJ, GHE variants possess the best performance. GHE HP, the developing variant with high power, provides the customer demands for fun-to-drive with 100kw/liter specific power and 40%+ BTE. This engine applies soft Miller cycle, the same combustion configuration to GHE with 10.5 compression ratio, higher flow intake port, and mechanical water pump with thermal management system. Furthermore, considering strong customers’ demand on noise and ride comfort from eastern countries such as China, Korea and Japan, NVH enhancement set in assessment of engine concept design. Suspended injector is deployed to cut-off the transfer path from 350 Bar FIS, cylinder pressure rise rate is well optimized. Structural attenuation achieves state of art by optimization of key engine components such as cylinder head, cylinder block, bedplate and oil pan. Mass balance shaft and dual mass flywheel are applied to improve vehicle integrated NVH performance. Die cast aluminum timing cover with additional acoustic cover significantly attenuates engine radiated noise to pass the EU pass-by legislation 2022. This paper describes the development concept of GHE variants in terms of development strategy, target, technology road map, system definition, etc.
Sliding Mode Control of Locomotion for a Biomimetic Robot Inspired by Pillbugs
Jongwon Park,Kyung-soo Kim,Soo-hyun Kim 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
Reconnaissance robots can reduce the danger of hazardous places by providing information before human personnel take action. In practice, the robot platform should be small and light. However, this fact leads to a scaling issue with terrain that poses a huge obstacle for the vehicle. The problem can be solved by the inspiration of nature. This paper presents a sliding mode control (SMC) of locomotion for a pill bug inspired robot, Pillbot. The performance of sliding mode control will be compared to that of PID through RecurDyn-Simulink cosimulation.
Metabolic Acidosis and Long-Term Clinical Outcomes in Kidney Transplant Recipients
Park, Seokwoo,Kang, Eunjeong,Park, Sehoon,Kim, Yong Chul,Han, Seung Seok,Ha, Jongwon,Kim, Dong Ki,Kim, Sejoong,Park, Su-Kil,Han, Duck Jong,Lim, Chun Soo,Kim, Yon Su,Lee, Jung Pyo,Kim, Young Hoon American Society of Nephrology 2017 Journal of the American Society of Nephrology Vol.28 No.6