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Study on the Anti-Melanogenic Effect of Porcine Placenta Extract
Ji-Eun Lee(이지은),Sang-Won Seo(서상원),Jae-Sung Hwang(황재성) 한국화장품미용학회 2016 한국화장품미용학회지 Vol.6 No.1
The effect of porcine placenta extract (PE) on melanin synthesis was studied. PE treatment reduced melanin contents and tyrosinase activity in melan-a melanocytes. The expressions of tyrosinase and microphthalamia associated transcription factor (MITF) were reduced by PE treatment in melan-a. These results suggest that PE has a potential for cosmetic agent with lightening effect.
Dissolution behavior and early bone apposition of calcium phosphate-coated machined implants
Hwang, Ji-Wan,Lee, Eun-Ung,Lee, Jung-Seok,Jung, Ui-Won,Lee, In-Seop,Choi, Seong-Ho Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.6
Purpose: Calcium phosphate (CaP)-coated implants promote osseointegration and survival rate. The aim of this study was to (1) analyze the dissolution behavior of the residual CaP particles of removed implants and (2) evaluate bone apposition of CaP-coated machined surface implants at the early healing phase. Methods: Mandibular premolars were extracted from five dogs. After eight weeks, the implants were placed according to drilling protocols: a nonmobile implant (NI) group and rotational implant (RI) group. For CaP dissolution behavior analysis, 8 implants were removed after 0, 1, 2, and 4 weeks. The surface morphology and deposition of the coatings were observed. For bone apposition analysis, block sections were obtained after 1-, 2-, and 4-week healing periods and the specimens were analyzed. Results: Calcium and phosphorus were detected in the implants that were removed immediately after insertion, and the other implants were composed mainly of titanium. There were no notable differences between the NI and RI groups in terms of the healing process. The bone-to-implant contact and bone density in the RI group showed a remarkable increase after 2 weeks of healing. Conclusions: It can be speculated that the CaP coating dissolves early in the healing phase and chemically induces early bone formation regardless of the primary stability.
Hwang, Eun-Ha,Ju, Jung-Ki,Cho, Min-Jung,Lee, Ji-Won,Lee, Hyoung-Doo The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.12
We present the case of a 5-year-old child with coronary complications due to Kawasaki disease; this patient unintentionally underwent both dual-source computed tomography (DSCT) coronary angiography and invasive coronary angiographic examination in 2 months. This case highlights the strong consistency of the results between DSCT coronary angiography and invasive coronary angiography. Compared to conventional invasive coronary angiography, DSCT coronary angiography offered additional advantages such as minimal invasiveness and less radiation exposure.
The Method for the Temperature Monitoring in a Reduction Gear of the High-Speed Railway
Ji-Seong Hwang,Seok-Jin Kwon,Dong-Hyong Lee,Jung-Won Seo 한국도시철도학회 2013 IJAR Vol.1 No.3
A reduction gear is commonly used in automobile or rolling stock drivelines to reduce the high rotational speeds of the engine or motor. It is important to monitor conditions of the reduction gear because accident caused by its problems is closely related with vehicle running stability. In the reduction gear, problems are caused by results from diverse factors as either external or internal such as the defect of bearing, problems of the lubricant oil, high-load of the railway, and a frequent impact generated by the rail joint. The technique which is monitoring temperature is one of the basic methods of diagnosis for the abnormal condition in the reduction gear as well as other objects. Monitoring of the temperature can be easy to install on the device without changes to its design and identify its condition in real time. However, Temperature Monitoring System is slow to react to the changes of the condition due to their location and characteristics. This paper describes a new method for the temperature diagnosis of the abnormal condition of the reduction gear. IC-type temperature sensors are installed the reduction gear box of high-speed railway in service. The temperature data of the reduction gear is acquired and analyzed while running rolling stock. Temperature Monitoring System frequently monitors the temperature of the reduction gear by using proposed methods such as Limited temperature monitoring, Ratio of the change of temperature monitoring and Reaction time temperature monitoring, etc. And diagnosis methods can be used for maintenance or alarmed to a driver when the problem occurred. These results are expected to use basic research material for diagnostics system of the different kinds of railway in the future.
Effect of Salviae Radix extract on renal function in cisplatin-intoxicated rabbits
Hwang, Won Man,Jeong, Ji Cheon 대한한방성인병학회 1999 韓方成人病學會誌 Vol.5 No.1
이전 연구에서 단삼추출물이 강력한 항산화 효과를 가지고 있음을 확인한바 있어 본 연구에서는 항암제인 cisplatin에 의해 유발된 시장기능 장애가 단삼추출물에 의해 방지될 수 있는 지를 조사하였다. 토끼에 cisplatin을 5㎎/㎏ 되게 복강내 주사하여 급성신부전을 유발하였고, 단삼추출물의 효과는 cisplatin을 주사하기 전 7일 동안 0.05%액 0.3 g/㎏용량을 구강을 통해 먹여 관찰하였다. Cisplatin을 주사하기 전 24시간 동안 요와 혈액을 채취하여 신장기능을 측정하여 대조시간 (basal period)의 값으로 하였고, cisplatin을 주사한 수 24시간 동안 요와 혈액을 얻어 cisplatin에 의한 신장기능 변화를 평가하였다. Cisplatin 처리에 의해 사구체여과율이 현저하게 감소하였고, 혈청내 creatinine 농도가 현저하게 증가되었다 이러한 결과들은 cisplatin 주사가 급성신부전을 유발하였음을 가르킨다. Cisplatin을 주사한 토끼의 신장에서 포도당 및 인산의 배설분율이 증가함으로서 신세뇨관 물질의 재흡수가 저해되었으며, 지질의 과산화가 증가하였다. 단삼추출물을 전 처리한 수 cisplatin을 주사한 경우 cisplatin에 의해 유발된 사구체여과율의 감소와 혈청내 cisplatin 농도증가 현상이 완화되었다. Cisplatin에 의한 세뇨관에서 물질의 재흡수장애가 단삼추출물의 전처치에 의해 방지되었다. 단삼추출물은 cisplatin에 의한 지질의 과산화를 억제하였다. 신피질절편을 이용한 실험관내 실험을 통해 cisplatin은 lactate dehydrogenase (LDH)유출을 증가시켰으며, 동시에 지질의 과산화를 증가시켰다. 이러한 증가는 단삼추출물에 의해 방지되었는데, 그 효과는 항산화제들과 유사하였다. 이상의 결과를 종합하면 cisplatin에 의한 급성신부전의 유발과정에 지질의 과산화가 중요한 역할을 할 가능성을 보이고 있으며, 단삼추출물은 cisplatin에 의한 신장기능 장애 및 지질의 과산화를 방지하였다. 이러한 단삼추출물의 방지 효과는 항산화 작용에 기인할 것으로 思料된다.
Hwang, Ji Sun,Kim, Gi-Cheon,Park, EunBee,Kim, Jung-Eun,Chae, Chang-Suk,Hwang, Won,Lee, Changhon,Hwang, Sung-Min,Wang, Hui Sun,Jun, Chang-Duk,Rudra, Dipayan,Im, Sin-Hyeog The American Association of Immunologists, Inc. 2015 JOURNAL OF IMMUNOLOGY Vol.194 No.4
<P>IL-31 is a key mediator of itching in atopic dermatitis (AD) and is preferentially produced by activated CD4<SUP>+</SUP> T cells and Th2 cells. Although pathophysiological functions of IL-31 have been suggested in diverse immune disorders, the molecular events underlying <I>IL-31</I> gene regulation are still unclear. In this study we identified the transcription start site and functional promoter involved in <I>IL-31</I> gene regulation in mouse CD4<SUP>+</SUP> T cells. TCR stimulation–dependent IL-31 expression was found to be closely linked with in vivo binding of NFAT1 and JunB to the <I>IL-31</I> promoter. Although NFAT1 alone enhanced <I>IL-31</I> promoter activity, it was further enhanced in the presence of JunB. Conversely, knockdown of either NFAT1 or JunB resulted in reduced <I>IL-31</I> expression. NFAT1-deficient CD4<SUP>+</SUP> T cells showed a significant defect in <I>IL-31</I> expression compared with wild-type CD4<SUP>+</SUP> T cells. In agreement with these findings, mice subjected to atopic conditions showed much higher levels of IL-31, which were closely correlated with a significant increase in the number of infiltrated NFAT1<SUP>+</SUP>CD4<SUP>+</SUP> T cells into the AD ears. Amelioration of AD progression by cyclosporin A treatment was well correlated with downregulation of IL-31 expressions in CD4<SUP>+</SUP> T cells and total ear residual cells. In summary, our results suggest a functional cooperation between NFAT1 and JunB in mediating <I>IL-31</I> gene expression in CD4<SUP>+</SUP> T cells and indicate that interference with this interaction or their activity has the potential of reducing IL-31–mediated AD symptoms.</P>