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Lee Ji Young,Kim Eun Hwa,Lee Myeongjee,Shin Jehee,Lim Sung Min,Baek Jee Yeon,Kim MinYoung,Ahn Jong Gyun,Kang Chung-Min,Jung Inkyung,Kang Ji-Man 대한소아감염학회 2024 Pediatric Infection and Vaccine Vol.31 No.1
Purpose: Tetracycline is not recommended for children under 12 by guideline due to the risk of tooth discoloration. We aimed to assess the incidence of dental discoloration in Korean children prescribed tetracyclines and investigate whether its risk was greater in tetracyclineexposed children than in the general population. Methods: This population-based cohort study using the Health Insurance Review and Assessment service database included children aged 0–12 years exposed to tetracyclines for at least 1 day between January 2008 and December 2020. The primary outcome was the incidence rate of dental discoloration ≥6 months after prescription, and the standardized incidence ratio (SIR) was evaluated as secondary outcome. Results: 56,990 children were included—1,735 and 55,255 aged <8 and 8–12 years, respectively. 61% children were prescribed tetracycline for <14 days with mostly secondgeneration tetracyclines, doxycycline (61%) and minocycline (35%). The 5- and 10-year cumulative incidence rates of dental discoloration were 4.1% (95% confidence interval [CI], 3.0–5.7%) and 5.7% (95% CI, 4.1% to 7.8%), respectively, in the 0–7 years age group and 0.8% (95% CI, 0.7% to 0.9%) and 1.3 (95% CI, 1.1% to 1.4%), respectively, in the 8–12 years age group. Tetracycline exposure did not increase such risk compared to that in the general population (SIR, 1.08; 95% CI, 0.69 to 1.60). Conclusions: The incidence of dental discoloration was lower than previously suggested. Relieving the age restriction for prescribing tetracyclines may be considered.
Lee, Seongdo,Elvitigala, Don Anushka Sandaruwan,Lee, Sukkyoung,Kim, Hyun Chul,Park, Hae-Chul,Lee, Jehee Elsevier 2017 Developmental and comparative immunology Vol.67 No.-
<P><B>Abstract</B></P> <P>Bactericidal permeability-increasing protein (BPI)/lipopolysaccharide (LPS) binding proteins (LBPs) are well-known proteins that play an indispensable role in host antimicrobial defense. Herein, we report a homolog of BPI/LBP from black rockfish (<I>Sebastes schlegelii</I>) (designated as RfBPI/LBP) and characterize its structural and functional features at the molecular level. We identified the putative complete open reading frame (1422 bp) of <I>RfLBP</I> that encodes a 474 amino acid protein with a predicted molecular mass of ∼51.5 kDa. The primary protein sequence of RfBPI/LBP contains domain features of BPI/LBP family proteins and shares significant sequence consistency with its homologs. Our phylogenetic analysis clearly demonstrated the vertebrate ancestral origin of RfBPI/LBP, further reinforcing its evolutionary relationship with teleostean homologs. Recombinant RfBPI/LBP demonstrated <I>in vitro</I> LPS-binding activity and antibacterial activity against <I>Escherichia coli</I>, but not against <I>Streptococcus iniae</I>. Moreover, <I>RfBPI/LBP</I> exhibited temporal transcriptional activation against pathogens and pathogen-associated molecular patterns. Collectively, our findings suggest that RfBPI/LBP plays an essential role in host antimicrobial defense, plausibly through selective eradication of invading bacteria.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Homolog of BPI/LBP was identified from black rockfish (RfBPI/LBP). </LI> <LI> Rf RfBPI/LBP resembled typical domain architecture of its homologues. </LI> <LI> Recombinant RfBPI/LBP showed selective antibacterial and LPS binding activity. </LI> <LI> <I>RfBPI/LBP</I> was ubiquitously expressed in tissues under physiological conditions. </LI> <LI> Transcriptional level of <I>RfBPI/LBP</I> was modulated under pathogenic stress. </LI> </UL> </P>
Lee Jehee,Munasinghe Helani,Song Choon Bok The Korean Society of Fisheries and Aquatic Scienc 2003 Fisheries and Aquatic Sciences Vol.6 No.3
Isolation and cloning of seven-band grouper (Epinephelus septemfasciatus) growth hormone cDNA from pituitary gland revealed an open reading frame of 612 bp coding for a pre-growth hormone of 204 amino acids with a 17 amino acid putative signal peptide. Deduced amino acid sequence showed that there was one possible N-glycosylation site at $Asn^{l84}$ and four cysteine residues $(Cys^{52},\;Cys^{160},\;Cys^{177},\;Cys^{185})$ on t e same positions as in some other species where they were involved in the stabilization of the tertiary structure. The seven-band grouper growth hormone (sbgGH) presented a $99.5\%$ amino acid sequence identity with the growth hormone of Epinephelus coioides and contained the conserved hormone domain region. Comparison of growth hormone sequences from evolutionarily diverse species revealed 25 amino acid residues conserved in jawless fishes to modern mammals. It also revealed an evolutionary trend to retain the same polypeptide sequence even in the distantly related animals while allowing alterations to occur in polypeptides of the closely related species. In order to create a recombinant system to produce high levels of the growth hormone, it was expressed in Escherichia coli (BL21) cells. The gel analysis revealed theoretically expected molecular weights for both mature and pre-sbgGHs.