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MSC p43 required for axonal development in motor neurons.
Zhu, Xiaodong,Liu, Yang,Yin, Yanqing,Shao, Aiyun,Zhang, Bo,Kim, Sunghoon,Zhou, Jiawei National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.37
<P>Neuron connectivity and correct neural function largely depend on axonal integrity. Neurofilaments (NFs) constitute the main cytoskeletal network maintaining the structural integrity of neurons and exhibit dynamic changes during axonal and dendritic growth. However, the mechanisms underlying axonal development and maintenance remain poorly understood. Here, we identify that multisynthetase complex p43 (MSC p43) is essential for NF assembly and axon maintenance. The MSC p43 protein was predominantly expressed in central neurons and interacted with NF light subunit in vivo. Mice lacking MSC p43 exhibited axon degeneration in motor neurons, defective neuromuscular junctions, muscular atrophy, and motor dysfunction. Furthermore, MSC p43 depletion in mice caused disorganization of the axonal NF network. Mechanistically, MSC p43 is required for maintaining normal phosphorylation levels of NFs. Thus, MSC p43 is indispensable in maintaining axonal integrity. Its dysfunction may underlie the NF disorganization and axon degeneration associated with motor neuron degenerative diseases.</P>
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Xiaodong Wang,Xingguo Liu1,Boqiang Qin,Zhaojun Gu,Hao Xu,Hao Zhu,Guofeng Cheng,Huang Liu 한국생태학회 2015 Journal of Ecology and Environment Vol.38 No.3
In order to understand the mechanisms of conversion between different algal dominance, an experiment was performed in a greenhouse from 22 June to 10 July 2011. The experiment included a treatment group subjected to three instances of nutrient enrichment and a control with no nutrient enrichment. The initial water was dominated by Ankistrodesmus of Chlorophyta. The average water temperature at 08:30 h and 14:00 h during the experiment was 31.6°C and 34.6°C, respec¬tively. The results showed that the total nitrogen (TN), total phosphorus (TP), dissolved total nitrogen (DTN), dissolved total phosphorus (DTP), and soluble reactive phosphorus (SRP) concentrations in the treatment were significantly higher than in the control (P < 0.05). However, the TN/TP and DTN/DTP in the control was higher than in the treatment (P < 0.05). The dominant algae in the control did not change during the experiment, while the dominant algae in the treat¬ment switched to Planktothrix of Cyanophyta on day 9. The chlorophyll a (Chl-a), wet weight of all algae, wet weight of Cyanophyta, and percentage of Cyanophyta in the control were all significantly lower than in the treatment (P < 0.05). Amounts of zooplankton, especially rotifers, were present at the end of the experimental period. The density of rotifers between the control and treatment was not significantly different (P > 0.05), while the copepod density in the treatment was higher than in the control (P < 0.05). We conclude that green algae dominance quickly switches to cyanobacteria dominance after nutrient enrichment in a greenhouse with elevated temperature
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Compact Band-notched UWB Antenna Design Based On Transmission Line Model
Zhu, Xiaoming,Yang, Xiaodong,Chen, Peng The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.1
In order to avoid the interference from existing narrowband communication systems, this paper proposes a compact band-notched UWB (ultra wideband) antenna with size of $12mm{\times}22mm{\times}1.6mm$. Transmission line model is applied to analyzing wide impedance matching characteristic of the modified base antenna, which has a gradual stepped impedance feeder structure. The proposed antenna realizes dual band-notched function by combining two biased T-shaped parasitic elements on the rear side with a window aperture on the radiation patch. The simulation current distributions of the antenna reflect resonant suppression validity of the two methods. In addition, the measured radiation characteristics demonstrate the proposed antenna prevents signal interference from WLAN (5.15-5.825GHz) and WiMAX (3.4-3.69GHz) effectively, and the measured patterns show the antenna omnidirectional radiation in working frequencies.
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Zhang, Xiaodong,Tao, Qiangqiang,Shang, Jinnan,Xu, Yiliang,Zhang, Liang,Ma, Yingchun,Zhu, Weihua,Yang, Min,Ding, Yueyun,Yin, Zongjun Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.4
Objective: Apoptosis of ovarian granulosa cells (GCs) affects mammalian follicular development and fecundity. This study aimed to explore the regulatory relationship between microRNA-26a (miR-26a) and the 3β-hydroxysteroid-Δ24-reductase gene (DHCR24) gene in porcine follicular granular cells (pGCs), and to provide empirical data for the development of methods to improve the reproductive capacity of pigs. Methods: The pGCs were transfected with miR-26a mimic, miR-26a inhibitor and DHCR24-siRNA in vitro. The cell apoptosis rate of pGCs was detected by the flow cytometry. The secretion levels of estradiol (E2) and progesterone (P) in pGCs were detected by enzyme-linked immunosorbent assay. Double luciferase validation system was used to detect the binding sites between miR-26a and DHCR24 3'-UTR region. Qualitative real-time polymerase chain reaction and Western blotting were used to verify the DHCR24 mRNA and protein expression in pGCs, respectively, after transfecting with miR-26a mimic and miR-26a inhibitor. Results: Results showed that enhancement of miR-26a promoted apoptosis, and inhibited E2 and P secretion in pGCs. Meanwhile, inhibition of DHCR24 also upregulated the Caspase-3 expression, reduced the BCL-2 expression, promoted pGCs apoptosis, and inhibited E2 and P secretion in pGCs. There were the binding sites of miR-26a located within DHCR24 3'-UTR. Up-regulation of miR-26a inhibited DHCR24 mRNA and protein expression in pGCs. Conclusion: This study demonstrates that miR-26a can promote cell apoptosis and inhibit E2 and P secretion by inhibiting the expression of DHCR24 in pGCs.
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Compact Band-notched UWB Antenna Design Based On Transmission Line Model
Xiaoming Zhu,Xiaodong Yang,Peng Chen 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.1
In order to avoid the interference from existing narrowband communication systems, this paper proposes a compact band-notched UWB (ultra wideband) antenna with size of 12mm×22mm ×1.6mm. Transmission line model is applied to analyzing wide impedance matching characteristic of the modified base antenna, which has a gradual stepped impedance feeder structure. The proposed antenna realizes dual band-notched function by combining two biased T-shaped parasitic elements on the rear side with a window aperture on the radiation patch. The simulation current distributions of the antenna reflect resonant suppression validity of the two methods. In addition, the measured radiation characteristics demonstrate the proposed antenna prevents signal interference from WLAN (5.15-5.825GHz) and WiMAX (3.4-3.69GHz) effectively, and the measured patterns show the antenna omnidirectional radiation in working frequencies.
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Wang, Xiaodong,Liu, Xingguo,Qin, Boqiang,Gu, Zhaojun,Wu, Zongfan,Xu, Hao,Zhu, Hao,Cheng, Guofeng,Liu, Huang The Ecological Society of Korea 2015 Journal of Ecology and Environment Vol.38 No.3
In order to understand the mechanisms of conversion between different algal dominance, an experiment was performed in a greenhouse from 22 June to 10 July 2011. The experiment included a treatment group subjected to three instances of nutrient enrichment and a control with no nutrient enrichment. The initial water was dominated by Ankistrodesmus of Chlorophyta. The average water temperature at 08:30 h and 14:00 h during the experiment was $31.6^{\circ}C$ and $34.6^{\circ}C$, respectively. The results showed that the total nitrogen (TN), total phosphorus (TP), dissolved total nitrogen (DTN), dissolved total phosphorus (DTP), and soluble reactive phosphorus (SRP) concentrations in the treatment were significantly higher than in the control (P < 0.05). However, the TN/TP and DTN/DTP in the control was higher than in the treatment (P < 0.05). The dominant algae in the control did not change during the experiment, while the dominant algae in the treatment switched to Planktothrix of Cyanophyta on day 9. The chlorophyll a (Chl-a), wet weight of all algae, wet weight of Cyanophyta, and percentage of Cyanophyta in the control were all significantly lower than in the treatment (P < 0.05). Amounts of zooplankton, especially rotifers, were present at the end of the experimental period. The density of rotifers between the control and treatment was not significantly different (P > 0.05), while the copepod density in the treatment was higher than in the control (P < 0.05). We conclude that green algae dominance quickly switches to cyanobacteria dominance after nutrient enrichment in a greenhouse with elevated temperature.
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Atomic-Scale Spectroscopy of Gated Monolayer MoS<sub>2</sub>
Zhou, Xiaodong,Kang, Kibum,Xie, Saien,Dadgar, Ali,Monahan, Nicholas R.,Zhu, X.-Y.,Park, Jiwoong,Pasupathy, Abhay N. American Chemical Society 2016 NANO LETTERS Vol.16 No.5
<P>The electronic properties of semiconducting monolayer transition-metal dichalcogenides can be tuned by electrostatic gate potentials. Here we report gate-tunable imaging and spectroscopy of monolayer MoS<SUB>2</SUB> by atomic-resolution scanning tunneling microscopy/spectroscopy (STM/STS). Our measurements are performed on large-area samples grown by metal–organic chemical vapor deposition (MOCVD) techniques on a silicon oxide substrate. Topographic measurements of defect density indicate a sample quality comparable to single-crystal MoS<SUB>2</SUB>. From gate voltage dependent spectroscopic measurements, we determine that in-gap states exist in or near the MoS<SUB>2</SUB> film at a density of 1.3 × 10<SUP>12</SUP> eV<SUP>–1</SUP> cm<SUP>–2</SUP>. By combining the single-particle band gap measured by STS with optical measurements, we estimate an exciton binding energy of 230 meV on this substrate, in qualitative agreement with numerical simulation. Grain boundaries are observed in these polycrystalline samples, which are seen to not have strong electronic signatures in STM imaging.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2016/nalefd.2016.16.issue-5/acs.nanolett.6b00473/production/images/medium/nl-2016-004733_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl6b00473'>ACS Electronic Supporting Info</A></P>
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Ning Zhu,Yi Gong,Jian He,Jingwen Xia,Xiaodong Chen 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.6
Purpose: Methylenetetrahydrofolate reductase (MTHFR) has been implicated in lung cancer risk and response to platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC). However, the results are controversial. We performed meta-analysis to investigate the effect of MTHFR C677T polymorphism on lung cancer risk and response to platinum-based chemotherapy in advanced NSCLC. Materials and Methods: The databases of PubMed, Ovid, Wanfang and Chinese Biomedicine were searched for eligible studies. Nineteen studies on MTHFR C677T polymorphism and lung cancer risk and three articles on C677T polymorphism and response to platinum-based chemotherapy in advanced NSCLC, were identified. Results: The results indicated that the allelic contrast, homozygous contrast and recessive model of the MTHFR C677T polymorphism were associated significantly with increased lung cancer risk. In the subgroup analysis,the C677T polymorphism was significantly correlated with an increased risk of NSCLC, with the exception of the recessive model. The dominant model and the variant T allele showed a significant association with lung cancer susceptibility of ever smokers. Male TT homozygote carriers had a higher susceptibility, but the allelic contrast and homozygote model had a protective effect in females. No relationship was observed for SCLC in any comparison model. In addition, MTHFR 677TT homozygote carriers had a better response to platinum-based chemotherapy in advanced NSCLC in the recessive model. Conclusion: The MTHFR C677T polymorphism might be a genetic marker for lung cancer risk or response to platinum-based chemotherapy in advanced NSCLC. However, our results require further verification.
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