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Xu, Zhong,Sun, Hao,Zhang, Zhe,Zhang, Cheng-Yue,Zhao, Qing-bo,Xiao, Qian,Olasege, Babatunde Shittu,Ma, Pei-Pei,Zhang, Xiang-Zhe,Wang, Qi-Shan,Pan, Yu-Chun Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.2
Objective: Porcine respiratory disease is one of the most important health problems causing significant economic losses. To understand the genetic basis for susceptibility to swine enzootic pneumonia (EP) in pigs, we detected 102,809 single nucleotide polymorphisms in a total of 249 individuals based on genome-wide sequencing data. Methods: Genome comparison of susceptibility to swine EP in three pig breeds (Jinhua, Erhualian, and Meishan) with two western lines that are considered more resistant (Duroc and Landrace) using cross-population extended haplotype homozygosity and F-statistic (F<sub>ST</sub>) statistical approaches identified 691 positively selected genes. Based on quantitative trait loci, gene ontology terms and literature search, we selected 14 candidate genes that have convincible biological functions associated with swine EP or human asthma. Results: Most of these genes were tested by several methods including transcription analysis and candidate genes association study. Among these genes: cytochrome P450 1A1 and catenin beta 1 (CTNNB1) are involved in fertility; transforming growth factor beta receptor 3 plays a role in meat quality traits; Wnt family member 2, CTNNB1 and transcription factor 7 take part in adipogenesis and fat deposition simultaneously; plasminogen activator, urokinase receptor (completely linked to AXL receptor tyrosine kinase, r<sup>2</sup> = 1) plays an essential role in the successful ovulation of matured oocytes in pigs; colipase like 2 (strongly linked to SAM pointed domain containing ETS transcription factor, r<sup>2</sup> = 0.848) is involved in male fertility. Conclusion: These adverse genes susceptible to swine EP may be selected while selecting for economic traits (especially reproduction traits) due to pleiotropic and hitchhiking effect of linked genes. Our study provided a completely new point of view to understand the genetic basis for susceptibility or resistance to swine EP in pigs thereby, provides insight for designing sustainable breed selection programs. Finally, the candidate genes are crucial due to their potential roles in respiratory diseases in a large number of species, including human.
Xu, Chun-Sheng,Zheng, Jian-Yong,Zhang, Hai-Long,Zhao, Hua-Dong,Zhang, Jing,Wu, Guo-Qiang,Wu, Lin,Wang, Qing,Wang, Wei-Zhong,Zhang, Jian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Esophageal carcinoma (EC) is one of the most aggressive cancers with a poor prognosis. Understanding the molecular mechanisms underlying esophageal cancer progression is a high priority for improved EC diagnosis and prognosis. Recently, MSP58 was shown to behave as an oncogene in colorectal carcinomas and gliomas. However, little is known about its function in esophageal carcinomas. We therefore examined the effects of MSP58 knockdown on the growth of esophageal squamous cell carcinoma (ESCC) cells in vitro and in vivo in order to gain a better understanding of its potential as a tumor therapeutic target. We employed lentiviral-mediated small hairpin RNA (shRNA) to knock down the expression of MSP58 in the ESCC cell lines Eca-109 and EC9706 and demonstrated inhibition of ESCC cell proliferation and colony formation in vitro. Furthermore, flow cytometry and western blot analyses revealed that MSP58 depletion induced cell cycle arrest by regulating the expression of P21, CDK4 and cyclin D1. Notably, the downregulation of MSP58 significantly inhibited the growth of ESCC xenografts in nude mice. Our results suggest that MSP58 may play an important role in ESCC progression.
Zhang, Chun,Huang, Jie-Zhong,Song, Gu-Quan,Dai, Lin,Li, Huo-Kun Techno-Press 2016 Structural monitoring and maintenance Vol.3 No.2
It is a challenging problem of assessing the location and extent of structural damages with vibration measurements. In this paper, an improved Extended Kalman filter (EKF) with Tikhonov regularization is proposed to identify structural damages. The state vector of EKF consists of the initial values of modal coordinates and damage parameters of structural elements, therefore the recursive formulas of EKF are simplified and modal truncation technique can be used to reduce the dimension of the state vector. Then Tikhonov regularization is introduced into EKF to restrain the effect of the measurement noise for improving the solution of ill-posed inverse problems. Numerical simulations of a seven-story shear-beam structure and a simply-supported beam show that the proposed method has good robustness and can identify the single or multiple damages accurately with the unknown initial structural state.
The Outlier Detection Algorithm Based on Cumulative Holoentropy in Clustering Subspace
Zhang Zhong-ping,Sun Ying,Fang Chun-zhen,Wang Ying 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.10
Subspace outlier mining has a very important significance in big data analysis. To a large extent, subspace clustering algorithm has impact on the efficiency of mining outliers in subspaces. To solve the problem that CMI method selects best clustering subspaces unstably and complexly, formulas of chain rule of Cumulative Entropy, Cumulative Total Correlation and Cumulative Holoentropy were given. Cumulative Holoentropy was used to mine the best clustering subspaces on continuous data sets in which outliers were detected. Subspace outlier detection algorithm based on Cumulative Holoentropy was then proposed. Finally, the validity and scalability of proposed method were tested on real datasets and virtual datasets. Experiment shows that the efficiency of mining outliers in subspaces is enhanced by the proposed algorithm.
No Blind Spot: Network Coverage Enhancement Through Joint Cooperation and Frequency Reuse
Zhong, Yi,Qiao, Pengcheng,Zhang, Wenyi,Zheng, Fu-chun The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.5
Both coordinated multi-point transmission and frequency reuse are effective approaches to mitigate inter-cell interference and improve network coverage. The motivation of this work is to explore the manner to effectively utilize the spectrum resource by reasonably combining cooperation and frequency reuse. The $Mat{\acute{e}}rn$ cluster process, which is appropriate to model networks with hot spots, is used to model the spatial distribution of base stations. Two cooperative mechanisms, coherent and non-coherent joint transmission (JT), are analyzed and compared. We also evaluate the effect of multiple antennas and imperfect channel state information. The simulation reveals that the proposed approach to combine cooperation and frequency reuse is effective to improve the network coverage for users located at both the center and the boundary of the cooperative region.
Study on Fault Prediction of Equipments Based on Extension Theory
Ti-chun Wang,Xiao-yi Chen,Shi-sheng Zhong,Yong-jian Zhang 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.5
Due to the lack of condition monitoring and health analysis of the equipment in the daily operations, serious accident happened and it caused the incorrect results of fault diagnosis. We propose a method of condition monitoring and fault prediction based on extension theory. The method established a matter element mode to give the formal description of the state of the equipment. It used dependent function to do the qualitative and quantitative analysis of the equipment state. Through the method, we can change the model of maintenance which is always done after fault occurred. We use the method on the example of turbines to prove the feasibility and effectiveness of the method.
No Blind Spot: Network Coverage Enhancement Through Joint Cooperation and Frequency Reuse
Yi Zhong,Pengcheng Qiao,Wenyi Zhang,Fu-chun Zheng 한국통신학회 2016 Journal of communications and networks Vol.18 No.5
Both coordinated multi-point transmission and frequencyreuse are effective approaches to mitigate inter-cell interferenceand improve network coverage. The motivation of thiswork is to explore the manner to effectively utilize the spectrum resourceby reasonably combining cooperation and frequency reuse. The Mat´ern cluster process, which is appropriate to model networkswith hot spots, is used to model the spatial distributionof base stations. Two cooperative mechanisms, coherent and noncoherentjoint transmission (JT), are analyzed and compared. Wealso evaluate the effect of multiple antennas and imperfect channelstate information. The simulation reveals that the proposed approachto combine cooperation and frequency reuse is effective toimprove the network coverage for users located at both the centerand the boundary of the cooperative region.