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      • Research on the Problems and Development Countermeasures of China's New Energy Vehicles : Based on SCP model

        ( Zhi-chun Yu ),( Young-jun Choi ) 국제지역학회 2020 국제지역학회 추계학술대회 자료집 Vol.2020 No.0

        The automobile industry is one of China's pillar industries. In recent years, consumers' awareness of new energy vehicles has increase d and the concept of low-carbon life consumption has deepened. New energy vehicles have entered the public's field of vision. However, due to the worldwide outbreak of the new coronavirus, the automotive industry is currently facing tremendous pressure, challenges and opportunities. This requires automotive companies to accelerate industrial transformation and optimize the pace of upgrading to overcome difficulties and grow stronger. This paper uses the SCP model framework to analyze China's new energy automobile industry from the aspects of market structure, corporate competitive behavior, and industry performance, so as to put forward corresponding policy recommendations for the development of China's new energy automobile industry

      • KCI등재

        GVC의 전방 및 후방 참여가 ASEAN에서 중국의 OFDI에 미치는 영향

        ( Zhi-chun Yu ),( Meng Li ),( Young-jun Choi ) 한국동남아학회 2021 동남아시아연구 Vol.31 No.3

        본 논문은 주로 ASEAN 글로벌 가치 사슬(GVC, global value chains)에 대한 전방 참여와 후방 참여가 중국의 아세안 투자에 미치는 영향을 연구한다. 연구 결과에 따르면 ASEAN 국가들의 GVC 전방 참여는 중국의 아세안 10개국 투자에 부정적인 영향을 미치는 반면 후방 참여는 긍정적인 영향을 미치는 것으로 나타났다. 아세안의 기술 발전, 고학력 노동력의 확대, 소비자 시장 소비 잠재력의 증가, 인프라 개선 및 시장 개방도는 중국의 아세안 투자를 유치하고 확대할 것이다. 이는 중국이 ASEAN 제조에 대한 투자 외에도 ASEAN 국가의 교육, 기술 연구 및 개발, 기반 시설 건설 및 3차 산업에 대한 투자를 촉진할 수 있음을 의미한다. 아세안 국가의 인건비는 아세안에 대한 중국의 투자와 긍정적인 상관관계가 있는 반면 천연자원은 부정적인 상관관계가 있다. 중국 기업은 아세안 국가의 풍부한 노동력을 최대한 활용하여 생산 비용을 절감하고 현지 소비 습관 및 선호도에 따라 시장을 적절하게 개발하여 가계 소비를 촉진하고 기업 이윤을 높일 것을 권장한다. 아세안 국가는 개방을 강화하고 인프라 건설을 개선하며 첨단 기술 인재 양성을 중시하고 중국을 포함한 더 많은 외국인 투자를 유치해야 한다. This paper mainly studies the impact of forward and backward participation in ASEAN global value chains on China's investment in ASEAN. The results show that forward participation in global value chains is negatively correlated with China's investment in ASEAN, while backward participation is positively correlated. The technological advancement of ASEAN, the expansion of the number of highly educated labor force, the increase of consumer market consumption potential, the improvement of infrastructure, and the degree of openness of the market will attract and expand China's investment in ASEAN. This means that in addition to investment in ASEAN manufacturing, China can also promote investment in education, technology research and development, infrastructure construction, and tertiary industries in ASEAN countries. The labor cost of ASEAN countries is positively correlated with China's investment in ASEAN, while natural resources are negatively correlated. It is recommended that Chinese companies make full use of the abundant labor resources of ASEAN countries, reduce production costs, and appropriately develop markets according to local consumption habits as well as preferences, stimulate household consumption, and increase corporate profits. ASEAN countries need to strengthen opening up, improve infrastructure construction, attach importance to the training of high-tech talents, and attract more foreign investment, including China.

      • KCI등재

        Nucleophosmin modulates the alleviation of atopic dermatitis caused by the marine-derived compound dihydroaustrasulfone alcohol

        Han-Chun Hung,Chien-Wei Feng,Yen-You Lin,Chun-Hong Chen,Kuan-Hao Tsui,Wu-Fu Chen,Chieh-Yu Pa,Jyh-Horng Sheu,Chun-Sung Sung,Zhi-Hong Wen 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

        Atopic dermatitis (AD) is a chronic inflammatory skin disease, and its prevalence is increasing. AD usually elicits skin barrier dysfunction, dry skin and itching. As the mechanisms of AD remain unknown, there is an urgent need to find effective therapies. Because of the diversity and complexity of marine environments, the discovery of drugs from marine organisms as novel therapeutic agents for human diseases has seen renewed interest. Dihydroaustrasulfone alcohol (WA-25), the synthetic precursor of austrasulfone, which is a natural product isolated from a Formosan soft coral, has been shown to possess many therapeutic effects in our previous studies. However, the detailed mechanisms and therapeutic effects of WA-25 on AD are incompletely understood. We performed in vitro and in vivo studies to examine the effects of WA-25 on AD. We showed that WA-25 blocks inflammation and oxidative stress. Simultaneously, we also found that WA-25 reduces the AD scores and AD-induced transepidermal water loss (TEWL), scratching behavior, and alloknesis. WA-25 is more effective in cases of AD than are the drugs that are currently used clinically. Importantly, we also found that when nucleophosmin (NPM) was inhibited or when its expression was reduced, the anti-inflammatory and anti-AD effects of WA-25 were blocked. These data suggest that NPM plays dual roles in inflammation and AD. Overall, these results suggest that WA-25 is a potential anti-inflammatory and AD therapeutic agent that is modulated by NPM.

      • Psychosocial Response and Symptom Burden for Male Smokers with Lung Cancer

        Niu, Zhi-Min,Liang, Chun-Shui,Yu, Min,Wang, Yong-Sheng,Yu, Hai-Xia,Zhang, Qiong-Wen,Wei, Yu-Quan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

        Purpose: Cigarette smoking causes many kinds of cancer, and it is more closely related with lung cancer, rather than other cancers. Smoking is the leading cause of lung cancer and ninety percent of the smokers are male in China, but there is little published data concerning the psychological responses in the male smokers with lung cancer and its influence on the symptom burden. The aim of the study was to verify the hypothesis that male smokers with lung cancer have more positive attitude and less symptom burden, comparing to male non-smokers. Methods: A total of 194 men with cancer in West China Hospital, Sichuan, China, were assessed by self-administered questionnaire. Psychological response was measured by the Chinese version of Mini-Mental Adjustment to Cancer scale (Mini-MAC), and symptom burden was measured by the physical symptom distress scale from the Rotterdam Symptom Checklist (RSCL). Results: We found that smokers with lung cancer got higher scores in positive attitude and a smaller symptom burden than non-smokers. Patients with education lower than high school got higher scores of positive attitude compared to college graduate patients (p=0.038). Smokers with lung cancer who knew the potential carcinogenicity of cigarette showed less negative emotions (p=0.011). The psychological response was not affected by age, clinical stage, cell type, smoking duration and amount. Conclusions: Male smokers with lung cancer have a more positive attitude and fewer symptoms, comparing to male non-smokers. Appropriate psychological intervention for non-smokers with lung cancer deserves more attention.

      • Screening for Metastatic Osteosarcoma Biomarkers with a DNA Microarray

        Diao, Chun-Yu,Guo, Hong-Bing,Ouyang, Yu-Rong,Zhang, Han-Cong,Liu, Li-Hong,Bu, Jie,Wang, Zhi-Hua,Xiao, Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

        Objective: The aim of this study was to screen for possible biomarkers of metastatic osteosarcoma (OS) using a DNA microarray. Methods: We downloaded the gene expression profile GSE49003 from Gene Expression Omnibus database, which included 6 gene chips from metastatic and 6 from non-metastatic OS patients. The R package was used to screen and identify differentially expressed genes (DEGs) between metastatic and non-metastatic OS patients. Then we compared the expression of DEGs in the two groups and sub-grouped into up-regulated and down-regulated, followed by functional enrichment analysis using the DAVID system. Subsequently, we constructed an miRNA-DEG regulatory network with the help of WebGestalt software. Results: A total of 323 DEGs, including 134 up-regulated and 189 down-regulated, were screened out. The up-regulated DEGs were enriched in 14 subcategories and most significantly in cytoskeleton organization, while the down-regulated DEGs were prevalent in 13 subcategories, especially wound healing. In addition, we identified two important miRNAs (miR-202 and miR-9) pivotal for OS metastasis, and their relevant genes, CALD1 and STX1A. Conclusions: MiR-202 and miR-9 are potential key factors affecting the metastasis of OS and CALD1 and STX1A may be possible targets beneficial for the treatment of metastatic OS. However, further experimental studies are needed to confirm our results.

      • KCI등재

        Research on the Impact of ASEAN s GVC Participation and Position on Its Domestic Employment

        여지춘(Zhi-chun Yu),장하(He Zhang),최영준(Young-jun Choi) 한국산업경영학회 2021 경영연구 Vol.36 No.3

        본 논문은 2005년부터 2016년까지 아세안 글로벌 가치사슬 분업이 고용(남녀 고용 포함)에 미치는 영향을연구하기 위해 GLS 회귀분석을 활용한다. 결과는 아세안 국가들의 GVC 참여가 일반적으로 높지 않고, 후방참여보다 전방참여가 높은 것으로 나타났다. GVC_participation가 고용에 미치는 영향은 부정적이어서 아세안국가들의 참여가 늘어나면 고용 수요가 감소한다는 것으로 보인다. GVC_position은 아세안 국가들의 남성고용률에 큰 영향을 미치지 않는다. 따라서 아세안 국가들은 풍부한 인력 자원을 최대한 활용하고, 외국인투자를 유치하고 글로벌 가치사슬에서 아세안 국가들의 참여도를 강화할 것을 권고한다. 아울러 정부는 실업자들의 농촌창업을 독려하고 직업훈련에 박차를 가하며 제3차 산업을 활발히 발전시켜 여성의 서비스업 노동참가율을 높여야 한다. 아세안 국가들은 여성 교육에 중요성을 부여하고 여성의 전문기술 개발을 촉진해야한다. 마지막으로 아세안 10개국이 글로벌 가치사슬에서 입지를 강화하기 위해서는 독자적 혁신역량 향상과첨단기술 인재 양성을 중시하며 GVC의 후방참여를 늘려야 된다. This paper uses GLS regression analysis to study the impact of the ASEAN global value chain(GVC) division of labor on its employment (including male and female employment) from 2005 to 2016. The results show that GVC participation in ASEAN countries is generally not high, and forward participation is higher than backward participation. The impact of GVC participation on employment is significantly negative, indicating that the extension in the participation of ASEAN countries will reduce the demand for employment. GVC_position has no significant impact on male employment rate of ASEAN countries. Therefore, it is recommended that ASEAN countries make full use of abundant labor resources, attract foreign investment, and expand the participation of ASEAN countries in the GVC. Besides, the government encourages unemployed people to start businesses in rural areas, speeds up vocational training, and vigorously develops the tertiary industry, thereby increasing the labor participation rate of women in the service industry. ASEAN countries need to attach importance to women’s education and promote the development of women’s professional skills. Finally, ASEAN countries should improve their independent innovation capabilities, attach importance to the training of high-tech talents, and increase the backward participation of GVCs, so as to enhance the position of the ten ASEAN countries in the global value chain.

      • Pretreatment Thrombocytosis as a Prognostic Factor in Women with Gynecologic Malignancies: a Meta-analysis

        Yu, Min,Liu, Lei,Zhang, Bing-Lan,Chen, Qi,Ma, Xue-Lei,Wu, Yu-Ke,Liang, Chun-Shui,Niu, Zhi-Min,Qin, Xin,Niu, Ting Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

        Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.

      • KCI등재

        Isocoumarin Derivatives from the Sea Squirt-derived Fungus Penicillium stoloniferum QY2-10 and the Halotolerant Fungus Penicillium notatum B-52

        Zhi-Hong Xin,Li-Tian,Tian-jiao Zhu,Wen-Liang Wang,Lin Du,Yu-chun Fang,Qian-Qun Gu,Wei-Ming Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7

        Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5α, 8α-epidioxy-23-methyl- (22E, 24R)-ergosta-6, 22-dien-3β-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 µM.

      • KCI등재

        Study on an Optimal Control Method for Energy Injection Resonant AC/AC High Frequency Converters

        Yu-Gang Su,Xin Dai,Zhi-Hui Wang,Chun-Sen Tang,Yue Sun 전력전자학회 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.2

        In energy injection resonant AC-AC converters, due to the low frequency effect of the AC input envelope and the low energy injection losses requirement, the constant and steady control of the high frequency AC output envelope is still a problem that has not been solved very well. With the aid of system modeling, this paper analyzes the mechanism of the envelope pit on the resonant AC current. The computing methods for the critical damping point, the falling time and the bottom value of the envelope pit are presented as well. Furthermore, this paper concludes the stability precondition of the system AC output. Accordingly, an optimal control method for the AC output envelope is put forward based on the envelope prediction model. This control method can predict system responses dynamically under different series of control decisions. In addition, this control method can select best series of control decisions to make the AC output envelope stable and constant. Simulation and experimental results for a contactless power transfer system verify the control method.

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