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RISS 인기검색어
- 검색키워드
- 저자 : Zheng Bo Qian (검색결과 5 건)
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CXCL12-CXCR4 Promotes Proliferation and Invasion of Pancreatic Cancer Cells
Shen, Bo,Zheng, Ma-Qing,Lu, Jian-Wei,Jiang, Qian,Wang, Tai-Hong,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Objective: CXCL12 exerts a wide variety of chemotactic effects on cells. Evidence indicates that CXCL12, in conjunction with its receptor, CXCR4, promotes invasion and metastasis of tumor cells. Our objective was to explore whether the CXCL12-CXCR4 biological axis might influence biological behavior of pancreatic cancer cells. Methods: Miapaca-2 human pancreatic cancer cells were cultured under three different conditions: normal medium (control), medium + recombinant CXCL12 (CXCL12 group), or medium + CXCR4-inhibitor AMD3100 (AMD3100 group). RT-PCR was applied to detect mRNA expression levels of CXCL12, CXCR4, matrix metalloproteinase 2 (MMP-2), MMP-9, and human urokinase plasminogen activator (uPA). Additionally, cell proliferation and invasion were performed using CCK-8 colorimetry and transwell invasion assays, respectively. Results: CXCL12 was not expressed in Miapaca-2 cells, but CXCR4 was detected, indicating that these cells are capable of receiving signals from CXCL12. Expression of extracellular matrix-degrading enzymes MMP-2, MMP-9, and uPA was upregulated in cells exposed to exogenous CXCL12 (P<0.05). Additionally, both proliferation and invasion of pancreatic cancer cells were enhanced in the presence of exogenous CXCL12, but AMD3100 intervention effectively inhibited these processes (P<0.05). Conclusions: The CXCL12-CXCR4 biological axis plays an important role in promoting proliferation and invasion of pancreatic cancer cells.
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Cancer Research Advances Regarding the CKLF-like MARVEL Transmembrane Domain Containing Family
Lu, Jia,Wu, Qian-Qian,Zhou, Ya-Bo,Zhang, Kai-Hua,Pang, Bing-Xin,Li, Liang,Sun, Nan,Wang, Heng-Shu,Zhang, Song,Li, Wen-Jian,Zheng, Wei,Liu, Wei Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products act between chemokines and the transmembrane-4 superfamily. Located in several human chromosomes, the CMTMs CKLF and CMTM1 to CMTM8 may be unregulated in tumors and act as potential tumor suppressor genes with important roles in the immune, male reproductive and hematopoietic systems. In-depth studies in recent years established a close relation between CMTMs and tumorigenesis and metastasis. The CMTM family has a significant clinical value in diagnosis and treatment of diseases linked to tumors and the immune system.
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Liu, Wen-Juan,Qian, Lei,Dong, Xiao-Bo,Jiang, Ning,Lira, Paulina,Cai, Zheng,Wang, Feige,Yang, Jinyi,Xiao, Ting,Kim, Minjin American Astronomical Society 2017 The Astrophysical journal Vol.837 No.2
<P>We report the discovery of a 20 kpc sized H alpha emission in SDSS J083803.68+540642.0, a ringed dwarf galaxy (M-V = -17.89 mag) hosting an accreting intermediate-mass black hole at z = 0.02957. Analysis of the Hubble Space Telescope images indicates that it is an early-type galaxy with a featureless low-surface brightness disk (mu(0) = 20.39 mag arcsec(-2) in the V band) and a prominent, relatively red bulge (V - I = 2.03, R-e = 0.28 kpc or 0 48) that accounts for approximate to 81% of the total light in the I band. A circumgalactic ring of a diameter 16 kpc is also detected, with a disperse shape on its south side. The optical emission lines reveal the nucleus to be a broad-line LINER. Our MMT longslit observation indicates that the kinematics of the extended H alpha emission is consistent with a rotational gaseous disk, with a mean blueshifted velocity of 162 km s(-1) and mean redshifted velocity of 86 km s(-1). According to our photoionization calculations, the large-scale H alpha emission is unlikely to be powered by the central nucleus or by hot evolved (post-AGB) stars interspersed in the old stellar populations, but by in situ star formation; this is vindicated by the line-ratio diagnostic of the extended emission. We propose that both the ring and large-scale H alpha-emitting gas are created by the tidal accretion in a collision-and then merger-with a gas-rich galaxy of a comparable mass.</P>
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Liu, Di,Xu, Wen,Zhang, Zhi-Wei,Qian, Ji,Zheng, Hui,Zhang, Jie,Su, Bo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: RB1 (retinoblastoma 1) was reportedly one of the major determinative factors for sensitivity to taxanes in previous studies. In this study, we investigated the influence of RB1 single nucleotide polymorphisms (SNPs) on the efficacy of platinum-taxane regimens in advanced NSCLC patients. Materials and Methods: 234 cases of patients with advanced NSCLC who were treated with first-line platinum-taxane agents were enrolled in this study. Genomic DNA was extracted from patients' peripheral blood samples using a QIAamp DNA Maxi Kit, and genotyped by iSelect HD Bead-Chip. Results: Regression analyses were conducted through the univariate and multivariate Cox proportional hazards model in the 234 patients. The results showed that of the eight RB1 tagSNPs, only rs4151510 was a positive predictive factor for the advanced NSCLC patients treated with platinum taxanes regimen. The patients with G/G genotype of RB rs4151510 had longer overall survival (OS) than the non-G/G genotype (p=0.018). The histology was also correlated with OS in the whole advanced NSCLC patients. Three tagSNPs of RB1, rs4151510, rs4151465, rs9568036 were significantly associated with OS in the advanced NSCLC patients with squamous cell histology using Kaplan-Meier overall survival analysis stratified by histology. Conclusions: RB1 genomic variants were correlated with the efficacy of platinum-taxanes regimen. RB rs4151510 is an independent factor of the prognosis of NSCLC patients receiving platinum-taxane chemotherapy.
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Dan Ni Li,Jing Huang,Zhao Hua Ren,Rui Sheng,Zheng Bo Qian,Bei Bei Li,Xiao Feng Quan,Ye Xi Zhang,Jun Ru Wang,Huan Tian 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
The phase separationphenomena or cloud points (CP) behaviorof nonionic octylphenol polyoxyethylene etherwith oxyethylene glycol ether unit of 15 (OP-15) were investigated in aqueous micellar solutions containinghigh concentrations of inorganic salts including NaCl, KCl, MgCl2, CaCl2, BaCl2, AlCl3, FeCl3, Na2SO4and Na2SiO3. The change in CP induced by salts and its mechanism are discussed theoretically. In aqueous solutionscontaining high concentration of salt, for thefirst time the linear relationship between CP and saltconcentrationiswellestablishedtocharacterizethedepressionofCP.Basedonpseudophaseseparationmodel,thermodynamic parameters are estimated and adopted to further describe the phase separation process andthe interactions between OP-15 molecules or the OP-15/water interactions. Thermodynamic parametersincluding standard Gibbs energy change (DG0CP), enthalpy change (DH0CP) and entropy change (DS0CP)indicate that the additions of different salts result in the change in entropy-driven nonspontaneousprocess of phase separation. These data, which are from the compensation temperatures and the changeof molar heat capacity, also prove that different ions induce the change in the interactions betweensurfactant molecules or the surfactant–water interaction and thus affect the depression of CP. Thesefindings help with understanding the effect of inorganic salts, especially the high concentration of salt, onCP of nonionic surfactant and then broadening the application of nonionic surfactant based on CP such asthe extraction of biomaterials in biological samples derived from animals or plants, etc.
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