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CoMFA 법을 이용한 3-아릴이소퀴놀린 화합물들의 SK-OV-3 암세포에 대한 가상의 약물 작용 수용체 해석
김의기,민선영,정병호,천승훈,최보길,조원제 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
We have performed a 3D-QSAR/ CoMFA analysis of the cytotoxiv activities of thirty-five 3-arylisoquinoline derivative against SK-OV-3 tumor cell line. The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinoline were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.841) was obtained through CoMFA.
Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
Choi, Bo Gil,Kim, Ok Young,Chung, Byung Ho,Cho, Won Jea,Cheon, Seung Hoon,Choi, Sang Un,Lee, Chong Ock 전남대학교 약품개발연구소 1998 약품개발연구지 Vol.7 No.1
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
Choi, Bo-Gil,Kim, Ok-Young,Chung, Byung-Ho,Cho, Won-Jea,Cheon, Seung-Hoon,Choi, Sang-Un,Lee, Chong-Ock The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL EXOMETHYLENE CYCLOPROPYL NECLEOSIDES
Choi, Bo Gil,Kwak, Eun Yee,Hong, Joon Hee,Lee, Chong Kyo 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Novel cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5. prepared from Feist's acid 1 was condensed with purine derivatives by the S_N2 type reaction. All the synthesized compounds were evaluated for antiviral activity.
Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity
Choi, Bo Gil,Seo, Hee Kyoung,Chung, Byung Ho,Choi, Sang Un,Lee, Chong Ock 전남대학교 약품개발연구소 1995 약품개발연구지 Vol.3 No.1
Some Mannish bases of Antineoplaston A10 which is antitumor agent under clinical investigation were synthesized and tested for cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.
Synthesis of Sesquiterpene Derivitives as Potential Antitumor Agents; Elemance Derivatives
Choi, Bo-Gil,Kwak, Eun-Yee,Chung, Byung-Ho,Cho, Won-Jae,Cheon, Seung-Hoon The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.6
Derivatives of elema-1,3-diene were synthesized in several steps as polar analogs of $\beta$-elemene, antitumor agent under clinical phase. The lactone ring of compound 1 was opened by LiAlH4 to give diol 2 which was selectively protected by TBDPSCI. After acetylation of the secondary alcohol, the acetylated product was ozonolyzed and reduced to give elemene derivative 4 which was converted to diolefin 8 via selenides subsequent deprotection by tetrabutylammonium fluoride gave two compounds 9, 10.
Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity
Choi, Bo-Gil,Seo, Hee-Kyoung,Chung, Byung-Ho,Choi, Sang-Un,Lee, Chong-Ock The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.6
Some Mannich bases of Antineoplaston A10 which is antitumor agent under chlinical investigation were synthesized and tested fro cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.
항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성
최보길(Bo Gil Choi),서희경(Hee Kyoung Seo),김옥영(Ok Young Kim),정병호(Bung Ho Chung),오인준(In Jun Oh),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon),박민수(Min Soo Park),최상운(Sang Un Choi),이정옥(Chong Ock Lee) 대한약학회 1997 약학회지 Vol.41 No.3
Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-naphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.
Dithiocarbohydrazone류의 합성과 항균작용에 관한 연구(I) 2-Formylpyridine Dithiocarbohydrazone류 및 이들의 Cu(II) 착물
최보길(Bo Gil Choi) 대한약학회 1986 약학회지 Vol.30 No.2
In order to study 2-formylpyridine dithiocarbohydrazones (DTCH''s) and their Cu(II) chelates as potential effective antimicrobial agents, twelve new compounds of six DTCH''s and their Cu(II) chelates were synthesized. The compositions of Cu(II) chelates were determined on the basis of the data obtained from elemental analysis, electronic and IR spectrophotometry, and other method. They were tested for antimicrobial activity in vitro against a gram-positive, seven gram-negative bacterial species and three fungal species. DTCH''s exhibited high antibacterial activity against the gram-positive Staphylococcus aureus, but low activity against the various gram-negative bacterial species. In contrast to DTCH'S, their Cu(II) chelates exhibited higher antibacterial activity against St. aureus, but weaker, if any, activity against the gram-negative bacterial species. Both DTCH''s and their Cu(II) chelates showed relatively potent antifungal activity against Cryptococcus neoformans, but weak activity against Candida albicans and Candida pseudotropicalis.