Study on Corner Reflectors Identification in Highway Deformation Monitoring

Xue Min Xing,De Bao Wen,Fang Bin Zhou 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.12

CRInSAR is a newly developed technique to monitor ground deformation. In CRInSAR algorithm, the identification of Corner Reflectors in SAR images is necessary. Due to the uncertainty of traditional identification method, a new method based on the intensity and correlation coefficient of each CR candidates in SAR images is presented. The method has been successfully used to determine the locations of 11 CRs installed along a highway in six SAR images over the study area. The results show that the identification accuracy of the new method is about 1 pixel. It is effective and reliable especially in the area with lots of lightspots around the CR points. The method proposed can play important role in the highway deformation monitoring within CRInSAR algorithm.

The dopamine D1–D2DR complex in the rat spinal cord promotes neuropathic pain by increasing neuronal excitability after chronic constriction injury

Bao Yi-Ni,Dai Wen-Ling,Fan Ji-Fa,Ma Bin,Li Shan-Shan,Zhao Wan-Li,Yu Bo-Yang,Liu Ji-Hua 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Dopamine D1 receptor (D1DR) and D2 receptor (D2DR) are closely associated with pain modulation, but their exact effects on neuropathic pain and the underlying mechanisms remain to be identified. Our research revealed that intrathecal administration of D1DR and D2DR antagonists inhibited D1–D2DR complex formation and ameliorated mechanical and thermal hypersensitivity in chronic constriction injury (CCI) rats. The D1–D2DR complex was formed in the rat spinal cord, and the antinociceptive effects of D1DR and D2DR antagonists could be reversed by D1DR, D2DR, and D1–D2DR agonists. Gαq, PLC, and IP3 inhibitors also alleviated CCI-induced neuropathic pain. D1DR, D2DR, and D1–D2DR complex agonists all increased the intracellular calcium concentration in primary cultured spinal neurons, and this increase could be reversed by D1DR, D2DR antagonists and Gαq, IP3, PLC inhibitors. D1DR and D2DR antagonists significantly reduced the expression of p-PKC γ, p-CaMKII, p-CREB, and p-MAPKs. Levo -corydalmine ( l -CDL), a monomeric compound in Corydalis yanhusuo W.T. Wang, was found to obviously suppress the formation of the spinal D1–D2DR complex to alleviate neuropathic pain in CCI rats and to decrease the intracellular calcium concentration in spinal neurons. l- CDL-induced inhibition of p-PKC γ, p-MAPKs, p-CREB, and p-CaMKII was also reversed by D1DR, D2DR, and D1–D2DR complex agonists. In conclusion, these results indicate that D1DR and D2DR form a complex and in turn couple with the Gαq protein to increase neuronal excitability via PKC γ, CaMKII, MAPK, and CREB signaling in the spinal cords of CCI rats; thus, they may serve as potential drug targets for neuropathic pain therapy.

Prognostic Role of Hepatoma-derived Growth Factor in Solid Tumors of Eastern Asia: a Systematic Review and Meta-Analysis

Bao, Ci-Hang,Liu, Kun,Wang, Xin-Tong,Ma, Wei,Wang, Jian-Bo,Wang, Cong,Jia, Yi-Bin,Wang, Na-Na,Tan, Bing-Xu,Song, Qing-Xu,Cheng, Yu-Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

Hepatoma-derived growth factor (HDGF) is a novel jack-of-all-trades in cancer. Here we quantify the prognostic impact of this biomarker and assess how consistent is its expression in solid tumors. A comprehensive search strategy was used to search relevant literature updated on October 3, 2014 in PubMed, EMBASE and WEB of Science. Correlations between HDGF expression and clinicopathological features or cancer prognosis was analyzed. All pooled HRs or ORs were derived from random-effects models. Twenty-six studies, primarily in Eastern Asia, covering 2,803 patients were included in the analysis, all of them published during the past decade. We found that HDGF overexpression was significantly associated with overall survival (OS) ($HR_{OS}=2.35$, 95%CI=2.04-2.71, p<0.001) and disease free survival (DFS) ($HR_{DFS}=2.25$, 95%CI =1.81-2.79, p<0.001) in solid tumors, especially in non-small cell lung cancer, hepatocellular carcinoma and cholangiocarcinoma (CCA). Moreover, multivariate survival analysis showed that HDGF overexpression was an independent predictor of poor prognosis ($HR_{OS}=2.41$, 95%CI: 2.02-2.81, p<0.001; $HR_{DFS}=2.39$, 95%CI: 1.77-3.24, p<0.001). In addition, HDGF overexpression was significantly associated with tumor category (T3-4 versus T1-2, OR=2.12, 95%CI: 1.17-3.83, p=0.013) and lymph node status (N+ versus N-, OR=2.37, 95%CI: 1.31-4.29, p=0.03) in CCA. This study provides a comprehensive examination of the literature available on the association of HDGF overexpression with OS, DFS and some clinicopathological features in solid tumors. Meta-analysis results provide evidence that HDGF may be a new indicator of poor cancer prognosis. Considering the limitations of the eligible studies, other large-scale prospective trials must be conducted to clarify the prognostic value of HDGF in predicting cancer survival.

Roles of microRNA-206 in Osteosarcoma Pathogenesis and Progression

Bao, Yun-Ping,Yi, Yang,Peng, Li-Lin,Fang, Jing,Liu, Ke-Bin,Li, Wu-Zhou,Luo, Hua-Song Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Backgroud and Aims: MicroRNA-206 has proven to be down-regulated in many human malignancies in correlation with tumour progression. Our study aimed to characterize miR-206 contributions to initiation and malignant progression of human osteosarcoma. Methods: MiR-206 expression was detected in human osteosarcoma cell 1ine MG63, human normal osteoblastic cell line hFOB 1.19, and paired osteosarcoma and normal adjacent tissues from 65 patients using quantitative RT-PCR. Relationships of miR-206 levels to clinicopathological characteristics were also investigated. Moreover, miR-206 mimics and negative control siRNA were transfected into MG63 cells to observe effects on cell viability, apoptosis, invasion and migration. Results: We found that miR-206 was down-regulated in the osteosarcoma cell line MG63 and primary tumor samples, and decreased miR-206 expression was significantly associated with advanced clinical stage, T classification, metastasis and poor histological differentiation. Additionally, transfection of miR-206 mimics could reduce MG-63 cell viability, promote cell apoptosis, and inhibit cell invasion and migration. Conclusions: These findings indicate that miR-206 may have a key role in osteosarcoma pathogenesis and development. It could serve as a useful biomarker for prediction of osteosarcoma progression, and provide a potential target for gene therapy.

Analysis of Port Hopping for Proactive Cyber Defense

Yue-Bin Luo,Bao-Sheng Wang,Gui-Lin Cai 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.2

Port hopping is a typical proactive cyber defense technology, which hides the service identity and confuses attackers during reconnaissance by constantly altering service ports. Although several kinds of port hopping mechanisms have been proposed and implemented, but it is still unknown how effective port hopping is and under what circumstances it is a viable moving target defense because the existed works are limited and they usually discuss only a few parameters. Besides, in many cases the defense effectiveness has been studied empirically. In order to have an insight into the effectiveness of port hopping, this paper introduces a quantitative analysis based on the urn model, which quantifies the probability of attacker success in terms of port pool size, number of probes, number of vulnerable services, and hopping frequency. Theoretical analysis shows that port hopping is an effective and promising proactive defense technology in thwarting cyber attacks.

Study on the mixing performance of mixing vane grids and mixing coefficient by CFD and subchannel analysis code in a 5×5 rod bundle

Han Bin,Zhu Xiaoliang,Yang Bao-Wen,Liu Aiguo,Xi Yanyan,Liu Lei,Liu Shenghui,Huang Junlin 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.10

Mixing Vane Grid (MVG) is one of the most important structures in fuel assembly due to its high performance in mixing the coolant and ultimately increasing Critical Heat Flux (CHF), which avoids the temperature rising suddenly of fuel rods. To evaluate the mixing performance of the MVG, a Total Diffusion Coefficient (TDC) mixing coefficient is defined in the subchannel analysis code. Conventionally, the TDC of the spacer grid is obtained from the combination of experiments and subchannel analysis. However, the processing of obtaining and determine a reasonable TDC is much challenging, it is affected by boundary conditions and MVG geometries. In is difficult to perform all the large and costing rod bundle tests. In this paper, the CFD method was applied in TDC analysis. A typical 5 5 MVG was simulated and validated to estimate the mixing performance of the MVG. The subchannel code was used to calculate the TDC. Firstly, the CFD method was validated from the aspect of pressure drop and lateral temperature distribution in the subchannels. Then the effect of boundary conditions including the inlet temperature, inlet velocities, heat flux ratio between hot and cold rods and the arrangement of hot and cold rods on MVG mixing and TDC were studied. The geometric effects on mixing are also carried out in this paper. The effect of vane pattern on mixing was investigated to determine which one is the best to represent the grid's mixing performance.

The detection efficiency study of NaI(Tl) scintillation detector with the different numbers of SiPMs

Wang Bao,Zhang Xiongjie,Wang Qingshan,Wang Dongyang,Li Dong,Xiahou Mingdong,Zhou Pengfei,Ye Hao,Hu Bin,Zhang Lijiao 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7

SiPMs are generally coupled into whole columns in gamma energy spectrum measurement, but the relationship between the distribution of whole SiPM columns and the energy resolution of the measured energy spectra is rarely reported. In this work, ∅ 3 3 inch NaI scintillator is placed on an 8 8 SiPM array, and the energy resolution of the 137Cs peak at 662 keV corresponding to the g-ray is selected as a reference. Each SiPM is switched to explore the influence of the number of SiPM arrays, distribution position, and reflective layer on the energy resolution of SiPMs. Results show that without coupling, the energy resolution is greatly improved when the number of SiPMs ranges from 4 to 32. However, after 32 slices (the area covered by SiPMs relative to the scintillator reaches 25.9%), the improvement in energy resolution and total pulse count is not obvious. In addition, the position of SiPMs relative to the scintillator does not exert much impact on the energy resolution. Results also indicate that by adding a reflective film (ESR), the energy resolution of the tested group increases by 10.38% on average. This work can provide a reference for the design and application of miniaturized SiPM gamma spectrometers

Optimal Relay Selection and Power Allocation in an Improved Low-Order-Bit Quantize-and-Forward Scheme

( Jianrong Bao ),( Dan He ),( Xiaorong Xu ),( Bin Jiang ),( Minhong Sun ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11

Currently, the quantize-and-forward (QF) scheme with high order modulation and quantization has rather high complexity and it is thus impractical, especially in multiple relay cooperative communications. To overcome these deficiencies, an improved low complex QF scheme is proposed by the combination of the low order binary phase shift keying (BPSK) modulation and the 1-bit and 2-bit quantization, respectively. In this scheme, the relay selection is optimized by the best relay position for best bit-error-rate (BER) performance, where the relays are located closely to the destination node. In addition, an optimal power allocation is also suggested on a total power constraint. Finally, the BER and the achievable rate of the low order 1-bit, 2-bit and 3-bit QF schemes are simulated and analyzed. Simulation results indicate that the 3-bit QF scheme has about 1.8~5 dB, 4.5~7.5 dB and 1~2.5 dB performance gains than those of the decode-and-forward (DF), the 1-bit and 2-bit QF schemes, at BER of 10^-2, respectively. For the 2-bit QF, the scheme of the normalized Source-Relay (S-R) distance with 0.9 has about 5dB, 7.5dB, 9dB and 15dB gains than those of the distance with 0.7, 0.5, 0.3 and 0.1, respectively, at BER of 10^-3. In addition, the proposed optimal power allocation saves about 2.5dB much more relay power on an average than that of the fixed power allocation. Therefore, the proposed QF scheme can obtain excellent features, such as good BER performance, low complexity and high power efficiency, which make it much pragmatic in the future cooperative communications.

A Method for Evaluation of the Quality of DNA Microarray Spots

Zhang, Bao,Ma, Wen-Li,Hu, Zi-You,Shi, Rong,Song, Yan-Bin,Zheng, Wen-Ling 한국생화학분자생물학회 2002 BMB Reports Vol.35 No.5

To establish a method to evaluate the quality of the printed microarray and DNA fragments' immobilization. The target gene fragments that were made with the restriction display PCR (RD-PCR) technique were printed on a superamine modified glass slide, then immobilized with UV cross-linking and heat. This chip was hybridized with universal primers that were labeled with cy3-dUTP, as well as cDNA that was labeled with cy3-dCTP, as the conventional protocol. Most of the target gene fragments on the chip showed positive signals, but the negative control showed no signal, and vice versa. We established a method that enables an effective evaluation of the quality of the microarrays.

Deflection of Castellated Beams Subjected to Uniformly Distributed Transverse Loading

Wei-bin Yuan,Nan-ting Yu,Zhao-shui Bao,Li-ping Wu 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.3

This paper presents an analytical solution for determining the deflection of castellated/cellular beams with hexagonal/circular web openings, subjected to a uniformly distributed transverse load. The solution is derived using the principle of minimum potential energy. To validate the derived analytical solution, three-dimensional linear finite element analysis is performed using four-node shell elements built-in ANSYS software. Good agreement between the finite element result and the present analytical solution is demonstrated.