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Isovitexin Is a Direct Inhibitor of Staphylococcus aureus Coagulase
( Hua Xiang ),( Panpan Yang ),( Li Wang ),( Jiaxin Li ),( Tiedong Wang ),( Junze Xue ),( Dacheng Wang ),( Hongxia Ma ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.10
Staphylococcus aureus (S. aureus) is a major pathogen that causes human pneumonia, leading to significant morbidity and mortality. S. aureus coagulase (Coa) triggers the polymerization of fibrin by activating host prothrombin, which then converts fibrinogen to fibrin and contributes to S. aureus pathogenesis and persistent infection. In our research, we demonstrate that isovitexin, an active traditional Chinese medicine component, can inhibit the coagulase activity of Coa but does not interfere with the growth of S. aureus. Furthermore, we show through thermal shift and fluorescence quenching assays that isovitexin directly binds to Coa. Dynamic simulation and structure-activity relationship analyses suggest that V191 and P268 are key amino acid residues responsible for the binding of isovitexin to Coa. Taken together, these data indicate that isovitexin is a direct Coa inhibitor and a promising candidate for drug development against S. aureus infection.
Microstructures and Properties of Molybdenum Wire Doped with Minim La2O3
Li DaCheng,Bu Chunyang,Zhu Yong-An,Wang Jin 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The microstructures and properties of pure molybdenum wire and Mo-La2O3 alloy wire annealed at different temperatures are investigated systematically in this paper. It is shown that the recrystallization temperature, toughness and strength at room temperature of this wire was increased greatly by addition of La2O3. The room temperature embrittlement of this wire annealed at high temperature is improved remarkably.
Distributed Finite-time Regulation of a Class of Networked Heterogeneous Multi-agent Systems
Yuan Liu,Shicheng Wang,Haibo Min,Long Ma,Dacheng Luo 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.1
In this paper, we investigate the finite-time regulation problem for heterogeneous multiagent system composed of linear first-order, second-order integrator agents and nonlinear Euler- Lagrange (EL) dynamical agents. Based on homogeneity approach, a continuous finite-time controller is designed. A distinctive feature of this work is to address the finite-time consensus problem of firstorder, second-order integrator agents and nonlinear EL agents in a unified theoretical framework. Simulation results are also provided to illustrate the effectiveness of the controller.
Li Lan,Jinfeng Wang,Shanhu Chen,Dacheng Li,Hongmei Li,Dayu Liu,Wei Wang,Yaoqiang Chen 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.71 No.-
In this work, an advanced Rh/CeO2–ZrO2 (Rh/CZ) three-way catalyst was synthesized with the assistanceof monoethanolamine. Compared with conventional Rh/CZ, the dispersion and oxidation state of Rhspecies, as well as the hydrothermal aging resistance are remarkably modified. That is, upon agingtreatment, conventional Rh/CZ undergoes severe agglomeration of Rh species and formation of largeamount of reduction-resistive RhO2, resulting in serious catalyst deactivation. Fortunately, after theintroduction of monoethanolamine, the sintering of Rh species and transformation into inactive RhO2upon aging are effectively suppressed. Consequently, improved reducibility and advanced three-waycatalytic activity are achieved for the modified catalyst.
Coverage and Energy Modeling of HetNet Under Base Station On-Off Model
Sida Song,Yongyu Chang,Xianling Wang,Dacheng Yang 한국전자통신연구원 2015 ETRI Journal Vol.37 No.3
Small cell networks, as an important evolution path for next-generation cellular networks, have drawn much attention. Different from the traditional base stations (BSs) always-on model, we proposed a BSs on-off model, where a new, simple expression for the probabilities of active BSs in a heterogeneous network is derived. This model is more suitable for application in practical networks. Based on this, we develop an analytical framework for the performance evaluation of small cell networks, adopting stochastic geometry theory. We derive the system coverage probability; average energy efficiency (AEE) and average uplink power consumption (AUPC) for different association strategies; maximum biased received power (MaBRP); and minimum association distance (MiAD). It is analytically shown that MaBRP is beneficial for coverage but will have some loss in energy saving. On the contrary, MiAD is not advocated from the point of coverage but is more energy efficient. The simulation results show that the use of range expansion in MaBRP helps to save energy but that this is not so in MiAD. Furthermore, we can achieve an optimal AEE by establishing an appropriate density of small cells.
Distributed Resource Allocation in Two-Hierarchy Networks
Shuhui Liu,Yongyu Chang,Guangde Wang,Dacheng Yang 한국전자통신연구원 2012 ETRI Journal Vol.34 No.2
In this paper, a new distributed resource allocation algorithm is proposed to alleviate the cross-tier interference for orthogonal frequency division multiplexing access macrocell and femtocell overlay. Specifically, the resource allocation problem is modeled as a non-cooperative game. Based on game theory, we propose an iterative algorithm between subchannel and power allocation called distributed resource allocation which requires no coordination among the two-hierarchy networks. Finally, a macrocell link quality protection process is proposed to guarantee the macrocell UE's quality of service to avoid severe cross-tier interference from femtocells. Simulation results show that the proposed algorithm can achieve remarkable performance gains as compared to the pure waterfilling algorithm.
Isovitexin, a Potential Candidate Inhibitor of Sortase A of Staphylococcus aureus USA300
( Dan Mu ),( Hua Xiang ),( Haisi Dong ),( Dacheng Wang ),( Tiedong Wang ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.9
Staphylococcus aureus causes a broad variety of diseases. The spread of multidrug-resistant S. aureus highlights the need to develop new ways to combat S. aureus infections. Sortase A (SrtA) can anchor proteins containing LPXTG binding motifs to the bacteria surface and plays a key role in S. aureus infections, making it a promising antivirulence target. In the present study, we used a SrtA activity inhibition assay to discover that isovitexin, a Chinese herbal product, can inhibit SrtA activity with an IC<sub>50</sub> of 28.98 μg/ml. Using a fibrinogen-binding assay and a biofilm formation assay, we indirectly proved the SrtA inhibitory activity of isovitexin. Additionally, isovitexin treatment decreased the amount of staphylococcal protein A (SpA) on the surface of the cells. These data suggest that isovitexin has the potential to be an anti-infective drug against S. aureus via the inhibition of sortase activity.