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대뇌 원발성 악성 임파종 1예 : A Case Report
한윤경,오석전,조해동,유영락,김남규,정환영,이중달 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.3
Primary malignant lymphoma is very rare and represents less than 1.5 % of all intracranial neoplasms. The authors have experienced a case of primary malignant lymphoma of the brain in a 66 year-old woman who presented with persistent headache, nausea and generalized weakness. Brain CT scan demonstrated typical deep seated tumor masses in the right temporal and left frontal lobes with strong contrast enhancement. We obtained a good result after surgery followed by radiation and chemotherapy and report our case with review of the articles.
Bee venom inhibits 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced mouse skin inflammation
Chung, Hwan-Suck,Kim, Hyung-Shik 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.1
Bee venom (BV) has been used to treat diseases such as arthritis, rheumatism and pain in many countries. Although BV has recently been used as an additive of functional cosmetics, there is no evidence of the effects of BVon skin inflammation or disease. Here, we show that BV patch attachment or intra-peritoneal injection inhibited in vivo acute inflammation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) using the mouse ear model of inflammation. When we examined the TNF-alpha and IL-1 beta mRNA expression in BV treated ear samples by real time PCR, even though BV treatment had no significant effects, it inhibited TNF-alpha and IL-1 beta mRNA expression when compared to samples treated with TPA alone. BV also inhibited edema (based on ear weight) and inhibited neutrophil infiltration (based on myeloperoxidase (MPO) activity measured as a neutrophil marker). Taken together, these results showed that BV exerted an anti-inflammatory effect in vivo and was beneficial in an animal model of skin inflammation. These results suggest that BV might be beneficial as a topical agent for the treatment of skin inflammation.
Chung, Hwan-Suck,Koo, Hyun-Na,Moon, Young-Hoe,Kim, Hyung-Min Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.1
The purpose of this study was to examine the effect of supplementary highly purified chitosan (HPC) on blood alcohol concentration in healthy human. The human study was performed with two sections. Each section of the study was conducted by two-phase cross-over design with a week wash-out period. All volunteers took HPC in one phase, and took a placebo in the next phase. Blood alcohol concentrations were different between in those taking HPC and in those taking the placebo in the human. And the concentration of serum aspartate aminotransferase (AST, GOT) and alanine aminotransferase (ALT, GPT), the indicator of liver cell damage, was lowered in those taking HPC, compared to those taking the placebo. In conclusion, taking HPC prior to drinking alcohol can somewhat reduce alcohol concentration in human blood and liver cell damage.
CHUNG, Hwan-Suck,KANG, Moonkyu,CHO, Chongwoon,PARVEZ, Shoukat,PARK, Chong-heong,KIM, Dongwoo,OH, Joonghwan,KIM, Hongyeoul,SHIN, Minkyu,HONG, Moochang,KIM, Yangseok,BAE, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the efTect of MC on lipopolysaccharide (LPS) and rccombinant interferon-gamma(rIF)-indiiced productioii ofnitric oxide (NO) and tumor necrosis factor (TNFγ)-aIpha were examined using mouse perituneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rlFN-γ-induced production of NO and TNF-atpha by MC is due to the inhibition of NF-kappaB activation.
Chung, Hwan-Suck,Kim, Hyunseong,Bae, Hyunsu Kluwer Academic/Plenum Publishers 2012 Neurochem Res Vol.37 No.10
<P>Phenelzine is a potent monoamine oxidase inhibitor that is used in patients with depression. It is also well known that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, which suggests that NO is involved in the pathogenesis of depression. The purpose of this study was to determine if phenelzine affects the production of NO and tumor necrosis factor-alpha (TNF-α) in activated microglia cells. BV-2 microglia cells and primary microglia cells were cultured in DMEM and DMEM/F12 and then cells were treated with LPS or LPS plus phenelzine for 24 h. The culture medium was collected for determination of NO, TNF-α, and IL-6 and cells were harvested by lysis buffer for Western blot analysis. Phenelzine increased the lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS), as well as the release of TNF-α and IL-6 in BV-2 microglia cells. It is also confirmed that phenelzine increased the levels of NO, TNF-α and IL-6 in LPS-activated primary microglia cells. Phenelzine increased nuclear translocation of NF-κB by phosphorylation of IκB-α in LPS-activated microglia cells. These findings suggest that high doses of phenelzine could aggravate inflammatory responses in microglia cells that are mediated by NO and TNF-α.</P>
Discrimination of velvet antlers' origin using DNA polymorphisms
Chung, Hwan-Suck,Lee, Hye-Jeong,Kim, Young-Eun,Shin, Min-Kyu,Hong, Moo-Chang,Kim, Yang-Seok,Bae, Hyun-Su 대한한약학회 2009 Journal of oriental pharmacy Vol.2 No.1
Velvet antlers from Cervus elaphus species are one of most famous, expensive and commonly used medicinal materials in traditional oriental medicine. Some distributor had illegal practice of disguising the origin of antlers in Korea market. Therefore, a test to distinguish antler essential to ensure the healthy development of the herbal industry. In this study, the variation in DNA sequences of the mitochondrial ATPase8 and cytochrome-coxidaseI (COI) genes of Cervus elaphus from China, the Republic of Altai, and Canada were evaluated. In addition, the sequence variation among, Rein deer and Cervus elaphus species was also evaluated. Although the sequences of deer from the Republic of Altai and Canada were very similar, polymorphisms that were conserved in each species were observed in the ATPase8 and COI genes. Therefore, these polymorphic markers could be used to distinguish Cervus elaphus antlers from different locations.
Foxp3 is a novel repressor of microglia activation
Chung, Hwan-Suck,Lee, Jun-Ho,Kim, Hyunseong,Lee, Hyo-Jung,Kim, Sung-Hoon,Kwon, Ho-Keun,Im, Sin-Hyeog,Bae, Hyunsu Wiley Subscription Services, Inc., A Wiley Company 2010 Glia Vol.58 No.10
<P>Forkhead transcription factor3 (Foxp3) is critical for generating CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells. However, its role in microglia has not been identified. Here, we show that Foxp3 is expressed in microglia and is upregulated upon activation. In Foxp3 mutant mice (Foxp3<SUP>sf</SUP>), microglia release higher levels of inflammatory cytokines and mediators such as NO, MCP-1, CXCL10, and ROS upon liposaccharide treatment than the wild type, while TNF-α and IL-1β were not significantly different between wild and mutant microglial cells. In addition, Foxp3 silencing enhances inflammatory responses, suggesting that the major role of Foxp3 in microglia is that of a repressor of activation. Similarly, Foxp3 overexpression reduces inflammatory responses in microglia. We also demonstrate that Foxp3 interacts directly with NF-κB and modulates its transcriptional activities. These findings point to the importance of Foxp3 in NF-κB mediated inflammatory responses in microglia. © 2010 Wiley-Liss, Inc.</P>
Chung, Hwan-Suck,Lee, Bong-Seon,Ma, Jin Yeul Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P><I>Mylabris phalerata</I> (MP) is an insect used in oriental herbal treatments for tumor, tinea infections, and stroke. Recent studies have shown that tumor-associated macrophages (TAM) have detrimental roles such as tumor progression, angiogenesis, and metastasis. Although TAM has phenotypes and characteristics in common with M2-polarized macrophages, M1 macrophages have tumor suppression and immune stimulation effects. Medicines polarizing macrophages to M1 have been suggested to have anticancer effects via the modulation of the tumor microenvironment. In this line, we screened oriental medicines to find M1 polarizing medicines in M2-polarized macrophages. Among approximately 400 types of oriental medicine, the ethanol extract of<I> M. phalerata</I> (EMP) was the most proficient in increasing TNF-<I>α</I> secretion in M2-polarized macrophages and TAM. Although EMP enhanced the levels of an M1 cytokine (TNF-<I>α</I>) and a marker (CD86), it significantly reduced the levels of an M2 marker (arginase-1) in M2-polarized macrophages. In addition, EMP-treated macrophages increased the levels of M1 markers (<I>Inos</I> and<I> Tnf-α</I>) and reduced those of the enhanced M2 markers (<I>Fizz-1, Ym-1,</I> and<I> arginase-1</I>). EMP-treated macrophages significantly reduced Lewis lung carcinoma cell migration in a transwell migration assay and inhibited EL4-luc2 lymphoma proliferation. In our mechanism study, EMP was found to inhibit STAT3 phosphorylation in M2-polarized macrophages. These results suggest that EMP is effective in treating TAM-mediated tumor progression and metastasis. </P>
Chung, Hwan-Suck,Kim, Sae-Noon,Jeong, Jin-Hyun,Bae, Hyunsu Kluwer Academic/Plenum Publishers 2013 Neurochem Res Vol.38 No.4
<P>Previously, we discovered a new compound, 1H,8H-Pyrano[3,4-c]pyran-1,8-dione (PPY), from Vitex rotundifolia L. and evaluated its anti-inflammatory and anti-asthmatic effects. In this study, we synthesized a new, modified compound 4-acetyl-3-methyl-6-(2-bromophenyl)pyrano[3,4-c]pyran-1,8-dione (PPY-Br) based on the PPY skeleton and evaluated its anti-inflammatory effects in lipopolysaccharide (LPS)-activated microglia. PPY-Br suppresses nitric oxide production, inducible nitric oxide synthase expression, and tumor necrosis factor-α and interleukin-6 production in LPS-activated BV-2 microglial cell line and mouse primary microglia. The effect of PPY-Br on the activation of nuclear factor (NF)-kappaB was examined to identify the mechanism involved. The LPS-induced translocation of NF-κB to the nucleus and phosphorylation of inhibitory-kappaB were almost completely blocked by PPY-Br. This study indicates that PPY-Br significantly attenuates the level of neurotoxic, proinflammatory mediators and proinflammatory cytokines via inhibition of the NF-κB signaling pathway. We suggest that PPY-Br presents a new candidate treatment for various neuro-inflammatory diseases.</P>