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      • KCI등재

        Touches on Screen as New Signs in Blended Ways to Think Mathematically

        Assis Alexandre Rodrigues de,Bairral Marcelo Almeida 대한수학교육학회 2022 수학교육학연구 Vol.32 No.4

        This study demonstrates how manipulations on the screen can play an important role in students’ cognitive development. Specifically, it analyzes Brazilian high school students solving a task concerning isometry in an environment designed to improve mathematics learning with touchscreen mobile devices. The data include videotapes, written answers, icon sheets, and screen recordings. Results suggest including touches on screen as a resource in the semiotic bundle. With the advancement of mobile technologies and the increase of online courses, a contribution of this study to the blended learning literature is investigating the design of learning environments that take touchscreen in task design and other instruction processes into account.

      • KCI등재

        Entrapment Characteristics of Hydrosoluble Vitamins Loaded into Chitosan and N,N,N-Trimethyl Chitosan Nanoparticles

        Douglas de Britto,Marcia R. de Moura,Fauze A. Aouada,Flávia G. Pinola,Lícia M. Lundstedt,Odilio B. G. Assis,Luiz H. C. Mattoso 한국고분자학회 2014 Macromolecular Research Vol.22 No.12

        Nanoencapsulation is a process suitable for use in reducing degradation of instable components. In thisstudy, chitosan and trimethyl chitosan with tripolyphosphate were used to nanoencapsulate vitamins C, B9, and B12. Analysis of the particle size showed that for a fix proportion of the polymer tripolyphosphate, the system showed awide variation in size with the amount of added vitamins: e.g., for vitamin B9, the particle size varied from 150±5nm to 809±150 nm. The zeta potential confirmed that trimethyl chitosan nanoparticles generally had a lower net positivecharge (20 mV) than chitosan nanoparticles (40 mV). The encapsulation efficiency was found to be dependenton nanoparticle structure and vitamin solubility, with vitamin B9 the most efficiently encapsulated (approximately40%). UV-Visible spectroscopy indicated different release profiles for vitamins C, B9, and B12 in a neutral PBSsolution with release rates of 36%, 52%, and 16% after 2, 24, and 4 h, respectively. In conclusion the liberation wasfound to be slower in acidic media.

      • KCI등재

        Metabolic Effects of Sulforaphane Oral Treatment in Streptozotocin-Diabetic Rats

        Carolina Guerini de Souza,José Augusto Sattler,Adriano Martimbianco de Assis,Anderson Rech,Marcos Luiz Santos Perry 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.9

        Diabetes has reached epidemic levels in the whole world, and the use of bioactive compounds that may have the capacity to prevent and treat diabetes is of great interest. Sulforaphane (SFN) is a compound which is found in cruciferous vegetables and that acts as both a potent antioxidant and regulator of gene expression. The aim of this study was to evaluate the effect of SFN in diabetes induced by streptozotocin (STZ). Male Wistar rats were gavaged with water or 0.1, 0.25, or 0.5 mg/kg of SFN before an injection of STZ (80 mg/kg). Animals treated with SFN showed fasting glycemia, insulin sensitivity, and hepatic glycogen concentrations, similar to the control group (nondiabetic), and different from the diabetic group. Diabetic animals also presented elevated levels of serum triacylglycerols (TAG), urea, and creatinine, and all SFN doses were able to reverse these alterations. However, the same doses of SFN accentuated alterations in total cholesterol, alanine, and aspartate aminotransferase levels, and had no effect on hepatic TAG, HDL cholesterol, and uptake of 2-deoxy glucose in adipose tissue and soleum muscle. Based on the effects inferred by the present data, SFN presented some positive effects against diabetes induction, although the impairment of hepatic function and cholesterol levels were aggravated after treatment with the compound.

      • KCI등재

        Inulinase from Rhodotorula mucilaginosa: immobilization and application in the production of fructooligosaccharides

        Geise Camila de Araujo Ribeiro,Pedro Fernandes,Dayse Alessandra Almeida Silva,Hugo Neves Brandao,Sandra Aparecida de Assis 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.7

        The crude extract containing inulinase fromRhodotorula mucilaginosa was obtained by submergedfermentation. Inulinase was immobilized on chicken eggshellby physical adsorption and covalent crosslinking,using glutaraldehyde as a crosslinking reagent, and Celiteby adsorption. Fructooligosaccharides production wasperformed using immobilized inulinase (5%, w/v) andinulin substrate solution under experimental conditionsevaluated through Doehlert experimental design. The productionof inulinase was optimized for concentrations ofD-glucose and yeast extract at 12.5 and 0.5 g/L, respectively,resulting in an optimal activity of 0.62 U. Theoptimal pH and temperature for enzyme activity were 8.0and 75 C, respectively, leading to an optimal activity of3.54 U. The highest immobilization efficiency (46.27%)was obtained upon immobilization on Celite. Immobilizationby adsorption to eggshell allowed for specific activityof 4.15 U/g, and adsorption to Celite resulted in specificactivity of 3.70 U/g. The highest titer in fructooligosaccharideswas obtained with an initial inulin concentrationof 250 g/L (25%, w/v), and a reaction time of 16 h. Hence,immobilized inulinase proved to be a promising catalyst forfructooligosaccharides production since the formulation isperformed through a simple, low-cost, and large-scaleapplicable methodology.

      • SCOPUSKCI등재

        Impaired Health-Related Quality of Life in Brazilian Children with Chronic Abdominal Pain: A Cross-Sectional Study

        Jesus, Carine Dias Ferreira de,Carvalho, Mary de Assis,Machado, Nilton Carlos The Korean Society of Pediatric Gastroenterology 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.6

        Purpose: We compared the health-related quality of life (HRQOL) of children and adolescents with functional abdominal pain disorders (FAPDs) and organic abdominal pain disorders (ORGDs). Methods: This was a single-center, cross-sectional, observational study. The PedsQL 4.0 generic cores scales parent proxy-report was administered to parents/caregivers of 130 and 56 pediatric patients with FAPDs and ORGDs respectively on their first visit. The self-reported pain intensity in the patients was assessed using a visual analog scale (VAS) and facial affective scale (FAS). Results: Irritable bowel syndrome was the most prevalent FAPDs, and the most prevalent ORGDs were reflux esophagitis (41.1%) and gastritis associated with Helicobacter pylori (21.4%). There was no difference in HRQOL among patients diagnosed with ORGDs and FAPDs (p>0.05). Patients with ORGDs and FAPDs had lower HRQOL Scale scores than healthy Brazilian and American children's references, with a high proportion of children at risk for impaired HRQOL (p<0.0001). There was no difference in the VAS and the FAS scores between the ORGDs and the FAPDs. FAPDs had a higher prevalence of girls' and couples' disagreement (p<0.02), although poor school performance (p<0.0007) and bullying (p<0.01) were higher in patients with ORGD. Conclusion: This study revealed that there was a difference in impaired HRQOL between patients with ORGDs and FAPDs. Thus, considering the high prevalence of chronic abdominal pain in children, a well-founded treatment plan is necessary for a multidisciplinary cognitive-behavioral Pain management program.

      • KCI등재

        Sugarcane bagasse as exclusive roughage for dairy cows in smallholder livestock system

        Gleidiana Amelia Pontes de Almeida,Marcelo de Andrade Ferreira,Janaina de Lima Silva,Juana Catarina Cariri Chagas,Antonia Sherlanea Chaves Veras,Leonardo Jose Assis de Barros,Gledson Luiz Pontes de Al 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.3

        Objective: The study aimed to evaluate sugarcane bagasse as roughage in lactating cow on feed intake, digestibility, ingestive behavior, milk production and composition, and microbial protein synthesis. Methods: Ten Girolando cows at initial body weight of 450±25.6 kg and at 143.7±30.7 days in milk were assigned in two 5×5 Latin square designs. Five 21-day experimental periods were adopted (1° to 14-day: diets adaptation period; 15° to 21-day: data collection and sampling period). The diets consisted of four different levels of sugarcane bagasse (45%, 50%, 55%, and 60%) and a control diet, commonly adopted in the region, based on spineless cactus (25% sugarcane bagasse), formulated to meet 12 kg/d milk yield. Results: The dry matter (DM), organic matter (OM), and total digestible nutrients intakes and DM and OM digestibilities observed for 45% and 50% bagasse inclusion were similar to control diet, while that 55% and 60% bagasse inclusion were lower. Cows fed control diet, and bagasse diets of 45%, and 50% levels had the nutritional requirements attended, that guaranteed 12 kg/d of milk yield. The crude protein intake and digestibility of cows fed 45%, 50%, and 55% of bagasse inclusion were similar to control diet. The neutral detergent fiber (NDF) intake and digestibility differ for all bagasse diets related to control diet, while the non-fiber carbohydrates intake and digestibility for cows fed 45% of bagasse were similar for control diet. The intakes and digestibilities of nutrients decreased linearly in function of bagasse inclusion; NDF and indigestible NDF intakes did not vary. The ruminating time, feeding and rumination efficiency, microbial protein synthesis and milk yield decreased linearly with sugarcane bagasse inclusion. Conclusion: Sugarcane bagasse decreases milk production; however, its inclusion level in between 45% to 50% associated to concentrate could replace diets based on spineless cactus for crossbred dairy cow's producing 12 kg/d of milk.

      • KCI등재

        Frequency and intensity of gastrointestinal symptoms in exercisers individuals at rest and during physical exercise: an internet-based survey

        Claudio Andre Barbosa de Lira,Ricardo Borges Viana,Kaylla Priscilla Mesquista,Douglas de Assis Teles Santos,Mário Hebling Campos,Marília Santos Andrade,Rodrigo Luiz Vancini 대한장연구학회 2019 Intestinal Research Vol.17 No.4

        Background/Aims: Despite the evidence of a modest to high prevalence of gastrointestinal (GI) symptoms in recreational runners and endurance athletes, the frequency and intensity of GI symptoms in exercisers, but nonathletes, individuals from different modalities have been less investigated. Therefore, the present study aimed to assess the prevalence of GI symptoms in individuals that practice moderate or vigorous physical exercise, at rest and during physical exercise training session. Methods: The sample consisted of 142 exercisers individuals (64 women and 78 men with mean age of 32.9±10.7 years). Out of the 142 participants, 71 reported to perform moderate physical exercise and 71 reported to perform vigorous physical exercise. Participants were assessed by an internet-based questionnaire designed to assess the frequency and intensity (at rest and during physical exercise training session) of 18 GI symptoms. Results: The GI symptoms most frequently reported by the respondents (during rest and physical exercise training session, respectively) were flatulence (90.8% and 69.7%), abdominal noise (77.5% and 41.5%), and eructation (73.9% and 52.1%). Overall, the frequency and intensity of symptoms were higher (P<0.050) during rest than physical exercise training session for who perform moderate and vigorous physical exercise. Conclusions: It can be concluded that GI symptoms in exercisers, but nonathletes, individuals are more prevalent during rest than during physical exercise training session, suggesting that moderate and vigorous physical exercise may act as a regulator of the GI tract.

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