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Choi, Mansoo,Lee, Sang-Hun,Jung, Yang-Il,Jung, Jun-Young,Park, Jung-Soon,Choi, Wang-Kyu,Park, Sang-Yoon,Won, Hui-Jun,Moon, Jei-Kwon,Choi, Jihoon,Kim, Seon-Byeong ELSEVIER SCIENCE 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.729 No.-
<P><B>Abstract</B></P> <P>NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film has been prepared by electron beam evaporation method and has been investigated as anode materials providing large reversible Li<SUP>+</SUP> capacity with high cycling performance for lithium ion batteries. The NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film crystallized with annealing process after NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film deposition. In electrochemical measurements, the first discharge and charge capacity of NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film were found to be 1693 mAh g<SUP>−1</SUP> and 1108 mAh g<SUP>−1</SUP>, which is above its theoretical capacity (915 mAh g<SUP>−1</SUP>). In addition, the cycle performance test of NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film also showed steady charge-discharge capacity at 0.1 C during 100 cycles compared to other NiFe<SUB>2</SUB>O<SUB>4</SUB> materials, indicating that the empty space or porous surface of electrode was beneficial for accessibility of electrolyte and served as buffer to alleviate stress.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film has been prepared by electron beam evaporation method. </LI> <LI> The first discharge and charge capacity of NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film were found to be 1693 mAh g<SUP>−1</SUP> and 1108 mAh g<SUP>−1</SUP>. </LI> <LI> The cycle performance test of NiFe<SUB>2</SUB>O<SUB>4</SUB> thin film also showed steady charge-discharge capacity at 0.1 C during 100 cycles. </LI> </UL> </P>
Differential Cytotoxic Effects of Jaspine B in Various Cancer Cells
Jihoon Lee(이지훈),Kwangik Choi(최광익),Mihwa Kwon(권미화),Dongjoo Lee(이동주),Min-Koo Choi(최민구),Im-Sook Song(송임숙) 한국생명과학회 2016 생명과학회지 Vol.26 No.12
Jaspine B는 석회해면류에서 추출된 sphingosine유도체로 인간 암세포에서의 항암활성이 보고되었다. 그러므로 본 연구는 다양한 인간 암세포주에서 항암활성을 비교하고, 암세포주에서의 Jaspine B의 농도를 측정하여 항암활성과의 연관성을 확인하고자 하였다. 항암활성은 MTT 방법을 이용하여 측정하였고, EC50 값으로 표현하였다. 암세포주내 Jaspine B의 농도는 LC-MS/MS를 이용하여 분석하였다. 항암활성은 세포주마다 다양하게 나타났는데, 유방암과 흑색종 세포주에서 항암활성이 높게 나타났으며(EC50 각각 2.3 μM과 2.6 μM), 신장암세포주에서는 EC50 값이 29.4 μM이었다. 암세포주에서의 EC50 값은 동일한 세포에서의 Jaspine B 농도와 높은 상관성을 나타내었으며(r=0.838), 암세포내 약물농도를 조절하는 것으로 잘 알려진 P-glycoprotein과 breast cancer resistance protein 등의 배출수송계와는 관련이 없음을 확인하였다. 이상의 결과는 세포내 약물농도를 높게 유지하는 것이 항암활성에 매우 중요하며, 세포내 약물농도가 암세포주에 따라 다른 약효를 보이는 원인으로 사료된다. Jaspine B is an anhydrophytosphingosine that is isolated from a marine sponge. Because of its structural similarity to sphingosine, it shows anti-cancer effects in human carcinomas. Therefore, this study aims to investigate its anti-proliferative effect on various cancer cells and to correlate its association with the intracellular accumulation of Jaspine B in relevant cancer cells. The anti-proliferative effect of Jaspine B in various cancer cells was determined by a cell viability test, and the intracellular concentration of Jaspine B in relevant cancer cells was determined using mass spectrometry coupled with liquid chromatography. The correlation coefficient and p value between the cytotoxicity and the cell accumulation of Jaspine B were determined using SPSS 16.1. The cytotoxicity of Jaspine B varied depending on the type of cancer cell when compared the EC50 values of Jaspine B. Breast and melanoma cancer cells were susceptible to Jaspine B, whereas renal carcinoma cells were resistant. The intracellular concentrations of Jaspine B had a reciprocal correlation with the EC50 values in the same cells (r = 0.838). The results suggested that the anti-proliferative effect of Jaspine B was associated with the cellular accumulation of this compound. However, Jaspine B was not a substrate for P-glycoprotein and breast cancer resistance protein, as major efflux pumps caused multidrug resistance. The maintenance of a high intracellular concentration is crucial for the cytotoxic effect of Jaspine B; however, efflux pumps may not be a controlling factor for Jaspine B-related resistance in cancer cells.
Jihoon Kim,Joo Myung Lee,Taek Kyu Park,Jeong Hoon Yang,Young Bin Song,Jin-Ho Choi,Seung-Hyuk Choi,Hyeon-Cheol Gwon,Sang Hoon Lee,Joo-Yong Hahn 대한의학회 2020 Journal of Korean medical science Vol.35 No.1
Background: Although current guidelines recommend noninvasive stress tests prior to elective percutaneous coronary intervention (PCI), it is unknown whether antecedent exercise stress test (EST) affects the outcomes of patients undergoing PCI for stable ischemic heart disease (SIHD). This study aimed to investigate long-term outcomes in patients undergoing elective PCI with or without EST. Methods: We studied 2,674 patients undergoing elective PCI using drug-eluting stents for SIHD. Patients were divided into the 2 groups: the test group underwent EST with a positive result within 180 days prior to PCI (n = 668), whereas the non-test group did not undergo any noninvasive stress tests (n = 2,006). The primary outcome was all-cause death or myocardial infarction (MI). Results: Over 5 years after the index PCI, the risk of all-cause death or MI was significantly lower in the test group than in the non-test group in overall population (3.3% vs. 10.9%; adjusted hazard ratio [HR], 0.34; 95% confidence interval [CI], 0.22–0.55; P < 0.001), and in propensity score-matched population (668 pairs) (3.3% vs. 6.3%; adjusted HR, 0.52; 95% CI, 0.30–0.89; P = 0.018). However, the incidence of any revascularization was similar between the 2 groups in overall (16.7% vs. 16.8%; adjusted HR, 0.99; 95% CI, 0.79–1.25; P = 0.962) and matched population (16.7% vs. 18.3%; adjusted HR, 0.91; 95% CI, 0.70–1.19; P = 0.509). Conclusion: Patients who underwent elective PCI with EST had a reduced risk of all-cause death or MI than those undergoing PCI without stress tests.
On the Calculation of the Maximal MOT Throughput in T-DMB
Jihoon Choi,Donghwan Lee,Jieun Yu,Kyunghwi Kim,Wonjun Lee IEEE 2007 IEEE transactions on consumer electronics Vol.53 No.3
<P>Digital multimedia broadcasting (DMB) is one of burgeoning communication technologies, which can provide audio, video, and data services to mobile terminals using broadcasting infrastructures. Data services in terrestrial- digital multimedia broadcasting (T-DMB) inherently have the disadvantage of retransmitting a lot of data unnecessarily for reliability. This paper proposes a novel optimized transmission policy using segment size and repetition number variability, which maximizes the object- level throughput as well as improves reliability. The theoretical modeling and simulation results demonstrate that our policy provides a throughput gain over the conventional protocol.</P>
Wettability Conversion of an Aluminum-hydroxide Nanostructure by Ion Implantation
Jihoon Jeon,Dukhyun Choi,김형대,Yong Tae Park,Min-Jun Choi,정권범 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.8
This work presents a method for controlling the wettability of an aluminum-hydroxide (Al(OH)3) nanostructure by using ion implantation. We implant Xe ions into Al(OH)3 nanostructures at dosages between 5 × 1014 to 1 × 1016 ions/cm2. The microscopic surface morphology of the nanostructure after implantation does not change under our dosing conditions. However, a drastic increase in the surface contact angle (CA) from 0 to 100 is observed at a dosage of 5 × 1015 ions/cm2. We attribute this significant change in CA to the composition and chemical bonding states of carbon contained within the Al(OH)3 nanostructure.
Choi, Jihoon,Lee, Bobin,Yu, Chan-Mo Royal Society of Chemistry 2011 Chemical communications Vol.47 No.13
<P>An enantioselective synthesis of the homoallenyl alcohols was achieved from the reaction of chiral 2-borylbutadiene with aldehydes through an allylic transfer reaction in good yields and enantioselectivities.</P> <P>Graphic Abstract</P><P>An enantioselective synthesis of the homoallenyl alcohols was achieved from the reaction of chiral 2-borylbutadiene with aldehydes through an allylic transfer reaction in good yields and enantioselectivities. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc05751g'> </P>
FTTP: A Fast Tree Traversal Protocol for Efficient Tag Identification in RFID Networks
Jihoon Choi,Inkyu Lee,Ding-Zhu Du,Wonjun Lee IEEE 2010 IEEE communications letters Vol.14 No.8
<P>This letter presents an efficient tag collision arbitration protocol, viz., the Fast Tree Traversal Protocol (FTTP). It estimates the number of tags using maximum likelihood estimation and adjusts the splitting factor to reduce the identification delay. We show that our protocol effectively reduces the identification delay via the performance analysis and simulation results.</P>