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Proteolysis of Glucagon Bound to Dimyristoylphosphatidylcholine Vesicle
Yi, Gwan-Su,Kim, Hyoung-Man Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.6
Glucagon was found to interact with DMPC vesicles electrostatically and hydrophobically. It appears that glucagon bound irreversibly to the vesicles through hydrophobic interaction was partially protected from the proteolysis by trypsin. Out of three possible sites, only the peptide bond preceded by Arg-18 was cleaved by a prolonged trypsin treatment. ${\alpha}$-chymotrysin did not affect the vesicle-bound glucagon. Based on these observations, possible structure of irreversibly bound glucagon on the vesicle surface is discussed.
( Yi Li ),( Nan-young Jung ),( Jae Cheal Yoo ),( Yul Kim ),( Gwan-su Yi ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5
The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.
Li, Yi,Jung, Nan-Young,Yoo, Jae Cheal,Kim, Yul,Yi, Gwan-Su The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5
The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.
Review Article : Postoperative stability of a LeFort I osteotomy: A Literature review
( Kye Joon Yi ),( Su Gwan Kim ),( Ji Su Oh ) 조선대학교 구강생물학연구소 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.1
A LeFort I osteotomy become increasingly popular because three dimensional correction is possible for treating skeletal Class III patients and has low complication rates. The purpose of this study was to describe the stability of the LeFort I osteotomy through review of the literature. An online search for studies in English was performed using MEDLINE, pre-MEDLINE. Publications from 1970 to 2008 were selected based on the following search terms: LeFort I osteotomy, stability, relapse, orthognathic surgery, two jaw surgery. It has been shown that the posterior and inferior movement of maxillary fragment is sensitive to skeletal relapse by the tension of soft tissues. However, surgical stability of LeFort I osteotomy can be achieved by various surgical techniques such as bone graft, rigid fixation using various methods or intermaxillary fixation. LeFort I osteotomy is thought to be a stable surgery, aesthetically as well as functionally satisfactory results may be obtained.
Hyungsub Lee,Gwan-Su Yi,Yoonkey Nam 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.4
Modularity is one of the important structural properties that affect information processing and other functionalities of neuronalnetworks. Researchers have developed in-vitro clustered network models for reproducing the modularity, but it is stillchallenging to control the segregation and integration of several sub-populations of them. We cultured clustered networkswith alginate patterning and collected the electrophysiological signals to investigate the changes in functional propertiesduring the development. We built inter-connected neuronal clusters using alginate micro-patterning with a circular shape onthe surface of the micro-electrode array. The neuronal clusters were enabled to be connected at 3 or 10 days-in-vitro (DIV)by removing the barrier. The neuronal signals from different types of networks were collected from 16 to 34 DIV, and functionalcharacteristics were examined. Connectivity and burst motif analysis were carried out to find out the relation betweenthe structure and function of the networks. Neuronal networks with clustered structure showed different activity propertiesfrom the random networks along the development. The clustered networks had more short-range connections compared tothe random networks. In the network burst motif analysis, the clustered networks showed more various patterns and a slowerpropagation of the activation patterns. In this study, we successfully cultured neuronal networks with clustered structure,and the structure affected the functional properties. The network model suggested in this study will be a good solution forobserving the effect of structure on function during their development.