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Evaluation on Dry Sliding Wear Behavior of (TiB+TiC)/Ti- 6Al-4V Matrix Composite
Zi-Run Yang,Hai-Xiang Huan,Cui-Feng Jiang,Wen-Min Li,Xue-Ran Liu,류성기 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.8
The dry sliding wear tests were performed for 10 vol.% (TiB+TiC)/Ti-6Al-4V matrix composites at various test conditions. The morphology and phases of worn surfaces and cross-sectional surfaces were investigated by using scanning electron microscopy (SEM) and X-ray diffraction (XRD). The wear loss of composites with the increase of load, but the wear behavior got more complex when the sliding speed and ambient temperature got higher. Low wear loss was achieved at lower sliding speed with higher temperature or higher sliding speed with lower temperature. A tribo-layer was always formed on worn surface during testing. It possessed different features and thus presented different effects during sliding wear. Meanwhile, the TiB and TiC particulates strengthened the Ti-6Al- 4V matrix, which increased the thermal stability of composites and postponed the occurrence of severe plastic deformation. In the mild wear region, those particulates could directly resist wear by reducing adhesive wear. In the steady stage, fractured TiB and TiC particulates participated in forming the tribo-layer together with wear debris, which effectively hindered the plastic deformation and thermal softening of the matrix. Experiment results suggest that the existence of different characteristic tribo-layers would result in the variation of wear behavior.
( Zi-jiang Li ),( Shilin Chen ),( Xiang-hao Yang ),( Rui Wang ),( Hee-jeong Min ),( Lei Wu ),( Chuan-ling Si ),( Young-soo Bae ) 한국목재공학회 2018 목재공학 Vol.46 No.2
Juglans mandshurica is a fast growing hard species, which is a tree in family of Juglandaceae and has a wide distribution in China, Korea and eastern Russia. Plant materials from J. mandshurica have extensively been used in folk medicines to prevent or cure gastric, esophageal, lung and cardiac cancer. As one chain of our searching for anticomplementary agents from natural sources, two epimeric ellagitannins, [2,3-O-4,4′,5,5′,6,6′,-hexahydroxydiphenoyl (HHDP))-(α,β)-D-glucose] (I) and pedunculagin (II) were purified from 70% acetone extracts of the stem barks of J. mandshurica by Thin Layer Chromatography and Sephadex LH-20 column chromatography approaches. The chemical structures of the isolated compounds were characterized by MS, NMR, and a careful comparation with published literatures. The epimeric ellagitannins I and II exhibited inhibitory properties against a classical pathway of complementary system with 50 % inhibitory concentrations (IC<sub>50</sub>) values of 65.3 and 47.7 μM, respectively, comparing with riliroside (IC<sub>50</sub>=104 μM) and rosmarinic acid (IC<sub>50</sub>=182 μM), which were used as positive controls. Thus, the work indicated both the two secondary metabolites possess excellent inhibitory activity and might be developed as potential anticomplementary chemicals.
( Won Seok Yang ),( Xiang Zi Han ),( Kyoung Soon Lee ),( Kyung Min Lee ),( Ji Hyun Ju ),( In Cheol Shin ) 한국환경생물학회 2011 환경생물 : 환경생물학회지 Vol.29 No.1
In this study we present a mammalian cell culture model that allows to study the effect of endocrine disruptors (EDCs) on aromatase activity of aquatic amphibian, Bombina orientalis. Bombina orientalis aromatase gene was subcloned into a mammalian expression vector and subsequently transfected to mammalian cells. Although the protein expression level of Bombina orientalis aromatase was low, it had a significant aromatase activity. When EDCs were added to aromatase transfected cells, aromatase activity was significantly decreased. We report here that this system may be used to monitor the effect of EDCs on aromatase activity of aquatic organisms.
OPTIMAL LAUNCHING-INTENTION-AWARE CONTROL STRATEGY FOR AUTOMATED CLUTCH ENGAGEMENT
Yi-yong Yang,Zao-bei Zhu,Xiang-yu Wang,Zheng Chen,Zi-lin Ma 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.3
Clutch engagement control is critical during launching process in a vehicle equipped with an automated manual transmission (AMT), which is a problem including muti-objective optimization and nonlinear control. In this paper, a optimal launching-intention-aware control strategy is proposed for clutch engagement. Firstly, a launching-intention-aware machine (LIAM) based on artificial neural network (ANN) is designed to identify the driver’s launching intentions. Then the optimal laws of clutch engagement for different launching conditions are obtained based on the dynamic programming (DP), which regard friction loss, vehicle shock, angular acceleration of engine and engine torque as the optimizing indexes. Next, a slidingmode controller (SMC) is designed for the clutch engagement. Finally, the performances of the optimal laws and the SMC are validated by the joint simulation of Simulink-AMESim, and the results show that the requirements of vehicle launching are met. The proposed clutch engagement control strategy would provide a better theoretical support for the practical-extended application of AMT.
Computational Prediction of Alzheimer's and Parkinson's Disease MicroRNAs in Domestic Animals
Wang, Hai Yang,Lin, Zi Li,Yu, Xian Feng,Bao, Yuan,Cui, Xiang-Shun,Kim, Nam-Hyung Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.6
As the most common neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the main health concerns for the elderly population. Recently, microRNAs (miRNAs) have been used as biomarkers of infectious, genetic, and metabolic diseases in humans but they have not been well studied in domestic animals. Here we describe a computational biology study in which human AD- and PD-associated miRNAs (ADM and PDM) were utilized to predict orthologous miRNAs in the following domestic animal species: dog, cow, pig, horse, and chicken. In this study, a total of 121 and 70 published human ADM and PDM were identified, respectively. Thirty-seven miRNAs were co-regulated in AD and PD. We identified a total of 105 unrepeated human ADM and PDM that had at least one 100% identical animal homolog, among which 81 and 54 showed 100% sequence identity with 241 and 161 domestic animal miRNAs, respectively. Over 20% of the total mature horse miRNAs (92) showed perfect matches to AD/PD-associated miRNAs. Pigs, dogs, and cows have similar numbers of AD/PD-associated miRNAs (63, 62, and 59). Chickens had the least number of perfect matches (34). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses suggested that humans and dogs are relatively similar in the functional pathways of the five selected highly conserved miRNAs. Taken together, our study provides the first evidence for better understanding the miRNA-AD/PD associations in domestic animals, and provides guidance to generate domestic animal models of AD/PD to replace the current rodent models.