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      • KCI등재

        Interaction Matrix Based Analysis and Asymptotic Cooperative Control of Multi-agent Systems

        Zhicheng Hou,Jianxin Xu,Gong Zhang,Weijun Wang,Changsoo Han 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.5

        In this paper, we investigate a decentralized asymptotic cooperative control problem of multi-agent systems with leader-follower configuration. We firstly develop a new method using a proposed “interaction matrix” for the analysis of cooperation convergence of multi-agent systems, i.e. both consensus of the agents states and trajectory tracking of the whole group can be instantaneously concluded only by observing the minimum eigenvalue of the interaction matrix. For a multi-agent system, the external given desired trajectory can be partially obtained (through sensing or detecting) by the leaders, but higher-order derivatives such as acceleration and jerk of the desired trajectory cannot be obtained. In this case, by using some conventional control methods, the trajectory tracking performance is always not satisfactory when a trajectory varies aggressively w.r.t. time. For the sake of asymptotic tracking of an arbitrary given external trajectory of a multi-agent system, we develop a nonlinear cooperative controller based on the robust integral of signum of cooperative error (RISCE) technique, where the interaction matrix is used. The simulation results show asymptotic convergence of cooperation by using the proposed control, and better performance compared to composited nonlinear feedback based PD (CNF-PD) control.

      • KCI등재

        Simultaneous optimization of ultrasound-assisted extraction for total flavonoid content and antioxidant activity of the tender stem of Triarrhena lutarioriparia using response surface methodology

        Qingming Cao,Jianye Yan,Zhicheng Sun,Limin Gong,Hongnian Wu,Shihan Tan,Yating Lei,Bo Jiang,Yuanqing Wang 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.1

        The asparagus of Triarrhena lutarioriparia (TL)is a popular vegetable with abundant chemical compoundsin China. This study aims to optimize the ultrasound-assistedextraction (UAE) method for its content of totalflavonoid and antioxidant activities by response surfacemethodology (RSM). Box-Behnken design was adopted toevaluate the influences of ethanol concentration, extractiontime and solvent-to-sample ratio on the extraction yield oftotal flavonoid and the antioxidant activity. Considering themaximum content of extracted total flavonoids andantioxidant activity, the optimal extraction conditions wereacquired with 70% (v/v) ethanol by UAE for 60 min at asolvent-to-sample ratio of 40 mL/g. The proportion of theextraction of total flavonoid was 15.88 mg/g and antioxidantactivity reached 79.53%. The RSM would be recommendedas an appropriate model for simultaneousoptimization of the UAE conditions for the content of totalflavonoid and the antioxidant activity of asparagus of TL.

      • KCI등재

        Myo-Inositol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy by Inhibiting PI3K/AKT Activation

        Xiaofang Hu,Ming Yang,Xiangyi Li,Zhicheng Gong,Jianxiu Duan 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.6

        Emerging evidence suggests that myo-inositol (MI) has a critical role in reducing renal inflammatory processes and improving podocyte function and preventing diabetes-related renal damage. We aimed to explore the function and underlying workings of MI in renal interstitial fibrosis (RIF). Based on a mouse model, we explored the effect of MI in unilateral ureteral obstruction (UUO) and in transforming growth factor-β1 (TGF-β1)-treated HK-2 cells. Pathological changes of the kidney tissues were examined following staining of the tissues with hematoxylin, eosin, and Masson's trichrome. The mRNA quantities of fibrosis markers, fibronectin, α-smooth muscle actin (α-SMA), and collagen I, were analyzed by means of real-time polymerase chain reaction, whereas those of protein levels were assessed with Western blotting. We also determined the expression of collagen I by immunofluorescence, and the levels of phosphorylated phosphotidylinositol-3-kinase and protein kinase B (PI3K/AKT) by Western blot. In vivo, histopathological examination in the UUO mice revealed renal tubular epithelial cell necrosis, inflammatory cell infiltration, and RIF. UUO mice showed higher expression levels of collagen I, fibronectin, α-SMA, pPI3K, and pAKT compared with sham-operated mice. However, MI treatment diminished the pathological alterations of RIF in UUO mice and downregulated the expression of fibrosis markers and phosphorylated PI3K/AKT. In vitro, TGF-β1 positively influenced the propagation and differentiation of HK-2 cells and upregulated the levels of α-SMA, fibronectin, collagen I, pPI3K, and pAKT, but these became significantly reversed by MI treatment. In conclusion, MI ameliorates RIF, possibly by negatively regulating TGF-β1-induced epithelial transdifferentiation and PI3K/AKT activation.

      • KCI등재

        Strength, deformation and failure behavior of bolted rock-like specimen with multiple cracks under uniaxial compression by particle flow simulation

        Wendong Yang,Yiwei Li,Ling Wang,Kaicheng Zhang,Zhicheng Gong 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.6

        Most of the rock mass in nature contains a large number of joints, faults and other defects, which make the rock mass have the characteristics of discontinuity and anisotropy, and easily lead to instability and failure of rock engineering. A great quantity of engineering practices show that the bolt has a significant supporting effect on jointed rock mass. Therefore, it is of great significance to study the deformation and failure characteristics of jointed rock mass and the crack arrest effect of bolt for the safety and stability of engineering. A reasonable numerical model of bolted rock samples with non-persistent joints is established by using a three-dimensional Particle Flow Code (PFC) based on the laboratory rock specimens, and the uniaxial compression numerical test is carried out. The results indicate that (1) the numerical simulation results are in good agreement with the laboratory test results, and the variation trend of strength is basically consistent; (2) the different joint angles and anchorage angles result in variations in the mechanical properties of bolted specimens with non-persistent joints; (3) the joint angle has a significant effect on the failure mode of the specimen; (4) the existence of bolts can effectively limit the initiation and propagation process of micro-cracks, and greatly improve the mechanical properties of the specimen containing non-persistent joints.

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