Salt taste enhancing effects of the FII revealed by c-Fos expression in the nucleus of the solitary tract

Jeongsoo Han,Yongho Kwak,Mee-Ra Rhyu,Bae Hwan Lee 한국실험동물학회 2013 한국실험동물학회 학술발표대회 논문집 Vol.2013 No.8

Development of Gustatory Stimulation System for the Imaging of Taste Information Processing

( Jeongsoo Han ),( Minjee Kwon ),( Yongho Kwak ),( Bong Soo Kim ),( Jin Woo Chang ),( Motomasa Tanioka ),( Minjee Kim ),( Bae Hwan Lee ) 한국감성과학회 2015 추계학술대회 Vol.2015 No.-

Research for taste function is necessary as there are increasing interests in food ingestion and appetite. However, imaging studies for taste have been sparse because there are few taste stimulation devices. As neuroimaging technique advances, researches of brain function take advantage of brain imaging system. Here, we developed the taste stimulation system using non-conductive materials for brain imaging tool which is sensitive to magnetic artifact. There are three parts of this stimulator: Air flow control box, heat insulating tastant reservoir including supply tubing and mouthpiece for spraying tastant and suctioning waste solution. Firstly, air flow control box can supply and stop the compressed air in accurate timing, cycle and duration which can be adjusted. This controller can be located in outside of the imaging room, so that researcher can manipulate easily. Secondly, we installed the insulating tastant reservoir and tastant supply pipe to maintain the tastant temperature to body temperature. It is important part to obtain only taste signals. Lastly, the mouthpiece provides comfortable wearing sensation. Moreover, the mouthpiece can apply tastant to the specific tongue area using Y-shaped tubing and provide suction of tastant and washing solution. Therefore, the imaging study of taste information processing can be achieved successfully by using this gustatory stimulation system. This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (No. 2015021989).

Impact of online community engagement on community loyalty and social well-being

Han, Jeongsoo,Jun, Mina,Kim, Miyea Scientific Journal Publishers 2019 SOCIAL BEHAVIOR AND PERSONALITY Vol.47 No.1

In vivo optical imaging of rat insular cortex by paw electrical stimulation after sciatic nerve injury

( Jeongsoo Han ),( Myeonghoon Cha ),( Un Jeng Kim ),( Minjee Kim ),( Young Hee Sa ),( Sun Joon Bai ),( Seong Karp Hong ),( Bae Hwan Lee ) 한국감성과학회 2016 춘계학술대회 Vol.2016 No.-

Pain-relieving effects of capsaicin acupuncture in formalin test of rats

Jeongsoo Han,Un Jeng Kim,Bae Hwan Lee 한국실험동물학회 2012 한국실험동물학회 학술발표대회 논문집 Vol.2012 No.8

Plasticity-Related PKM <b><i>ζ</i></b> Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury

Han, Jeongsoo,Kwon, Minjee,Cha, Myeounghoon,Tanioka, Motomasa,Hong, Seong-Karp,Bai, Sun Joon,Lee, Bae Hwan Hindawi Publishing Corporation 2015 Neural plasticity Vol.2015 No.-

<P>The insular cortex (IC) is associated with important functions linked with pain and emotions. According to recent reports, neural plasticity in the brain including the IC can be induced by nerve injury and may contribute to chronic pain. Continuous active kinase, protein kinase M<I>ζ</I> (PKM<I>ζ</I>), has been known to maintain the long-term potentiation. This study was conducted to determine the role of PKM<I>ζ</I> in the IC, which may be involved in the modulation of neuropathic pain. Mechanical allodynia test and immunohistochemistry (IHC) of zif268, an activity-dependent transcription factor required for neuronal plasticity, were performed after nerve injury. After <I>ζ</I>-pseudosubstrate inhibitory peptide (ZIP, a selective inhibitor of PKM<I>ζ</I>) injection, mechanical allodynia test and immunoblotting of PKM<I>ζ</I>, phospho-PKM<I>ζ</I> (p-PKM<I>ζ</I>), and GluR1 and GluR2 were observed. IHC demonstrated that zif268 expression significantly increased in the IC after nerve injury. Mechanical allodynia was significantly decreased by ZIP microinjection into the IC. The analgesic effect lasted for 12 hours. Moreover, the levels of GluR1, GluR2, and p-PKM<I>ζ</I> were decreased after ZIP microinjection. These results suggest that peripheral nerve injury induces neural plasticity related to PKM<I>ζ</I> and that ZIP has potential applications for relieving chronic pain.</P>

휴먼 브랜드 팬 커뮤니티 동일시의 선행요인에 관한 연구

한정수(Han JeongSoo),신선진(Shin SeonJin) 한국산업경영학회 2017 경영연구 Vol.32 No.2

휴먼 브랜드의 인기가 높아질수록 이들이 사람들에게 미치는 영향 또한 커지고 중요해지고 있다. 특정 휴먼 브랜드의 팬들은 자신들이 좋아하는 휴먼 브랜드에 대한 관심과 열정을 공유하고자 팬 커뮤니티를 만들거나 가입해서 활동을 하는 행동을 보이기도 한다. 이러한 과정에서 이들은 자신이 속한 팬 커뮤니티와 자신을 동일시하기도 하고 이런 동일시를 바탕으로 커뮤니티 기반의 그룹 활동을 통해서 자신들이 좋아하는 휴먼 브랜드를 지지하는 행동을 보이기도 한다. 이에 본 연구는 팬 커뮤니티 동일시에 영향을 미치는 선행요인을 찾고 이 관계를 더 강하게 하는 조절변수를 살펴보았다. 연구결과, 휴먼 브랜드에 대한 애착이 팬 커뮤니티 동일시에 긍정적으로 영향을 주는 선행변수로, 더 나아가, 이러한 관계를 더 강하게 만드는 요인으로 휴먼 브랜드-팬 커뮤니티 유사 성과 소속감 욕구가 조절변수의 역할을 하는 것으로 나타났다. 본 연구의 결과는 관련 분야에 이론적인 시사점 뿐 아니라 실무적 시사점 또한 제공한다. As the human brands are becoming more popular and influential, their influences on the lives of people also getting more significant. Fans of certain human brands create or participate in the fan community to seek like-minded others for sharing same interests and enthusiasms. In doing so, fan community members identify themselves with the fan community and support the human brand they like by doing communitybased group behaviors. Thus, well-established fan communities are very influential and provide great marketing opportunities, suggesting the importance of the studying the fan communities. This study examined the dynamics among human brand, fans, and fan community identification. Results of the study found that attachment to human brand influences fan community identification positively. Furthermore, one community-related variable, human brand-fan community similarity, and one consumer-related variable, need for belongingness, were found to strengthen the relationship between human brand attachment and fan community identification. Implications that the results of this study provides are also discussed.

Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis

Han, Sang Jun,Noh, Mi Ra,Jung, Jung-Min,Ishii, Isao,Yoo, Jeongsoo,Kim, Jee In,Park, Kwon Moo Elsevier 2017 FREE RADICAL BIOLOGY AND MEDICINE Vol.112 No.-

<P><B>Abstract</B></P> <P>Cystathionine γ-lyase (CSE), the last key enzyme of the transsulfuration pathway, is involved in the production of hydrogen sulfide (H<SUB>2</SUB>S) and glutathione (GSH), which regulate redox balance and act as important antioxidant molecules. Impairment of the H<SUB>2</SUB>S- and GSH-mediated antioxidant system is associated with the progression of chronic kidney disease (CKD), characterized by kidney fibrosis and dysfunction. Here, we evaluated the role of CSE in the progression of kidney fibrosis after unilateral ureteral obstruction (UUO) using mice deficient in the <I>Cse</I> gene. UUO of wild-type mice reduced the expression of H<SUB>2</SUB>S-producing enzymes, CSE, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase in the obstructed kidneys, resulting in decreased H<SUB>2</SUB>S and GSH levels. <I>Cse</I> gene deletion lowered H<SUB>2</SUB>S and GSH levels in the kidneys. Deleting the <I>Cse</I> gene exacerbated the decrease in H<SUB>2</SUB>S and GSH levels and increase in superoxide formation and oxidative damage to proteins, lipids, and DNA in the kidneys after UUO, which were accompanied by greater kidney fibrosis, deposition of extracellular matrixes, expression of α-smooth muscle actin, tubular damage, and infiltration of inflammatory cells. Furthermore, <I>Cse</I> gene deletion exacerbated mitochondrial fragmentation and apoptosis of renal tubule cells after UUO. The data provided herein constitute in vivo evidence that <I>Cse</I> deficiency impairs renal the H<SUB>2</SUB>S- and GSH-producing activity and exacerbates UUO-induced kidney fibrosis. These data propose a novel therapeutic approach against CKD by regulating CSE and the transsulfuration pathway.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ureteral obstruction (UO) impairs H<SUB>2</SUB>S-producing enzymes, CSE, CBS, and 3-MST. </LI> <LI> UO reduces levels of H<SUB>2</SUB>S and GSH in the kidney. </LI> <LI> CSE deletion reduces H<SUB>2</SUB>S and GSH and exacerbates UO-induced those in the kidney. </LI> <LI> CSE deletion worsens oxidative injury and apoptosis, resulting in fibrosis. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

지식 기반 서비스를 위한 사실 지향 온톨로지 기반의 프로세스 모델링 접근법

이정수(Jeongsoo Lee),김광수(Kwangsoo Kim),김철한(Cheol-Han Kim) 대한산업공학회 2009 대한산업공학회지 Vol.35 No.1

온톨로지의 상호운용성을 위한 온톨로지 아키텍처에 관한 연구

이정수(Jeongsoo Lee),채희권(Heekwon Chae),김광수(Kwangsoo Kim),김철한(Cheol-Han Kim) 한국전자거래학회 2008 한국전자거래학회지 Vol.13 No.1

온톨로지는 사람들 간의 정확한 의사소통을 가능하게 하고 시스템 사이의 상호운용성을 달성하기 위한 도구로서 다양한 분야에서 많은 기대를 받고 있는 기술이다. 온톨로지의 구축은 기존 온톨로지들 간의 통합을 통해 더욱 효율적으로 이루어질 수 있다. 그러나 기존 온톨로지들이 표현 언어, 대상 도메인, 온톨로지 구성요소 등의 측면에서 다양한 형태와 특성을 가지므로, 온톨로지 통합이 이루어지기 위해서는 온톨로지들 간의 상호운용성의 확보가 필수적이다. 본 논문에서는 온톨로지를 분류하는 체계적인 프레임워크의 제공을 통해 온톨로지들 간의 상호운용성 확보를 지원하는 온톨로지 아키텍처를 제안한다. 본 논문에서 제안하는 온톨로지 아키텍처는 온톨로지를 바라보는 3가지 관점에 따라 온톨로지 메타계층 분류축, 시맨틱 도메인 분류축, 온톨로지 구성요소 분류축의 3개의 분류축으로 이루어져 있다. 온톨로지 아키텍처의 3개의 분류축은 온톨로지들 간의 문법적인 상호운용성과 의미적인 상호운용성을 향상시키기 위해 조화롭게 설계됨으로써 온톨로지 통합이 유연하게 이루어지도록 지원한다. Ontologies are expected in various areas as promising tools to improve communication among people and to achieve interoperability among systems. For communications bet-ween different business domains, building an ontology through integrating existing ontologies is more efficient way than building the ontology without them. However, integration of ontologies is very struggling work since languages, domains, and structures of ontologies are different from each other. In this paper, we suggest an Ontology Architecture which solves this problem by providing a systematic framework to classify ontologies from three kinds of viewpoints:language, domain range, constructs. The Ontology Architecture consists of 3 axes according to the 3 viewpoints:Ontology Meta Layer axis, Semantic Domain Layer axis, and Ontology Constructs Layer axis. Because 3 axes in Ontology Architecture are designed to improve the syntactic and semantic interoperability among ontologies, the integration of ontologies can be readily achieved.