Long-term results in the treatment of fistula-in-ano with fibrin glue

Gokturk Maralcan,?lyas Ba?konu?,Avni Gokalp,Ersin Borazan,Ahmet Balk 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.81 No.3

Purpose: This prospective study was done to analyze the efficacy of commercial fibrin glue application in the healing of patients with fistulas-in-ano from a long-term (mean 4.5 years) research period. Methods: This clinical trial of forty-six patients was performed during the period from January 2004 to February 2005. Thirty-nine men and seven women were treated for a fistula-in-ano with a commercial fibrin glue application. In the operating room, the patients underwent an anorectal examination under spinal anesthesia. The external and internal fistula tract openings were then identified. The fistula tract was curetted. Fibrin glue was injected into the external fistula opening until the fibrin glue could be seen coming from the internal opening. Results: The overall initial success rate was 86.95% (40/46). Recurrence rate was 41.30% (19/46). Two patients underwent a re-application with fibrin glue and the fistulas of these patients closed. The total recurrence rate was 36.95% (17/46). The long-term overall success rate was 63.04% (29/46). Conclusion: Fibrin glue application was thus found to be an easy, safe, acceptable, successful alternative treatment in the management of fistulas-in-ano. Choosing the patient correctly is very important because long (more than 4 cm) and non-ramificate fistula tracts usually close with commercial fibrin glue.

An Investigation of SDF1/CXCR4 Gene Polymorphisms in Autism Spectrum Disorder: A Family-Based Study

Tayfun Kara,İ,smail Akaltun,Bedia Cakmakoglu,İ,lyas Kaya,Salih Zoroğ,lu 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.3

Objective-Autism spectrum disorders (ASD) have a complex pathophysiology including genetic, inflammatory and neurodevelopmental components. We aim to investigate the relationship between ASD and gene polymorphisms of stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor-4 (CXCR4), which may affect inflammatory and neurodevelopmental processes. Methods-101 children diagnosed with ASD aged 2–18 and their biological parents were included in the study. All participants were assessed using an information form and the Children were assessed using Childhood Autism Rating Scale (CARS). SDF-1 G801→A and CXCR4 C13→T polymorphisms were detected by genetic techniques. The results were evaluated using the transmission disequilibrium test (TDT) and haplotype relative risk (HRR). Results-Following TDT evaluation for CXCR4, the assumption of equality was not rejected (χ2=1.385, p=0.239). HRR for the C allele was 1.037 [HRR (95%CI)=0.937 (0.450-2.387), χ2=0.007, p=0.933] and HRR for the T allele was 0.965 [HRR (95%CI)=0.965 (0.419-2.221), χ2=1.219, p=0.270], but the findings were statistically insignificant. Based on TDT evaluation for SDF1, the assumption of equality cannot be rejected (χ2=0, p=0.999). HRR for the A allele was 0.701 [HRR (95%CI)=0.701 (0.372-1.319), χ2=1.219, p=0.270] and HRR for the G allele was 1.427 [HRR (95%CI)=1.427 (0.758-2.686), χ2=1.219, p=0.270], but the findings were statistically insignificant. Conclusion-The genetic screening of blood samples from mother, father and child trios could not show a significant association between SDF1/CXCR4 genes and ASD on the basis of TDT and HRR tests. More extensive genetic studies are now needed to investigate the relationship between SDF1/CXCR4 gene polymorphisms and ASD.

Effect of Alternative Boronizing Mixtures on Boride Layer and Tribological Behaviour of Boronized SAE 1020 Steel

İlyas Türkmen,Emre Yalamaç 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.5

In this study, SAE 1020 steel samples were boronized at 850 °C for 4 h with different boronizing mixtures by powder-packboronizing method. H3BO3or Na2B8O13was used as the boron source, KBF4or NaBF4was used as the activator and SiCwas used as the diluent. Thus, 4 different boronizing mixtures (M1-M4) were prepared. Thickness, morphology and phasestructure of the formed boride layers were studied by X-ray diffraction and microstructural analyzes. The single phase (Fe2B)boride layer with saw-tooth morphology was formed on surface of the samples. The thickest boride layers were obtained byusing M1 and M2 boronizing mixtures. Microhardness measurements were performed to determine hardness of the 3 zones(core, transition zone and boride layer). The means of boride layer hardness of the samples were compared according to 95%Confidence Intervals analysis. It was determined that the average hardness value of the boride layers was about 1475 HV. Wear tests were fulfilled by ball on disc type wear test method under dry sliding condition and at 25 °C. According to thefriction coefficient and specific wear rate values of boronized samples, it was identified that the sample SM4boronized withM4 boronizing mixture has the lowest wear rate (1.64 mm3/N.m) and friction coefficient value (0.63).

Investigation of the Performance of a V-shaped Inner Plate Array Armor System Against 7.62 mm Caliber Bullets

Erdal Camcı,Mehmet Calıskan,İlyas Berkay Tural,Ozgecan Ergu,Fehim Findik 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.2

In this study, the impact resistance performance of the steel internal structure, which is fixed with screws between the front and rear plate, has a 90° bent form and is placed to deflect the penetrating bullet, was measured. This article presents the ballistic performance of the designed armor system against 7.62 mm armor-piercing projectiles with a velocity of 630 to 870 ± 10 m/s, coming at an angle of 90° to the front plate. The study was carried out both experimentally and numerically. Experimental results showed that remarkable ballistic results were obtained among the investigated materials examined in 32 mm thick aluminum-steel-aluminum sheet structures. Numerical and experimental results were compared and a significant correlation was found. In addition to the ballistic performance results, the samples were examined for fracture mechanisms by scanning electron microscopy and EDS analysis.

Effect of Cr Addition on Properties and Tribological Behavior at Elevated Temperature of Boride Layers Grown on Borosintered Powder Metallurgy Alloys

Ali Günen,Ömer Saltuk Bölükbaşı,Yasin Özgürlük,Derviş Özkan,Okan Odabaş,İlyas Somunkıran 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.3

This study focused on chromium addition (0 wt%, 3 wt%, 6 wt%, 9 wt% and 12 wt%) on the boride layer formation, microhardness,fracture toughness and elevated temperature friction and wear behaviour of alloys formed by powder metallurgy(P/M). The boride layers obtained on P/M alloys were characterized by examining density, porosity, surface roughness,scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, surface profilometry, microhardness,and fracture toughness. The addition of Cr has a significant effect on both boride layer formation and friction-wearbehaviour of P/M alloys. Increasing the Cr addition up to 6 wt% has an improving effect on the microhardness, fracturetoughness and wear resistance of the P/M alloys, whereas in the case of 9–12 wt% Cr addition causes exfoliation in the boridelayer and low fracture toughness, thus reducing wear resistance. Coefficients of friction and wear volume losses at elevatedtemperatures are higher than room temperature. The best wear resistance at room temperature was obtained in the samplecontaining 3 wt% Cr with the highest fracture toughness, while the best wear resistance at 250 °C and 500 °C was obtainedin the sample containing 6 wt% Cr, where the highest hardness value was obtained.

Cystic fibrosis of pancreas and nephrotic syndrome:a rare association

Selvi Kelekçi,Müsemma Karabel,Aydın Ece,Velat Şen,Ali Güneş,İlyas Yolbaş 대한소아청소년과학회 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.10

Cystic fibrosis (CF) is a genetic disease with autosomal recessive inheritance and is common in Caucasian people. The prevalence of this disease is between 1/2,000 and 1/3,500 live births, and the incidence varies between populations. Although the CF transmembrane conductance regulator gene is expressed in the kidneys, renal involvement is rare. With advances in the treatment of CF, life expectancy has increased, and some previously unobserved disease associations are now seen in patients with CF. It is important to follow patients with CF for possible abnormalities that may accompany CF. In this paper, we present two rare cases of CF accompanied by nephrotic syndrome.

Properties of Aluminum Nano Composites Bearing Alumina Particles and Multiwall Carbon Nanotubes Manufactured by Mechanical Alloying and Microwave Sintering

Ali Günen,Ömer Saltuk Bölükbaşı,Yasin Özgürlük,Derviş Özkan,Okan Odabaş,İlyas Somunkıran 대한금속ᆞ재료학회 2023 METALS AND MATERIALS International Vol.29 No.2

This study focused on chromium addition (0 wt%, 3 wt%, 6 wt%, 9 wt% and 12 wt%) on the boride layer formation, microhardness,fracture toughness and elevated temperature friction and wear behaviour of alloys formed by powder metallurgy(P/M). The boride layers obtained on P/M alloys were characterized by examining density, porosity, surface roughness,scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, surface profilometry, microhardness,and fracture toughness. The addition of Cr has a significant effect on both boride layer formation and friction-wearbehaviour of P/M alloys. Increasing the Cr addition up to 6 wt% has an improving effect on the microhardness, fracturetoughness and wear resistance of the P/M alloys, whereas in the case of 9–12 wt% Cr addition causes exfoliation in the boridelayer and low fracture toughness, thus reducing wear resistance. Coefficients of friction and wear volume losses at elevatedtemperatures are higher than room temperature. The best wear resistance at room temperature was obtained in the samplecontaining 3 wt% Cr with the highest fracture toughness, while the best wear resistance at 250 °C and 500 °C was obtainedin the sample containing 6 wt% Cr, where the highest hardness value was obtained.

An Approach to Manufacture of Fresh Chicken Sausages Incorporated with Black Cumin and Flaxseed Oil in Water Gelled Emulsion

Hü,lya Serpil Kavuş,an,Meltem Serdaroğ,lu,Berker Nacak,Gamze İ,pek 한국축산식품학회 2020 한국축산식품학회지 Vol.40 No.3

In order to investigate the use of oil in water gelled emulsion (GE) prepared with healthier oil combinations as beef fat replacer in the fresh chicken sausage formulations, four batches of fresh sausages were produced. The first batch was control (C) sample formulated with %100 beef fat, other batches were codded as GE50, GE75, and GE100 respective to the percentage of beef fat replaced with GE. The addition of GE to sausage formulation resulted in an increment in moisture and protein contents while a decrement was observed in fat content (p<0.05). pH, cooking yield and water holding capacity values of GE added samples were found lower than C (p<0.05). GE addition caused lower CIE L* values in samples, however, this trend was not observed in CIE a* and CIE b* values. Initially, the lowest peroxide and the highest TBARS values were recorded in GE100 samples on the 0th d (p<0.05). Peroxide and TBARS values were in the limits. The texture of samples was softened while total saturated fatty acid content reduced up to 52.61% with the incorporation of GE (p<0.05). Taken together, our results showed that GEs can be used as fat replacers in meat product formulations without causing undesirable quality changes.

Grafting of poly(3-hydroxyalkanoate) and linoleic acid onto chitosan

Arslan, Hü,lya,Hazer, Baki,Yoon, Sung C. Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of applied polymer science Vol.103 No.1

<P>Poly(3-hydroxy octanoate) (PHO), poly(3-hydroxy butyrate-co-3-hydroxyvalerate) (PHBV), and linoleic acid were grafted onto chitosan via condensation reactions between carboxylic acids and amine groups. Unreacted PHAs and linoleic acid were eliminated via chloroform extraction and for elimination of unreacted chitosan were used 2 wt % of HOAc solution. The pure chitosan graft copolymers were isolated and then characterized by FTIR, <SUP>13</SUP>C-NMR (in solid state), DSC, and TGA. Microbial polyester percentage grafted onto chitosan backbone was varying from 7 to 52 wt % as a function of molecular weight of PHAs, namely as a function of steric effect. Solubility tests were also performed. Graft copolymers were soluble, partially soluble or insoluble in 2 wt % of HOAc depending on the amount of free primary amine groups on chitosan backbone or degree of grafting percent. Thermal analysis of PHO-g-Chitosan graft copolymers indicated that the plastizer effect of PHO by means that they showed melting transitions T<SUB>m</SUB>s at 80, 100, and 113°C or a broad T<SUB>m</SUB>s between 60.5–124.5°C and 75–125°C while pure chitosan showed a sharp T<SUB>m</SUB> at 123°C. In comparison of the solubility and thermal properties of graft copolymers, linoleic acid derivatives of chitosan were used. Thus, the grafting of poly(3-hydroxyalkanoate) and linoleic acid onto chitosan decrease the thermal stability of chitosan backbone. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103:81–89, 2007</P>

Formulating Reduced-fat Sausages with Quinoa or Teff Flours: Effects on Emulsion Characteristics and Product Quality

Burcu Ö,ztü,rk-Kerimoğ,lu,Hü,lya Serpil Kavuş,an,Damla Tabak,Meltem Serdaroğ,lu 한국축산식품학회 2020 한국축산식품학회지 Vol.40 No.5

This study dealt with the use of quinoa flour (QF) or teff flour (TF) as partial beef fat replacers in the formulation of emulsion-type sausages. A control (C) group was manufactured with 20% beef fat, while the other three groups were formulated with 10% beef fat plus 5% QF (Q), 5% TF (T), and 2.5% QF+2.5% TF (QT). Water-holding capacity of the emulsions was higher in Q (81.81%), T (82.20%), and QT (84.10%) samples than in C (64.83%) samples. Total expressible fluid and expressible fat were the lowest in Q and T samples, indicating the highest emulsion stability of those groups. Incorporation of QF and TF into formulations increased moisture and carbohydrate contents while decreased fat and energy values. Besides, the use of QF was effective to increase protein and dietary fiber contents. T sausages had lower luminosity (L*) and higher yellowness (b*) than C sausages, whilst Q sausages did not result in significant color changes. Higher cook yield values were recorded in Q (97.96%), T (98.21%), and QT (98.15%) samples compared with C (96.44%) samples. Inclusion of QF and TF to formulation led to lower hardness and gumminess, while utilization of TF was also effective to decrease chewiness. Consequently, healthier emulsified sausages were obtained by the inclusion of QF or TF that could decrease the fat content more than 50% without sacrificing overall quality, bringing advantages by quinoa over teff for increasing nutritional value and leading minimal modifications on color and texture.