Modulation of Gene Expressions and Enzyme Activities of Methionine Sulfoxide Reductases by Cold, Aba or High Salt Treatments in Arabidopsis

Oh, Jee-Eun,Hong, Suk-Whan,Lee, Yunsook,Koh, Eun-Ji,Kim, Kideok,Seo, Youngwon,Chung, Namhyun,Jeong, Moonsoo,Chang,Chang, Cheolseong,Lee, Byoungcheon,Kim, Kyoung Heon,Lee, Kwangwon,Lee, Hojoung 생명자원연구 2005 생명자원연구 Vol.13 No.-

A-431 세포주의 방사선 및 항암제의 감수성에 관한 실험적 연구

고광준,최은숙,홍성우 大韓口腔顎顔面 放射線學會 1999 Imaging Science in Dentistry Vol.29 No.1

Objectives: The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. Material and Methods: Human epidermoid carcinoma A-431 cell lines were irradiated by 2, 4, 6, 8, 10Gy at a dose rate of 210cGy/min using Co Irradiator ALDORADO 8 and then were exposed to bleomycin or cisplatin at concentration of 2㎍/ml for 1 hour. The viable cells were determined for each radiation dose and/or each drug at the 4th day and cell surviving curves were obtained using semiautomated MTT assay. Results: The surviving fraction after irradiation of 2Gy was 0.99, and there was not significant difference of surviving fraction in comparison with the control group on A-431 cell line(P>0.05). But there were significant differences of surviving fractions at doses of 4, 6, 8, 10Gy in comparison with the control group(P<0.05). The cytotoxicity of bleomycin or cisplatin was significantly different in comparison with the control group on A-431 cell line (P<0.05). And the cytotoxicity of cisplatin was greater than that of bleomycin on A 431 cell line (P<0.05). There were significant differences of surviving fractions after irradiation of 2, 4, 6, 8, 10Gy with bleomycin or cisplatin in comparison with each group of irradiation only on A-431 cell line(P0.05). There were significant differences of surviving fractions between the groups of irradiation with bleomycin and cisplatin at doses of 2, 4Gy(P<0.05), but there were not significant differences of surviving fractions at doses of 6, 8, 10Gy on A-431 cell line(P>0.05).(J Korean Oral Maxillofac Radiol 1999:29:325-337)

기관의 용골부위에서 발생한 염증근섬유모세포종 1예

고은석,권계원,김희경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Inflammatory myofibroblastic tumor is an uncommon, benign tumor of various organ and tissue which is vary rare in the carina of the trachea. We report a 36-year-old male patient with inflammatory myofibroblastic tumor arising in the carina of the trachea. Histologically, the tumor was composed of mainly myofibroblastic cells a few lymphoplasma cells.

디지털 치근단방사선영상에 관한 시각 특성 연구

고광준,최은숙 大韓口腔顎顔面 放射線學會 1999 Imaging Science in Dentistry Vol.29 No.1

Objectives: The purpose of this study was to evaluate the optimal distance and angle of observers by modulation transfer functions(MTFs) and receiver operating characteristics(ROCs). Material and Methods: Digital periapical radiograms were taken from 43 patients who have dental diseases(19 patients : dental caries, 12 patients : periapical lesions, 12 patients : periodontal diseases). Segmental images(4×4cm) were evaluated by 4 MTFs and ROC analysis. Results: The optimal distance(magnification) using MTF by Mannos & Sakrison was 12.97, and those by Nill, Ngan and Rao were 8.39, 4.78, 5.84 respectively. The optimal distance obtained from 4 radiologists by ROC analysis was 32cm(Az value : 0.89), and it was 40cm(Az value : 0.78) from 4 non-radiologists. There were significant differences of Az values between 4 radiologists and 4 non-radiologists at 24, 32 and 40cm (P<0.05). No significant differences of optimal distances were observed using 4 MTFs among +20, +10, 0, -10, -20 degrees(P>0.05). The optimal angle obtained from 4 radiologists by ROC analysis was +20 degree(Az value : 0.91), and no significant differences of Az value were observed among +20, +10, 0, -10 and -20 degrees(P>0.05). The optimal angle obtained from 4 non-radiologists by ROC analysis was 0 degree(Az value : 0.81), and no significant differences of Az values were observed among +20, +10, 0, -10 and -20 degrees(P>0.05). And there was significant difference of Az value between 4 radiologists and 4 non-radiologists at +20 degree(P<0.05), but no significant differences of Az values were observed among +10, 0, -10 and -20 degrees(P>0.05).(J Korean Oral Maxillofac Radiol 1999:29:259-272)

노인자원봉사활동 참여 여부에 영향을 미치는 요인 : 서울노인복지센터 참여·비참여 집단을 중심으로 Focused on the participation & non-participation group of Seoul Senior Welfare Center

고은숙 가톨릭대학교 사회복지연구소 2003 사회복지리뷰 Vol.8 No.-

This study is intended to provide a basic data for a development of the aged volunteering program by analyzing factors through a comparison of factors influencing the participation of the aged volunteering activities after collecting the aged who participate or don't participate in the volunteering activities in the same place. To achieve this objective, there are several answers to the following questions; which factors make the aged participate in the volunteering activities?, what is the major factor among factors influencing the volunteering activities? In this study, the factors are divided into the personal background factor, situation factor and socio-psychological factor. In order to explore theres questions, data wre gathered from 94elderly volunteers and 139 non-volunteers in Seoul senier welfare senter, through the structured questionnaire. the statistical methods used for the data analysis were descriptive statistics and logistic regression. The results of the analysis are summarized as follows Firstly, as the personal factor, women and the aged who don't have children and have economically a high position are highly likely to participate in the volunteering activities. Secondly, as the situation factor, the better the health status is, the higher the positive recognition on a leisure time, the easier the volunteering place access is, the higher the participating frequency of volunteering activities is, a possibility of participating in the volunteering activities is high. Thirdly, the high a desire on social responsibility recovery and desire on leisure time, the possibility of participating in the volunteering activities was high for the health maintenance through volunteering. Based on the result of analysis, the following suggestions are made. There must be policies to attract the participation of high educated elderly and male citizen's volunteering activities through development of professional volunteering program. Also, there must be a variety of active promotion and collecting method for the volunteering activities. Finally, there must be an improvement of recognition for the existing the aged volunteering activities.

시험관내 KB세포주의 방사선 및 항암제감수성에 관한 연구

고광준,최은숙,홍성우 大韓口腔顎顔面 放射線學會 1998 Imaging Science in Dentistry Vol.28 No.1

The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. For this study, cell surviving curves were obtained for human squamous cell carcinoma KB cell line after radiation exposure and/or administration of antitumor drugs. 2, 4, 6, 8, 10Gy were irradiated at a dose rate of 210cGy/min using ?? Irradiator ALDORADO 8. After irradiation. KB cell lines(3×104cells/ml) were exposed to 2㎍/ml of bleomycin or cisplatin for 1 hour. The viable cells were determined by MTT assay for each radiation dose and/or each drug at the 4th day. And they were compared to control values. The obtained results were as follows: 1. The slope of the surviving curve after irradiation of 2, 4, 6, 8, 10Gy on KB cell line was relatively steep. 2. There was no significant difference between the cytotoxicity of bleomycin compared to control group. But, there was significant difference between the cytotoxicity of cisplatin compared to control group. And the cytotoxicity of cisplatin was greater than that of bleomycin on KB cell line. 3. There were significant differences of surviving fractions after irradiation of 2Gy and 10Gy with 2㎍/ml of bleomycin compared with the groups of irradiation only on KB cell line. 4. There were significant differences of surviving fractions after irradiation of 2, 4, 6, 8, 10Gy with 2㎍/ml of cisplatin compared with the groups of irradiation only on KB cell line. 5. There was significant difference of surviving fraction between groups after irradiation of 10Gy with 2㎍/ml of bleomycin and cisplatin.

폐흡충증 1예

고은석,권계원,김희경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Pulmonary paragonimiasis is one of the most important endemic parasite disease in Korea despite decreased prevalence recently which clinically manifest cough, hemoptysis and chest pain, and radiologically necessitate differential diagnosis with tuberculosis or lung cancer. We experienced a case of pulmonary paragonimiasis in a 64-year-old female with cough and intermittent hemoptysis. A thoracic computed tomography (CT) scan revealed variable sized nodules with central necrosis suggesting chronic organizing pneumonia with abscess formation of fungus granuloma. Histopathologically, necrotizing granulomatous inflammation and egg granulomas were prominent and the surrounding lung parenchyma showed chronic organizing pneumonia.

안면골 외상환자의 전산화단층상을 이용한 삼차원재구성상의 비교 연구

최은숙,고광준 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to clarify the spatial relationship in presurgical examination and to aid surgical planning and postoperative evaluation of patients with facial bone injury. For this study, three-dimensional images of facial bone fracture were reconstructed by computed image analysis system and three-dimensional reconstructive program integrated in computed tomography. The obtained results were as follows: 1. Serial conventional computed tomograms were value in accurately depicting the facial bone injuries and three-dimensional reconstructive images demonstrated an overall look. 2. The degree of deterioration of spatial resolution was proportional to the thickness of the slice. 3. Facial bone fractures were the most distinctly demonstrated on inferoanterior views of three-dimensional reconstructive images. 4. Although three-dimensional reconstructive images made diagnosis of fracture lines, it was difficult to identify maxillary fractures. 5. The diagnosis of zygomatic fractures could be made equally well with computed image analysis system and three-dimensional reconstructive program integrated in computed tomography. 6. The diagnosis of mandibular fractures could be made equally well with computed image analysis system and three-dimensional reconstructive program integrated in computed tomography.

다발성 골수종

최은숙,고광준 大韓口腔顎顔面 放射線學會 1993 Imaging Science in Dentistry Vol.23 No.2

This is a report of multiple myeloma occurred in the left mandibular body and skull. 66-year-old patient was referred to our hospital with a complaint of painful swelling on the left mandibular body area. The author diagnosed it as a multiple myeloma by the clinical examination, radiographic findings, laboratory findings and the histopathological findings. The purpose of this report is to aid in the diagnosis of multiple myeloma and to aid to differentiate it from malignant tumours. The characteristic features are as follows: 1. In clinical examination, painful swelling was observed in left mandibular body area. 2. In radiographic findings, radiograms showed relatively ill-defined radiolucency without sclerotic border in left mandibular body area. And also represented multiple punched-out radiolucency in the skull and pathologic fracture of vertebral body on lumbar 3 level. 3. In histopathologic findings, infiltration of abnormal plasma cells was observed. 4. In laboratory findings, decreasing of albumin/globulin ratio, hypercalcemia, renal impairment was observed, but we could not find the Bence-Jones protein in urin.

난소에 발생한 원발성 소세포암종 : 2예 보고 Two cases reports

권계원,고은석,김희경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Primary small cell carcinoma of the ovary is a rare, aggressive tumor of young women and has two subtypes. The pulmonary type small cell carcinomas of the ovary that resembled small cell carcinoma of the lung and differed from both clinically and pathologically from small cell carcinoma of the ovary, usually associated with hypercalcemia. The histogenesis of the primary ovarian small cell carcinoma has not been established. We have identified two cases of small cell carcinomas primary in the ovary. One has microscopic features of pulmonary type, and the other has hypercalcemic type. Pulmonary type small cell carcinoma patient was a 40-year-old woman. She was admitted due to known ovarian mass. She was well before this episode. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Gross examination revealed 15cm sized right ovarian mass which was mostly solid with multifocal necrosis. Histologically, the tumor was composed of small to medium sized round cells with scanty cytoplasm, hyperchromatic nuclei, inconspicuous nucleoli, numerous mitotic figures forming large sheets and diffuse pattern. Hypercalcemic type small cell carcinoma patient was a 43-year-old woman. She was also complained of right abdominal swelling and discomfort of 1 month duration. She was received total abdominal hysterectomy due to myoma in 3 years ago. The serum calcium levels was elevated. Right salpingo-oophorectomy and omentectomy was performed. Gross examination revealed 15cm sized huge ovarian mass which was mainly solid with small cystic components and hemorrhagic necrosis. The omentum showed several oval shaped metastatic nodules. Microscopic examination reveals closely packed tumor cells with scanty cytoplasm, vesicular nuclei that contains single nucleoli, and numerous mitotic figures. Many folliculoid spaces are present. Pulmonary type small cell carcinoma patient died 13 months after surgery. Hypercalcemic type small cell carcinoma patient was alive without evidence of disease 2 months after surgery but lost to follow up thereafter.