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Roles of Heat Shock Protein gp96 in the ER Quality Control: Redundant or Unique Function?
Zihai Li,Yi Yang 한국분자세포생물학회 2005 Molecules and cells Vol.20 No.2
Heat shock protein gp96 is an endoplasmic reticulum chaperone, belonging to the HSP90 family. The function of gp96 as a molecular chaperone was discovered more than 10 years ago, but its importance has been overshadowed by the brilliance of its role in immune responses. It is now clear that gp96 is instrumental in the initiation of both the innate and adaptive immunity. Recently, the roles of gp96 in protein homeostasis, as well as in cell differentiation and development, are beginning to draw more attention due to rapid development in the structural study of HSP90 and some surprising new discoveries from genetic studies of gp96. In this review, we focus on the aspect of gp96 as an ER molecular chaperone in protein maturation, peptide binding and the regulation of its activity.
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Application of a 3-D crack analysis model to RC cantilever decks of excessive cracking
Shi, Zihai,Nakano, Masaaki Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.12 No.4
The excessive cracking of RC cantilever decks, which often requires special attention for structural engineers, is studied using a three-dimensional crack analysis model. The model is based on a fracture energy approach for analyzing cracks in concrete, and the numerical analysis is carried out using a modified load control method. The problem of excessive cracking is then studied with four different span-ratios. Based on the numerical results, the crack behavior with respect to the patterns of crack propagation, dissipation of the fracture energy, and effects on the structural integrity are discussed. The mechanisms which cause the excessive cracking are also explained.
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Xu Xu,Jinhong Yu,Zihai He,Shaorong Lu,Dong Guo 한국고분자학회 2014 Macromolecular Research Vol.22 No.10
A reactive compatibilizer containing flexible segment (RCFS) was synthesized and characterized by Fouriertransform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The RCFS was used as acompatibilizer for the preparation of lignin/polypropylene (PP) wood plastic composites, and the effect of the RCFSon the properties of composites (e.g., mechanical properties, thermal properties, crystal structure, and morphology)were investigated in detail. Experimental results indicated that the lignin/PP composite displayed the best performancewith the addition of 2 wt% RCFS. Its impact strength, flexural strength, and modulus were 56.8%, 37.3%,and 20.6%, respectively, which are higher than those of the untreated composites. Moreover, RCFS treatment couldalso increase the thermal stability, crystallization rate, and degree of crystallinity of lignin/PP composites.
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Pan Ding,Luying Ju,Ri-Qing Xu,Zihai Yan,Mingming Wu,Gangping Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5
This paper presents the experimental investigation carried out for evaluation of the rheological behaviours of Hangzhou soft clay, and proposes a three-dimensional elastic viscoplastic model to describe the rheological characteristics under triaxial condition. Firstly, the time-dependent behaviours of Hangzhou soft clay, such as creep and strain rate effects, were observed and discussed based on the analysis of rheological tests. Subsequently, a constitutive model was formulated under the framework of Perzyna’s overstress theory and incorporates other developments, including: 1) A smooth and continuous egg-shaped yield surface, whose shape can change from an ellipse to a teardrop shape, thus providing greater flexibility for better modelling; 2) An equivalent time concept, which enables the model to describe the time-dependent behaviours under different loading paths. By varying the shape parameter, the newly established model can be degenerated into modified Cam-clay (MCC) model or Yin-Graham elastic viscoplastic model. Finally, the model was solved numerically using the fourth-order convergent iterative method combined with the Runge-Kutta method. Comparison of simulation results and experimental data shows that the newly proposed model has an ability to predict creep characteristics and strain rate effects of soft clay.
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Han, Jung Min,Park, Sang Gyu,Liu, Bei,Park, Bum-Joon,Kim, Jin Young,Jin, Cheng He,Song, Yeong Wook,Li, Zihai,Kim, Sunghoon Elsevier 2007 The American journal of pathology Vol.170 No.6
<P>Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1; previously known as p43) is a multifunctional protein that was initially found in multitRNA synthetase complex. In the present study, screening of the AIMP1-binding proteins revealed that AIMP1 can form a molecular complex with heat shock protein gp96. AIMP1 enhances gp96 dimerization and the interaction between gp96 and KDEL receptor-1 (KDELR-1), which mediates the retrieval of KDEL-containing proteins from Golgi to the endoplasmic reticulum (ER). The interaction between gp96 and KDELR-1 was reduced in AIMP1-deficient cells, and this disturbed ER retention of gp96 and increased its cell surface localization. Moreover, this localization of gp96 at the cell surface was suppressed by its interaction with AIMP1 and enhanced by the depletion of endogenous AIMP1. In addition, AIMP1-deficient mice showed dendritic cell activation attributable to increased gp96 surface presentation and lupus-like autoimmune phenotypes. These results suggest that AIMP1 acts as a regulator of the ER retention of gp96 and provide a new perspective of the regulatory mechanism underlying immune stimulation by gp96.</P>
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