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- 저자 : Zhenxing Guo (검색결과 3 건)
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Zhaoxia Wang,Zhenxing Zhang,Yanling Guo,Huifeng Shui,Guoqi Liu,Tianbo Jin,Huijie Wang 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods: We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. Results: Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p< 0.05). When the RTLs were categorized into tertiles, we found that the lowest RTL was significantly associated with increased breast cancer risk compared with the highest RTL (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.40–3.90; p=0.001). Subgroup analyses indicated that risk of breast cancer was also significantly increased in the lowest RTL compared with the highest RTL in age >40 years (OR, 2.41; 95% CI, 1.31–4.43; p=0.005), body mass index ≤24 kg/m2 (OR, 2.81; 95% CI, 1.55–5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63–9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p= 0.011). Conclusion: Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.
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The Development and Experimental Test of a New Pore-forming Grouted Precast Shear Wall Connector
Dongyue Wu,Shuting Liang,Zhenxing Guo,Xiaojun Zhu,Qian Fu 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.4
Pore-forming grouted connection characterized with great economic superiorities and application potentials has weaker mechanical properties comparing to the steel sleeve grouted connector. To improve the mechanical properties of pore-forming grouted connector, the NPGCS was generated using welded closure confinement steels in buckle configuration. Experimental tests and finial element analysis of two NPGCS precast shear wall specimens and one cast-in-situ shear wall specimen was carried out to test mechanical performances. Results indicated that the mechanical properties of NPGCS can match the connection requirements even under the adverse effects from grouted interface gap opening and slip. Contributing to the excessive confinement steels, the mechanical properties of NPGCS specimens are better than that of the cast-in-situ specimen. So, according to the suggestions given out in this paper, the NPGCS can be widely applied into precast buildings in certain areas and conditions.
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Shi Guangli,Sun Dan,Wang Zhenxing,Liu Xiaoying,Guo Jianhui,Zhang Susu,Zhao Ying,Ai Jun 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.4
A high-density genetic map is a prerequisite for marker-assisted selection of crop species. Here, we developed a high-density genetic map of Vitis using 92 F1 progeny derived from the cross between two wine grape cultivars, ‘Shuanghong’ and ‘Italian Riesling’. Whole genome resequencing (WGS) technology was used to generate SNP markers for the map. The map consisted of 1351 recombination bin markers (210,873 SNPs), distributed on 19 linkage groups (LGs), with an average distance of 0.65 cM between adjacent bin markers and a map distance of 860.46 cM. The high levels of uniform coverage and collinearity between the 19 LGs and the grape reference genome indicated that the map is of high quality and can serve as a powerful platform for evaluating grapevines and deciphering the genetic mechanism of important economic and agronomic traits. Our findings will facilitate the process of mapping quantitative trait loci (QTL) that control important horticultural and economic traits of grape.
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