http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
De Oliveira, Greison Rabelo,Pozzer, Leandro,Cavalieri-Pereira, Lucas,De Moraes, Paulo Hemerson,Olate, Sergio,De Albergaria Barbosa, Jose Ricardo Korean Academy of Periodontology 2012 Journal of Periodontal & Implant Science Vol.42 No.6
Purpose: Several parameters have been described for determining the success or failure of dental implants. The surface properties of transgingival implant components have had a great impact on the long-term success of dental implants. The purpose of this study was to compare the tendency of two periodontal pathogens to adhere to and colonize zirconia abutments and titanium alloys both in hard surfaces and soft tissues. Methods: Twelve patients participated in this study. Three months after implant placement, the abutments were connected. Five weeks following the abutment connections, the abutments were removed, probing depth measurements were recorded, and gingival biopsies were performed. The abutments and gingival biopsies taken from the buccal gingiva were analyzed using real-time polymerase chain reaction to compare the DNA copy numbers of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and total bacteria. The surface free energy of the abutments was calculated using the sessile water drop method before replacement. Data analyses used the Mann Whitney U-test, and P-values below 0.05 find statistical significance. Results: The present study showed no statistically significant differences between the DNA copy numbers of A. actinomycetemcomitans, P. gingivalis, and total bacteria for both the titanium and zirconia abutments and the biopsies taken from their buccal gingiva. The differences between the free surface energy of the abutments had no influence on the microbiological findings. Conclusions: Zirconia surfaces have comparable properties to titanium alloy surfaces and may be suitable and safe materials for the long-term success of dental implants.
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion
de Moraes, Izadora Quintela Souza,do Nascimento, Ticiano Gomes,da Silva, Antonio Thomas,de Lira, Lilian Maria Santos Silva,Parolia, Abhishek,de Moraes Porto, Isabel Cristina Celerino The Korean Academy of Conservative Dentistry 2020 Restorative Dentistry & Endodontics Vol.45 No.3
Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were "matrix metalloproteinases", "collagen", and "dentin" and "hybrid layer". MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.
Resin infiltrant protects deproteinized dentin against erosive and abrasive wear
de Albuquerque Ana Theresa Queiroz,Bezerra Bruna Oliveira,Leal Isabelly de Carvalho,de Moraes Maria Denise Rodrigues,Melo Mary Anne S.,Passos Vanara Florêncio 대한치과보존학회 2022 Restorative Dentistry & Endodontics Vol.47 No.3
Objectives This study aimed to investigate the anti-erosive/abrasive effect of resin infiltration of previous deproteinized dentin. Materials and Methods Dentin slabs were randomly assigned to 3 groups (n = 15): Control (no deproteinization; no resin infiltrant applied), RI (no deproteinization; resin infiltrant applied), and DRI (deproteinization; resin infiltrant applied). After undergoing the assigned treatment, all slabs were subjected to an in vitro cycling model for 5 days. The specimens were immersed in citric acid (0.05 M, pH = 3.75; 60 seconds; 3 times/day) and brushed (150 strokes). Between the challenges, the specimens were exposed to a remineralizing solution (60 minutes). The morphological alterations were analyzed by mechanical profilometry (µm) and scanning electron microscopy (SEM). Data were submitted to one-way analysis of variance (ANOVA) and Tukey tests (p < 0.05). Results Control and RI groups presented mineral wear and did not significantly differ from each other (p = 0.063). DRI maintained a protective layer preserving the dentin (p < 0.001). After erosive/abrasive cycles, it was observed that in group RI, only 25% of the slabs partially evidenced the presence of the infiltrating, while, in the DRI group, 80% of the slabs presented the treated surface entirely covered by a resin-component layer protecting the dentin surface as observed in SEM images. Conclusions The removal of the organic content allows the resin infiltrant to efficiently protect the dentin surface against erosive/abrasive lesions.
Luciana de Almeida Vittori Gouveia,Carolina Alves Cardoso,Glaucia Maria Moraes de Oliveira,Glorimar Rosa,Annie Seixas Bello Moreira 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.4
This study is aimed at assessing the scientific evidence on the effect of the intake of sesame seeds and derivatives on oxidative stress of individuals with systemic hypertension, dyslipidemia, and type 2 diabetes mellitus. A systematic review was conducted in seven databases (Lilacs, PubMed, ISI Web of Knowledge, Cochrane Library, Scopus, Trip Database, and Scielo) from September 2013 to January 2014. Clinical trials on the intake of sesame seeds and derivatives assessing the outcomes related to oxidative stress were retrieved. The risk of bias in the results of the studies selected was assessed according to the criteria of the Cochrane Handbook for Systematic Reviews of Interventions. This review included seven clinical trials showing that the intake of sesame resulted in the increase in enzymatic and nonenzymatic antioxidants, as well as in a reduction in oxidative stress markers. This was mainly observed with the use of sesame oil for hypertensive individuals during 2 months and black sesame meal capsules for prehypertensive individuals during four weeks. Most studies involved a small number of participants, sample size being considered a limiting factor for this review. In addition, a significant heterogeneity was observed in the type of population studied and the type of sesame and derivatives used, as well as their amount. The follow-up time was considered a limiting factor, because it varied in the different studies. The high risk of randomization and blinding biases found in the studies assessed determines lower scientific evidence of the results. Despite the limitations and biases identified in this systematic review, sesame showed relevant effects on oxidative stress, suggesting it could increase the antioxidant capacity.
Liquid–liquid extraction of succinic acid using a hollow fiber membrane contactor
Luciana de Souza Moraes,Frederico de Araujo Kronemberger,Helen Conceic¸a˜o Ferraz,Alberto Claudio Habert 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Extraction with membrane contactors is an attractive technological alternative for organic acidseparation from fermentation broths. This work aims at studying the recovery process of succinic acid,integrating both extraction and re-extraction steps. It was proposed to use a non-porous membrane,which allows more flexibility of operation without loss of efficiency. For the integrated process, a 5-foldincrease in the recovery of acid from the feed stream was observed when compared to the singleextraction process, leading to an overall recovery close to 50%.
Walclecio de Moraes Lira,Fabio Vieira dos Santos,Miriam Sannomiya,Clenilson Martins Rodrigues,Wagner Vilegas,Eliana Aparecida Varanda 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian “cerrado” (tropical Americansavanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceaefamily, and it is commonly known as “murici.” Considering the popular use of B. basilobaderivatives and the lack of phar-macological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) andchloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella ty-phimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and in-direct mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B1, benzo[a]pyrene,and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level(89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B1. Phytochemical analysis of theextracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (. )-catechin, quercetin-3-O-.-L-arabinopyra-noside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2.-O-galloyl)-.-D-galactopyranoside, andquercetin-3-O-(2.-O-galloyl)-.-L-arabinopyranoside.
Cytogenotoxic study of aqueous fruit extract of Morinda citrifolia in Wistar albino rats
Germano Pinho de Moraes,Marcus Vinícius Oliveira Barros de Alencar,Lidiane da Silva Araújo,Débora Cássia Vieira Gomes,Márcia Fernanda Correia Jardim Paz,Muhammad Torequl Islam,Ana Amélia de Carvalho M 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3
The use of herbal products and/or their derivatives as an alternative or complementary medicine becomes globally popular. To date, various biological activities have been reported in Morinda citrifolia Linn, especially antioxidants, antimicrobial, anti-infammatory and antitumor efects. This study aimed to investigate the genotoxicity and DNA repair capacity of the aqueous fruit extract of M. citrifolia (AEMC). Additionally, we checked the mutagenic capacity of AEMC by the comet assay and micronucleus tests in rats. For this, rats (n=10; 5 males and 5 females) were divided into fve groups as: negative control (distilled water); positive control (25 mg/kg of cyclophosphamide, i.p.); and three groups for AEMC (2.5, 5 and 10 mg/kg, i.p.). The results suggest that, the AEMC induced genotoxicity in white blood cells, but a DNA repair capacity was also observed after 72 h of AEMC exposure. AEMC also showed cytotoxicity and mutagenicity in liver and kidney cells of rats at 5 and 10 mg/kg doses. In conclusion, AEMC exhibited a dose-dependent cytotoxicity, genotoxicity and mutagenicity along with a time-dependent DNA repair capacity in rats. Further studies are necessary regarding the safe use of this medicinal plant for human consumption.
Greison Rabelo de Oliveira,Leandro Pozzer,Lucas Cavalieri-Pereira,Paulo Hemerson de Moraes,Sergio Olate,Jose Ricardo de Albergaría Barbosa 대한치주과학회 2012 Journal of Periodontal & Implant Science Vol.42 No.6
Purpose: Several parameters have been described for determining the success or failure of dental implants. The surface properties of transgingival implant components have had a great impact on the long-term success of dental implants. The purpose of this study was to compare the tendency of two periodontal pathogens to adhere to and colonize zirconia abutments and titanium alloys both in hard surfaces and soft tissues. Methods: Twelve patients participated in this study. Three months after implant placement, the abutments were connected. Five weeks following the abutment connections, the abutments were removed, probing depth measurements were recorded,and gingival biopsies were performed. The abutments and gingival biopsies taken from the buccal gingiva were analyzed using real-time polymerase chain reaction to compare the DNA copy numbers of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and total bacteria. The surface free energy of the abutments was calculated using the sessile water drop method before replacement. Data analyses used the Mann Whitney U-test, and P-values below 0.05 find statistical significance. Results: The present study showed no statistically significant differences between the DNA copy numbers of A. actinomycetemcomitans,P. gingivalis, and total bacteria for both the titanium and zirconia abutments and the biopsies taken from their buccal gingiva. The differences between the free surface energy of the abutments had no influence on the microbiological findings. Conclusions: Zirconia surfaces have comparable properties to titanium alloy surfaces and may be suitable and safe materials for the long-term success of dental implants.